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Research Output 1993 2019

2009

Delivering proteins for export from the cytosol.

Cross, B. C., Sinning, I., Luirink, S. & High, S., 2009, In : Nature Reviews Molecular Cell Biology. 10, 4, p. 255-264

Research output: Contribution to JournalArticleAcademicpeer-review

Cytosol
Membranes
Proteins
Bacterial Proteins
Guanosine Triphosphate

Flexibility in targeting and insertion during bacterial membrane protein biogenesis.

van Bloois, D. W., ten Hagen-Jongman, C. M. & Luirink, S., 2009, In : Biochemical and Biophysical Research Communications. 362, p. 727-733 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacterial Proteins
Membrane Proteins
Signal Recognition Particle
Proton-Motive Force
Escherichia coli

Pbp, a cell-surface exposed plasminogen binding protein of Bacteroides fragilis.

Sijbrandi, R., Stork, M., Luirink, S. & Otto, B. R., 2009, In : Microbes and Infection. 10, p. 514-521 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacteroides fragilis
Plasminogen
Carrier Proteins
Virulence Factors
Proteins

The Bam (Omp85) complex is involved in secretion of the autotransporter haemoglobin protease.

Sauri, A., Soprova, Z., Wickstrom, D., de Gier, J-W., van der Schors, R. C., Smit, A. B., Jong, W. S. P. & Luirink, S., 2009, In : Microbiology. 155, 12, p. 3982-3991

Research output: Contribution to JournalArticleAcademicpeer-review

Hemoglobins
Peptide Hydrolases
Membranes
Virulence Factors
Protein Transport

The conserved third transmembrane segment of YidC contacts nascent Escherichia coli inner membrane proteins.

Yu, Z., Koningstein, G. M., Pop, O. I. & Luirink, S., 2009, In : Journal of Biological Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli
Membrane Proteins
Membranes
Substrates

Type VII secretion in mycobacteria: classification in line with cell envelope structure.

Bitter, W., Houben, E. N. G., Luirink, S. & Appelmelk, B. J., 2009, In : Trends In Microbiology. 8, p. 337-338

Research output: Contribution to JournalArticleAcademicpeer-review

YidC is required for the assembly of the MscL homopentameric pore.

Pop, O. I., Soprova, Z., Koningstein, G. M., Scheffers, D. J., van Ulsen, J. P., Wickstrom, D., de Gier, J-W. & Luirink, S., 2009, In : The FEBS Journal. 276, 17, p. 4891-4899

Research output: Contribution to JournalArticleAcademicpeer-review

Membranes
Escherichia coli
Signal Recognition Particle
Lipid bilayers
Lipid Bilayers
2008

Across the inner membrane and beyond: Signal peptide-mediated protein transport via the Tat and autotransporter pathways of Escherichia coli

Jong, W. S., 2008, Amsterdam.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC.

Wagner, S., Pop, O. I., Haan, G. J., Koningstein, G. M., Klepsch, M. M., Genevaux, P., Luirink, S. & de Gier, J-W., 2008, In : Journal of Biological Chemistry. 283, p. 17881-1790

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Maltose
Escherichia coli
Membrane Proteins

Characterization of the evolutionarily conserved role of Escherichia coli YidC in membrane protein biogenesis

van Bloois, D. W., 2008, Amsterdam.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins

van Bloois, E., Dekker, H. L., Froderberg, L., Houben, E. N. G., Urbanus, M. L., de Koster, C. G., de Gier, J. W. & Luirink, J., 2008, In : FEBS Letters. 2008, 582, p. 1419-1424

Research output: Contribution to JournalArticleAcademicpeer-review

Quality Control
Quality control
Membrane Proteins
Membranes
Escherichia coli

Specialised protein secretion systems of Mycobacteria

Bitter, W., Houben, E. N. G. & Luirink, S., 2008, Mycobacterium, Genomics and Molecular Biology. Parish, T. & Brown, A. S. (eds.). p. 189-205

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Protein Sorting Signals
Hemoglobins
Peptide Hydrolases
Gram-Negative Bacteria
Bacteria
2007

Contribution of the FtsQ transmembrane segment to loclization to the cell division site.

Scheffers, D. J., Robichon, C., den Blaauwen, T., Haan, G. J., Koningstein, G. M., van Bloois, D. W., Beckwith, J. & Luirink, S., 2007, In : Journal of Bacteriology. 189, 20, p. 7273-7280

Research output: Contribution to JournalArticleAcademic

Cell Division
Membrane Proteins
Cell Membrane
Escherichia coli
Membranes

COTRANSLATIONAL PROTEIN TARGETING IN ESCHERICHIA COLI

Ullers, R. S., Genevaux, P. & Luirink, S., 2007, The Enzymes, Molecular Machines involved in Protein Transport across Cellular Membranes.. Carla Koehler Fuyuhiko Tamanoi, R. E. D. (ed.).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Flexibility in targeting and insertion during bacterial membrane protein biogenesis.

van Bloois, D. W., ten Hagen-Jongman, C. M. & Luirink, S., 2007, In : Biochemical and Biophysical Research Communications. 362, 3, p. 727-733

Research output: Contribution to JournalArticleAcademic

Bacterial Proteins
Membrane Proteins
Signal Recognition Particle
Proton-Motive Force
Escherichia coli

Limited tolerance towards folded elements during secretion of the autotransporter Hbp.

Jong, W. S. P., ten Hagen-Jongman ten, C. M., den Blaauwen, T., Slotboom, D. J., Tame, J. R. H., Wickstrom, D., de Gier, J-W., Otto, B. R. & Luirink, S., 2007, In : Molecular Microbiology. 63, 5, p. 1524-1536

Research output: Contribution to JournalArticleAcademic

Hemoglobins
Peptide Hydrolases
Disulfides
Membranes
Periplasm

Saccharomyces cerevisiae Cox 18 complements the essential Sec-independent function of Escherichia coli YidC.

van Bloois, D. W., Koningstein, G. M., Bauerschmitt, H., Herrmann, J. M. & Luirink, S., 2007, In : The FEBS Journal. 274, 21, p. 5704-5713

Research output: Contribution to JournalArticleAcademic

Yeast
Escherichia coli
Saccharomyces cerevisiae
Membrane Proteins
Mitochondria

Type VII secretion-mycobacteria show the way.

Abdallah, A. M., Gey van Pittius, N. C., Champion, P. A., Cox, J., Luirink, S., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J. & Bitter, W., 2007, In : Nature Reviews Microbiology. 5, 11, p. 883-891

Research output: Contribution to JournalArticleAcademic

Mycobacterium
Secretory Pathway
Gram-Positive Bacteria
Terminology
Cell Wall
2006

A specific secretion system mediates PPE41 transport in pathogenic mycobacteria

Abdallah, A. M., Verboom, T., Hannes, F., Safi, M., Strong, M., Eisenberg, D., Musters, R. J. P., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J., Luirink, S. & Bitter, W., 2006, In : Molecular Microbiology. 62, 3, p. 667-679 13 p.

Research output: Contribution to JournalArticleAcademic

Mycobacterium
Mycobacterium marinum
Mycobacterium smegmatis
Genes
Macrophages

Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.

van Bloois, D. W., Haan, G. J., de Gier, J-W., Oudega, B. & Luirink, S., 2006, In : Journal of Biological Chemistry. 14, 281

Research output: Contribution to JournalArticleAcademic

Open Access
File
Escherichia coli
Membrane Proteins
Protein Subunits
Capsid Proteins
Membranes

Iron uptake in Vibrio anguillarum. Regulation, siderophore biosynthesis and transport of iron-siderophore complexes

Stork, M., 2006, 152 p.

Research output: PhD ThesisPhD Thesis - Research external, graduation VUAcademic

Molecular insight into the pathogenetic synergy between E. coli and B. fragilis in secondary peritonitis

Sijbrandi, R., 2006

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle.

Ullers, R. S., Houben, E. N. G., Oudega, B., Harms, N. & Luirink, S., 2006, In : Journal of Biological Chemistry. 281, 20, p. 13999-144005 7 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Signal Recognition Particle
Escherichia coli
Protein Sorting Signals
Anchors
Peptides
2005

Biogenesis of inner membrane proteins in Escherichia coli

Luirink, S., von Heijne, G., Houben, E. N. G. & de Gier, J-W., 2005, In : Annual Review of Microbiology. 59, p. 329-355 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Membrane Proteins
Escherichia coli
Membranes
Signal Recognition Particle
Protein Folding

Characterization of an iron-regulated alpha-enolase of Bacteroides fragilis

Sijbrandi, R., den Blaauwen, T., Tame, J. R. H., Oudega, B., Luirink, S. & Otto, B. R., 2005, In : Microbes and Infection. 7, p. 9-18 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacteroides fragilis
Phosphopyruvate Hydratase
Iron
Plasminogen
Proteins

Close encounters of nascent polypeptides during targeting and membrane insertion in Escherichia coli

Ullers, R. S., 2005, Enschede: Febodruk BV. 157 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli

Otto, B. R., Sijbrandi, R., Luirink, S., Oudega, B., Heddle, J. G., Mizutani, K., Park, S. Y. & Tame, J. R. H., 2005, In : Journal of Biological Chemistry. 280, p. 17339-17345 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli Proteins
Heme
Hemoglobins
Peptide Hydrolases
Crystal structure

Early encounters of a nascent membrane protein : specificity and timing of contacts inside and outside the ribosome

Houben, E. N. G., Zarivach, R., Brunner, J., Oudega, B. & Luirink, S., 2005, In : Journal of Cell Biology. 170, p. 27-35 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Ribosomes
Membrane Proteins
Signal Recognition Particle
Peptidyl Transferases
Molecular Probes

Evolution of mitochondrial oxa proteins from bacterial YidC: inherited and acquired functions of a conserved insertion machinery

Preuss, M., Ott, M., Funes, G., Luirink, S. & Herrmann, J. M., 2005, In : Journal of Biological Chemistry. 280, p. 13004-13011 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Mitochondria
Bacterial Proteins
Mitochondrial Proteins
Machinery
Ribosomes

From ribosome to membrane : sequential interactions of Escherichia coli inner membrane proteins during biogenesis

Houben, E. N. G., 2005, Enschede: Febodruk bv Enschede. 142 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Signal peptide hydrophobicity is critical for early stages in protein export by Bacillus subtilis

van Zanen, L. F., Houben, E. N. G., Meima, R. B., Tjalsma, H., Jongbloed, J. D. H., Westers, T. M., Oudega, B., Luirink, S., Dijl, J. M. & Quax, W. J., 2005, In : The FEBS Journal. 272, p. 4617-4630 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacilli
Hydrophobicity
Protein Sorting Signals
Bacillus subtilis
Hydrophobic and Hydrophilic Interactions

The Sec-independent function of Escherichia coli YidC is evolutionary conserved and essential

van Bloois, D. W., Nagamori, S., Koningstein, G. M., Ullers, R. S., Preuss, M., Oudega, B., Harms, N., Kaback, H. R. & Luirink, S., 2005, In : Journal of Biological Chemistry. 280, p. 12996-13003 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli
Thylakoid Membrane Proteins
Membranes
Assays
Protein Transport
2004

F1F0 ATP synthase subunit c is targeted by SRP to YidC in the Escherichia coli inner membrane.

van Bloois, D. W., Haan, G. J., Gier de, J. W., Oudega, B. & Luirink, S., 2004, In : FEBS Letters. 576, p. 97-100 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Escherichia coli
Membrane Proteins
Membranes
F1F0-ATP synthase

SecB is a bona fide generalized chaperone in Escherichia coli

Ullers, R. S., Luirink, S., Harms, N., Schwager, F., Georgopoulos, C. & Genevaux, P., 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, p. 7583-7588 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Escherichia coli Proteins
Escherichia coli
Temperature
Ribosomes
Phenotype

SRP-mediated protein targeting: structure and function revisited.

Luirink, S. & Sinning, I., 2004, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. p. 17-35 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Targeting and translocation of the two lipoproteins in Escherichia coli via the SRP/Sec/YidC pathway.

Froderberg, L., Houben, E. N. G., Baars, L., Luirink, S. & Gier de, J. W., 2004, In : Journal of Biological Chemistry. 279, p. 31026-31032 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli
Lipoproteins
Bacteriocins
Peptidoglycan
Lipid Bilayers

The two membrane segments of leader peptidase partition one by one into the lipid bilayer via a Sec/YidC interface.

Houben, E. N. G., ten Hagen-Jongman ten, C. M., Brunner, J., Oudega, B. & Luirink, S., 2004, In : EMBO Reports. 5, p. 970-975 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Lipid bilayers
Lipid Bilayers
Membranes
Lipids
Escherichia coli Proteins

Trigger factor interacts with the signal peptide of nascent Tat substrates but does not play a critical role in tat-mediated export.

Jong, W. S., ten Hagen-Jongman ten, C. M., Genevaux, P., Brunner, J., Oudega, B. & Luirink, S., 2004, In : European Journal of Biochemistry. 271, p. 4779-4787 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Protein Sorting Signals
Arginine
Substrates
Protein Transport
Ribosomes
2003

A conserved function of YidC in the biogenesis of respiratory chain complexes.

van der Laan, M., Urbanus, M. L., ten Hagen-Jongman ten, C. M., Nouwen, N., Oudega, B., Harms, N., Driessen, A. J. M. & Luirink, S., 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, p. 5801-5806 6 p.

Research output: Contribution to JournalArticleAcademic

Inosine Monophosphate
Electron Transport
Proton-Motive Force
Capsid Proteins
Bacteriophages

Assembly of inner Membrane Proteins in Escherichia coli

Drew, D., Froderberg, L., Baars, L., Luirink, S. & de Gier, J-W., 2003, Protein Secretion Pathways in Bacteria. Boston/Dordrecht/London: Kluwer Academic Publishers, p. 65-82 17 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Escherichia coli YidC, an evolutionary conserved facilitator of membrane protein integration.

Urbanus, M. L., 2003, Amsterdam: Thesis.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome

Ullers, R. S., Houben, E. N. G., Raine, A., ten Hagen-Jongman ten, C. M., Ehrenberg, M., Brunner, J., Oudega, B., Harms, N. & Luirink, S., 2003, In : Journal of Cell Biology. 161, p. 679-684 6 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Signal Recognition Particle
Ribosomes
Escherichia coli
Membrane Proteins
Protein Sorting Signals

Protein Targeting to the Inner Membrane

Luirink, S. & Oudega, B., 2003, Protein Secretion Pathways in Bacteria. Boston/Dordrecht/London: Kluwere Academic Publishers, p. 1-21 21 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Signal recognition particle (SRP)- mediated targeting and Sec-dependent translocation of an extracellular E. coli protein.

Sijbrandi, R., Urbanus, M. L., ten Hagen-Jongman ten, C. M., Bernstein, H. D., Oudega, B., Otto, B. R. & Luirink, S., 2003, In : Journal of Biological Chemistry. 278, p. 4654-4659 6 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Signal Recognition Particle
Escherichia coli Proteins
Hemoglobins
Peptide Hydrolases
Membranes

Targeting and insertion of heterologous membrane proteins in E. coli.

Raine, A., Ullers, R. S., Pavlov, M., Luirink, S., Wikberg, J. E. S. & Ehrenberg, M., 2003, In : Biochimie. 85, p. 659-668 9 p.

Research output: Contribution to JournalArticleAcademic

Proton Pumps
Escherichia coli
Membrane Proteins
Membranes
human MC4R protein

The ribosome and YidC: new insights into the biogenesis of Escherichia coli inner membrane proteins.

de Gier, J-W. & Luirink, S., 2003, In : EMBO Reports. 4, p. 939-943 5 p.

Research output: Contribution to JournalArticleAcademic

Ribosomes
Escherichia coli
Membrane Proteins
Signal Recognition Particle
Periplasm

Versatility of inner membrane protein biogenesis in Escherichia coli.

Froderberg, L., Houben, E. N. G., Samuleson, J. C., Chen, M., Park, S. K., Philips, G. J., Dalbey, R. E., Luirink, S. & de Gier, J-W., 2003, In : Molecular Microbiology. 47, p. 1015-1027 13 p.

Research output: Contribution to JournalArticleAcademic

Inosine Monophosphate
Membrane Proteins
Escherichia coli
Signal Recognition Particle
Membranes
2002

Defective translocation of a signal sequence mutant in a prlA4 suppressor strain of Escherichia coli.

Adams, H., Scottie, P. A., Luirink, S. & Tommassen, J., 2002, In : European Journal of Biochemistry. 269, p. 5572-5580 8 p.

Research output: Contribution to JournalArticleAcademic

Signal Recognition Particle
Protein Sorting Signals
Escherichia coli
Membrane Proteins
Endopeptidase K

Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis.

Otto, B. R., van Dooren, S. J. M., Dozois, C. M., Luirink, S. & Oudega, B., 2002, In : Infection and Immunity. 70, p. 5-10 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Bacteroides fragilis
Heme
Abscess
Intraabdominal Infections
Hemoglobins