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Personal profile



Basisprakticum Farmacochemie (coordinator)

Farmacokinetiek en ADME-processen (lecturer)

Bioanalyse en Farmaceutische Toxicologie (lecturer)

Prakticum Moleculaire Toxicologie (coordinator)

Bachelorprojecten Moleculaire Toxicologie (coordinator)



ADMET (coordinator/lecturer)

Drug-Induced Stress and Cellular Responses (coordinator/lecturer)


Postgraduate courses:

PET-module Molecular Toxicology  (coordinator/lecturer)

Safescimet-module: Biochemical and Molecular Toxicologie  (coordinator/lecturer)


Role of biotransformation in chemically-induced toxicity.  Consequences of genetic polymorphisms of bioactivating (P450's) and bioinactivating (GST's, NQO's) enzymes for susceptibility to drug-induced toxicity.

Ancillary activities

Board of section Pharmaceutical Toxicology of the Dutch Society of Toxicology (NVT)

Member Commissie van Toezicht of programme of Postgratuate Education in Toxicology

Ancillary activities

No ancillary activities

Ancillary activities are updated daily

Education/Academic qualification

Molecular Toxicology, PhD, Vrije Universiteit Amsterdam

Farmacochemie, Master, Vrije Universiteit Amsterdam

Scheikunde, Bachelor, Vrije Universiteit Amsterdam

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 6 Similar Profiles
Cytochrome P-450 Enzyme System Medicine & Life Sciences
Rats Chemical Compounds
Glutathione Transferase Medicine & Life Sciences
Cytochrome P-450 CYP2D6 Medicine & Life Sciences
Liver Chemical Compounds
Metabolites Chemical Compounds
Selenocysteine Medicine & Life Sciences
Metabolism Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1987 2018

A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants

Luirink, R. A., Dekker, S. J., Capoferri, L., Kuiper, C. L., Janssen, L. F. H., Ari, M. E., Vermeulen, N. P. E., Vos, J. C., Commandeur, J. N. M. & Geerke, D. P., Jul 2018, In : Journal of Inorganic Biochemistry. 184, p. 115-122 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Cytochrome P-450 Enzyme System
Open Access

Drug induced liver injury: assessment of inter-individual variation in the balance of bioactivation and inactivation as risk factor

den Braver, M. W., 2018, 288 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access

Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism

Lazarska, K. E., Dekker, S. J., Vermeulen, N. P. E. & Commandeur, J. N. M., 1 Mar 2018, In : Toxicology Letters. 284, 1 March, p. 70-78 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chemical and Drug Induced Liver Injury

Glutathione S-transferase P1 protects against Amodiaquine Quinoneimines-induced cytotoxicity but does not prevent activation of endoplasmic reticulum stress in HepG2 cells

Zhang, Y., den Braver-Sewradj, S. P., den Braver, M. W., Hiemstra, S., Vermeulen, N. P. E., van de Water, B., Commandeur, J. N. M. & Vos, J. C., 18 Apr 2018, In : Frontiers in Pharmacology. 9, APRIL, p. 1-13 13 p., 388

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Endoplasmic Reticulum Stress
Hep G2 Cells
Glutathione Transferase

Activities 1997 1999

  • 6 Lecture / Presentation

Cytochrome P450 in Drug Research: practical aspects.

Commandeur, J. N. M. (Speaker)

Activity: Lecture / PresentationAcademic

Cytochrome P450 in Drug Research: enzymology

Commandeur, J. N. M. (Speaker)

Activity: Lecture / PresentationAcademic

Chemical reactivity and selectivity of reactive intermediates.

Commandeur, J. N. M. (Speaker)
26 Aug 1997

Activity: Lecture / PresentationAcademic

Enzymology of glutathione S-transferases.

Commandeur, J. N. M. (Speaker)
24 Aug 1997

Activity: Lecture / PresentationAcademic