H.F. Vischer

dr.

19972019
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Research Output 1997 2019

  • 80 Article
  • 6 Review article
  • 5 Chapter
  • 4 PhD Thesis - Research VU, graduation VU
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Article
2019

A Photoswitchable Agonist for the Histamine H 3 Receptor, a Prototypic Family A G-Protein-Coupled Receptor

Hauwert, N. J., Mocking, T. A. M., Da Costa Pereira, D., Lion, K., Huppelschoten, Y., Vischer, H. F., De Esch, I. J. P., Wijtmans, M. & Leurs, R., 26 Mar 2019, In : Angewandte Chemie - International Edition. 58, 14, p. 4531-4535 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine Agonists
G-Protein-Coupled Receptors
Histamine
Proteins
Chemical activation
Open Access
Histamine H3 Receptors
histamines
Bioluminescence
bioluminescence
Energy Transfer

Identification of Key Structural Motifs Involved in 7 Transmembrane Signaling of Adhesion GPCRs

Arimont Segura, M., van der Woude, M., Leurs, R., Vischer, H. F., de Graaf, C. & Nijmeijer, S., 21 Jan 2019, In : ACS Pharmacology & Translational Science. 2, 2, p. 101-113 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Physiological Phenomena
Drug Design
Molecular Dynamics Simulation
Site-Directed Mutagenesis

Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor

Bosma, R., Stoddart, L. A., Georgi, V., Bouzo-Lorenzo, M., Bushby, N., Inkoom, L., Waring, M. J., Briddon, S. J., Vischer, H. F., Sheppard, R. J., Fernández-Montalván, A., Hill, S. J. & Leurs, R., 1 Dec 2019, In : Scientific Reports. 9, 1, 7906.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
G-Protein-Coupled Receptors
Rate constants
Ligands
Kinetics
Kinetic parameters

Route to prolonged residence time at the histamine H1 receptor: Growing from desloratadine to rupatadine

Bosma, R., Wang, Z., Kooistra, A. J., Bushby, N., Kuhne, S., Van Den Bor, J., Waring, M. J., De Graaf, C., De Esch, I. J., Vischer, H. F., Sheppard, R. J., Wijtmans, M. & Leurs, R., 25 Jul 2019, In : Journal of Medicinal Chemistry. 62, 14, p. 6630-6644 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H1 Receptors
Pharmaceutical Preparations
Amines
Ligands
rupatadine

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

Adlere, I., Sun, S., Zarca, A., Roumen, L., Gozelle, M., Viciano Perpiñá, C., Caspar, B., Arimont, M., Bebelman, J. P., Briddon, S. J., Hoffmann, C., Hill, S. J., Smit, M. J., Vischer, H. F., Wijtmans, M., de Graaf, C., de Esch, I. J. P. & Leurs, R., 15 Jan 2019, In : European Journal of Medicinal Chemistry. 162, p. 631-649 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

CXCR4 Receptors
Quantitative Structure-Activity Relationship
Chemokine Receptors
Screening
Pharmacology
2018

Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells

Stoddart, L. A., Vernall, A. J., Bouzo-Lorenzo, M., Bosma, R., Kooistra, A. J., De Graaf, C., Vischer, H. F., Leurs, R., Briddon, S. J., Kellam, B. & Hill, S. J., 1 Dec 2018, In : Scientific Reports. 8, 1, 1572.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine H1 Antagonists
Histamine H1 Receptors
Cells
Ligands
Kinetics

Homogeneous, Real-Time NanoBRET Binding Assays for the Histamine H3 and H4 Receptors on Living Cells

Mocking, T. A. M., Verweij, E. W. E., Vischer, H. F. & Leurs, R., Dec 2018, In : Molecular pharmacology. 94, 6, p. 1371-1381 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H3 Receptors
Ligands
Histamine Receptors
Energy Transfer
Membranes

Photoswitching the Efficacy of a Small-Molecule Ligand for a Peptidergic GPCR: from Antagonism to Agonism

Gómez-Santacana, X., de Munnik, S. M., Vijayachandran, P., Da Costa Pereira, D., Bebelman, J. P. M., de Esch, I. J. P., Vischer, H. F., Wijtmans, M. & Leurs, R., 3 Sep 2018, In : Angewandte Chemie - International Edition. 57, 36, p. 11608-11612 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Ligands
Molecules
Chemical activation
Electrophysiology
Proteins

Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology

Hauwert, N. J., Mocking, T. A. M., Da Costa Pereira, D., Kooistra, A. J., Wijnen, L. M., Vreeker, G. C. M., Verweij, E. W. E., De Boer, A. H., Smit, M. J., De Graaf, C., Vischer, H. F., De Esch, I. J. P., Wijtmans, M. & Leurs, R., 28 Mar 2018, In : Journal of the American Chemical Society. 140, 12, p. 4232-4243 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine H3 Receptors
G-Protein-Coupled Receptors
Ligands
Proteins
Electrophysiology

The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth

Heukers, R., Fan, T. S., de Wit, R. H., van Senten, J. R., de Groof, T. W. M., Bebelman, M. P., Lagerweij, T., Vieira, J., de Munnik, S. M., Smits-de Vries, L., van Offenbeek, J., Rahbar, A., van Hoorick, D., Söderberg-Naucler, C., Würdinger, T., Leurs, R., Siderius, M., Vischer, H. F. & Smit, M. J., 30 Apr 2018, In : Oncogene. 2018, p. 1-12 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chemokine Receptors
Glioblastoma
Cytomegalovirus
Single-Domain Antibodies
Growth
Open Access
Non-Sedating Histamine H1 Antagonists
Histamine H1 Receptors
fexofenadine
Pharmaceutical Preparations
Pyrilamine
2017

CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome

de Wit, R. H., Heukers, R., Brink, H. J., Arsova, A., Maussang, D., Cutolo, P., Strubbe, B., Vischer, H. F., Bachelerie, F. & Smit, M. J., Oct 2017, In : The Journal of Pharmacology and Experimental Therapeutics. 363, 1, p. 35-44 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Single-Domain Antibodies
Therapeutics
Leukocytes
WHIM syndrome
Antibodies

The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor

Bosma, R., Witt, G., Vaas, L. A. I., Josimovic, I., Gribbon, P., Vischer, H. F., Gul, S. & Leurs, R., 2017, In : Frontiers in Pharmacology. 8, p. 667

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine H1 Receptors
Histamine Antagonists
GTP-Binding Proteins
Pharmaceutical Preparations
Competitive Binding
2016

Adhesion CPCRs in immunology

Nijmeijer, S., Vischer, H. F. & Leurs, R., 2016, In : Biochemical Pharmacology. 114, p. 88-102

Research output: Contribution to JournalArticleAcademicpeer-review

Immunology
Allergy and Immunology
Leukocytes
Adhesion
Membranes

BRET-based beta-arrestin2 recruitmanet to the histamine H1 receptor for investigating antihistamine binding kinetics.

Bosma, R., Moritani, R., Leurs, R. & Vischer, H. F., 2016, In : Pharmacological Research. 111, p. 679-687

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H1 Receptors
Histamine Antagonists
Histamine
Ligands
Pharmaceutical Preparations

Function-specific virual screening for GPCR ligands using a combined scoring method.

Kooistra, A. J., Vischer, H. F., McNaught-Flores, D., Leurs, R., de Esch, I. J. P. & de Graaf, C., 2016, In : Scientific Reports. 2016, 6, 28288.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
G-Protein-Coupled Receptors
Screening
Ligands
Molecular interactions
Histamine

Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.

Kuhne, S., Kooistra, A. J., Bosma, R., Bortolato, A., Wijtmans, M., Vischer, H. F., Mason, J. S., de Graaf, C., de Esch, I. J. P. & Leurs, R., 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9047-9061

Research output: Contribution to JournalArticleAcademicpeer-review

Molecular pharmocology of chemokine receptors.

de Wit, R. H., de Munnik, S. M., Leurs, R., Vischer, H. F. & Smit, M. J., 2016, In : Methods in Enzymology. 570, p. 457-515

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
Chemokines
Ligands
Modulators
Molecules

The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R.

de Munnik, S. M., van der Lee, R., Velders, D. M., van Offenbeek, J., Smits-de Vries, L., Leurs, R., Smit, M. J. & Vischer, H. F., 2016, In : Cellular Signalling. 28, 6, p. 595-605

Research output: Contribution to JournalArticleAcademicpeer-review

Receptor Protein-Tyrosine Kinases
Type C Phospholipases
Viral Proteins
Somatomedins
G-Protein-Coupled Receptors
2015

Combinatorial consensus scoring for ligand-based virtual fragment screening: A comparative case study for serotonin 5-HT3A, histamine H1, and Histamine H4 receptors

Schultes, S., Kooistra, A. J., Vischer, H. F., Nijmeijer, S., Haaksma, E. E. J., Leurs, R., De Esch, I. J. P. & de Graaf, C., 26 May 2015, In : Journal of Chemical Information and Modeling. 55, 5, p. 1030-44 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H1 Receptors
Histamine
Serotonin
Screening
Fusion reactions

Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptor

Istyastono, E. P., Kooistra, A. J., Vischer, H. F., Kuijer, M., Roumen, L., Nijmeijer, S., Smits, R. A., De Esch, I. J. P., Leurs, R. & de Graaf, C., 1 Jun 2015, In : MedChemComm. 6, 6, p. 1003-1017 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine Receptors
GTP-Binding Proteins
Histamine
Screening
Ligands

The viral G protein-coupled receptor ORF74 hijacks β-arrestins for endocytic trafficking in response to human chemokines

De Munnik, S. M., Kooistra, A. J., Van Offenbeek, J., Nijmeijer, S., de Graaf, C., Smit, M. J., Leurs, R. & Vischer, H. F., 20 Apr 2015, In : PLoS ONE. 10, 4, e0124486.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Arrestins
arrestins
Endosomes
Viral Proteins
chemokines
2014

Chemokine cooperativity is caused by competitive glycosaminoglycan binding.

Verkaar, F., van Offenbeek, J., van der Lee, M. M., Lith, L. H., Watts, A. O., Rops, A. L., Aguilar, D. C., Ziarek, J. J., van der Vlag, J., Handel, T. M., Volkman, B. F., Proudfoot, A. E., Vischer, H. F., Zaman, G. J. & Smit, M. J., 2014, In : Journal of Immunology.

Research output: Contribution to JournalArticleAcademicpeer-review

Competitive Binding
Glycosaminoglycans
Chemokines
Inflammation
Chemokine Receptors

Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?

Vischer, H. F., Siderius, M. H., Leurs, R. & Smit, M. J., 2014, (Accepted/In press) In : Nature Reviews Drug Discovery.

Research output: Contribution to JournalArticleAcademicpeer-review

2013

Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode

Engelhardt, H., Schultes, S., de Graaf, C., Nijmeijer, S., Vischer, H. F., Zuiderveld, O. B., Dobler, J., Stachurski, K., Mayer, M., Arnhof, H., Scharn, D., Haaksma, E. J. J., de Esch, I. J. P. & Leurs, R., 2013, In : Journal of Medicinal Chemistry. 2013, 56, p. 4264-4276

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Structure-Activity Relationship
Histamine
Ligands

Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor

Nijmeijer, S., Engelhardt, H., Schultes, S., van de Stolpe, A., Lusink, V., de Graaf, C., Wijtmans, M., Haaksma, E. E., de Esch, I. J. P., Stachurski, K., Vischer, H. F. & Leurs, R., 2013, In : British Journal of Pharmacology. 2013, 170, p. 89-100

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine
Cysteine
Pharmacology
2-aminopyrimidine
4-(4-methylpiperazin-1-yl)-6-phenyl-2-vinylpyrimidine

Detailed analysis of biased histamine H4 receptor signalling by JNJ 7777120 analogues

Nijmeijer, S., Vischer, H. F., Sirci, F., Schultes, S., Engelhardt, H., de Graaf, C., Rosethorne, E., Charlton, S. & Leurs, R., 2013, In : British Journal of Pharmacology. 2013, 170, p. 78-88

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Histamine
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine

Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes

Watts, A. O., van Lipzig, M. M. H., Jaeger, W. C., Seeber, L. M. S., van Zwam, M., Vinet, J., van der Lee, M. M. C., Siderius, M. H., Zaman, G. J., Boddeke, HW., Smit, M. J., Pfleger, K. D., Leurs, R. & Vischer, H. F., 2013, In : British Journal of Pharmacology. 168, 7, p. 1662-1674

Research output: Contribution to JournalArticleAcademicpeer-review

CXC Chemokines
Chemokine Receptors
CC Chemokines
Chemokines
CCR2 Receptors

Inhibition of CXCR3-Mediated Chemotaxis by the Human Chemokine Receptor-like Protein CCX-CKR

Vinet, J., van Zwam, M., Dijkstra, I. M., Brouwer, N., van Weering, H. R. J., Meijer, M., Fokkens, M., Verzijl, D., Watts, A. O., Vischer, H. F., Smit, M. J., Leurs, R., Biber, K. & Boddeke, H. W. G. M., 2013, In : British Journal of Pharmacology. 168, 6, p. 1376-1387

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
Chemotaxis
Chemokines
Cell Migration Inhibition
Proteins

Llama-derived single variable domains (Nanobodies) directed against CXCR7 reduce head and neck cancer cell growth in vivo

Maussang, D., Mujic-Delic, A., Descamps, F. J., Stortelers, C., Stigter-van Walsum, M., Vischer, H. F., van Roy, M., Vosjan, M. J. W. D., Gonzalez-Pajuelo, M., van Dongen, G. A., Merchiers, P., van Rompaey, P. & Smit, M. J., 2013, In : Journal of Biological Chemistry. 288, 41, p. 29562-29572

Research output: Contribution to JournalArticleAcademicpeer-review

Single-Domain Antibodies
New World Camelids
Cell growth
Head and Neck Neoplasms
Growth

Small and colorful stones make beautiful mosaics: Fragment-Based Chemogenomics

de Graaf, C., Vischer, H. F., de Kloe, G. E., Kooistra, A. J., Nijmeijer, S., Kuijer, M., Verheij, M. H. P., England, P., van Muijlwijk-Koezen, J. E., Leurs, R. & de Esch, I. J. P., 2013, In : Drug Discovery Today. 2013, 18, p. 323-330

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Protein Binding
Color
Binding Sites
Proteins

β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR

Watts, A. O., Verkaar, F., van der Lee, M. M. C., Timmerman, C. A. W., Kuijer, M., van Offenbeek, J., van Lith, L. H. J. C., Smit, M. J., Leurs, R., Zaman, G. J. R. & Vischer, H. F., 2013, In : Journal of Biological Chemistry. 288, 10, p. 7169-7181

Research output: Contribution to JournalArticleAcademicpeer-review

Arrestin
Chemokine Receptors
Pertussis Toxin
Chemokines
GTP-Binding Proteins
2012

Analysis of Multiple Histamine H4 Receptor Compound Classes Uncovers Gαi Protein- and β-Arrestin2-Biased Ligands

Nijmeijer, S., Vischer, H. F., Rosethorne, E. M., Charlton, S. J. & Leurs, R., 2012, In : Molecular Pharmacology. 82, 6, p. 1174-1182

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Histamine
Ligands
Proteins

A Prospective Cross-Screening Study on G Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design

Sanders, M. P. A., Roumen, L., van der Horst, E., Lane, J. R., Vischer, H. F., van Offenbeek, J., de Vries, H., Verhoeven, S., Show, K. Y., Verkaar, F., Beukers, M. W., McGuire, R., Leurs, R., IJzerman, A. P., de Vlieg, J., de Esch, I. J. P., Zaman, G. J., Klomp, J. P. G., Bender, A. & de Graaf, C., 2012, In : Journal of Medicinal Chemistry. 8, p. 455-464

Research output: Contribution to JournalArticleAcademicpeer-review

CCR10 Receptors
Digital Libraries
G-Protein-Coupled Receptors
Adenosine
Ligands

Biochemical and pharmacological characterization of the histamine H4 receptor

Nijmeijer, S., de Graaf, C., Leurs, R. & Vischer, H. F., 2012, In : Frontiers in Bioscience. 17, p. 2089-2106

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Histamine
Pharmacology

Constitutive β-catenin signaling by the viral chemokine receptor US28

Langemeijer, E. V., Slinger, E., de Munnik, S. M., Schreiber, A., Maussang, D., Vischer, H. F., Verkaar, F., Leurs, R., Siderius, M. H. & Smit, M. J., 2012, In : PLoS ONE. 7, p. e48935

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Catenins
Chemokine Receptors
colorectal neoplasms
receptors
hepatoma

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling.

Nijmeijer, S., Vischer, H. F., Rudebeck, A. F., Fleurbaaij, F., Falck, D., Leurs, R., Niessen, W. M. A. & Kool, J., 2012, In : Journal of Biomolecular Screening. 17, p. 1329-1338

Research output: Contribution to JournalArticleAcademicpeer-review

Chromatography
Reporter Genes
Mass spectrometry
Assays
Mass Spectrometry

High-resolution metabolic profiling towards G-protein coupled receptors: rapid and comprehensive screening of histamine H4 receptor ligands

Kool, J., Rudebeck, A. F., Fleurbaaij, F., Nijmeijer, S., Falck, D., Smits, R. A., Vischer, H. F., Leurs, R. & Niessen, W. M. A., 2012, In : Journal of Chromatography A. 1259, p. 213-220

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Bioassay
G-Protein-Coupled Receptors
Biological Assay
Histamine
Artificial Receptors
Chemokine Receptors
G-Protein-Coupled Receptors
Electric Impedance
Labels
Histamine Receptors
Histamine
Ligands
Structure-Activity Relationship
Protein Interaction Maps

Mapping histamine H4 receptor-ligand binding modes

Schultes, S., Nijmeijer, S., Engelhardt, H., Kooistra, A. J., Vischer, H. F., De Esch, I. J. P., Haaksma, E. E. J., Leurs, R. & de Graaf, C., 2012, In : MedChemComm. 4, 1, p. 193-204 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Histamine
Ligands
Structure-Activity Relationship
Protein Interaction Maps

Optimizing virtual fragment screening for GPCRs: Identification of novel ligands for the histamine H3 receptor using ligand- and structure-based molecular fingerprints

Sirci, F., Istyastono, E. P., Vischer, H. F., Nijmeijer, S., Kuijer, M., Kooistra, A. J., Wijtmans, M., Mannhold, R., Leurs, R., de Esch, I. J. P. & de Graaf, C., 2012, In : Journal of Chemical Information and Modeling. 52, p. 3308-3324

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H3 Receptors
Screening
Ligands
Molecules
drug

Pharmacological Modulation of Chemokine Receptor Function

Scholten, D. J., Canals, M., Maussang Detaille, D. A. B., Roumen, L., Smit, M. J., Wijtmans, M., de Graaf, C., Vischer, H. F. & Leurs, R., Mar 2012, In : British Journal of Pharmacology. 165, 6, p. 1617-1643 27 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Chemokine Receptors
Pharmacology
Ligands
HIV Infections
HIV-1
2011

Crystal structure-based virtual screening for novel fragment-like ligands of the human histamine H1 receptor

de Graaf, C., Kooistra, A. J., Vischer, H. F., Katritch, V., Kuijer, M., Shiroishi, M., Shimamura, T., Iwata, S., Stevens, R. C., de Esch, I. J. P. & Leurs, R., 2011, In : Journal of Medicinal Chemistry. 54, p. 8195-81206 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H1 Receptors
G-Protein-Coupled Receptors
Histamine
Ligands
Proteins

En route to new blockbuster antihistamines:surveying the offspring of the expanding histamine receptor family

Leurs, R., Vischer, H. F., Wijtmans, M. & De Esch, I. J., 2011, In : Trends in Pharmacological Sciences. 32, p. 250

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Histamine Antagonists
Surveying
G-Protein-Coupled Receptors
Histamine

fragment library screening reveals remarkable similarities between histamine H4 receptors and serotonin 5-HT3 receptors

Verheij, M. H. P., de Graaf, C., de Kloe, G. E., Nijmeijer, S., Vischer, H. F., Smits, R. A., Zuiderveld, O. P., Thompson, A. J., van Muijlwijk- Koezen, J. E., Lummis, S. C. R., Leurs, R. & De Esch, I. J., 2011, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Receptors, Serotonin, 5-HT3
Histamine Receptors
GTP-Binding Proteins
Histamine
Screening

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A

Verheij, M. H. P., de Graaf, C., de Kloe, G. E., Nijmeijer, S., Vischer, H. F., Smits, R. A., Zuiderveld, O. P., Hulscher, T. M., Silvestri, A., Thompson, A. J., van Muijlwijk-Koezen, J. E., Lumnis, S. C. R., Leurs, R. & de Esch, I. J. P., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, p. 5460-5464

Research output: Contribution to JournalArticleAcademicpeer-review

G-protein-coupled receptors: walking hand-in-hand, talking hand-in-hand?

Vischer, H. F., Watts, A. O., Nijmeijer, S. & Leurs, R., 2011, In : British Journal of Pharmacology. p. 163-246

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Walking
Pharmacology
Ligands
Protein Subunits

Molecular determinants of ligand binding modes in the histamine H4 receptor: Linking ligand-based 3D-QSAR models to in silico guided receptor mutagenesis studies

Istyastono, E. P., Nijmeijer, S., Lim, H. D., van de Stolpe, A., Roumen, L., Kooistra, A. J., Vischer, H. F., de Esch, I. J. P., Leurs, R. & de Graaf, C., 2011, In : Journal of Medicinal Chemistry. 54, p. 8136-8147 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Quantitative Structure-Activity Relationship
Mutagenesis
Computer Simulation
Histamine