J.N.M. Commandeur

dr.

1987 …2019
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Personal profile

Teaching

Bachelorcourses:

Basisprakticum Farmacochemie (coordinator)

Farmacokinetiek en ADME-processen (lecturer)

Bioanalyse en Farmaceutische Toxicologie (lecturer)

Prakticum Moleculaire Toxicologie (coordinator)

Bachelorprojecten Moleculaire Toxicologie (coordinator)

 

Mastercourses:

ADMET (coordinator/lecturer)

Drug-Induced Stress and Cellular Responses (coordinator/lecturer)

 

Postgraduate courses:

PET-module Molecular Toxicology  (coordinator/lecturer)

Safescimet-module: Biochemical and Molecular Toxicologie  (coordinator/lecturer)

Research

Role of biotransformation in chemically-induced toxicity.  Consequences of genetic polymorphisms of bioactivating (P450's) and bioinactivating (GST's, NQO's) enzymes for susceptibility to drug-induced toxicity.

Ancillary activities

Board of section Pharmaceutical Toxicology of the Dutch Society of Toxicology (NVT)

Member Commissie van Toezicht of programme of Postgratuate Education in Toxicology

Ancillary activities

No ancillary activities

Ancillary activities are updated daily

Education/Academic qualification

Molecular Toxicology, PhD, Vrije Universiteit Amsterdam

Farmacochemie, Master, Vrije Universiteit Amsterdam

Scheikunde, Bachelor, Vrije Universiteit Amsterdam

Fingerprint Dive into the research topics where J.N.M. Commandeur is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Cytochrome P-450 Enzyme System Medicine & Life Sciences
Cytochrome P-450 CYP2D6 Medicine & Life Sciences
Rats Chemical Compounds
Glutathione Transferase Medicine & Life Sciences
Metabolites Chemical Compounds
Selenocysteine Medicine & Life Sciences
Liver Chemical Compounds
Enzymes Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1987 2019

Open Access
Sulfaphenazole
Floxacillin
Cytochrome P-450 CYP3A
Cytochromes
Hydroxylation

Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis

Ortega Ugalde, S., Ma, D., Cali, J. J. & Commandeur, J. N. M., 1 Aug 2019, In : SLAS Discovery. 24, 7, p. 745-754 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium tuberculosis
Cytochrome P-450 Enzyme System
Substrates
Luminescence
Lanosterol

Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?

Ortega Ugalde, S., Boot, M., Commandeur, J. N. M., Jennings, P., Bitter, W. & Vos, J. C., 2 May 2019, In : Applied Microbiology and Biotechnology. 103, 9, p. 3597-3614 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mycobacterium tuberculosis
Cytochrome P-450 Enzyme System
Oxidation-Reduction
Pharmaceutical Preparations
Ferredoxins

Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

Frydenvang, K., Verkade-Vreeker, M. C. A., Dohmen, F., Commandeur, J. N. M., Rafiq, M., Mirza, O., Jørgensen, F. S. & Geerke, D. P., 1 May 2019, In : PLoS ONE. 14, 5, e0217292.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
dithiothreitol
Dithiothreitol
cytochrome P-450
Structural analysis
Cytochrome P-450 Enzyme System

A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants

Luirink, R. A., Dekker, S. J., Capoferri, L., Kuiper, C. L., Janssen, L. F. H., Ari, M. E., Vermeulen, N. P. E., Vos, J. C., Commandeur, J. N. M. & Geerke, D. P., Jul 2018, In : Journal of Inorganic Biochemistry. 184, p. 115-122 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Floxacillin
Hydroxylation
Cytochrome P-450 Enzyme System
Metabolites
Enzymes

Activities 1997 1999

  • 6 Lecture / Presentation

Cytochrome P450 in Drug Research: practical aspects.

J.N.M. Commandeur (Speaker)
1999

Activity: Lecture / PresentationAcademic

Cytochrome P450 in Drug Research: enzymology

J.N.M. Commandeur (Speaker)
1999

Activity: Lecture / PresentationAcademic

Chemical reactivity and selectivity of reactive intermediates.

J.N.M. Commandeur (Speaker)
26 Aug 1997

Activity: Lecture / PresentationAcademic

Enzymology of Cytochrome P450.

J.N.M. Commandeur (Speaker)
24 Aug 1997

Activity: Lecture / PresentationAcademic