prof. dr. I.J.P. de Esch

prof. dr.

19972019
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Research Output 1997 2019

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Review article
2019

The Landscape of Atypical and Eukaryotic Protein Kinases

Kanev, G. K., de Graaf, C., de Esch, I. J. P., Leurs, R., Würdinger, T., Westerman, B. A. & Kooistra, A. J., Nov 2019, In : Trends in Pharmacological Sciences. 40, 11, p. 818-832 15 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Protein Kinases
Phosphotransferases
Spine
Single Nucleotide Polymorphism
Tumors
2018

When fragments link: a bibliometric perspective on the development of fragment-based drug discovery

Romasanta, A. K. S., van der Sijde, P., Hellsten, I., Hubbard, R. E., Keseru, G. M., van Muijlwijk-Koezen, J. & de Esch, I. J. P., Sep 2018, In : Drug Discovery Today. 23, 9, p. 1596-1609 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Bibliometrics
Drug Discovery
Authorship
Pharmaceutical Chemistry
Physics
2017

Structural Analysis of Chemokine Receptor-Ligand Interactions

Arimont, M., Sun, S-L., Leurs, R., Smit, M., De Esch, I. J. P. & de Graaf, C., 22 Jun 2017, In : Journal of Medicinal Chemistry. 60, 12, p. 4735-4779 45 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Chemokine Receptors
Ligands
Molecular Models
Structure-Activity Relationship
Site-Directed Mutagenesis
2011

Molecular determinants of selective agonist and antagonist binding to the histamine H₄ receptor

Istyastono, E. P., de Graaf, C., de Esch, I. J. P. & Leurs, R., 2011, In : Current Topics in Medicinal Chemistry. 11, 6, p. 661-79 19 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Histamine Receptors
Ligands
Structure-Activity Relationship
Computer Simulation
Histamine
2009

A new generation of anti-histamines: Histamine H4 receptor antagonists on their way to the clinic

Engelhardt, H., Smits, R. A., Leurs, R., Haaksma, E. & de Esch, I. J. P., Sep 2009, In : Current Opinion in Drug Discovery and Development. 12, 5, p. 628-643 16 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Histamine Receptors
Histamine
Ligands
Drug Industry
Human Genome
2006

The emerging role of the histamine H4 receptor in anti-inflammatory therapy

Lim, H. D., Smits, R. A., Leurs, R. & De Esch, I. J. P., 2006, In : Current Topics in Medicinal Chemistry. 6, 13, p. 1365-73 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Histamine Receptors
Histamine Antagonists
Histamine
Anti-Inflammatory Agents
Ligands
G-Protein-Coupled Receptors
Viruses
Pharmaceutical Preparations
Virus Receptors
Human Herpesvirus 8
2004

Histamine H3 receptor agonists

De Esch, I. J. P. & Belzar, K. J., Nov 2004, In : Mini-Reviews in Medicinal Chemistry. 4, 9, p. 955-63 9 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Histamine Agonists
Protein Isoforms
Ligands