Jacqueline van Muijlwijk-Koezen

prof.dr.

19982019
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Research Output 1998 2019

2019

From Insight to Modulation of CXCR4 and ACKR3 (CXCR7) Function

Smit, M. J. & van Muijlwijk-Koezen, J. E., 1 Dec 2019, In : Molecular pharmacology. 96, 6, p. 735-736 2 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chemokine Receptors
Immunologic Receptors
Neoplasms
G-Protein-Coupled Receptors
Phosphorylation
2018

Onderzoek & onderwijs: van OΙ2 naar O2

van Muijlwijk-Koezen, J. E., 16 Mar 2018, Amsterdam: Vrije Universiteit Amsterdam. 28 p.

Research output: Book / ReportInaugural speechProfessional

Open Access
File

When fragments link: a bibliometric perspective on the development of fragment-based drug discovery

Romasanta, A. K. S., van der Sijde, P., Hellsten, I., Hubbard, R. E., Keseru, G. M., van Muijlwijk-Koezen, J. & de Esch, I. J. P., Sep 2018, In : Drug Discovery Today. 23, 9, p. 1596-1609 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Bibliometrics
Drug Discovery
Authorship
Pharmaceutical Chemistry
Physics
2015

Exploration of the Molecular Architecture of the Orthosteric Binding Site in the 42 Nicotinic Acetylcholine Receptor with Analogs of 3-(Dimethylamino)butyl Dimethylcarbamate (DMABC) and 1-(Pyridin-3-yl)-1,4-diazepane

Bach, T. T., Jensen, A. A., Petersen, J. G., Sørensen, T. E., Della Volpe, S., Liu, J., Blaazer, A. R., van Muijlwijk-Koezen, J. E., Balle, T. & Frølund, B., 2015, In : European Journal of Medicinal Chemistry. 102, p. 425-444

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2014

Activating students' interest in lectures and practical courses using their electronic devices

Wijtmans, M., van Rens, L. & van Muijlwijk- Koezen, J. E., 2014, In : Journal of Chemical Education. 91, 11, p. 1830-1837

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
electronics
Students
Teaching
student
teaching program
2013

Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands

Thompson, A. J., Verheij, M. H. P., van Muijlwijk-Koezen, J. E., Lummis, S. C. R., Leurs, R. & de Esch, I., Jun 2013, In : ChemMedChem. 8, 6, p. 946-955 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Quinoxalines
Structure-Activity Relationship
Ligands
Granisetron
Binding Sites
2012

Design, Synthesis, and Structure-Activity Relationships of Highly Potent 5-HT(3) Receptor Ligands

Verheij, M. H. P., Thompson, A. J., van Muijlwijk-Koezen, J. E., Lumnis, S. C. R., Leurs, R. & de Esch, I. J. P., 2012, In : Journal of Medicinal Chemistry. 55, p. 8603-8614

Research output: Contribution to JournalArticleAcademicpeer-review

Ligand-, Structure-and Pharmacophore-based Molecular Fingerprints: A Case Study on Adenosine A1, A2A, A2B, and A3 Receptor Antagonists

Sirci, F., Goracci, L., van Muijlwijk-Koezen, J. E., Gutiérrez-de-Terán, H., Rodriguez, D. & Mannhold, R., Nov 2012, In : Journal of Computer-aided Molecular Design. 26, 11, p. 1247-1266 20 p.

Research output: Contribution to JournalArticleAcademicpeer-review

adenosines
Dermatoglyphics
Adenosine
Purinergic P1 Receptors
Ligands

Quinazolines and (iso)quinolines as potent 5HT3 ligands

van Muijlwijk-Koezen, J. E., Verheij, M. H. P., Thompson, A. J., Smit, A. B., Lumnis, S. C. R., Leurs, R. & de Esch, I. J. P., 24 Sep 2012, In : Journal of Medicinal Chemistry. 55, 20, p. 8603-8614 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Quinolines
Quinazolines
Receptors, Serotonin, 5-HT3
Granisetron
Ligands

Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein

Edink, E. S., Akdemir, A., Jansen, C. J. W., van Elk, R., Zuiderveld, O. P., de Kanter, F. J. J., van Muijlwijk- Koezen, J. E., Smit, A. B., Leurs, R. & de Esch, I. J. P., 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 3, p. 1448-1454 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Benzoates
Nicotinic Receptors
Structure-Activity Relationship
Acetylcholine
Carrier Proteins
2011

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis

Edink, E. S., Rucktooa, P., Retra, K., Akdemir, A., Nahar, T. T., Zuiderveld, O. P., van Elk, R., Janssen, E., van Nierop, P., van Muijlwijk-Koezen, J. E., Smit, A. B., Sixma, T. K., Leurs, R. & de Esch, I. J. P., 15 Feb 2011, In : Journal of the American Chemical Society. 133, 14, p. 5363-5371 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Thermodynamics
Acetylcholine
Carrier Proteins
Ligands
Cysteine Loop Ligand-Gated Ion Channel Receptors

fragment library screening reveals remarkable similarities between histamine H4 receptors and serotonin 5-HT3 receptors

Verheij, M. H. P., de Graaf, C., de Kloe, G. E., Nijmeijer, S., Vischer, H. F., Smits, R. A., Zuiderveld, O. P., Thompson, A. J., van Muijlwijk- Koezen, J. E., Lummis, S. C. R., Leurs, R. & De Esch, I. J., 2011, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Receptors, Serotonin, 5-HT3
Histamine Receptors
GTP-Binding Proteins
Histamine
Screening

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A

Verheij, M. H. P., de Graaf, C., de Kloe, G. E., Nijmeijer, S., Vischer, H. F., Smits, R. A., Zuiderveld, O. P., Hulscher, T. M., Silvestri, A., Thompson, A. J., van Muijlwijk-Koezen, J. E., Lumnis, S. C. R., Leurs, R. & de Esch, I. J. P., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, p. 5460-5464

Research output: Contribution to JournalArticleAcademicpeer-review

Online parallel fragment screening and rapid hit exploration for nicotinic acetylcholine receptors.

de Kloe, G. E., Kool, J., van Elk, R., van Muijlwijk-Koezen, J. E., Smit, A. B., Lingeman, H., Irth, H., Niessen, W. M. A. & de Esch, I. J. P., 2011, In : MedChemComm. 2, p. 590-595

Research output: Contribution to JournalArticleAcademicpeer-review

Nicotinic Receptors
Screening
Proteins
Throughput
Injections

Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholinebinding protein

Edink, E. S. E., Akdemir, A., Jansen, C. J. W., van Elk, R., Zuiderveld, O. P., de Kanter, F. J. J., van Muijlwijk-Koezen, J. E., Smit, A. B., Leurs, R. & de Esch, I. J. P., 2011, In : Bioorganic and Medicinal Chemistry Letters. 22, p. 1448-1454

Research output: Contribution to JournalArticleAcademicpeer-review

Upper Secondary Chemistry Students in a Pharmacochemistry Research Community

van Rens, L., van Muijlwijk, J., Beishuizen, J. J. & van der Schee, J. A., 2011, In : International Journal of Science Education. 35, 6, p. 1012-1036

Research output: Contribution to JournalArticleAcademicpeer-review

chemistry
community
student
participation
allergy
2010

Medicijnen-van Molecuul tot Mens: Natuur, Leven en Technologie, vwo 5,6. domein F, Biomedische technologie en biotechnologie

Rongen, G., Gijzen, E., Mesman, H., Hoogvliet, M., Wal, M. & van Muijlwijk-Koezen, J. E., 2010, stuurgroep NLT. 111 p.

Research output: Book / ReportBookProfessional

Surface Plasmon Resonance biosensor analysis as a useful tool in FBDD

Retra, K., Irth, H. & van Muijlwijk- Koezen, J. E., Oct 2010, In : Drug Discovery Today: Technologies. 7, 3, p. e181-e187 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Surface Plasmon Resonance
Biosensing Techniques
Drug Discovery
Thermodynamics
Solubility

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

de Kloe, G. E., Retra, K., Geitmann, M., Kallblad, B., Nahar, T. T., van Elk, R., Smit, A. B., van Muijlwijk- Koezen, J. E., Leurs, R., Irth, H., Danielson, U. H. & de Esch, I. J. P., 9 Sep 2010, In : Journal of Medicinal Chemistry. 53, 19, p. 7192-7201 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Surface Plasmon Resonance
Nicotinic Receptors
Biosensing Techniques
Acetylcholine
Carrier Proteins
2008

A community of researchers

van Rens, L., Harms, N., van Muijlwijk-Koezen, J. E. & Beishuizen, J. J., 2008, Paper presented at ESERA. Malmö

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademic

2002

Modulation of agonist responses at the A(1) adenosine receptor by an irreversible antagonist, receptor-G protein uncoupling and by the G protein activation state.

Lorenzen, A., Beukers, M. W., van der Graaf, P. H., Lang, H., van Muijlwijk-Koezen, J. E., de Groote, M., Menge, W. M. P. B., Schwabe, U. & AP., IJ., 2002, In : Biochemical Pharmacology. 64, p. 1251-1265

Research output: Contribution to JournalArticleAcademicpeer-review

2001

Allosteric modulation of A(3) adenosine receptors by a series of 3-(2-pyridinyl)isoquinoline derivatives. Mol. Pharmacol

Gao, Z. G., van Muijlwijk-Koezen, J. E., Chen, A., Müller, C. E., IJzerman, A. P. & Jacobson, K. A., 2001, In : Molecular Pharmacology. 60, p. 1057-1063

Research output: Contribution to JournalArticleAcademicpeer-review

antagonists for the human adenosine A3 receptor

van Muijlwijk-Koezen, J. E., 2001

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'receptor knock-down' tool

van Muijlwijk- Koezen, J. E., Timmerman, H., van der Sluis, RP., van de Stolpe, A., Menge, W. M. P. B., Beukers, M. W., Graaf, PW., de Groote, M. & AP., IJ., 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, p. 815-818

Research output: Contribution to JournalArticleAcademicpeer-review

Adenosine

Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a ‘receptor knock-down’ tool

van Muijlwijk-Koezen, J. E., Timmerman, H., van der Sluis, RP., Stolpe, A. C., Menge, W. M. P. B., Beukers, M. W., van der Graaf, P. H., de Groote, M. & IJzerman, A. P., 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, p. 815-818

Research output: Contribution to JournalArticleAcademicpeer-review

The Adenosine A3 Receptor and its Ligands

van Muijlwijk-Koezen, J. E., Timmerman, H. & IJzerman, A. P., 2001, In : Progress in medicinal chemistry. 38, p. 61-113

Research output: Contribution to JournalArticleAcademicpeer-review

Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists

van Muijlwijk-Koezen, J. E., Timmerman, H., Vollinga, R. C., Frijtag von Drabbe Kunzel, F., de Groote, M., Visser, S. & AP., IJ., 2001, In : Journal of Medicinal Chemistry. 44, p. 749-762

Research output: Contribution to JournalArticleAcademicpeer-review

2000

Isoquinoline and quinazoline urea analogues as antagonists for the Human Adenosine A3 receptor

van Muijlwijk-Koezen, J. E., Timmerman, H., van der Goot, H., Menge, W. M. P. B., Frijtag von Drabbe Kunzel, F., de Groot, M. & IJzerman, A. P., 2000, In : Journal of the American Chemical Society.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
1999

Medicinal Chemistry of the Human Adenosine A3 Receptor.

Tilburg, E. W., van Muijlwijk-Koezen, J. E. & IJzerman, A. P., 1999, In : Drug Development Research. 45, p. 182-189

Research output: Contribution to JournalArticleAcademicpeer-review

1998

A novel class of adenosine A3 receptor ligands. 1.3-(2-Pyridinyl)isoquinoline derivatives.

van Muijlwijk-Koezen, J. E., Timmerman, H., Link, R., van der Goot, H. & IJzerman, A. P., 1998, In : Journal of Medicinal Chemistry. 41, p. 3987-3993

Research output: Contribution to JournalArticleAcademicpeer-review

Adenosine A3 Receptors
Adenosine
Ligands
isoquinoline
Isoquinolines
Adenosine A3 Receptors
Quinazolines
Adenosine
Ligands