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Personal profile

Teaching

Bachelorcourses:

Basisprakticum Farmacochemie (coordinator)

Farmacokinetiek en ADME-processen (lecturer)

Bioanalyse en Farmaceutische Toxicologie (lecturer)

Prakticum Moleculaire Toxicologie (coordinator)

Bachelorprojecten Moleculaire Toxicologie (coordinator)

 

Mastercourses:

ADMET (coordinator/lecturer)

Drug-Induced Stress and Cellular Responses (coordinator/lecturer)

 

Postgraduate courses:

PET-module Molecular Toxicology  (coordinator/lecturer)

Safescimet-module: Biochemical and Molecular Toxicologie  (coordinator/lecturer)

Research

Role of biotransformation in chemically-induced toxicity.  Consequences of genetic polymorphisms of bioactivating (P450's) and bioinactivating (GST's, NQO's) enzymes for susceptibility to drug-induced toxicity.

Ancillary activities

Board of section Pharmaceutical Toxicology of the Dutch Society of Toxicology (NVT)

Member Commissie van Toezicht of programme of Postgratuate Education in Toxicology

Ancillary activities

No ancillary activities

Ancillary activities are updated daily

Education/Academic qualification

Molecular Toxicology, PhD, Vrije Universiteit Amsterdam

Farmacochemie, Master, Vrije Universiteit Amsterdam

Scheikunde, Bachelor, Vrije Universiteit Amsterdam

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Cytochrome P-450 Enzyme System Medicine & Life Sciences
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Glutathione Transferase Medicine & Life Sciences
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Liver Chemical Compounds
Metabolites Chemical Compounds
Selenocysteine Medicine & Life Sciences
Metabolism Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1987 2018

Floxacillin
Hydroxylation
Cytochrome P-450 Enzyme System
Metabolites
Enzymes

Drug induced liver injury: assessment of inter-individual variation in the balance of bioactivation and inactivation as risk factor

den Braver, M. W. 2018 288 p.

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
File

Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism

Lazarska, K. E., Dekker, S. J., Vermeulen, N. P. E. & Commandeur, J. N. M. 1 Mar 2018 In : Toxicology Letters. 284, 1 March, p. 70-78 9 p.

Research output: Contribution to journalArticle

Open Access
Diclofenac
Polymorphism
Metabolism
Liver
Chemical and Drug Induced Liver Injury

Glutathione S-transferase P1 protects against Amodiaquine Quinoneimines-induced cytotoxicity but does not prevent activation of endoplasmic reticulum stress in HepG2 cells

Zhang, Y., den Braver-Sewradj, S. P., den Braver, M. W., Hiemstra, S., Vermeulen, N. P. E., van de Water, B., Commandeur, J. N. M. & Vos, J. C. 18 Apr 2018 In : Frontiers in Pharmacology. 9, APRIL, p. 1-13 13 p., 388

Research output: Contribution to journalArticle

Open Access
Endoplasmic Reticulum Stress
Hep G2 Cells
Amodiaquine
Glutathione Transferase
Glutathione
High performance liquid chromatography
Glutathione Transferase
Liver
Sulfates
Assays