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Research Output 2009 2019

  • 56 Article
  • 4 Poster
  • 3 Meeting Abstract
  • 1 PhD Thesis - Research VU, graduation VU
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Article
2019

A linear mixed-model approach to study multivariate gene-environment interactions

BIOS Consortium, 't Hoen, P. A., van Meurs, J. B. J., Isaacs, A., Jansen, R., Franke, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, A., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J. & 30 othersvan Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M., van Galen, M., Bot, J., van’t Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Zhernakova, D. V., Luijk, R., Jan Bonder, M., van Dijk, F., Arindrarto, W., Kielbasa, P. S. M., Swertz, M. A. & van Zwet, E. W., Jan 2019, In : Nature Genetics. 51, 1, p. 180-186 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Gene-Environment Interaction
Linear Models
Body Mass Index
Genotype
Diet

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P-C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S-J. & 37 othersBressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M-F., Rotter, J. I., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D. I., Bell, J. T., Demirkan, A. & van Duijn, C. M., 13 Jun 2019, In : Nature Communications. 10, 1, p. 2581

Research output: Contribution to JournalArticleAcademicpeer-review

homeostasis
insulin
methylation
Methylation
DNA Methylation

Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

BIOS Consortium & Rodrigues Zilhao Nogueira, N., 1 Mar 2019, In : Biological Psychiatry.

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Methylation
DNA Methylation
Netherlands
Meta-Analysis

Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci

Gupta, R., Van Dongen, J., Fu, Y., Abdellaoui, A., Tyndale, R. F., Velagapudi, V., Boomsma, D. I., Korhonen, T., Kaprio, J., Loukola, A. & Ollikainen, M., 5 Jan 2019, In : Clinical epigenetics. 11, 1, p. 1-13 13 p., 1.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cotinine
Nicotine
DNA Methylation
Smoking
Serum

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

eQTLGen Consortium, 15 Jan 2019, In : eLife. 8, p. 1-40 40 p., e39856.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genomics
Genes
Furin
Transport Vesicles
Peer Review

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Küpers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., Page, C. M., Reese, S. E., Wilcox, A. J., Czamara, D., Starling, A. P., Novoloaca, A., Lent, S., Roy, R., Hoyo, C., Breton, C. V., Allard, C., Just, A. C., Bakulski, K. M., Holloway, J. W. & 107 othersEverson, T. M., Xu, C. J., Huang, R. C., van der Plaat, D. A., Wielscher, M., Merid, S. K., Ullemar, V., Rezwan, F. I., Lahti, J., van Dongen, J., Langie, S. A. S., Richardson, T. G., Magnus, M. C., Nohr, E. A., Xu, Z., Duijts, L., Zhao, S., Zhang, W., Plusquin, M., DeMeo, D. L., Solomon, O., Heimovaara, J. H., Jima, D. D., Gao, L., Bustamante, M., Perron, P., Wright, R. O., Hertz-Picciotto, I., Zhang, H., Karagas, M. R., Gehring, U., Marsit, C. J., Beilin, L. J., Vonk, J. M., Jarvelin, M. R., Bergström, A., Örtqvist, A. K., Ewart, S., Villa, P. M., Moore, S. E., Willemsen, G., Standaert, A. R. L., Håberg, S. E., Sørensen, T. I. A., Taylor, J. A., Räikkönen, K., Yang, I. V., Kechris, K., Nawrot, T. S., Silver, M. J., Gong, Y. Y., Richiardi, L., Kogevinas, M., Litonjua, A. A., Eskenazi, B., Huen, K., Mbarek, H., Maguire, R. L., Dwyer, T., Vrijheid, M., Bouchard, L., Baccarelli, A. A., Croen, L. A., Karmaus, W., Anderson, D., de Vries, M., Sebert, S., Kere, J., Karlsson, R., Arshad, S. H., Hämäläinen, E., Routledge, M. N., Boomsma, D. I., Feinberg, A. P., Newschaffer, C. J., Govarts, E., Moisse, M., Fallin, M. D., Melén, E., Prentice, A. M., Kajantie, E., Almqvist, C., Oken, E., Dabelea, D., Boezen, H. M., Melton, P. E., Wright, R. J., Koppelman, G. H., Trevisi, L., Hivert, M. F., Sunyer, J., Munthe-Kaas, M. C., Murphy, S. K., Corpeleijn, E., Wiemels, J., Holland, N., Herceg, Z., Binder, E. B., Davey Smith, G., Jaddoe, V. W. V., Lie, R. T., Nystad, W., London, S. J., Lawlor, D. A., Relton, C. L., Snieder, H. & Felix, J. F., 23 Apr 2019, In : Nature Communications. 10, p. 1-11 11 p., 1893.

Research output: Contribution to JournalArticleAcademicpeer-review

methylation
DNA Methylation
Meta-Analysis
Methylation
deoxyribonucleic acid

Multivariate genome-wide analyses of the well-being spectrum

BIOS Consortium, Mar 2019, In : Nature Genetics. 51, 3, p. 445-451 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Genome
Meta-Analysis
Interneurons
Computational Biology
Twin Studies
Apgar Score
Dizygotic Twins
Monozygotic Twins
Labor Presentation

Skewed X-inactivation is common in the general female population

BIOS Consortium, Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J. & Willemsen, G., Mar 2019, In : European Journal of Human Genetics. 27, 3, p. 455-465 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

X Chromosome Inactivation
X Chromosome
Population
Genes
Alleles
2018

A SNP panel for identification of DNA and RNA specimens

Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van 't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P., 't Hoen, P. A. C., BIOS consortium, Boomsma, D. I., van Dongen, J., Hottenga, J. J. & Pool, R., 25 Jan 2018, In : BMC Genomics. 19, 1, p. 90

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Single Nucleotide Polymorphism
RNA
DNA
Genotype
RNA Sequence Analysis

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

BIOS Consortium, Luijk, R., Wu, H., Ward-Caviness, C. K., Hannon, E., Carnero-Montoro, E., Min, J. L., Mandaviya, P., Müller-Nurasyid, M., Mei, H., van der Maarel, S. M., Beekman, M., der Breggen, R. V., Deelen, J., Lakenberg, N., Moed, M., Suchiman, H. E. D., Arindrarto, W., van’t Hof, P., Jan Bonder, M. & 32 othersDeelen, P., Tigchelaar, E. F., Zhernakova, A., Zhernakova, D. V., van Dongen, J., Hottenga, J. J., Pool, R., Isaacs, A., Hofman, B. A., Jhamai, M., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., van den Berg, L. H., van Galen, M., Vermaat, M., van Rooij, J., Uitterlinden, A. G., Verbiest, M., Verkerk, M., Kielbasa, P. S. M., Bot, J., Nooren, I., van Dijk, F., Swertz, M. A., van Heemst, D., Relton, C., Mill, J., Waldenberger, M., Bell, J. T., Jansen, R. & Boomsma, D. I., 14 Sep 2018, In : Nature Communications. 9, 1, p. 1-9 9 p., 3738.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
X Chromosome Inactivation
methylation
chromosomes
DNA Methylation
Chromosomes

Brain reward responses to food stimuli among female monozygotic twins discordant for BMI

Doornweerd, S., De Geus, E. J., Barkhof, F., van Bloemendaal, L., Boomsma, D. I., van Dongen, J., Drent, M. L., Willemsen, G., Veltman, D. J. & IJzerman, R. G., 8 Jun 2018, In : Brain Imaging and Behavior. 12, 3, p. 718-727

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Reward
Food
Brain
Obesity

Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3–16 years from multiple raters in six cohorts in the EU-ACTION project

Bartels, M., Hendriks, A., Mauri, M., Krapohl, E., Whipp, A., Bolhuis, K., Conde, L. C., Luningham, J., Fung Ip, H., Hagenbeek, F., Roetman, P., Gatej, R., Lamers, A., Nivard, M., van Dongen, J., Lu, Y., Middeldorp, C., van Beijsterveldt, T., Vermeiren, R., Hankemeijer, T. & 16 othersKluft, C., Medland, S., Lundström, S., Rose, R., Pulkkinen, L., Vuoksimaa, E., Korhonen, T., Martin, N. G., Lubke, G., Finkenauer, C., Fanos, V., Tiemeier, H., Lichtenstein, P., Plomin, R., Kaprio, J. & Boomsma, D. I., Sep 2018, In : European Child and Adolescent Psychiatry. 27, 9, p. 1105-1121 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aggression
Psychopathology
Anxiety
Problem Behavior
Depression

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., Haller, T., Singh-Manoux, A., Verhoeven, A., Willemsen, G., de Leeuw, F. A., Wagner, H., van Dongen, J., Hertel, J., Budde, K., Willems van Dijk, K. & 28 othersWeinhold, L., Ikram, M. A., Pietzner, M., Perola, M., Wagner, M., Friedrich, N., Slagboom, P. E., Scheltens, P., Yang, Q., Gertzen, R. E., Egert, S., Li, S., Hankemeier, T., van Beijsterveldt, C. E. M., Vasan, R. S., Maier, W., Peeters, C. F. W., Jörgen Grabe, H., Ramirez, A., Seshadri, S., Metspalu, A., Kivimäki, M., Salomaa, V., Demirkan, A., Boomsma, D. I., van der Flier, W. M., Amin, N. & van Duijn, C. M., Jun 2018, In : Alzheimers & Dementia. 14, 6, p. 707-722 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aptitude
Cognition
Dementia
Cohort Studies
Life Style

DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis

Ward-Caviness, C. K., Huffman, J. E., Everett, K., Germain, M., Van Dongen, J., Hill, W. D., Jhun, M. A., Brody, J. A., Ghanbari, M., Du, L., Roetker, N. S., De Vries, P. S., Waldenberger, M., Gieger, C., Wolf, P., Prokisch, H., Koenig, W., O’Donnell, C. J., Levy, D., Liu, C. & 34 othersTruong, V., Wells, P. S., Trégouët, D. A., Tang, W., Morrison, A. C., Boerwinkle, E., Wiggins, K. L., McKnight, B., Guo, X., Psaty, B. M., Sotoodenia, N., Boomsma, D. I., Willemsen, G., Ligthart, L., Deary, I. J., Zhao, W., Ware, E. B., Kardia, S. L. R., Van Meurs, J. B. J., Uitterlinden, A. G., Franco, O. H., Eriksson, P., Franco-Cereceda, A., Pankow, J. S., Johnson, A. D., Gagnon, F., Morange, P. E., De Geus, E. J. C., Starr, J. M., Smith, J. A., Dehghan, A., Björck, H. M., Smith, N. L. & Peters, A., 25 Oct 2018, In : Blood. 132, 17, p. 1842-1850 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Hemostatics
DNA Methylation
Epigenomics
Meta-Analysis
Aging of materials

DNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort

Sandanger, T. M., Nøst, T. H., Guida, F., Rylander, C., Campanella, G., Muller, D. C., van Dongen, J., Boomsma, D. I., Johansson, M., Vineis, P., Vermeulen, R., Lund, E. & Chadeau-Hyam, M., 13 Nov 2018, In : Scientific Reports. 8, p. 1-10 10 p., 16714.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
DNA Methylation
Lung Neoplasms
Smoking
Gene Expression
Neoplasms

DNA methylation signatures of educational attainment

Dongen, J. V., Bonder, M. J., Dekkers, K. F., Nivard, M. G., Iterson, M. V., Willemsen, G., Beekman, M., Spek, A. V. D., Meurs, J. B. J. V., Franke, L., Heijmans, B. T., Duijn, C. M. V., Slagboom, P. E. & Boomsma, D. I., 23 Mar 2018, In : npj Science of Learning 2018 3:1. 3, p. 1-14 14 p., 7.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
DNA Methylation
Smoking
Methylation
Air Pollution
Brain

Genome-wide analysis of DNA methylation in buccal cells: A study of monozygotic twins and mQTLs

Van Dongen, J., Ehli, E. A., Jansen, R., Van Beijsterveldt, C. E. M., Willemsen, G., Hottenga, J. J., Kallsen, N. A., Peyton, S. A., Breeze, C. E., Kluft, C., Heijmans, B. T., Bartels, M., Davies, G. E. & Boomsma, D. I., 25 Sep 2018, In : Epigenetics and Chromatin. 11, p. 1-14 14 p., 54.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Cheek
DNA Methylation
Methylation
Quantitative Trait Loci

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

eQTLGen Consortium, Qi, T., Wu, Y., Zeng, J., Zhang, F., Xue, A., Jiang, L., Zhu, Z., Kemper, K., Yengo, L., Zheng, Z. & van Dongen, J., 1 Dec 2018, In : Nature Communications. 9, 1, 2282.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
genes
blood
brain
Brain
Blood
2017

Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

van Iterson, M., van Zwet, E. W., Heijmans, B. T., ’t Hoen, P. A. C., van Meurs, J. B. J., Jansen, R., Franke, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Eline Slagboom, P., Beekman, M. & 31 othersDeelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Isaacs, A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Galen, M., Bot, J., Zhernakova, D. V., van 't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Luijk, R., Bonder, M. J., van Dijk, F., Arindrarto, W., Kielbasa, S. M., Swertz, M. A. & 't Hoen, P. B., 27 Jan 2017, In : Genome Biology. 18, 1, 19.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
inflation
Economic Inflation
Transcriptome
transcriptome
Social Adjustment

C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis

Lepik, K., Annilo, T., Kukuškina, V., Kisand, K., Kutalik, Z., Peterson, P., Peterson, H., eQTLGen Consortium, Boomsma, D. I., Nivard, M. G. & van Dongen, J., Sep 2017, In : PLoS Computational Biology. 13, 9, p. e1005766

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
C-reactive protein
C-Reactive Protein
Blood
Up-Regulation
blood

Disease variants alter transcription factor levels and methylation of their binding sites

Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., van Iterson, M., van Dijk, F., van Galen, M., Bot, J., Slieker, R. C., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Arindrarto, W., Kielbasa, S. M. & 31 othersJonkers, I., van 't Hof, P., Nooren, I., Beekman, M., Deelen, J., van Heemst, D., Zhernakova, A., Tigchelaar, E. F., Swertz, M. A., Hofman, A., Uitterlinden, A. G., Pool, R., van Dongen, J., Hottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., van den Berg, L. H., van Zwet, E. W., Mei, H., Li, Y., Lemire, M., Hudson, T. J., Slagboom, P. E., Wijmenga, C., Veldink, J. H., Van Greevenbroek, M. J., van Duijn, C. M., Boomsma, D. I., Isaacs, A. & BIOS Consortium, Jan 2017, In : Nature Genetics. 49, 1, p. 131-138 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Methylation
Transcription Factors
Binding Sites
DNA Methylation
Single Nucleotide Polymorphism

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

Richard, M. A., Huan, T., Ligthart, S., Gondalia, R., Jhun, M. A., Brody, J. A., Irvin, M. R., Marioni, R., Shen, J., Tsai, P-C., Montasser, M. E., Jia, Y., Syme, C., Salfati, E. L., Boerwinkle, E., Guan, W., Mosley, T. H., Bressler, J., Morrison, A. C., Liu, C. & 31 othersMendelson, M. M., Uitterlinden, A. G., van Meurs, J. B., Franco, O. H., Zhang, G., Li, Y., Stewart, J. D., Bis, J. C., Psaty, B. M., Chen, Y-D. I., Kardia, S. L. R., Zhao, W., Turner, S. T., Absher, D., Aslibekyan, S., Starr, J. M., McRae, A. F., Hou, L., Just, A. C., Schwartz, J. D., Vokonas, P. S., Menni, C., Spector, T. D., Shuldiner, A., Damcott, C. M., Rotter, J. I., BIOS Consortium, Boomsma, D. I., Pool, R., van Dongen, J. & Hottenga, J. J., 7 Dec 2017, In : American Journal of Human Genetics. 101, 6, p. 888-902 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

DNA Methylation
Blood Pressure
Methylation
Gene Expression
Mendelian Randomization Analysis

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Nolte, I. M., Munoz, M. L., Tragante, V., Amare, A. T., Jansen, R., Vaez, A., von der Heyde, B., Avery, C. L., Bis, J. C., Dierckx, B., van Dongen, J., Gogarten, S. M., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S-J., Jaju, D., Kerr, K. F., Kluttig, A., Krijthe, B. P. & 144 othersKumar, J., van der Laan, S. W., Lyytikäinen, L-P., Maihofer, A. X., Minassian, A., van der Most, P. J., Müller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J. D., Thayer, J. F., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M. H., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D. G., de Bakker, P. I. W., Barcella, M., Bayoumi, R., Bieringa, R. J., Boomsma, D., Boucher, G., Britton, A. R., Christophersen, I., Dietrich, A., Ehret, G. B., Ellinor, P. T., Eskola, M., Felix, J. F., Floras, J. S., Franco, O. H., Friberg, P., Gademan, M. G. J., Geyer, M. A., Giedraitis, V., Hartman, C. A., Hemerich, D., Hofman, A., Hottenga, J-J., Huikuri, H., Hutri-Kähönen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A. M., Kors, J. A., Kumari, M., Kuznetsova, T., Laurie, C. C., Lefrandt, J. D., Li, Y., Li, Y., Liao, D., Limacher, M. C., Lin, H. J., Lindgren, C. M., Lubitz, S. A., Mahajan, A., McKnight, B., Zu Schwabedissen, H. M., Milaneschi, Y., Mononen, N., Morris, A. P., Nalls, M. A., Navis, G., Neijts, M., Nikus, K., North, K. E., O'Connor, D. T., Ormel, J., Perz, S., Peters, A., Psaty, B. M., Raitakari, O. T., Risbrough, V. B., Sinner, M. F., Siscovick, D., Smit, J. H., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Staessen, J. A., Stein, P. K., Stilp, A. M., Stolarz-Skrzypek, K., Strauch, K., Sundström, J., Swenne, C. A., Syvänen, A-C., Tardif, J-C., Taylor, K. D., Teumer, A., Thornton, T. A., Tinker, L. E., Uitterlinden, A. G., van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K. C., Willemsen, G., Wong, Q., Zhang, Z-M., Zonderman, A. B., Cusi, D., Evans, M. K., Greiser, H. K., van der Harst, P., Hassan, M., Ingelsson, E., Järvelin, M-R., Kääb, S., Kähönen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimäki, T., Lind, L., Nievergelt, C. M., O'Donnell, C. J., Oldehinkel, A. J., Penninx, B., Reiner, A. P., Riese, H., Van Roon, A. M., Rioux, J. D., Rotter, J. I., Sofer, T., Stricker, B. H., Tiemeier, H., Vrijkotte, T. G. M., Asselbergs, F. W., Brundel, B. J. J. M., Heckbert, S. R., Whitsel, E. A., den Hoed, M., Snieder, H. & de Geus, E. J. C., 14 Jun 2017, In : Nature Communications. 8, p. 15805

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
heart rate
Genetic Loci
loci
Heart Diseases
Heart Rate

Genetic loci associated with heart rate variability and their effects on cardiac disease risk (vol 8, pg 15805, 2017)

Nolte, I. M., Munoz, M. L., Tragante, V., Amare, A. T., Jansen, R., Vaez, A., von der Heyde, B., Avery, C. L., Bis, J. C., Dierckx, B., van Dongen, J., Gogarten, S. M., Goyette, P., Hernesniemi, J., Huikari, V., Hwang, S-J., Jaju, D., Kerr, K. F., Kluttig, A., Krijthe, B. P. & 144 othersKumar, J., van der Laan, S. W., Lyytikainen, L-P., Maihofer, A. X., Minassian, A., van der Most, P. J., Mueller-Nurasyid, M., Nivard, M., Salvi, E., Stewart, J. D., Thayer, J. F., Verweij, N., Wong, A., Zabaneh, D., Zafarmand, M. H., Abdellaoui, A., Albarwani, S., Albert, C., Alonso, A., Ashar, F., Auvinen, J., Axelsson, T., Baker, D. G., de Bakker, P. I. W., Barcella, M., Bayoumi, R., Bieringa, R. J., Boomsma, D., Boucher, G., Britton, A. R., Christophersen, I., Dietrich, A., Ehret, G. B., Ellinor, P. T., Eskola, M., Felix, J. F., Floras, J. S., Franco, O. H., Friberg, P., Gademan, M. G. J., Geyer, M. A., Giedraitis, V., Hartman, C. A., Hemerich, D., Hofman, A., Hottenga, J-J., Huikuri, H., Hutri-Kahonen, N., Jouven, X., Junttila, J., Juonala, M., Kiviniemi, A. M., Kors, J. A., Kumari, M., Kuznetsova, T., Laurie, C. C., Lefrandt, J. D., Li, Y., Li, Y., Liao, D., Limacher, M. C., Lin, H. J., Lindgren, C. M., Lubitz, S. A., Mahajan, A., McKnight, B., zu Schwabedissen, H. M., Milaneschi, Y., Mononen, N., Morris, A. P., Nalls, M. A., Navis, G., Neijts, M., Nikus, K., North, K. E., O'Connor, D. T., Ormel, J., Perz, S., Peters, A., Psaty, B. M., Raitakari, O. T., Risbrough, V. B., Sinner, M. F., Siscovick, D., Smit, J. H., Smith, N. L., Soliman, E. Z., Sotoodehnia, N., Staessen, J. A., Stein, P. K., Stilp, A. M., Stolarz-Skrzypek, K., Strauch, K., Sundstrom, J., Swenne, C. A., Syvanen, A-C., Tardif, J-C., Taylor, K. D., Teumer, A., Thornton, T. A., Tinker, L. E., Uitterlinden, A. G., van Setten, J., Voss, A., Waldenberger, M., Wilhelmsen, K. C., Willemsen, G., Wong, Q., Zhang, Z-M., Zonderman, A. B., Cusi, D., Evans, M. K., Greiser, H. K., van der Harst, P., Hassan, M., Ingelsson, E., Jarvelin, M-R., Kaab, S., Kahonen, M., Kivimaki, M., Kooperberg, C., Kuh, D., Lehtimaki, T., Lind, L., Nievergelt, C. M., O'Donnell, C. J., Oldehinkel, A. J., Penninx, B., Reiner, A. P., Riese, H., van Roon, A. M., Rioux, J. D., Rotter, J. I., Sofer, T., Stricker, B. H., Tiemeier, H., Vrijkotte, T. G. M., Asselbergs, F. W., Brundel, B. J. J. M., Heckbert, S. R., Whitsel, E. A., den Hoed, M., Snieder, H. & de Geus, E. J. C., 2 Aug 2017, In : Nature Communications. 8

Research output: Contribution to JournalArticleAcademicpeer-review

Identification of context-dependent expression quantitative trait loci in whole blood

Zhernakova, D. V., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H-J., Bonder, M. J., van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R., van Dongen, J. & 27 othersHottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Zhernakova, A., Li, Y., Tigchelaar, E. F., de Klein, N., Beekman, M., Deelen, J., van Heemst, D., van den Berg, L. H., Hofman, A., Uitterlinden, A. G., Van Greevenbroek, M. J., Veldink, J. H., Boomsma, D. I., van Duijn, C. M., Wijmenga, C., Slagboom, P. E., Swertz, M. A., Isaacs, A., van Meurs, J. B. J., Jansen, R., Heijmans, B. T., ’t Hoen, P. A. C. & Franke, L., Jan 2017, In : Nature Genetics. 49, 1, p. 139-145 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Quantitative Trait Loci
Interferon Type I
Genetic Association Studies
Single Nucleotide Polymorphism
Transcription Factors

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

Ferreira, M. A., Vonk, J. M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J. D., Helmer, Q., Tillander, A., Ullemar, V., van Dongen, J., Lu, Y., Rüschendorf, F., Esparza-Gordillo, J., Medway, C. W., Mountjoy, E., Burrows, K., Hummel, O., Grosche, S., Brumpton, B. M., Witte, J. S. & 31 othersHottenga, J-J., Willemsen, G., Zheng, J., Rodríguez, E., Hotze, M., Franke, A., Revez, J. A., Beesley, J., Matheson, M. C., Dharmage, S. C., Bain, L. M., Fritsche, L. G., Gabrielsen, M. E., Balliu, B., Nielsen, J. B., Zhou, W., Hveem, K., Langhammer, A., Holmen, O. L., Løset, M., Abecasis, G. R., Willer, C. J., Arnold, A., Homuth, G., Schmidt, C. O., Thompson, P. J., Martin, N. G., Duffy, D. L., Novak, N., Boomsma, D. I. & 23andMe Research Team, Dec 2017, In : Nature Genetics. 49, 12, p. 1752-1757 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Seasonal Allergic Rhinitis
Eczema
Asthma
Genome-Wide Association Study
Genes
2016

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, D. V., Moed, M. H., Mei, H., van Galen, M., Deelen, P., Bonder, M. J., Zhernakova, A., Uitterlinden, A. G., Tigchelaar, E. F., Stehouwer, C. D. A., Schalkwijk, C. G., van der Kallen, C. J. H., Hofman, A., van Heemst, D., de Geus, E. J. C., van Dongen, J. & 14 othersDeelen, J., Van den Berg, L. H., van Meurs, J., Jansen, R., 't Hoen, P. A. C., Franke, L., Wijmenga, C., Veldink, J. H., Swertz, M. A., van Greevenbroek, M. M. J., van Duijn, C. M., Boomsma, D. I., Slagboom, P. E. & Heijmans, B. T., 2016, In : Genome Biology. 17, 191, p. 1-13

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
DNA Methylation
Polycomb Repressive Complex 2
Methylation
methylation
Genes

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Ried, J. S., Jeff, J. M., Chu, A. Y., Bragg-Gresham, J. L., van Dongen, J., Huffman, J. E., Ahluwalia, T. S., Cadby, G., Eklund, N., Eriksson, J., de Geus, E. J. C., Hottenga, J. J., Penninx, B. W. J. H., Willemsen, G., Boomsma, D. I., McCarthy, M. I., North, K. E., O'Connell, J. R., Schlessinger, D., Thorsteinsdottir, U. & 5 othersStrachan, D. P., Frayling, T. M., Hirschhorn, J. N., Müller-Nurasyid, M. & Loos, R. J. F., 2016, In : Nature Communications. 7, 13357.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
loci
Principal Component Analysis
phenotype
Meta-Analysis
Phenotype

Blood lipids influence DNA methylation in circulating cells

Dekkers, K. F., van Iterson, M., Slieker, R. C., Moed, M. H., Bonder, M. J., van Galen, M., Mei, H., Zhernakova, D. V., Van den Berg, L. H., Deelen, J., van Dongen, J., van Heemst, D., Hofman, A., Hottenga, J. J., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., Tigchelaar, E. F., Uitterlinden, A. G., Willemsen, G. & 14 othersZhernakova, A., Franke, L., 't Hoen, P. A. C., Jansen, R., van Meurs, J., Boomsma, D. I., van Duijn, C. M., van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., van Zwet, E. W., Slagboom, P. E., Jukema, J. W. & Heijmans, B. T., 2016, In : Genome Biology. 17, 138, p. 1-12

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
methylation
DNA methylation
DNA Methylation
blood lipids
blood

eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data

Breeze, C. E., Paul, D. S., van Dongen, J., Butcher, L. M., Ambrose, J. C., Barrett, J. E., Lowe, R., Rakyan, V. K., Iotchkova, V., Frontini, M., Downes, K., Ouwehand, W. H., Laperle, J., Jacques, P. E., Bourque, G., Bergmann, A. K., Siebert, R., Vellenga, E., Saeed, S., Matarese, F. & 7 othersMartens, J. H., Stunnenberg, H. G., Teschendorff, A. E., Herrero, J. L., Birney, E., Dunham, I. & Beck, S., 2016, In : Cell Reports. 17, 8, p. 2137-2150

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genetic and environmental influences interact with age and sex in shaping the human methylome

van Dongen, J., Nivard, M. G., Willemsen, G., Hottenga, J. J., Helmer, Q., Dolan, C. V., Ehli, E. A., Davies, G. E., van Iterson, M., Breeze, C. E., Beck, S., Pool, R., Suchiman, H. E. D., Jansen, R., van Meurs, J. B., Heijmans, B. T., Slagboom, P. E. & Boomsma, D. I., 2016, In : Nature Communications. 7, 11115, p. 1-13 11115.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
methylation
genome
Methylation
Genes
Genome

Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

Roos, L., van Dongen, J., Bell, C. G., Burri, A., Deloukas, P., Boomsma, D. I., Spector, T. D. & Bell, J. T., 2016, In : Clinical epigenetics. 8, 7, p. 1-16

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Tumor Biomarkers
DNA
DNA Methylation
Neoplasms

Physical activity and dietary intake in BMI discordant identical twins

Doornweerd, S., IJzerman, R. G., van Eijk, L., Neter, J. E., van Dongen, J., van der Ploeg, H. P. & de Geus, E. J. C., 2016, In : Obesity. 24, 6, p. 1349-1355

Research output: Contribution to JournalArticleAcademicpeer-review

Monozygotic Twins
Obesity
Exercise
Genes

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

Ricano-Ponce, I., Zhernakova, D. V., Deelen, P., Luo, O., Li, X., Isaacs, A., Karjalainen, J., Di. Tommaso, J., Borek, Z. A., Zorro, M. M., Gutierrez-Achury, J., Uitterlinden, A. G., Hofman, A., van Meurs, J., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Neteaf, M. G., Jonkers, I. H. & 7 othersWithoff, S., van Duijn, C. M., Li, Y., Ruan, Y., Franke, L., Wijmenga, C. & Kumar, V., 2016, In : Journal of Autoimmunity. 68, p. 62-74

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2015

DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

Tsai, P. C., van Dongen, J., Tan, Q., Willemsen, G., Christiansen, L., Boomsma, D. I., Spector, T. D., Valdes, A. M. & Bell, J. T., 2015, In : Twin Research and Human Genetics. 18, 6, p. 635-646 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Monozygotic Twins
Low Birth Weight Infant
DNA Methylation
Birth Weight
Metabolic Diseases

Epigenome-Wide Association Study of Aggressive Behavior

van Dongen, J., Nivard, M. G., Baselmans, B. M. L., Rodrigues Zilhao Nogueira, N., Ligthart, R. S. L., Heijmans, B. T., Bartels, M. & Boomsma, D. I., 2015, In : Twin Research and Human Genetics. 18, 6, p. 686-698 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

DNA Methylation
Netherlands
Longitudinal Studies
Epigenomics
Self Report

Epigenome-Wide Association Study of Tic Disorders

Rodrigues Zilhao Nogueira, N., Padmanabhuni, S. S., Pagliaroli, L., Barta, C., Smit, D. J. A., Cath, D. C., Nivard, M. G., Baselmans, B. M. L., van Dongen, J., Paschou, P. & Boomsma, D. I., 2015, In : Twin Research and Human Genetics. 18, 6, p. 699-709 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Tic Disorders
Netherlands
DNA Methylation
Tics
Self Report

Epigenome-Wide Association Study of Wellbeing

Baselmans, B. M. L., van Dongen, J., Nivard, M. G., Lin, B., Rodrigues Zilhao Nogueira, N., Boomsma, D. I. & Bartels, M., 2015, In : Twin Research and Human Genetics. 18, 6, p. 710-719 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

DNA Methylation
Netherlands
Longitudinal Studies
Twin Studies
Epigenomics

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

Shah, S., Bonder, M. J., Marioni, R. E., Zhu, Z., McRae, A. F., Zhernakova, A., Harris, S. E., Liewald, D. C. M., Henders, A. K., Mendelson, M. M., Liu, C., Joehanes, R., Liang, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Levy, D., Martin, N. G., Starr, J. M. & 7 othersWijmenga, C., Wray, N. R., Yang, J., Montgomery, G. W., Franke, L., Deary, I. J. & Visscher, P. M., 2015, In : American Journal of Human Genetics. 97, 1, p. 75-85 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Epigenomics
Body Mass Index
Methylation
Genome-Wide Association Study
DNA Methylation

Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins

van Dongen, J., Willemsen, G., Heijmans, B. T., Neuteboom, J., Kluft, C., Jansen, R., Penninx, B. W. J. H., Slagboom, P. E., de Geus, E. J. C. & Boomsma, D. I., 2015, In : International Journal of Obesity. 39, 6, p. 899-909 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Body Mass Index
Biomarkers
Gene Expression
Weights and Measures

Low Birth Weight in MZ Twins Discordant for Birth Weight is Associated with Shorter Telomere Length and lower IQ, but not Anxiety/Depression in Later Life

Strohmaier, J., van Dongen, J., Willemsen, G., Nyholt, DR., Zhu, G., Codd, V., Novakovic, B., Hansell, N. K., Wright, M. J., Rietschel, L., Streit, F., Henders, A. K., Montgomery, G. W., Samani, N. J., Gillespie, N. A., Hickie, I. B., Craig, J. M., Saffery, R., Boomsma, D. I., Rietschel, M. & 1 othersMartin, N. G., 2015, In : Twin Research and Human Genetics. 18, 2, p. 198-209 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Monozygotic Twins
Telomere
Low Birth Weight Infant
Birth Weight
Anxiety
Open Access
2014

Epigenetic Variation in Monozygotic Twins: A Genome-Wide Analysis of DNA Methylation in Buccal Cells

van Dongen, J., Ehli, E. A., Slieker, R. C., Bartels, M., Weber, Z. M., Davies, G. E., Slagboom, P. E., Heijmans, B. T. & Boomsma, D. I., 2014, In : Genes. 5, 2, p. 347-365 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Cheek
DNA Methylation
Epigenomics
Genome

No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80607 Subjects

Baumert, J., Huang, J., McKnight, B., Sabater-Lleal, M., Steri, M., Chu, A. Y., Trompet, S., Lopez, L. M., Fornage, M., Teumer, A., Tang, W., Rudnicka, A. R., Mälarstig, A., Hottenga, J. J., Kavousi, M., Lahti, J., Tanaka, T., Hayward, C., Huffman, J. E., Morange, P. E. & 83 othersRose, L. M., Basu, S., Rumley, A., Stott, D. J., Buckley, B. M., de Craen, A. J., Sanna, S., Masala, M., Biffar, R., Homuth, G., Silveira, A., Sennblad, B., Goel, A., Watkins, H., Müller-Nurasyid, M., Rückerl, R., Taylor, K., Chen, M. H., de Geus, E. J. C., Hofman, A., Witteman, J. C. M., de Maat, M. P. M., Palotie, A., Davies, G. E., Siscovick, D. S., Kolcic, I., Wild, S. H., Song, J., McArdle, W. L., Ford, I., Sattar, N., Schlessinger, D., Grotevendt, A., Franzosi, M. G., Illig, T., Waldenberger, M., Lumley, T., Tofler, G. H., Willemsen, G., Uitterlinden, A. G., Rivadeneira, F., Räikkönen, K., Chasman, D. I., Folsom, A. R., Lowe, G. D., Westendorp, R. G. J., Slagboom, P. E., Cucca, F., Wallaschofski, H., Strawbridge, R. J., Seedorf, U., Koenig, W., Bis, J. C., Mukamal, K. J., van Dongen, J., Widen, E., Franco, O. H., Starr, J. M., Liu, K., Ferrucci, L., Polasek, O., Wilson, J. F., Oudot-Mellakh, T., Campbell, H., Navarro, P., Bandinelli, S., Eriksson, J., Boomsma, D. I., Dehghan, A., Clarke, R., Hamsten, A., Boerwinkle, E., Jukema, J. W., Naitza, S., Ridker, P. M., Völzke, H., Deary, I. J., Reiner, A. P., Trégouët, D. A., O'Donnell, C. J., Strachan, D. P., Peters, A. & Smith, N. L., 2014, In : PLoS ONE. 9, 12, 18 p., e111156.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
fibrinogen
Beam plasma interactions
Alcohol Drinking
Fibrinogen
body mass index

The Contribution of the Functional IL6R Polymorphism rs2228145, eQTLs and Other Genome-Wide SNPs to the Heritability of Plasma sIL-6R Levels

van Dongen, J., Jansen, R., Smit, D. J. A., Hottenga, J. J., Mbarek, H., Willemsen, G., Kluft, C., Penninx, B. W. J. H., Ferreira, M. A., Boomsma, D. I. & de Geus, E. J. C., 2014, In : Behavior Genetics. 44, 4, p. 368-382 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

heritability
Single Nucleotide Polymorphism
polymorphism
genome
genetic polymorphism
2013

Genetic Architecture of the Pro-Inflammatory State in an Extended Twin-Family Design

Neijts, M., van Dongen, J., Kluft, C., Boomsma, D. I., Willemsen, G. & de Geus, E. J. C., 2013, In : Twin Research and Human Genetics. 16, 05, p. 931-940

Research output: Contribution to JournalArticleAcademicpeer-review

Fibrinogen
C-Reactive Protein
Interleukin-6
Tumor Necrosis Factor-alpha
Lymphotoxin-beta

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

Sabater-Lleal, M., Huang, J., Chasman, D. I., Naitza, S., Dehghan, A., Johnson, A. D., Teumer, A., Reiner, A. P., Folkersen, L., Basu, S., Rudnicka, A. R., Trompet, S., Mälarstig, A., Baumert, J., Bis, J. C., Guo, X., Hottenga, J. J., Shin, S. Y., Lopez, L. M., Lahti, J. & 125 othersTanaka, T., Yanek, L. R., Oudot-Mellakh, T., Wilson, J. F., Navarro, P., Huffman, J. E., Zemunik, T., Redline, S., Mehra, R., Pulanic, D., Rudan, I., Wright, A. F., Kolcic, I., Polasek, O., Wild, S. H., Campbell, H., Curb, J. D., Wallace, R., Liu, S., Eaton, C. B., Becker, D. M., Becker, L. C., Bandinelli, S., Räikkönen, K., Widén, E., Palotie, A., Fornage, M., Green, D., Gross, M., Davies, G. E., Harris, S. E., Liewald, D. C., Starr, J. M., Williams, F. M., Grant, P. J., Spector, T. D., Strawbridge, R. J., Silveira, A., Sennblad, B., Rivadeneira, F., Uitterlinden, A. G., Franco, O. H., Hofman, A., van Dongen, J., Willemsen, G., Boomsma, D. I., Yao, J., Swords Jenny, N., Haritunians, T., McKnight, B., Lumley, T., Taylor, K. D., Rotter, J. I., Psaty, B. M., Peters, A., Gieger, C., Illig, T., Grotevendt, A., Homuth, G., Völzke, H., Kocher, T., Goel, A., Franzosi, M. G., Seedorf, U., Clarke, R., Steri, M., Tarasov, K. V., Sanna, S., Schlessinger, D., Stott, D. J., Sattar, N., Buckley, B. M., Rumley, A., Lowe, G. D., McArdle, W. L., Chen, M. H., Tofler, G. H., Song, J., Boerwinkle, E., Folsom, A. R., Rose, L. M., Franco-Cereceda, A., Teichert, M., Ikram, M. A., Mosley, T. H., Bevan, S., Dichgans, M., Rothwell, P. M., Sudlow, C. L., Hopewell, J. C., Chambers, J. C., Saleheen, D., Kooner, J. S., Danesh, J., Nelson, C. P., Erdmann, J., Reilly, M. P., Kathiresan, S., Schunkert, H., Morange, P. E., Ferrucci, L., Eriksson, J. G., Jacobs, D., Deary, I. J., Soranzo, N., Witteman, J. C., de Geus, E. J. C., Tracy, R. P., Hayward, C., Koenig, W., Cucca, F., Jukema, J. W., Eriksson, P., Seshadri, S., Markus, H. S., Watkins, H., Samani, N. J., Wallaschofski, H., Smith, N. L., Tregouet, D. A., Ridker, P. M., Tang, W., Strachan, D. P., Hamsten, A. & O'Donnell, C. J., 2013, In : Circulation. 128, 12, p. 1310-1324

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Fibrinogen
Meta-Analysis
Cardiovascular Diseases
Coronary Artery Disease

The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection

Willemsen, G., Vink, J. M., Abdellaoui, A., den Braber, A., van Beek, J. H. D. A., Draisma, H. H. M., van Dongen, J., van t Ent, D., Geels, L. M., van Lien, R., Ligthart, R. S. L., Kattenberg, V. M., Mbarek, H., de Moor, M. H. M., Neijts, M., Pool, R., Stroo, N., Kluft, C., Suchiman, H. E. D., Slagboom, P. E. & 2 othersde Geus, E. J. C. & Boomsma, D. I., 2013, In : Twin Research and Human Genetics. 16, 1, p. 271-281

Research output: Contribution to JournalArticleAcademicpeer-review

Netherlands
Life Style
RNA Sequence Analysis
Gene-Environment Interaction
Metabolomics

The evolutionary paradox and the missing heritability of schizophrenia

van Dongen, J. & Boomsma, D. I., 2013, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 162, 2, p. 122-136

Research output: Contribution to JournalArticleAcademicpeer-review

Schizophrenia
Psychiatry
Gene-Environment Interaction
Genome-Wide Association Study
Genomics