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Huib Mansvelder received his PhD in Neurophysiology from the Vrije Universiteit Amsterdam in 1999. In his thesis, he investigated the control of large dense-core vesicle release by voltage-gated calcium channels in neuroendocrine cells in the pituitary. During his postdoctoral research with Dan McGehee at the University of Chicago, he studied drug-induced synaptic plasticity in dopamine neurons, and found mechanisms by which nicotinic receptors alter glutamatergic and GABAergic synaptic transmission in the VTA. During his second postdoc at Columbia University New York with Rafael Yuste, rapid calcium dynamics in dendritic spines were studied using 2photon imaging. In the summer of 2002, Huib started his own lab at VU University in Amsterdam. He became full professor in 2008 and heads the department of Integrative Neurophysiology since. His research focuses on how the prefrontal cortex orchestrates attention behaviour in rodents, in particular in interaction with subcortical brain areas, such as the basal forebrain. In addition, his lab investigates how neuronal microcircuits in the human neocortex are organized, both anatomically as well as functionally, and how properties of human neurons relate to human cognition.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Astrocyte-specific deletion of LRRC8A causes neurological dysfunction but not chronic white matter edema
Kerst, S., Hoogterp, L., Breur, M., van Rooijen-van Leeuwen, G. M., Bugiani, M., Sah, R., Mansvelder, H. D., van der Knaap, M. S. & Min, R., Mar 2026, In: Neurobiology of Disease. 220, p. 1-11 11 p., 107313.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Altered Mechanical Properties of Astrocytes Lacking MLC1: Implications for the Leukodystrophy MLC
Bisseling, Q., Passchier, E. M. J., Kirwan, F. M., Antonovaite, N., Camerini, S., Brignone, M. S., Freal, A., Mansvelder, H. D., Ambrosini, E., van der Knaap, M. S. & Min, R., Feb 2026, In: Glia. 74, 2, p. 1-18 18 p., e70104.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Basic Science and Pathogenesis
Dougalis, A., Abushik, P., Pelkonen, A., Giudice, L., Gomez-Budia, M., Novosolova, N., Välimäki, N. N., Rezaie, M., Nurkhametova, D., Giniatullina, R., Shakirzyanova, A., Mali, A., de Kock, C. P., Mertens, E. J., Mansvelder, H. D., Stevens, B., Macosko, E., Hiltunen, M., Rauramaa, T. & Leinonen, V. & 1 others, , Dec 2025, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 21, 2 p., e097565.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
What makes the human brain special: from cellular function to clinical translation
van Loo, K. M. J., Bak, A., Hodge, R., Bedogni, F., Ramirez, J. S. B., Emerson, S. N., Höllig, A., Mansvelder, H. D., Goriounova, N. A., Ramirez, J. M. & Koch, H., Oct 2025, In: Journal of Neurophysiology. 134, 4, p. 1197-1213 17 p.Research output: Contribution to Journal › Review article › Academic › peer-review
Open Access -
Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts
Kerst, S., Meesters, N., Heistek, T. S., van der Knaap, M. S., Mansvelder, H. D. & Min, R., Sept 2025, In: Glia. 73, 9, p. 1899-1909 11 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access
Courses
Activities
- 1 Membership
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De Jonge Akademie, KNAW (External organisation)
Mansvelder, H. (Member)
1 Apr 2006 → 1 Apr 2011Activity: Membership › Academic
Datasets
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Data from: High bandwidth synaptic communication and frequency tracking in human neocortex
Testa-Silva, G. (Contributor), Verhoog, M. B. (Contributor), Linaro, D. (Contributor), De Kock, C. P. J. (Contributor), Baayen, J. C. (Contributor), Meredith, R. M. (Contributor), De Zeeuw, C. I. (Contributor), Giugliano, M. (Contributor) & Mansvelder, H. D. (Contributor), Unknown, 1 Jan 2014
DOI: 10.5061/dryad.3723p, http://datadryad.org/stash/dataset/doi:10.5061/dryad.3723p
Dataset / Software: Dataset
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Data from: Large and fast human pyramidal neurons associate with intelligence
Goriounova, N. A. (Contributor), Heyer, D. B. (Contributor), Wilbers, R. (Contributor), Verhoog, M. B. (Contributor), Giugliano, M. (Contributor), Verbist, C. (Contributor), Obermayer, J. (Contributor), Kerkhofs, A. (Contributor), Smeding, H. (Contributor), Verberne, M. (Contributor), Idema, S. (Contributor), Baayen, J. C. (Contributor), Pieneman, A. W. (Contributor), de Kock, C. P. J. (Contributor), Klein, M. (Contributor) & Mansvelder, H. D. (Contributor), Zenodo, 2018
DOI: 10.5061/dryad.83dv5j7, https://zenodo.org/record/4983466
Dataset / Software: Dataset
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Data from: Large and fast human pyramidal neurons associate with intelligence
Goriounova, N. A. (Contributor), Heyer, D. B. (Contributor), Wilbers, R. (Contributor), Verhoog, M. B. (Contributor), Giugliano, M. (Contributor), Verbist, C. (Contributor), Obermayer, J. (Contributor), Kerkhofs, A. (Contributor), Smeding, H. (Contributor), Verberne, M. (Contributor), Idema, S. (Contributor), Baayen, J. C. (Contributor), Pieneman, A. W. (Contributor), De Kock, C. P. (Contributor), Klein, M. (Contributor) & Mansvelder, H. D. (Contributor), Unknown, 1 Jan 2018
DOI: 10.5061/dryad.83dv5j7, http://datadryad.org/stash/dataset/doi:10.5061/dryad.83dv5j7
Dataset / Software: Dataset
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Data from: High bandwidth synaptic communication and frequency tracking in human neocortex
Testa-Silva, G. (Contributor), Verhoog, M. B. (Contributor), Linaro, D. (Contributor), de Kock, C. P. J. (Contributor), Baayen, J. C. (Contributor), Meredith, R. M. (Contributor), De Zeeuw, C. I. (Contributor), Giugliano, M. (Contributor) & Mansvelder, H. D. (Contributor), Zenodo, 2015
DOI: 10.5061/dryad.3723p, https://zenodo.org/record/4969716
Dataset / Software: Dataset
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Data from: High bandwidth synaptic communication and frequency tracking in human neocortex
Giugliano, M. (Contributor), Testa-Silva, G. (Contributor), Mansvelder, H. D. (Contributor), de Zeeuw, C. I. (Contributor), Verhoog, M. B. (Contributor), Baayen, J. C. (Contributor), Linaro, D. (Contributor), de Kock, C. P. J. (Contributor) & Meredith, R. M. (Contributor), Unknown, 23 Oct 2015
DOI: 10.5061/dryad.3723p, https://zenodo.org/record/4969716
Dataset / Software: Dataset