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After his Molecular Sciences study in Wageningen, Chris Vos obtained his PhD degree from the UvA based on research performed at the European Molecular Biology Laboratory (EMBL) at Heidelberg, Germany in the group of Henk Stunnenberg (1986-1990), where he studied transcription regulation in vaccinia virus. Then he moved to the Netherlands Cancer Institute (Amsterdam) where he had two post-doc positions, first in the group of Ronald Plasterk on DNA transposition in Ceanorabditis elegans and second in the group of Sjaak Neefjes on the structure of the transporter associated with antigen presentation (TAP). In 2000, he became lecturer at the Vrije Universiteit in the Biochemistry division headed by Prof. Raué investigating the biogenesis of ribosomes in Saccharomyces cerevisiae.  Later, he joined the Molecular Toxicology division headed by Prof. Vermeulen focusing on drug metabolism and drug-induced cellular responses. He has coordinated scientific activities at VU University in the context of ASAT, the IMI-JU MIP-DILI project on characterization of cellular model systems and the educational IMI-JU SafeSciMET project. Currently, he is programme director for BSc Farmaceutische wetenschappen and MSc Drug Discovery and Safety. As a lecturer, he covers topics in Biochemistry, Molecular Biology and Toxicology.

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  • 8 Similar Profiles
Saccharomyces cerevisiae Medicine & Life Sciences
RNA Precursors Medicine & Life Sciences
Cytochrome P-450 Enzyme System Medicine & Life Sciences
Yeast Chemical Compounds
Yeasts Medicine & Life Sciences
Toxicity Chemical Compounds
Diclofenac Medicine & Life Sciences
Metabolites Chemical Compounds

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Research Output 1987 2019

  • 49 Article
  • 6 PhD Thesis - Research VU, graduation VU

Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?

Ortega Ugalde, S., Boot, M., Commandeur, J. N. M., Jennings, P., Bitter, W. & Vos, J. C., 2 May 2019, In : Applied Microbiology and Biotechnology. 103, 9, p. 3597-3614 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium tuberculosis
Cytochrome P-450 Enzyme System
Oxidation-Reduction
Pharmaceutical Preparations
Ferredoxins

Mistaken identity: Paracetamol induces amino acid starvation through mimicry of tyrosine and changes ubiquitin homeostasis

Huseinovic, A., 2019, 202 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion

Huseinovic, A., Dekker, S. J., Boogaard, B., Vermeulen, N. P. E., Kooter, J. M. & Vos, J. C., Oct 2018, In : Amino Acids. 50, 10, p. 1377-1390 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Amino Acid Transport Systems
Acetaminophen
Tryptophan
Proteins
Yeast

A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants

Luirink, R. A., Dekker, S. J., Capoferri, L., Kuiper, C. L., Janssen, L. F. H., Ari, M. E., Vermeulen, N. P. E., Vos, J. C., Commandeur, J. N. M. & Geerke, D. P., Jul 2018, In : Journal of Inorganic Biochemistry. 184, p. 115-122 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Floxacillin
Hydroxylation
Cytochrome P-450 Enzyme System
Metabolites
Enzymes
Open Access
File

Activities 2001 2001

  • 2 Lecture / Presentation

alternative RNA processing in its 1 requires RNa family member rex4p

J.C. Vos (Speaker), E.A. Eppens (Speaker), A.W. Faber (Speaker), H.A. Raue (Speaker)
31 May 2001

Activity: Lecture / PresentationAcademic

Cis-acting elements involved in 3' end formation of 18S rRNA

T.H. Geerlings (Speaker), C.A. van Beekvelt (Speaker), H.A. Raue (Speaker), J.C. Vos (Speaker)
30 May 2001

Activity: Lecture / PresentationAcademic