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Dr. Jessica Legradi works as an assistant Professor at the department Environment and Health. She teaches toxicology at BSc and MSc level at the VU. Her research focuses on studying the toxicological effects of environmental contaminants using zebrafish embryos (Danio rerio). She identifies mechanisms of toxicity of environmental pollutants and develops new specific bioassays also applicable for chemical toxicity screening. Within several European projects she characterized the toxic potential and identified the mechanisms of toxicity of different chemicals found in the environment. Therefore she applied and adapted state of the art genomics, proteomics and metabolomics technologies. Moreover, she worked on biological test systems that can guide contaminant detection in complex environmental samples by combining bioassays with analytical chemical analysis methods (EDA). During the last years she developed a strong interest for  behavioural testing and neurotoxicity.

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Research Output 2007 2019

Effects of 25 thyroid hormone disruptors on zebrafish embryos: A literature review of potential biomarkers

Spaan, K., Haigis, A. C., Weiss, J. & Legradi, J., 15 Mar 2019, In : Science of the Total Environment. 656, p. 1238-1249 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Biomarkers
Thyroid Hormones
literature review
hormone
biomarker

An ecotoxicological view on neurotoxicity assessment

Legradi, J. B. , Di Paolo, C. , Kraak, M. H. S. , van der Geest, H. G. , Schymanski, E. L. , Williams, A. J. , Dingemans, M. M. L. , Massei, R. , Brack, W. , Cousin, X. , Begout, M. L. , van der Oost, R. , Carion, A. , Suarez-Ulloa, V. , Silvestre, F. , Escher, B. I. , Engwall, M. , Nilén, G. , Keiter, S. H. , Pollet, D. & 18 others Waldmann, P., Kienle, C., Werner, I., Haigis, A. C., Knapen, D., Vergauwen, L., Spehr, M., Schulz, W., Busch, W., Leuthold, D., Scholz, S., vom Berg, C. M., Basu, N., Murphy, C. A., Lampert, A., Kuckelkorn, J., Grummt, T. & Hollert, H., 14 Dec 2018, In : Environmental Sciences Europe. 30, p. 1-34 34 p., 46

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Risk assessment
Ecosystems
Assays
Online systems
Screening

Combining ex-ante LCA and EHS screening to assist green design: A case study of cellulose nanocrystal foam

Tan, L., Mandley, S. J., Peijnenburg, W., Waaijers-van der Loop, S. L., Giesen, D., Legradi, J. B. & Shen, L., 3 Jan 2018, In : Journal of Cleaner Production. 178, p. 494-506 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
health and safety
foam
Nanocrystals
Foams
cellulose

Time-Integrative Passive sampling combined with TOxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment

Hamers, T., Legradi, J., Zwart, N., Smedes, F., de Weert, J., van den Brandhof, E. J., van de Meent, D. & de Zwart, D., Dec 2018, In : Environmental Toxicology and Pharmacology. 64, p. 48-59 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Water Quality
Rivers
Water quality
Toxicity
Sampling

Bisphenol A alternatives in thermal paper from the Netherlands, Spain, Sweden and Norway. Screening and potential toxicity

Björnsdotter, M. K., Jonker, W., Legradi, J., Kool, J. & Ballesteros-Gómez, A., 1 Dec 2017, In : Science of the Total Environment. 601-602, p. 210-221 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Toxicity
Screening
Liquid chromatography
Impurities
toxicity

Activities 2014 2017

  • 12 Lecture / Presentation
  • 2 Workshop
  • 2 PhD thesis examination

How to assess neurotoxicity

Legradi, J. B. (Speaker)
13 Nov 2017

Activity: Lecture / PresentationAcademic

SETAC

Legradi, J. B. (Chair)
11 May 2017

Activity: Participating in or organising an eventWorkshopAcademic

ZEBRAFISH AS A MODEL TO IDENTIFY THE TOXICITY OF COMPOUNDS

Legradi, J. B. (Examiner)
19 Sep 2017

Activity: PhD thesis ExaminationPhD thesis examination

Application of novel omics tools for zebrafish (neuro-) toxicological research

Legradi, J. B. (Speaker)
12 Apr 2017

Activity: Lecture / PresentationAcademic