1993 …2019
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Research Output 1993 2019

2005

Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli

Otto, B. R., Sijbrandi, R., Luirink, S., Oudega, B., Heddle, J. G., Mizutani, K., Park, S. Y. & Tame, J. R. H., 2005, In : Journal of Biological Chemistry. 280, p. 17339-17345 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli Proteins
Heme
Hemoglobins
Peptide Hydrolases
Crystal structure

Early encounters of a nascent membrane protein : specificity and timing of contacts inside and outside the ribosome

Houben, E. N. G., Zarivach, R., Brunner, J., Oudega, B. & Luirink, S., 2005, In : Journal of Cell Biology. 170, p. 27-35 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Ribosomes
Membrane Proteins
Signal Recognition Particle
Peptidyl Transferases
Molecular Probes

Evolution of mitochondrial oxa proteins from bacterial YidC: inherited and acquired functions of a conserved insertion machinery

Preuss, M., Ott, M., Funes, G., Luirink, S. & Herrmann, J. M., 2005, In : Journal of Biological Chemistry. 280, p. 13004-13011 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Mitochondria
Bacterial Proteins
Mitochondrial Proteins
Machinery
Ribosomes

From ribosome to membrane : sequential interactions of Escherichia coli inner membrane proteins during biogenesis

Houben, E. N. G., 2005, Enschede: Febodruk bv Enschede. 142 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Signal peptide hydrophobicity is critical for early stages in protein export by Bacillus subtilis

van Zanen, L. F., Houben, E. N. G., Meima, R. B., Tjalsma, H., Jongbloed, J. D. H., Westers, T. M., Oudega, B., Luirink, S., Dijl, J. M. & Quax, W. J., 2005, In : The FEBS Journal. 272, p. 4617-4630 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacilli
Hydrophobicity
Protein Sorting Signals
Bacillus subtilis
Hydrophobic and Hydrophilic Interactions

The Sec-independent function of Escherichia coli YidC is evolutionary conserved and essential

van Bloois, D. W., Nagamori, S., Koningstein, G. M., Ullers, R. S., Preuss, M., Oudega, B., Harms, N., Kaback, H. R. & Luirink, S., 2005, In : Journal of Biological Chemistry. 280, p. 12996-13003 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli
Thylakoid Membrane Proteins
Membranes
Assays
Protein Transport
2006

A specific secretion system mediates PPE41 transport in pathogenic mycobacteria

Abdallah, A. M., Verboom, T., Hannes, F., Safi, M., Strong, M., Eisenberg, D., Musters, R. J. P., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J., Luirink, S. & Bitter, W., 2006, In : Molecular Microbiology. 62, 3, p. 667-679 13 p.

Research output: Contribution to JournalArticleAcademic

Mycobacterium
Mycobacterium marinum
Mycobacterium smegmatis
Genes
Macrophages

Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.

van Bloois, D. W., Haan, G. J., de Gier, J-W., Oudega, B. & Luirink, S., 2006, In : Journal of Biological Chemistry. 14, 281

Research output: Contribution to JournalArticleAcademic

Open Access
File
Escherichia coli
Membrane Proteins
Protein Subunits
Capsid Proteins
Membranes

Iron uptake in Vibrio anguillarum. Regulation, siderophore biosynthesis and transport of iron-siderophore complexes

Stork, M., 2006, 152 p.

Research output: PhD ThesisPhD Thesis - Research external, graduation VUAcademic

Molecular insight into the pathogenetic synergy between E. coli and B. fragilis in secondary peritonitis

Sijbrandi, R., 2006, 170 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle.

Ullers, R. S., Houben, E. N. G., Oudega, B., Harms, N. & Luirink, S., 2006, In : Journal of Biological Chemistry. 281, 20, p. 13999-144005 7 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Signal Recognition Particle
Escherichia coli
Protein Sorting Signals
Anchors
Peptides
2007

Contribution of the FtsQ transmembrane segment to loclization to the cell division site.

Scheffers, D. J., Robichon, C., den Blaauwen, T., Haan, G. J., Koningstein, G. M., van Bloois, D. W., Beckwith, J. & Luirink, S., 2007, In : Journal of Bacteriology. 189, 20, p. 7273-7280

Research output: Contribution to JournalArticleAcademic

Cell Division
Microbiology
Membrane Proteins
Cell Membrane
Escherichia coli

COTRANSLATIONAL PROTEIN TARGETING IN ESCHERICHIA COLI

Ullers, R. S., Genevaux, P. & Luirink, S., 2007, The Enzymes, Molecular Machines involved in Protein Transport across Cellular Membranes.. Carla Koehler Fuyuhiko Tamanoi, R. E. D. (ed.).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Flexibility in targeting and insertion during bacterial membrane protein biogenesis.

van Bloois, D. W., ten Hagen-Jongman, C. M. & Luirink, S., 2007, In : Biochemical and Biophysical Research Communications. 362, 3, p. 727-733

Research output: Contribution to JournalArticleAcademic

Bacterial Proteins
Membrane Proteins
Signal Recognition Particle
Proton-Motive Force
Escherichia coli

Limited tolerance towards folded elements during secretion of the autotransporter Hbp.

Jong, W. S. P., ten Hagen-Jongman ten, C. M., den Blaauwen, T., Slotboom, D. J., Tame, J. R. H., Wickstrom, D., de Gier, J-W., Otto, B. R. & Luirink, S., 2007, In : Molecular Microbiology. 63, 5, p. 1524-1536

Research output: Contribution to JournalArticleAcademic

Hemoglobins
Peptide Hydrolases
Disulfides
Membranes
Periplasm

Saccharomyces cerevisiae Cox 18 complements the essential Sec-independent function of Escherichia coli YidC.

van Bloois, D. W., Koningstein, G. M., Bauerschmitt, H., Herrmann, J. M. & Luirink, S., 2007, In : The FEBS Journal. 274, 21, p. 5704-5713

Research output: Contribution to JournalArticleAcademic

Yeast
Escherichia coli
Saccharomyces cerevisiae
Membrane Proteins
Mitochondria

Type VII secretion-mycobacteria show the way.

Abdallah, A. M., Gey van Pittius, N. C., Champion, P. A., Cox, J., Luirink, S., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J. & Bitter, W., 2007, In : Nature Reviews Microbiology. 5, 11, p. 883-891

Research output: Contribution to JournalArticleAcademic

Mycobacterium
Secretory Pathway
Gram-Positive Bacteria
Terminology
Cell Wall
2008

Across the inner membrane and beyond: Signal peptide-mediated protein transport via the Tat and autotransporter pathways of Escherichia coli

Jong, W. S., 2008, Amsterdam. 148 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC.

Wagner, S., Pop, O. I., Haan, G. J., Koningstein, G. M., Klepsch, M. M., Genevaux, P., Luirink, S. & de Gier, J-W., 2008, In : Journal of Biological Chemistry. 283, p. 17881-1790

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Maltose
Escherichia coli
Membrane Proteins

Characterization of the evolutionarily conserved role of Escherichia coli YidC in membrane protein biogenesis

van Bloois, D. W., 2008, Amsterdam. 171 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins

van Bloois, E., Dekker, H. L., Froderberg, L., Houben, E. N. G., Urbanus, M. L., de Koster, C. G., de Gier, J. W. & Luirink, J., 2008, In : FEBS Letters. 2008, 582, p. 1419-1424

Research output: Contribution to JournalArticleAcademicpeer-review

Quality Control
Quality control
Membrane Proteins
Membranes
Escherichia coli

Specialised protein secretion systems of Mycobacteria

Bitter, W., Houben, E. N. G. & Luirink, S., 2008, Mycobacterium, Genomics and Molecular Biology. Parish, T. & Brown, A. S. (eds.). p. 189-205

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Protein Sorting Signals
Hemoglobins
Peptide Hydrolases
Gram-Negative Bacteria
Bacteria
2009

Delivering proteins for export from the cytosol.

Cross, B. C., Sinning, I., Luirink, S. & High, S., 2009, In : Nature Reviews Molecular Cell Biology. 10, 4, p. 255-264

Research output: Contribution to JournalArticleAcademicpeer-review

Cytosol
Membranes
Proteins
Bacterial Proteins
Guanosine Triphosphate

Flexibility in targeting and insertion during bacterial membrane protein biogenesis.

van Bloois, D. W., ten Hagen-Jongman, C. M. & Luirink, S., 2009, In : Biochemical and Biophysical Research Communications. 362, p. 727-733 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacterial Proteins
Membrane Proteins
Signal Recognition Particle
Proton-Motive Force
Escherichia coli

Pbp, a cell-surface exposed plasminogen binding protein of Bacteroides fragilis.

Sijbrandi, R., Stork, M., Luirink, S. & Otto, B. R., 2009, In : Microbes and Infection. 10, p. 514-521 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacteroides fragilis
Plasminogen
Carrier Proteins
Virulence Factors
Proteins

The Bam (Omp85) complex is involved in secretion of the autotransporter haemoglobin protease.

Sauri, A., Soprova, Z., Wickstrom, D., de Gier, J-W., van der Schors, R. C., Smit, A. B., Jong, W. S. P. & Luirink, S., 2009, In : Microbiology. 155, 12, p. 3982-3991

Research output: Contribution to JournalArticleAcademicpeer-review

Hemoglobins
Peptide Hydrolases
Membranes
Virulence Factors
Protein Transport

The conserved third transmembrane segment of YidC contacts nascent Escherichia coli inner membrane proteins.

Yu, Z., Koningstein, G. M., Pop, O. I. & Luirink, S., 2009, In : Journal of Biological Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli
Membrane Proteins
Membranes
Substrates

Type VII secretion in mycobacteria: classification in line with cell envelope structure.

Bitter, W., Houben, E. N. G., Luirink, S. & Appelmelk, B. J., 2009, In : Trends In Microbiology. 8, p. 337-338

Research output: Contribution to JournalArticleAcademicpeer-review

YidC is required for the assembly of the MscL homopentameric pore.

Pop, O. I., Soprova, Z., Koningstein, G. M., Scheffers, D. J., van Ulsen, J. P., Wickstrom, D., de Gier, J-W. & Luirink, S., 2009, In : The FEBS Journal. 276, 17, p. 4891-4899

Research output: Contribution to JournalArticleAcademicpeer-review

Membranes
Escherichia coli
Signal Recognition Particle
Lipid bilayers
Lipid Bilayers
2010

A conserved aromatic residue in the autochaperone domain of the autotransporter Hbp is critical for initiation of outer membrane translocation

Soprova, Z., Sauri, A., van Ulsen, J. P., Tame, J. R. H., den Blaauwen, T., Jong, W. S. P. & Luirink, S., 2010, In : Journal of Biological Chemistry. 285, 49, p. 38224-38233 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobins
Peptide Hydrolases
Membranes
Virulence Factors
Mutation

Characterization of ftsZ mutations that render Bacillus subtilis resistant to MinC

de Oliveira, I. F. F., Sousa Borges, A., Kooij, V., Bartosiak-Jentys, J., Luirink, S. & Scheffers, D. J., 2010, In : PLoS ONE. 5, 8, p. e12048-e12057 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Bacilli
Bacillus subtilis
Cell Division
Cells
mutation

Extracellular production of recombinant proteins using bacterial autotransporters.

Jong, W. S. P., Sauri, A. & Luirink, S., 2010, In : Current Opinion in Biotechnology. 21, 5, p. 646-652 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Recombinant proteins
Recombinant Proteins
Escherichia coli
Display devices
Proteins

Role of domains within the autotransporter Hbp/Tsh.

Nishimura, K., Yoon, Y. H., Kurihara, A., Unzai, S., Luirink, S., Park, S. Y. & Tame, J. R. H., 2010, In : Acta Crystallographica Section D. Biological Crystallography. 66, 12, p. 1295-1300 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Agglutinins
Heme
Hemoglobins
Peptide Hydrolases
Temperature

YidC is in involved in the biogenesis of the secreted autotransporter Hemoglobin Protease

Jong, W. S. P., ten Hagen-Jongman ten, C. M., Ruijter, E., Orru, R. V. A., Genevaux, P. & Luirink, S., 2010, In : Journal of Biological Chemistry. 285, 51, p. 39682-39690 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobins
Peptide Hydrolases
Membranes
Periplasm
Signal Recognition Particle
2011

Activators of the glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli

Yu, Z., Bekker, M., Tramonti, A., Cook, G. M., van Ulsen, P., Scheffers, D. J., De Mattos, J. T., De Biase, D. & Luirink, J., 2011, In : Journal of Bacteriology. 193, p. 1308-16

Research output: Contribution to JournalArticleAcademicpeer-review

Glutamic Acid
Escherichia coli
Acids
Inosine Monophosphate
Membrane Proteins

Autotransporter beta-domains have a specific function in protein secretion beyond outer-membrane targeting

Sauri, A., Oreshkova, N., Soprova, Z., Jong, W. S. P., Sani, M., Peters, P. J., Luirink, J. & van Ulsen, P., 2011, In : Journal of Molecular Biology. 412, p. 553-67

Research output: Contribution to JournalArticleAcademicpeer-review

Membranes
Proteins
Mutant Proteins
Gram-Negative Bacteria
Membrane Proteins

Channel properties of the translocator domain of the autotransporter Hbp of Escherichia coli

Roussel-Jazede, V., van Gelder, P., Sijbrandi, R., Rutten, L., Otto, B. R., Luirink, J., Gros, P., Tommassen, J. & van Ulsen, P., 2011, In : Molecular Membrane Biology. 28, p. 158-70

Research output: Contribution to JournalArticleAcademicpeer-review

IgA-specific serine endopeptidase
Neisseria meningitidis
Neisseria gonorrhoeae
Inclusion Bodies
Lipid Bilayers

Characterization of the consequences of YidC depletion on the inner membrane proteome of E. coli using 2D blue native/SDS-PAGE

Wickstrom, D., Wagner, S., Simonsson, P., Pop, O., Baars, L., Ytterberg, A. J., van Wijk, K. J., Luirink, J. & de Gier, J. W., 2011, In : Journal of Molecular Biology. 409, p. 124-35

Research output: Contribution to JournalArticleAcademicpeer-review

Native Polyacrylamide Gel Electrophoresis
Inosine Monophosphate
Proteome
Polyacrylamide Gel Electrophoresis
Escherichia coli

Consequences of depletion of the signal recognition particle in Escherichia coli

Wickstrom, D., Wagner, S., Baars, L., Ytterberg, A. J., Klepsch, M., van Wijk, K. J., Luirink, J. & de Gier, J. W., 2011, In : Journal of Biological Chemistry. 286, 286, p. 4598-609 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Signal Recognition Particle
Escherichia coli
Proteome
Cell Membrane
Membrane Proteins

Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) Protein Domains Target LipY Lipases of Pathogenic Mycobacteria to the Cell Surface via the ESX-5 Pathway

Daleke, M. H., Cascioferro, A., de Punder, K., Ummels, R., Abdallah, A. M., Wel, N., Peters, P. J., Luirink, S., Manganelli, R. & Bitter, W., 2011, In : Journal of Biological Chemistry. 286, 21, p. 19024-19034

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
prolylglutamic acid
Mycobacterium
Lipase
Proline
Glutamic Acid

Role for Escherichia coli YidD in Membrane Protein Insertion

Yu, Z., Laven, M., Klepsch, M., de Gier, J. W., Bitter, W., van Ulsen, J. P. & Luirink, S., 2011, In : Journal of Bacteriology. 193, 19, p. 5242-5251

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Membrane Proteins
Escherichia coli
Gene Order
Protein Folding
Multigene Family
2012

A general secretion signal for the mycobacterial type VII secretion pathway

Daleke, M. H., Ummels, R., Bawono, P., Heringa, J., Vandenbroucke-Grauls, C. M. J. E., Luirink, S. & Bitter, W., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11342-11347

Research output: Contribution to JournalArticleAcademicpeer-review

Secretory Pathway
Virulence Factors
Proteins
Mycobacterium
Site-Directed Mutagenesis

A structurally informed autotransporter platform for efficient heterologous protein secretion and display.

Jong, W. S. P., Soprova, Z., de Punder, K., ten Hagen-Jongman, C. M., Wagner, S., de Gier, J. W., Andersen, P., van der Wel, N. N. & Luirink, S., 2012, In : Microbial Cell Factories. 11, 85

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobin
Hemoglobins
Peptide Hydrolases
Display devices
Proteins

Biogenesis of inner membrane proteins in Escherichia coli.

Luirink, S., Yu, Z., Wagner, S. & de Gier, J. W., 2012, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1817, 6, p. 965-976

Research output: Contribution to JournalArticleAcademic

Open Access
Escherichia coli
Membrane Proteins
Proteome
Membranes
Protein folding

Composition of the type VII secretion system membrane complex.

Houben, E. N. G., Bestebroer, J., Ummels, R., Wilson, L., Piersma, S. R., Jimenez, C. R., Ottenhoff, T. H. M., Luirink, S. & Bitter, W., 2012, In : Molecular Microbiology. 86, 2, p. 472-484

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium bovis
Mycobacterium marinum
Native Polyacrylamide Gel Electrophoresis
Membranes
Secretory Pathway

Estimating the size of the active translocation pore of an autotransporter.

Sauri, A., ten Hagen-Jongman, C. M., van Ulsen, J. P. & Luirink, S., 2012, In : Journal of Molecular Biology. 416, 3, p. 335-345

Research output: Contribution to JournalArticleAcademic

Peptides
Virulence Factors
Gram-Negative Bacteria
Disulfides
Cysteine

Hsp 33 Controls Elongation Factor-Tu Stability and allows Escherichia coli growth in the absence of the major DnaK and Trigger Factor Chaperones

Bruel, N., Castanié-Cornet, M. P., Cirinesi, A. M., Koningstein, G. M., Georgopoulos, C., Luirink, J. & Genevaux, P., 2012, In : Journal of Biological Chemistry. 287, p. 44435-44446

Research output: Contribution to JournalArticleAcademicpeer-review

Peptide Elongation Factor Tu
Protein folding
Protein Folding
Escherichia coli
Protease La

Tail(or)-made Protein Secretion in Pathogenic Mycobacteria

Daleke, M. H., 2012

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum.

van der Woude, A. D., Sarkar, D., Bhatt, A., Sparrius, M., Raadsen, S. A., Boon, L., Geurtsen, J. J. G., Houben, E. N. G., Besra, G. S., Bitter, W., van der Sar, A. M. & Luirink, S., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20417-20429

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium marinum
Biosynthesis
Membrane Proteins
GC Rich Sequence
Virulence