1993 …2020
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Research Output 1993 2020

Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis.

Otto, B. R., van Dooren, S. J. M., Dozois, C. M., Luirink, S. & Oudega, B., 2002, In : Infection and Immunity. 70, p. 5-10 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Bacteroides fragilis
Heme
Abscess
Intraabdominal Infections
Hemoglobins

Escherichia coli SecB, SecA, and SecY proteins are required for expression and membrane insertion of the bacteriocin release protein, a small lipoprotein

Oudega, B., Mol, O., Van Ulsen, P., Stegehuis, F., Van der Wal, F. J. & Luirink, J., 1 Jan 1993, In : Journal of Bacteriology. 175, 5, p. 1543-1547 5 p.

Research output: Contribution to JournalComment / Letter to the editorAcademic

Bacteriocins
Lipoproteins
Escherichia coli
Membranes
Protein Precursors

Escherichia coli signal recognition particle: a historical perspective

Valent, Q. A., O'Gorman, E. N. S., Scotti, P. A., Luirink, S. & High, S., 1999, Transport of molecules across microbial membranes.. Broome-Smith, J. K., Baumberg, S., Stirling, C. J. & Ward, F. B. (eds.). Cambridge, UK: Cambridge University Press, p. 169-185

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Escherichia coli YidC, an evolutionary conserved facilitator of membrane protein integration.

Urbanus, M. L., 2003, Amsterdam: Thesis.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Estimating the size of the active translocation pore of an autotransporter.

Sauri, A., ten Hagen-Jongman, C. M., van Ulsen, J. P. & Luirink, S., 2012, In : Journal of Molecular Biology. 416, 3, p. 335-345

Research output: Contribution to JournalArticleAcademic

Peptides
Virulence Factors
Gram-Negative Bacteria
Disulfides
Cysteine

Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY.

Herkovits, A. A., Seluanov, A., Rasjbaum, R., ten Hagen, C. M., Henrichs, T., Bochkareva, E. S., Philips, G. J., Probst, F. J., Nakae, T., Ehrmann, M., Luirink, S. & Bibi, E., 2001, In : EMBO Reports. 2, p. 1040-1046 6 p.

Research output: Contribution to JournalArticleAcademic

Membranes
Proteolysis
Escherichia coli
Catalytic Domain
Synchronization

Evolution of mitochondrial oxa proteins from bacterial YidC: inherited and acquired functions of a conserved insertion machinery

Preuss, M., Ott, M., Funes, G., Luirink, S. & Herrmann, J. M., 2005, In : Journal of Biological Chemistry. 280, p. 13004-13011 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Mitochondria
Bacterial Proteins
Mitochondrial Proteins
Machinery
Ribosomes

Extracellular production of recombinant proteins using bacterial autotransporters.

Jong, W. S. P., Sauri, A. & Luirink, S., 2010, In : Current Opinion in Biotechnology. 21, 5, p. 646-652 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Recombinant proteins
Recombinant Proteins
Escherichia coli
Display devices
Proteins

F1F0 ATP synthase subunit c is targeted by SRP to YidC in the Escherichia coli inner membrane.

van Bloois, D. W., Haan, G. J., Gier de, J. W., Oudega, B. & Luirink, S., 2004, In : FEBS Letters. 576, p. 97-100 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Escherichia coli
Membrane Proteins
Membranes
F1F0-ATP synthase

Fine-mapping the contact sites of the Escherichia coli cell division proteins FtsB and FtsL on the FtsQ protein

van den Berg van Saparoea, H. B., Glas, M., Vernooij, I. G., Bitter, W., den Blaauwen, T. & Luirink, S., 2013, In : Journal of Biological Chemistry. 288, p. 24340-24350 34.

Research output: Contribution to JournalArticleAcademicpeer-review

Cell Division
Escherichia coli
Cells
Proteins
Periplasm

Flexibility in targeting and insertion during bacterial membrane protein biogenesis.

van Bloois, D. W., ten Hagen-Jongman, C. M. & Luirink, S., 2007, In : Biochemical and Biophysical Research Communications. 362, 3, p. 727-733

Research output: Contribution to JournalArticleAcademic

Bacterial Proteins
Membrane Proteins
Signal Recognition Particle
Proton-Motive Force
Escherichia coli

Flexibility in targeting and insertion during bacterial membrane protein biogenesis.

van Bloois, D. W., ten Hagen-Jongman, C. M. & Luirink, S., 2009, In : Biochemical and Biophysical Research Communications. 362, p. 727-733 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacterial Proteins
Membrane Proteins
Signal Recognition Particle
Proton-Motive Force
Escherichia coli

From ribosome to membrane : sequential interactions of Escherichia coli inner membrane proteins during biogenesis

Houben, E. N. G., 2005, Enschede: Febodruk bv Enschede. 142 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Functional analysis of Escherichia coli FtsY in signal recognition particle mediated protein targeting

de Leeuw, E. P. H., 2000, 141 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Getting across the Cell Envelope: Mycobacterial Protein Secretion

van der Woude, A. D., Luirink, S. & Bitter, W., 2013, In : Current Topics in Microbiology and Immunology. 374, p. 109-134

Research output: Contribution to JournalArticleAcademicpeer-review

Hsp 33 Controls Elongation Factor-Tu Stability and allows Escherichia coli growth in the absence of the major DnaK and Trigger Factor Chaperones

Bruel, N., Castanié-Cornet, M. P., Cirinesi, A. M., Koningstein, G. M., Georgopoulos, C., Luirink, J. & Genevaux, P., 2012, In : Journal of Biological Chemistry. 287, p. 44435-44446

Research output: Contribution to JournalArticleAcademicpeer-review

Peptide Elongation Factor Tu
Protein folding
Protein Folding
Escherichia coli
Protease La

Immunization with Skp delivered on outer membrane vesicles protects mice against enterotoxigenic Escherichia coli CHALLENGE

Hays, M. P., Houben, D., Yang, Y., Luirink, J. & Hardwidge, P. R., 1 May 2018, In : Frontiers in Cellular and Infection Microbiology. 8, MAY, 132.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Enterotoxigenic Escherichia coli
Immunization
Glutathione Transferase
Membranes
Antigens

Important role of the tetraloop region of 4,5 S RNA in SRP binding to its receptor FtsY.

Jagath, J. R., Matassova, N. B., de Leeuw, E., Warnecke, J. M., Lentzen, G., Rodina, M. V., Luirink, S. & Wintermeyer, W., 2001, In : RNA. 7, p. 293-301 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Signal Recognition Particle
RNA
Base Pairing
Hydroxyl Radical
Gels

Inhibition of autotransporter biogenesis by small molecules

Steenhuis, M., Abdallah, A. M., de Munnik, S. M., Kuhne, S., Sterk, G. J., van den Berg van Saparoea, B., Westerhausen, S., Wagner, S., van der Wel, N. N., Wijtmans, M., van Ulsen, P., Jong, W. S. P. & Luirink, J., Jul 2019, In : Molecular Microbiology. 112, 1, p. 81-98 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Membrane Proteins
Virulence Factors
Libraries
Hemoglobins
Peptide Hydrolases

Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome

Ullers, R. S., Houben, E. N. G., Raine, A., ten Hagen-Jongman ten, C. M., Ehrenberg, M., Brunner, J., Oudega, B., Harms, N. & Luirink, S., 2003, In : Journal of Cell Biology. 161, p. 679-684 6 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Signal Recognition Particle
Ribosomes
Escherichia coli
Membrane Proteins
Protein Sorting Signals

Interrogating the essential bacterial cell division protein FtsQ with fragments using target immobilized NMR screening (TINS)

Glas, M., Eiso, A. B., Hollander, J., Siegal, G., Luirink, J. & de Esch, I., 1 Aug 2019, In : International Journal of Molecular Sciences. 20, 15, 3684.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
cell division
Cell Division
affinity
Screening
screening

Iron uptake in Vibrio anguillarum. Regulation, siderophore biosynthesis and transport of iron-siderophore complexes

Stork, M., 2006, 152 p.

Research output: PhD ThesisPhD Thesis - Research external, graduation VUAcademic

Is Ffh required for export of secretory proteins.

Kim, J., Rusch, S., Luirink, S. & Kendall, D. A., 2001, In : FEBS Letters. 505, p. 245-248 3 p.

Research output: Contribution to JournalArticleAcademic

Signal Recognition Particle
Protein Sorting Signals
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Membrane Proteins

Limited tolerance towards folded elements during secretion of the autotransporter Hbp.

Jong, W. S. P., ten Hagen-Jongman ten, C. M., den Blaauwen, T., Slotboom, D. J., Tame, J. R. H., Wickstrom, D., de Gier, J-W., Otto, B. R. & Luirink, S., 2007, In : Molecular Microbiology. 63, 5, p. 1524-1536

Research output: Contribution to JournalArticleAcademic

Hemoglobins
Peptide Hydrolases
Disulfides
Membranes
Periplasm

LOSt and found across the mycobacterial cell envelope

van der Woude, A. D., 2013

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Molecular characterization of Escherichia coli FtsE and FtsX.

de Leeuw, E. P. H., Graham, B., Philips, G. J., ten Hagen-Jongman ten, C. M., Oudega, B. & Luirink, S., 1999, In : Molecular Microbiology. 31, p. 983-993 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Membrane Proteins
Salts
Escherichia coli
ATP-Binding Cassette Transporters
Membranes

Molecular insight into the pathogenetic synergy between E. coli and B. fragilis in secondary peritonitis

Sijbrandi, R., 2006, 170 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Mutagenesis-Based Characterization and Improvement of a Novel Inclusion Body Tag

Jong, W. S. P., ten Hagen-Jongman, C. M., Vikström, D., Dontje, W., Abdallah, A. M., de Gier, J. W., Bitter, W. & Luirink, J., 10 Jan 2020, In : Frontiers in Bioengineering and Biotechnology. 7, 442.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mutagenesis
Inclusion Bodies
Protein Sorting Signals
Agglomeration
Proteins

Nascent Lep insert into the Escherichia coli inner membrane in the vicinity of YidC, SecA.

Houben, E. N. G., Scotti, P. A., Valent, Q. A., Brunner, J., de Gier, J-W., Oudega, B. & Luirink, S., 2000, In : FEBS Letters. 476, p. 229-233

Research output: Contribution to JournalArticleAcademicpeer-review

Die casting inserts
Escherichia coli
Membranes
Membrane Proteins
Signal Recognition Particle

Of linkers and autochaperones: an unambiguous nomenclature to identify common and uncommon themes for autotransporter secretion.

Drobnak, I., Braselmann, E., Chaney, J. L., Leyton, D. L., Bernstein, H. D., Lithgow, T., Luirink, S., Nataro, J. P. & Clark, P. L., 2015, In : Molecular Microbiology. 95, 1, p. 1-16 1.

Research output: Contribution to JournalArticleAcademicpeer-review

Terminology
Conserved Sequence
Virulence
Proteins
Bacterial Translocation

On display: Autotransporter secretion and application

Van Ulsen, P., Zinner, K. M., Jong, W. S. P. & Luirink, J., 1 Sep 2018, In : FEMS Microbiology Letters. 365, 18, p. 1-10 10 p., fny165.

Research output: Contribution to JournalReview articleAcademicpeer-review

Membranes
Proteins
Secretory Pathway
Virulence Factors
Gram-Negative Bacteria

Optimizing E. coli-based membrane protein production using Lemo21(DE3) or pReX and GFP-Fusions

Kuipers, G., Peschke, M., Ismail, N. B., Hjelm, A., Schlegel, S., Vikström, D., Luirink, J. & de Gier, J. W., 2017, Methods in Molecular Biology. Humana Press Inc, Vol. 1586. p. 109-126 18 p. (Methods in Molecular Biology; vol. 1586).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Green Fluorescent Proteins
Membrane Proteins
Escherichia coli
Gene Expression Regulation
Protein C

Optimizing heterologous protein production in the periplasm of E. coli by regulating gene expression levels

Schlegel, S., Rujas, E., Ytterberg, A. J., Zubarev, R. A., Luirink, J. & de Gier, J. W., 2013, In : Microbial Cell Factories. 12, p. 24

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Periplasm
Gene expression
Escherichia coli
Proteins
Gene Expression

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8 + T cells

Schetters, S. T. T., Jong, W. S. P., Horrevorts, S. K., Kruijssen, L. J. W., Engels, S., Stolk, D., Daleke-Schermerhorn, M. H., Garcia-Vallejo, J., Houben, D., Unger, W. W. J., den Haan, J. M. M., Luirink, J. & van Kooyk, Y., 1 Jun 2019, In : Acta Biomaterialia. 91, p. 248-257 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cross-Priming
T-cells
Antigens
Dendritic Cells
Membranes

Pbp, a cell-surface exposed plasminogen binding protein of Bacteroides fragilis.

Sijbrandi, R., Stork, M., Luirink, S. & Otto, B. R., 2009, In : Microbes and Infection. 10, p. 514-521 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacteroides fragilis
Plasminogen
Carrier Proteins
Virulence Factors
Proteins

Processing of cell-surface signalling anti-sigma factors prior to signal recognition is aconserved autoproteolytic mechanism that produces two functional domains.

Bastiaansen, K. C. J. T., Otero-Asman, J. R., Luirink, J., Bitter, W. & Llamas, M. A., 2015, In : Environmental Microbiology. 17, 9, p. 3263-3277

Research output: Contribution to JournalArticleAcademicpeer-review

sigma factors
Sigma Factor
cells
membrane
Pseudomonas

Protein Targeting to the Inner Membrane

Luirink, S. & Oudega, B., 2003, Protein Secretion Pathways in Bacteria. Boston/Dordrecht/London: Kluwere Academic Publishers, p. 1-21 21 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Purification of the autotransporter protein Hbp of Escherichia coli.

van Dooren, S. J. M., Tame, J. R. H., Luirink, S., Oudega, B. & Otto, B. R., 2001, In : FEMS Microbiology Letters. 205, p. 147-150 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Hemoglobins
Peptide Hydrolases
Escherichia coli
Proteins
Heme

Reconstitution of SecYEG-dependent membrane protein insertion: nacent FtsQ interacts with YidC in a SecYEG-dependent manner.

Van der laan, M., Houben, E. N. G., Nouwen, N., Luirink, S. & Driessen, A. J. M., 2001, In : EMBO Reports. 2, p. 519-523 4 p.

Research output: Contribution to JournalArticleAcademic

Role for Escherichia coli YidD in Membrane Protein Insertion

Yu, Z., Laven, M., Klepsch, M., de Gier, J. W., Bitter, W., van Ulsen, J. P. & Luirink, S., 2011, In : Journal of Bacteriology. 193, 19, p. 5242-5251

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Membrane Proteins
Escherichia coli
Gene Order
Protein Folding
Multigene Family

Role of domains within the autotransporter Hbp/Tsh.

Nishimura, K., Yoon, Y. H., Kurihara, A., Unzai, S., Luirink, S., Park, S. Y. & Tame, J. R. H., 2010, In : Acta Crystallographica Section D. Biological Crystallography. 66, 12, p. 1295-1300 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Agglutinins
Heme
Hemoglobins
Peptide Hydrolases
Temperature

Saccharomyces cerevisiae Cox 18 complements the essential Sec-independent function of Escherichia coli YidC.

van Bloois, D. W., Koningstein, G. M., Bauerschmitt, H., Herrmann, J. M. & Luirink, S., 2007, In : The FEBS Journal. 274, 21, p. 5704-5713

Research output: Contribution to JournalArticleAcademic

Yeast
Escherichia coli
Saccharomyces cerevisiae
Membrane Proteins
Mitochondria

Salmonella outer membrane vesicles displaying high densities of pneumococcal antigen at the surface offer protection against colonization.

Kuipers, K., Daleke, M. H., Jong, W. S. P., ten Hagen-Jongman ten, C. M., van Opzeeland, F., Simonneti, E., Luirink, S. & de Jonge, M. I., 2015, In : Vaccine. 33, 17, p. 2022-2029

Research output: Contribution to JournalArticleAcademicpeer-review

Surface Antigens
Salmonella
antigens
Membranes
Antigens

SecA is not required for SRP-mediated targeting and initial membrane insertion of a nascent inner membrane protein.

Scotti, P. A., Valent, Q. A., Manting, E. H., Urbanus, M. L., Driessen, A. J. M., Oudega, B. & Luirink, S., 1999, In : Journal of Biological Chemistry. 274, p. 29883-29888 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Signal Recognition Particle
Membrane Proteins
Membranes
Guanosine Triphosphate
Ribosomes

SecB dependence of an exported protein is a continuum influenced by the charaterisitics of the signal peptide or early mature region.

Kim, J., Luirink, S. & Kendell, D. A., 2000, In : Journal of Bacteriology. 182, p. 4108-4112

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Protein Sorting Signals
Alkaline Phosphatase
Proteins
Escherichia coli

SecB is a bona fide generalized chaperone in Escherichia coli

Ullers, R. S., Luirink, S., Harms, N., Schwager, F., Georgopoulos, C. & Genevaux, P., 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, p. 7583-7588 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Escherichia coli Proteins
Escherichia coli
Temperature
Ribosomes
Phenotype

Sec-dependent membrane insertion: sequentail interaction of nascent FtsQ with SecY and YidC.

Urbanus, M. L., Scottie, P. A., Froderberg, L., Saaf, A., de Gier, J-W., Brunner, J., Samulelson, T., Dalbey, R. E., Oudega, B. & Luirink, S., 2001, In : EMBO Reports. 2, p. 524-529 5 p.

Research output: Contribution to JournalArticleAcademic

Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle.

Ullers, R. S., Houben, E. N. G., Oudega, B., Harms, N. & Luirink, S., 2006, In : Journal of Biological Chemistry. 281, 20, p. 13999-144005 7 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Signal Recognition Particle
Escherichia coli
Protein Sorting Signals
Anchors
Peptides

Signal peptide hydrophobicity is critical for early stages in protein export by Bacillus subtilis

van Zanen, L. F., Houben, E. N. G., Meima, R. B., Tjalsma, H., Jongbloed, J. D. H., Westers, T. M., Oudega, B., Luirink, S., Dijl, J. M. & Quax, W. J., 2005, In : The FEBS Journal. 272, p. 4617-4630 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacilli
Hydrophobicity
Protein Sorting Signals
Bacillus subtilis
Hydrophobic and Hydrophilic Interactions