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Research Output 1998 2018

  • 106 Article
  • 11 PhD Thesis - Research VU, graduation VU
  • 7 Chapter
  • 1 PhD Thesis - Research external, graduation VU
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Article
2018

Comparing autotransporter β-domain configurations for their capacity to secrete heterologous proteins to the cell surface

Jong, W. S. P., Schillemans, M., ten Hagen-Jongman, C. M., Luirink, J. & van Ulsen, P., 7 Feb 2018, In : PLoS ONE. 13, 2, e0191622

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
IgA-specific serine endopeptidase
recombinant proteins
Membrane Proteins
Recombinant Proteins
Membranes

Display of recombinant proteins on bacterial outer membrane vesicles by using protein ligation

van den Berg van Saparoea, H. B., Houben, D., de Jonge, M. I., Jong, W. S. P. & Luirink, J., Apr 2018, In : Applied and Environmental Microbiology. 84, 8, p. 1-17 17 p., e02567-17

Research output: Contribution to JournalArticleAcademicpeer-review

hemoglobin
vesicle
Recombinant Proteins
recombinant proteins
Ligation

Immunization with Skp delivered on outer membrane vesicles protects mice against enterotoxigenic Escherichia coli CHALLENGE

Hays, M. P., Houben, D., Yang, Y., Luirink, J. & Hardwidge, P. R., 1 May 2018, In : Frontiers in Cellular and Infection Microbiology. 8, MAY, 132

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Enterotoxigenic Escherichia coli
Immunization
Glutathione Transferase
Membranes
Antigens
2017

Application of an E. coli signal sequence as a versatile inclusion body tag

Jong, W. S. P., Vikström, D., Houben, D., Berg van Saparoea, H. B., de Gier, J. W. & Luirink, J., 21 Mar 2017, In : Microbial Cell Factories. 16, 1, 50

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Inclusion Bodies
Protein Sorting Signals
Escherichia coli
Proteins
Fusion reactions

SRP, FtsY, DnaK and YidC Are Required for the Biogenesis of the E. coli Tail-Anchored Membrane Proteins DjlC and Flk

Peschke, M., Le Goff, M., Koningstein, G. M., Karyolaimos, A., de Gier, J. W., van Ulsen, P. & Luirink, J., 1 Jan 2017, (Accepted/In press) In : Journal of Molecular Biology.

Research output: Contribution to JournalArticleAcademicpeer-review

Signal Recognition Particle
Membrane Proteins
Escherichia coli
Membranes
Hydrophobic and Hydrophilic Interactions

Th17-mediated cross protection against pneumococcal carriage by vaccination with a variable antigen

Kuipers, K., Jong, W. S. P., van der Gaast-de Jongh, C. E., Houben, D., van Opzeeland, F., Simonetti, E., van Selm, S., de Groot, R., Koenders, M. I., Azarian, T., Pupo, E., van der Ley, P., Langereis, J. D., Zomer, A., Luirink, J. & de Jonge, M. I., 1 Jan 2017, In : Infection and Immunity. 85, 10, e00281-17

Research output: Contribution to JournalArticleAcademicpeer-review

Cross Protection
Vaccination
Vaccines
Antigens
Salmonella enterica
2015

An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines.

Jong, W. S. P., Daleke, M. H., Vikström, D., ten Hagen, C. M., de Punder, K., van der Wel, N. N., van de Sandt, C. E., Rimmelzwaan, G. F., Follmann, F., Agger, E. M., Andersen, P., de Gier, J. W. & Luirink, S., 2015, In : Microbial Cell Factories. 13, p. 162

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Bacterial Vaccines
Synthetic Vaccines
Vaccines
Hemoglobin
Hemoglobins

Autotransporter-based antigen display in bacterial ghosts.

Hjelm, A., Söderström, B., Vikström, D., Jong, W. S. P., Luirink, S. & de Gier, J. W., 2015, In : Applied and Environmental Microbiology. 81, p. 726-735 2

Research output: Contribution to JournalArticleAcademicpeer-review

lysis
antigen
vaccine
Escherichia coli
antigens

Cell age dependent concentration of Escherichia coli divisome proteins analyzed with ImageJ and ObjectJ.

Vischer, N. O., Verheul, J., Postma, M., van den Berg van Saparoea, H. B., Galli, E., Natale, P., Gerdes, K., Luirink, J., Vollmer, W., Vicente, M. & den Blaauwen, T., 2015, In : Frontiers in Microbiology. 11, p. 586 6

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Escherichia coli Proteins
Proteins
Cell Cycle
Spatio-Temporal Analysis
Cell Cycle Proteins

Of linkers and autochaperones: an unambiguous nomenclature to identify common and uncommon themes for autotransporter secretion.

Drobnak, I., Braselmann, E., Chaney, J. L., Leyton, D. L., Bernstein, H. D., Lithgow, T., Luirink, S., Nataro, J. P. & Clark, P. L., 2015, In : Molecular Microbiology. 95, 1, p. 1-16 1

Research output: Contribution to JournalArticleAcademicpeer-review

Terminology
Conserved Sequence
Virulence
Proteins
Bacterial Translocation

Processing of cell-surface signalling anti-sigma factors prior to signal recognition is aconserved autoproteolytic mechanism that produces two functional domains.

Bastiaansen, K. C. J. T., Otero-Asman, J. R., Luirink, J., Bitter, W. & Llamas, M. A., 2015, In : Environmental Microbiology. 17, 9, p. 3263-3277

Research output: Contribution to JournalArticleAcademicpeer-review

sigma factors
Sigma Factor
cells
membrane
Pseudomonas

Salmonella outer membrane vesicles displaying high densities of pneumococcal antigen at the surface offer protection against colonization.

Kuipers, K., Daleke, M. H., Jong, W. S. P., ten Hagen-Jongman ten, C. M., van Opzeeland, F., Simonneti, E., Luirink, S. & de Jonge, M. I., 2015, In : Vaccine. 33, 17, p. 2022-2029

Research output: Contribution to JournalArticleAcademicpeer-review

Surface Antigens
Salmonella
antigens
Membranes
Antigens

The Soluble Periplasmic Domains of Escherichia coli Cell Division Proteins FtsQ/FtsB/FtsL Form a Trimeric Complex with Submicromolar Affinity.

Glas, M., van den Berg van Saparoea, H. B., Mclaughlin, S. H., Roseboom, W., Liu, F., Koningstein, G. M., Fish, A., den Blaauwen, T., Heck, A. J., de Jong, L. D., Bitter, W., de Esch, I. J. P. & Luirink, S., 2015, In : Journal of Biological Chemistry. 290, 35, p. 21498-21509

Research output: Contribution to JournalArticleAcademicpeer-review

Cell Division
Escherichia coli
Cells
Proteins
Membranes
2014

Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector.

van der Woude, A. D., Stoop, E. J. M., Stiess, M., Wang, Q., Ummels, R., van Stempvoort, G., Piersma, S. R., Cascioferro, A., Jimenez, C. R., Houben, E. N. G., Luirink, J., Pieters, J., van der Sar, A. M. & Bitter, W., 2014, In : Cellular Microbiology. 16, 2, p. 280-295

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium marinum
Cyclic GMP-Dependent Protein Kinases
Virulence
Mycobacterium
Virulence Factors

An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines.

Jong, W. S. P., Daleke, M. H., Vikstrom, D., ten Hagen-Jongman ten, C. M., de Punder, K., van der Wel, N. N., van de Sandt, C. E., Rimmelzwaan, G. F., Follman, F., Agger, E., Andersen, P., de Gier, J-W. & Luirink, J., 2014, In : Microbial Cell Factories. 13, 1, p. 162

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Bacterial Vaccines
Synthetic Vaccines
Vaccines
Hemoglobin
Hemoglobins

Autotransporter-based antigen display in bacterial ghosts.

Hjelm, A., Soderstrom, B., Vikstrom, D., Jong, W. S. P., Luirink, J. & de Gier, J-W., 2014, (Accepted/In press) In : Applied and Environmental Microbiology. aem 02733-14

Research output: Contribution to JournalArticleAcademicpeer-review

lysis
antigen
vaccine
Escherichia coli
antigens

Cryo-Electron Microscopic Structure of SecA Bound to the 70S Ribosome.

Singh, R., Kraft, C., Jaiswal, R., Sejwal, K., Kasaragod, V. B., Kuper, J., Berger, J., Mielke, T., Luirink, J. & Bhushan, S., 2014, In : Journal of Biological Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Ribosomes
Bacteria
Tunnels
Electrons
Peptides

Decoration of outer membrane vesicles with multiple antigens using an autotransporter approach.

Daleke, M. H., Felix, T., Soprova, Z., ten Hagen-Jongman ten, C. M., Vikström, D., Majlessi, L., Beskers, J., Follman, F., de Punder, K., van der Wel, N. N., Baumgarten, T., Pham, T. V., Piersma, S. R., Jimenez, C. R., van Ulsen, P., de Gier, J. W., Leclerc, C., Jong, W. S. & Luirink, S., 2014, In : Applied and Environmental Microbiology. 80, 18, p. 5854-5864

Research output: Contribution to JournalArticleAcademicpeer-review

vesicle
antigen
membrane
antigens
Antigens

Type V secretion: From biogenesis to biotechnology

van Ulsen, P., Rahman, S. U., Jong, W. S. P., Daleke, M. H. & Luirink, J., 2014, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1843, 8, p. 1592-1611

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Biotechnology
Membranes
Proteins
Membrane Proteins
Virulence Factors
2013

Differential Detergent Extraction of Mycobacterium marinum Cell Envelope Proteins Identifies an Extensively Modified Threonine-Rich Outer Membrane Protein with Channel Activity

van der Woude, A. D., Mahendran, K. R., Ummels, R., Piersma, S. R., Pham, T. V., Jimenez, C. R., de Punder, K., van der Wel, N. N., Winterhalter, M., Luirink, S., Bitter, W. & Houben, E. N. G., 2013, In : Journal of Bacteriology. 195, 9, p. 2050-2059

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium marinum
Threonine
Detergents
Membrane Proteins
Proteins

Fine-mapping the contact sites of the Escherichia coli cell division proteins FtsB and FtsL on the FtsQ protein

van den Berg van Saparoea, H. B., Glas, M., Vernooij, I. G., Bitter, W., den Blaauwen, T. & Luirink, S., 2013, In : Journal of Biological Chemistry. 288, p. 24340-24350 34

Research output: Contribution to JournalArticleAcademicpeer-review

Cell Division
Escherichia coli
Cells
Proteins
Periplasm

Getting across the Cell Envelope: Mycobacterial Protein Secretion

van der Woude, A. D., Luirink, S. & Bitter, W., 2013, In : Current Topics in Microbiology and Immunology. 374, p. 109-134

Research output: Contribution to JournalArticleAcademicpeer-review

Optimizing heterologous protein production in the periplasm of E. coli by regulating gene expression levels

Schlegel, S., Rujas, E., Ytterberg, A. J., Zubarev, R. A., Luirink, J. & de Gier, J. W., 2013, In : Microbial Cell Factories. 12, p. 24

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Periplasm
Gene expression
Escherichia coli
Proteins
Gene Expression
2012

A general secretion signal for the mycobacterial type VII secretion pathway

Daleke, M. H., Ummels, R., Bawono, P., Heringa, J., Vandenbroucke-Grauls, C. M. J. E., Luirink, S. & Bitter, W., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 28, p. 11342-11347

Research output: Contribution to JournalArticleAcademicpeer-review

Secretory Pathway
Virulence Factors
Proteins
Mycobacterium
Site-Directed Mutagenesis

A structurally informed autotransporter platform for efficient heterologous protein secretion and display.

Jong, W. S. P., Soprova, Z., de Punder, K., ten Hagen-Jongman, C. M., Wagner, S., de Gier, J. W., Andersen, P., van der Wel, N. N. & Luirink, S., 2012, In : Microbial Cell Factories. 11, 85

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobin
Hemoglobins
Peptide Hydrolases
Display devices
Proteins

Biogenesis of inner membrane proteins in Escherichia coli.

Luirink, S., Yu, Z., Wagner, S. & de Gier, J. W., 2012, In : Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1817, 6, p. 965-976

Research output: Contribution to JournalArticleAcademic

Open Access
Escherichia coli
Membrane Proteins
Proteome
Membranes
Protein folding

Composition of the type VII secretion system membrane complex.

Houben, E. N. G., Bestebroer, J., Ummels, R., Wilson, L., Piersma, S. R., Jimenez, C. R., Ottenhoff, T. H. M., Luirink, S. & Bitter, W., 2012, In : Molecular Microbiology. 86, 2, p. 472-484

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium bovis
Mycobacterium marinum
Native Polyacrylamide Gel Electrophoresis
Membranes
Secretory Pathway

Estimating the size of the active translocation pore of an autotransporter.

Sauri, A., ten Hagen-Jongman, C. M., van Ulsen, J. P. & Luirink, S., 2012, In : Journal of Molecular Biology. 416, 3, p. 335-345

Research output: Contribution to JournalArticleAcademic

Peptides
Virulence Factors
Gram-Negative Bacteria
Disulfides
Cysteine

Hsp 33 Controls Elongation Factor-Tu Stability and allows Escherichia coli growth in the absence of the major DnaK and Trigger Factor Chaperones

Bruel, N., Castanié-Cornet, M. P., Cirinesi, A. M., Koningstein, G. M., Georgopoulos, C., Luirink, J. & Genevaux, P., 2012, In : Journal of Biological Chemistry. 287, p. 44435-44446

Research output: Contribution to JournalArticleAcademicpeer-review

Peptide Elongation Factor Tu
Protein folding
Protein Folding
Escherichia coli
Protease La

Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum.

van der Woude, A. D., Sarkar, D., Bhatt, A., Sparrius, M., Raadsen, S. A., Boon, L., Geurtsen, J. J. G., Houben, E. N. G., Besra, G. S., Bitter, W., van der Sar, A. M. & Luirink, S., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20417-20429

Research output: Contribution to JournalArticleAcademicpeer-review

Mycobacterium marinum
Biosynthesis
Membrane Proteins
GC Rich Sequence
Virulence
2011

Activators of the glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli

Yu, Z., Bekker, M., Tramonti, A., Cook, G. M., van Ulsen, P., Scheffers, D. J., De Mattos, J. T., De Biase, D. & Luirink, J., 2011, In : Journal of Bacteriology. 193, p. 1308-16

Research output: Contribution to JournalArticleAcademicpeer-review

Glutamic Acid
Escherichia coli
Acids
Inosine Monophosphate
Membrane Proteins

Autotransporter beta-domains have a specific function in protein secretion beyond outer-membrane targeting

Sauri, A., Oreshkova, N., Soprova, Z., Jong, W. S. P., Sani, M., Peters, P. J., Luirink, J. & van Ulsen, P., 2011, In : Journal of Molecular Biology. 412, p. 553-67

Research output: Contribution to JournalArticleAcademicpeer-review

Membranes
Proteins
Mutant Proteins
Gram-Negative Bacteria
Membrane Proteins

Channel properties of the translocator domain of the autotransporter Hbp of Escherichia coli

Roussel-Jazede, V., van Gelder, P., Sijbrandi, R., Rutten, L., Otto, B. R., Luirink, J., Gros, P., Tommassen, J. & van Ulsen, P., 2011, In : Molecular Membrane Biology. 28, p. 158-70

Research output: Contribution to JournalArticleAcademicpeer-review

IgA-specific serine endopeptidase
Escherichia coli
Neisseria meningitidis
Neisseria gonorrhoeae
Inclusion Bodies

Characterization of the consequences of YidC depletion on the inner membrane proteome of E. coli using 2D blue native/SDS-PAGE

Wickstrom, D., Wagner, S., Simonsson, P., Pop, O., Baars, L., Ytterberg, A. J., van Wijk, K. J., Luirink, J. & de Gier, J. W., 2011, In : Journal of Molecular Biology. 409, p. 124-35

Research output: Contribution to JournalArticleAcademicpeer-review

Native Polyacrylamide Gel Electrophoresis
Inosine Monophosphate
Proteome
Polyacrylamide Gel Electrophoresis
Escherichia coli

Consequences of depletion of the signal recognition particle in Escherichia coli

Wickstrom, D., Wagner, S., Baars, L., Ytterberg, A. J., Klepsch, M., van Wijk, K. J., Luirink, J. & de Gier, J. W., 2011, In : Journal of Biological Chemistry. 286, 286, p. 4598-609 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Signal Recognition Particle
Escherichia coli
Proteome
Cell Membrane
Membrane Proteins

Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) Protein Domains Target LipY Lipases of Pathogenic Mycobacteria to the Cell Surface via the ESX-5 Pathway

Daleke, M. H., Cascioferro, A., de Punder, K., Ummels, R., Abdallah, A. M., Wel, N., Peters, P. J., Luirink, S., Manganelli, R. & Bitter, W., 2011, In : Journal of Biological Chemistry. 286, 21, p. 19024-19034

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
prolylglutamic acid
Mycobacterium
Lipase
Proline
Glutamic Acid

Role for Escherichia coli YidD in Membrane Protein Insertion

Yu, Z., Laven, M., Klepsch, M., de Gier, J. W., Bitter, W., van Ulsen, J. P. & Luirink, S., 2011, In : Journal of Bacteriology. 193, 19, p. 5242-5251

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Membrane Proteins
Escherichia coli
Gene Order
Protein Folding
Multigene Family
2010

A conserved aromatic residue in the autochaperone domain of the autotransporter Hbp is critical for initiation of outer membrane translocation

Soprova, Z., Sauri, A., van Ulsen, J. P., Tame, J. R. H., den Blaauwen, T., Jong, W. S. P. & Luirink, S., 2010, In : Journal of Biological Chemistry. 285, 49, p. 38224-38233 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobins
Peptide Hydrolases
Membranes
Virulence Factors
Mutation

Characterization of ftsZ mutations that render Bacillus subtilis resistant to MinC

de Oliveira, I. F. F., Sousa Borges, A., Kooij, V., Bartosiak-Jentys, J., Luirink, S. & Scheffers, D. J., 2010, In : PLoS ONE. 5, 8, p. e12048-e12057 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Bacilli
Bacillus subtilis
Cell Division
Cells
mutation

Extracellular production of recombinant proteins using bacterial autotransporters.

Jong, W. S. P., Sauri, A. & Luirink, S., 2010, In : Current Opinion in Biotechnology. 21, 5, p. 646-652 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Recombinant proteins
Recombinant Proteins
Escherichia coli
Display devices
Proteins

Role of domains within the autotransporter Hbp/Tsh.

Nishimura, K., Yoon, Y. H., Kurihara, A., Unzai, S., Luirink, S., Park, S. Y. & Tame, J. R. H., 2010, In : Acta Crystallographica Section D. Biological Crystallography. 66, 12, p. 1295-1300 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Agglutinins
Heme
Hemoglobins
Peptide Hydrolases
Temperature

YidC is in involved in the biogenesis of the secreted autotransporter Hemoglobin Protease

Jong, W. S. P., ten Hagen-Jongman ten, C. M., Ruijter, E., Orru, R. V. A., Genevaux, P. & Luirink, S., 2010, In : Journal of Biological Chemistry. 285, 51, p. 39682-39690 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Hemoglobins
Peptide Hydrolases
Membranes
Periplasm
Signal Recognition Particle
2009

Delivering proteins for export from the cytosol.

Cross, B. C., Sinning, I., Luirink, S. & High, S., 2009, In : Nature Reviews Molecular Cell Biology. 10, 4, p. 255-264

Research output: Contribution to JournalArticleAcademicpeer-review

Cytosol
Membranes
Proteins
Bacterial Proteins
Guanosine Triphosphate

Flexibility in targeting and insertion during bacterial membrane protein biogenesis.

van Bloois, D. W., ten Hagen-Jongman, C. M. & Luirink, S., 2009, In : Biochemical and Biophysical Research Communications. 362, p. 727-733 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacterial Proteins
Membrane Proteins
Signal Recognition Particle
Proton-Motive Force
Escherichia coli

Pbp, a cell-surface exposed plasminogen binding protein of Bacteroides fragilis.

Sijbrandi, R., Stork, M., Luirink, S. & Otto, B. R., 2009, In : Microbes and Infection. 10, p. 514-521 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacteroides fragilis
Plasminogen
Carrier Proteins
Virulence Factors
Proteins

The Bam (Omp85) complex is involved in secretion of the autotransporter haemoglobin protease.

Sauri, A., Soprova, Z., Wickstrom, D., de Gier, J-W., van der Schors, R. C., Smit, A. B., Jong, W. S. P. & Luirink, S., 2009, In : Microbiology. 155, 12, p. 3982-3991

Research output: Contribution to JournalArticleAcademicpeer-review

Hemoglobins
Peptide Hydrolases
Membranes
Virulence Factors
Protein Transport

The conserved third transmembrane segment of YidC contacts nascent Escherichia coli inner membrane proteins.

Yu, Z., Koningstein, G. M., Pop, O. I. & Luirink, S., 2009, In : Journal of Biological Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli
Membrane Proteins
Membranes
Substrates

Type VII secretion in mycobacteria: classification in line with cell envelope structure.

Bitter, W., Houben, E. N. G., Luirink, S. & Appelmelk, B. J., 2009, In : Trends In Microbiology. 8, p. 337-338

Research output: Contribution to JournalArticleAcademicpeer-review

YidC is required for the assembly of the MscL homopentameric pore.

Pop, O. I., Soprova, Z., Koningstein, G. M., Scheffers, D. J., van Ulsen, J. P., Wickstrom, D., de Gier, J-W. & Luirink, S., 2009, In : The FEBS Journal. 276, 17, p. 4891-4899

Research output: Contribution to JournalArticleAcademicpeer-review

Membranes
Escherichia coli
Signal Recognition Particle
Lipid bilayers
Lipid Bilayers
2008

Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC.

Wagner, S., Pop, O. I., Haan, G. J., Koningstein, G. M., Klepsch, M. M., Genevaux, P., Luirink, S. & de Gier, J-W., 2008, In : Journal of Biological Chemistry. 283, p. 17881-1790

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Maltose
Escherichia coli
Membrane Proteins