Photo of J.N.M. Commandeur

dr. J.N.M. Commandeur

    1987 …2020

    Research output per year

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    Personal profile

    Teaching

    Bachelorcourses:

    Basisprakticum Farmacochemie (coordinator)

    Farmacokinetiek en ADME-processen (lecturer)

    Bioanalyse en Farmaceutische Toxicologie (lecturer)

    Prakticum Moleculaire Toxicologie (coordinator)

    Bachelorprojecten Moleculaire Toxicologie (coordinator)

     

    Mastercourses:

    ADMET (coordinator/lecturer)

    Drug-Induced Stress and Cellular Responses (coordinator/lecturer)

     

    Postgraduate courses:

    PET-module Molecular Toxicology  (coordinator/lecturer)

    Safescimet-module: Biochemical and Molecular Toxicologie  (coordinator/lecturer)

    Research

    Role of biotransformation in chemically-induced toxicity.  Consequences of genetic polymorphisms of bioactivating (P450's) and bioinactivating (GST's, NQO's) enzymes for susceptibility to drug-induced toxicity.

    Ancillary activities

    Board of section Pharmaceutical Toxicology of the Dutch Society of Toxicology (NVT)

    Member Commissie van Toezicht of programme of Postgratuate Education in Toxicology

    Ancillary activities

    No ancillary activities

    Ancillary activities are updated daily

    Academic qualification

    Molecular Toxicology, PhD, Vrije Universiteit Amsterdam

    Award Date: 31 Jan 1991

    Farmacochemie, Master, Vrije Universiteit Amsterdam

    Award Date: 31 May 1985

    Scheikunde, Bachelor, Vrije Universiteit Amsterdam

    Award Date: 30 Jun 1981

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    Research Output

    Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis

    Ortega Ugalde, S., Wallraven, K., Speer, A., Bitter, W., Grossmann, T. N. & Commandeur, J. N. M., Jul 2020, In : Biochemical Pharmacology. 177, 47 p., 113938.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access
  • A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450-Catalyzed Substrate Conversion

    Luirink, R. A., Verkade-Vreeker, M. C. A., Commandeur, J. N. M. & Geerke, D. P., 15 May 2020, In : ChemBioChem. 21, 10, p. 1461-1472 12 p.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access
  • Open Access
  • Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis

    Ortega Ugalde, S., Ma, D., Cali, J. J. & Commandeur, J. N. M., 1 Aug 2019, In : SLAS Discovery. 24, 7, p. 745-754 10 p.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access
  • Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?

    Ortega Ugalde, S., Boot, M., Commandeur, J. N. M., Jennings, P., Bitter, W. & Vos, J. C., 2 May 2019, In : Applied Microbiology and Biotechnology. 103, 9, p. 3597-3614 18 p.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access
  • Activities

    • 6 Lecture / Presentation

    Cytochrome P450 in Drug Research: enzymology

    J.N.M. Commandeur (Speaker)

    1999

    Activity: Lecture / PresentationAcademic

    Cytochrome P450 in Drug Research: practical aspects.

    J.N.M. Commandeur (Speaker)

    1999

    Activity: Lecture / PresentationAcademic

    Enzymology of Cytochrome P450.

    J.N.M. Commandeur (Speaker)

    24 Aug 1997

    Activity: Lecture / PresentationAcademic

    Chemical reactivity and selectivity of reactive intermediates.

    J.N.M. Commandeur (Speaker)

    26 Aug 1997

    Activity: Lecture / PresentationAcademic