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Research Output 1987 2019

  • 49 Article
  • 6 PhD Thesis - Research VU, graduation VU
2019

Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?

Ortega Ugalde, S., Boot, M., Commandeur, J. N. M., Jennings, P., Bitter, W. & Vos, J. C., 2 May 2019, In : Applied Microbiology and Biotechnology. 103, 9, p. 3597-3614 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium tuberculosis
Cytochrome P-450 Enzyme System
Oxidation-Reduction
Pharmaceutical Preparations
Ferredoxins

Mistaken identity: Paracetamol induces amino acid starvation through mimicry of tyrosine and changes ubiquitin homeostasis

Huseinovic, A., 2019, 202 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2018

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion

Huseinovic, A., Dekker, S. J., Boogaard, B., Vermeulen, N. P. E., Kooter, J. M. & Vos, J. C., Oct 2018, In : Amino Acids. 50, 10, p. 1377-1390 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Amino Acid Transport Systems
Acetaminophen
Tryptophan
Proteins
Yeast

A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants

Luirink, R. A., Dekker, S. J., Capoferri, L., Kuiper, C. L., Janssen, L. F. H., Ari, M. E., Vermeulen, N. P. E., Vos, J. C., Commandeur, J. N. M. & Geerke, D. P., Jul 2018, In : Journal of Inorganic Biochemistry. 184, p. 115-122 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Floxacillin
Hydroxylation
Cytochrome P-450 Enzyme System
Metabolites
Enzymes
Open Access
File

Drug induced liver injury: assessment of inter-individual variation in the balance of bioactivation and inactivation as risk factor

den Braver, M. W., 2018, 288 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine

Huseinovic, A., van Dijk, M., Vermeulen, N. P. E., van Leeuwen, F., Kooter, J. M. & Vos, J. C., Mar 2018, In : Toxicology in Vitro. 47, p. 259-268 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Acetaminophen
Drug-Related Side Effects and Adverse Reactions
Yeast
Toxicity
Saccharomyces cerevisiae

Glutathione S-transferase P1 protects against Amodiaquine Quinoneimines-induced cytotoxicity but does not prevent activation of endoplasmic reticulum stress in HepG2 cells

Zhang, Y., den Braver-Sewradj, S. P., den Braver, M. W., Hiemstra, S., Vermeulen, N. P. E., van de Water, B., Commandeur, J. N. M. & Vos, J. C., 18 Apr 2018, In : Frontiers in Pharmacology. 9, APRIL, p. 1-13 13 p., 388.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Endoplasmic Reticulum Stress
Hep G2 Cells
Amodiaquine
Glutathione Transferase
Glutathione

Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 Individuals

den Braver-Sewradj, S. P., den Braver, M. W., van Dijk, M., Zhang, Y., Dekker, S. J., Wijaya, L., Vermeulen, N. P. E., Richert, L., Commandeur, J. N. M. & Vos, J. C., 8 Jan 2018, In : Current Drug Metabolism. 19, 4

Research output: Contribution to JournalArticleAcademicpeer-review

Liver
Glucuronosyltransferase
Oxidoreductases
Cytochromes
Glutathione Transferase

Inter-individual variation in hepatic drug metabolism: The potential of in vitro assays in unraveling the role of metabolism in drug induced liver toxicity

den Braver-Sewradj, S. P., 2018, 252 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

Ortega Ugalde, S., de Koning, C. P., Wallraven, K., Bruyneel, B., Vermeulen, N. P. E., Grossmann, T. N., Bitter, W., Commandeur, J. N. M. & Vos, J. C., Nov 2018, In : Applied Microbiology and Biotechnology. 102, 21, p. 9231-9242 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Ferredoxins
Mycobacterium tuberculosis
Cytochrome P-450 Enzyme System
Oxidation-Reduction
Genome

Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H: Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations

den Braver-Sewradj, S. P., den Braver, M. W., Toorneman, R. M., Van Leeuwen, S., Zhang, Y., Dekker, S. J., Vermeulen, N. P. E., Commandeur, J. N. M. & Vos, J. C., 19 Feb 2018, In : Chemical Research in Toxicology. 31, 2, p. 116-126 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Scavenging
Metabolites
NAD
Oxidoreductases
Liver

Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance

El Hassouni, B., Sarkisjan, D., Vos, J. C., Giovannetti, E. & Peters, G. J., 3 Dec 2018, In : Current Medicinal Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Ribosomes
oxaliplatin
Molecules
Oncology
Methyltransferases
2017

Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors

den Braver-Sewradj, S. P., den Braver, M. W., Baze, A., Decorde, J., Fonsi, M., Bachellier, P., Vermeulen, N. P. E., Commandeur, J. N. M., Richert, L. & Vos, J. C., 1 Aug 2017, In : European Journal of Pharmaceutical Sciences. 109, p. 96-110 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Glucuronosyltransferase
Liver Microsomes
Human Activities
Cytochrome P-450 Enzyme System
Hepatocytes

From Face-to-Face training to blended learning in the postgraduate program SafeSciMET - a case study

Vos, J. C., Dragovic, S., Jochimsen, M., Dirach, J., Foth, H., Wiese, J. & Bjerrum, O. J., 1 Jan 2017, In : European Journal of Pharmaceutical Sciences. 96, p. III-VIII

Research output: Contribution to JournalArticleAcademic

Amodiaquine
Glutathione Transferase
Liver
NAD
Toxicity

The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae

Huseinovic, A., van Leeuwen, J., van Welsem, T., Stulemeijer, I., van Leeuwen, F., Vermeulen, N. P. E., Kooter, J. M. & Vos, J. C., 14 Mar 2017, In : PLoS ONE. 12, 3, p. 1-19 19 p., e0173573.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
acetaminophen
Acetaminophen
ubiquitin
Ubiquitin
Yeast
2016

Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer.

Sewradj, S. P., den Braver, M. W., Vermeulen, N. P. E., Commandeur, J. N. M., Richert, L. & Vos, J. C., 2016, In : Toxicology in Vitro. 33, p. 71-79 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

2015

Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants

Vredenburg, G., den Braver-Sewradj, S., van Vugt-Lussenburg, B. M. A., Vermeulen, N. P. E., Commandeur, J. N. M. & Vos, J. C., 5 Jan 2015, In : Toxicology Letters. 232, 1, p. 182-92 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Ifosfamide
Cyclophosphamide
Cytochrome P-450 Enzyme System
Chemical activation
Pharmaceutical Preparations

Interplay between phase I and phase II biotransformation of drugs: In vitro approaches to study the formation and fate of reactive metabolites

Vredenburg, G., 2015, 173 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
Biotransformation
Pharmaceutical Preparations
In Vitro Techniques

Selective whole-cell biosynthesis of the designer drug metabolites 15- or 16-betahydroxynorethisterone by engineered Cytochrome P450 BM3 mutants

Reinen, J., Vredenburg, G., Klaering, K., Vermeulen, N. P. E., Commandeur, J. N. M., Honing, M. & Vos, J. C., 1 Nov 2015, In : Journal of Molecular Catalysis B. Enzymatic. 121, p. 64-74 11 p., 3212.

Research output: Contribution to JournalArticleAcademicpeer-review

Designer Drugs
Norethindrone
Hydroxylation
Biosynthesis
Metabolites
2014

Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid

Vredenburg, G., Elias, N. S., Venkataraman, H., Hendriks, D. F. G., Vermeulen, N. P. E., Commandeur, J. N. M. & Vos, J. C., 21 Apr 2014, In : Chemical Research in Toxicology. 27, 4, p. 576-86 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Mefenamic Acid
Diclofenac
Acetaminophen
Metabolites
Drug-Related Side Effects and Adverse Reactions
2013

Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast.

Vredenburg, G., Vassell, K. P., Commandeur, J. N. M., Vermeulen, N. P. E. & Vos, J. C., 2013, In : Toxicology Letters. 222, 3, p. 247-256

Research output: Contribution to JournalArticleAcademicpeer-review

Clozapine
Glutathione Transferase
Metabolism
Yeast
Cytochrome P-450 Enzyme System
2012

Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs

van Leeuwen, J. S., Unlü, B., Vermeulen, N. P. E. & Vos, J. C., 2012, In : Toxicology in Vitro. 26, 2, p. 197-205

Research output: Contribution to JournalArticleAcademicpeer-review

Active Biological Transport
Cytochrome P-450 Enzyme System
Toxicity
Anti-Inflammatory Agents
Pharmaceutical Preparations

Yeast as a humanized model organism for biotransformation-related toxicity

van Leeuwen, J. S., Vermeulen, N. P. E. & Vos, J. C., 2012, In : Current Drug Metabolism. 13, 10, p. 1464-1475

Research output: Contribution to JournalArticleAcademicpeer-review

Biotransformation
Yeast
Toxicity
Yeasts
Enzymes
2011
drug resistance
Saccharomyces
Diclofenac
homeostasis
protein kinase C

Yeast as a model eukaryote in drug safety studies: New insights on diclofenac-induced toxicity

van Leeuwen, J. S., 2011

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2010

Metabolism related toxicity of diclofenac in yeast as model system

van Leeuwen, J. S., Vredenburg, G., Dragovic, S., Tjong, T. F., Vos, J. C. & Vermeulen, N. P. E., 2010, In : Toxicology Letters. nov 24, p. 200(3): 162-8 doi: 10.1016/j.toxlet.2010.11.010.

Research output: Contribution to JournalArticleAcademicpeer-review

Diclofenac
Metabolism
Yeast
Toxicity
Yeasts

Subunits Rip1 and Cox9p of the respiratory chain contribute to diclofenac-induced mitochondrial dysfunction

van Leeuwen, J. S., Orij, R., Luttik, M. A., Smits, G. J., Vermeulen, N. P. E. & Vos, J. C., 2010, In : Microbiology. dec 9

Research output: Contribution to JournalArticleAcademicpeer-review

Diclofenac
Electron Transport
Reactive Oxygen Species
Respiration
Electron Transport Complex III
2006

5'-end formation of yeast 5.8SL rRNA is an endonucleolytic event

Faber, A. W., Vos, H. R., Vos, J. C. & Raue, H. A., 2006, In : Biochemical and Biophysical Research Communications. 345, 2, p. 796-802

Research output: Contribution to JournalArticleAcademicpeer-review

Rrp5p, a trans-acting factor in yeast ribosome biogenesis, is an RNA-binding protein with a pronounced preference for U-rich sequences

de Boer, P., Vos, H. R., Faber, A. W., Vos, J. C. & Raué, H. A., 2006, In : RNA. 12, p. 263-271 9 p., 2.

Research output: Contribution to JournalArticleAcademicpeer-review

Trans-Activators
RNA-Binding Proteins
Ribosomes
Yeasts
RNA Precursors

Saccharomyces cerevisiae Sof1p associates with 35S Pre-rRNA independent from U3 snoRNA and Rrp5p

Bax, R., Vos, H. R., Raue, H. A. & Vos, J. C., 2006, In : Eukaryotic Cell. 5, 3, p. 427-34

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
RNA Precursors
Saccharomyces cerevisiae
Small Nucleolar Ribonucleoproteins
Eukaryotic Small Ribosome Subunits
Proteins

Slx9p facilitates efficient ITS1 processing of pre-rRNA in Saccharomyces cerevisiae

Bax, R., Raue, H. A. & Vos, J. C., 2006, In : RNA. 12, 11, p. 2005-13

Research output: Contribution to JournalArticleAcademicpeer-review

RNA Precursors
Saccharomyces cerevisiae
Ribosomes
Yeasts
DNA Helicases
2004

Deletion of the three distal S1 motifs of Saccharomyces cerevisiae Rrp5p abolishes pre-rRNA processing at site A(2) without reducing the production of functional 40S subunits

Vos, H. R., Faber, A. W., de Gier, M., Vos, J. C. & Raue, H. A., 2004, In : Eukaryotic Cell. 3, 6, p. 1504-12

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Ribosome Subunits
RNA Precursors
Saccharomyces cerevisiae
Yeasts
Proteins

The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA

Faber, A. W., Vos, J. C., Vos, H. R., Ghazal, G., Elela, S. A. & Raue, H. A., 2004, In : RNA. 10, 12, p. 1946-56

Research output: Contribution to JournalArticleAcademicpeer-review

Trans-Activators
RNA Precursors
Eukaryota
Ribosomes
Saccharomyces cerevisiae

U3 snoRNP and Rrp5p associate independently with Saccharomyces cerevisiae 35S pre-rRNA, but Rrp5p is essential for association of Rok1p

Vos, H. R., Bax, R., Faber, A. W., Vos, J. C. & Raue, H. A., 2004, In : Nucleic Acids Research. 32, 19, p. 5827-33

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Trans-Activators
RNA Precursors
Ribosomes
Saccharomyces cerevisiae
RNA Helicases
2003

Rio2p, an evolutionarily conserved, low abundant protein kinase essential for processing of 20 S Pre-rRNA in Saccharomyces cerevisiae

Geerlings, T. H., Faber, A. W., Bister, M. D., Vos, J. C. & Raue, H. A., 2003, In : Journal of Biological Chemistry. 278, 25, p. 22537-45

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
RNA Precursors
Yeast
Protein Kinases
Saccharomyces cerevisiae
Phosphotransferases
2002

Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 of yeast pre-rRNA that depends on Rex4p

Eppens, N. A., Faber, A. W., rondaij, M., Jahangir, R. S., van Hemert, S., Vos, J. C., Venema, J. & Raue, H. A., 2002, In : Nucleic Acids Research. 30, 19, p. 4222-31

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae

Faber, A. W., Van Dijk, M., Raue, H. A. & Vos, J. C., 2002, In : RNA. 8, 9, p. 1095-101

Research output: Contribution to JournalArticleAcademicpeer-review

Ribonucleases
Saccharomyces cerevisiae
Genes
Proteins
2000

Head-head/tail-tail relative orientation of the pore-forming domains of the heterodimeric ABC transporter TAP

Vos, J. C., Reits, E. A., Wojcik-Jacobs, E. A. & Neefjes, J., 2000, In : Current Biology. 13, 10, p. 1-7 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The final step in the formation of 25S rRNA in saccharomyces cerevisiae is performed by 5'->3' exonucleases

Geerlings, T. H., Vos, J. C. & Raue, H. A., 2000, In : RNA. 6, p. 1698-1703 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

spleen exonuclease
RNA Precursors
Saccharomyces cerevisiae
Exonucleases
Exosomes

The major substrates for TAP in vivo are derived from newly synthesized proteins

Reits, E. A., Vos, J. C., Grommé, M. & Neefjes, J., 2000, In : Nature. 404, 6779, p. 774-778 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

1999

Membrane topology and dimerization of the two subunits of the transporter associated with antigen processing reveal a three-domain structure

Vos, J. C., Spee, P., Momburg, F. & Neefjes, J., 15 Dec 1999, In : Journal of Immunology. 163, 12, p. 6679-85 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Antigen Presentation
Dimerization
Endoplasmic Reticulum
Membranes
Nucleotides
1996

Transposase is the only nematode protein required for in vitro transposition of Tc1

Vos, J. C., De Baere, I. & Plasterk, R. H. A., 15 Mar 1996, In : Genes and Development. 10, 6, p. 755-61 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Transposases
Gene Transfer Techniques
DNA Transposable Elements
Cell-Free System
Terminal Repeat Sequences
1994

Tc1 transposase of Caenorhabditis elegans is an endonuclease with a bipartite DNA binding domain

Vos, J. C. & Plasterk, R. H. A., 15 Dec 1994, In : EMBO Journal. 13, 24, p. 6125-32 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Endonucleases
Caenorhabditis elegans
Transposases
DNA
Binding Sites
1993

Characterization of the Caenorhabditis elegans Tc1 transposase in vivo and in vitro

Vos, J. C., van Luenen, H. G. A. M. & Plasterk, R. H. A., Jul 1993, In : Genes and Development. 7, 7A, p. 1244-53 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Caenorhabditis elegans
Transposases
DNA
Deoxyribonuclease I
Electrophoretic Mobility Shift Assay
1992

In vitro recognition of an orf virus early promoter in a vaccinia virus extract

Vos, J. C., Mercer, A. A., Fleming, S. B. & Robinson, A. J., 1992, In : Archives of Virology. 123, 1-2, p. 223-8 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Orf virus
Vaccinia virus
Parapoxvirus
Orthopoxvirus
Deoxycholic Acid
1991

Promoter melting by a stage-specific vaccinia virus transcription factor is independent of the presence of RNA polymerase

Vos, J. C., Sasker, M. & Stunnenberg, H. G., 5 Apr 1991, In : Cell. 65, 1, p. 105-13 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Vaccinia virus
DNA-Directed RNA Polymerases
Transcription
Viruses
Freezing

Vaccinia virus capping enzyme is a transcription initiation factor

Vos, J. C., Sasker, M. & Stunnenberg, H. G., Sep 1991, In : EMBO Journal. 10, 9, p. 2553-8 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Peptide Initiation Factors
Transcription
Transcription Factors
Enzymes
DNA-Directed RNA Polymerases