1993 …2019
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Research Output 1993 2019

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Article
2009

The conserved third transmembrane segment of YidC contacts nascent Escherichia coli inner membrane proteins.

Yu, Z., Koningstein, G. M., Pop, O. I. & Luirink, S., 2009, In : Journal of Biological Chemistry.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli
Membrane Proteins
Membranes
Substrates

Type VII secretion in mycobacteria: classification in line with cell envelope structure.

Bitter, W., Houben, E. N. G., Luirink, S. & Appelmelk, B. J., 2009, In : Trends In Microbiology. 8, p. 337-338

Research output: Contribution to JournalArticleAcademicpeer-review

YidC is required for the assembly of the MscL homopentameric pore.

Pop, O. I., Soprova, Z., Koningstein, G. M., Scheffers, D. J., van Ulsen, J. P., Wickstrom, D., de Gier, J-W. & Luirink, S., 2009, In : The FEBS Journal. 276, 17, p. 4891-4899

Research output: Contribution to JournalArticleAcademicpeer-review

Membranes
Escherichia coli
Signal Recognition Particle
Lipid bilayers
Lipid Bilayers
2008

Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC.

Wagner, S., Pop, O. I., Haan, G. J., Koningstein, G. M., Klepsch, M. M., Genevaux, P., Luirink, S. & de Gier, J-W., 2008, In : Journal of Biological Chemistry. 283, p. 17881-1790

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Maltose
Escherichia coli
Membrane Proteins

Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins

van Bloois, E., Dekker, H. L., Froderberg, L., Houben, E. N. G., Urbanus, M. L., de Koster, C. G., de Gier, J. W. & Luirink, J., 2008, In : FEBS Letters. 2008, 582, p. 1419-1424

Research output: Contribution to JournalArticleAcademicpeer-review

Quality Control
Quality control
Membrane Proteins
Membranes
Escherichia coli
Protein Sorting Signals
Hemoglobins
Peptide Hydrolases
Gram-Negative Bacteria
Bacteria
2007

Contribution of the FtsQ transmembrane segment to loclization to the cell division site.

Scheffers, D. J., Robichon, C., den Blaauwen, T., Haan, G. J., Koningstein, G. M., van Bloois, D. W., Beckwith, J. & Luirink, S., 2007, In : Journal of Bacteriology. 189, 20, p. 7273-7280

Research output: Contribution to JournalArticleAcademic

Cell Division
Microbiology
Membrane Proteins
Cell Membrane
Escherichia coli

Flexibility in targeting and insertion during bacterial membrane protein biogenesis.

van Bloois, D. W., ten Hagen-Jongman, C. M. & Luirink, S., 2007, In : Biochemical and Biophysical Research Communications. 362, 3, p. 727-733

Research output: Contribution to JournalArticleAcademic

Bacterial Proteins
Membrane Proteins
Signal Recognition Particle
Proton-Motive Force
Escherichia coli

Limited tolerance towards folded elements during secretion of the autotransporter Hbp.

Jong, W. S. P., ten Hagen-Jongman ten, C. M., den Blaauwen, T., Slotboom, D. J., Tame, J. R. H., Wickstrom, D., de Gier, J-W., Otto, B. R. & Luirink, S., 2007, In : Molecular Microbiology. 63, 5, p. 1524-1536

Research output: Contribution to JournalArticleAcademic

Hemoglobins
Peptide Hydrolases
Disulfides
Membranes
Periplasm

Saccharomyces cerevisiae Cox 18 complements the essential Sec-independent function of Escherichia coli YidC.

van Bloois, D. W., Koningstein, G. M., Bauerschmitt, H., Herrmann, J. M. & Luirink, S., 2007, In : The FEBS Journal. 274, 21, p. 5704-5713

Research output: Contribution to JournalArticleAcademic

Yeast
Escherichia coli
Saccharomyces cerevisiae
Membrane Proteins
Mitochondria

Type VII secretion-mycobacteria show the way.

Abdallah, A. M., Gey van Pittius, N. C., Champion, P. A., Cox, J., Luirink, S., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J. & Bitter, W., 2007, In : Nature Reviews Microbiology. 5, 11, p. 883-891

Research output: Contribution to JournalArticleAcademic

Mycobacterium
Secretory Pathway
Gram-Positive Bacteria
Terminology
Cell Wall
2006

A specific secretion system mediates PPE41 transport in pathogenic mycobacteria

Abdallah, A. M., Verboom, T., Hannes, F., Safi, M., Strong, M., Eisenberg, D., Musters, R. J. P., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J., Luirink, S. & Bitter, W., 2006, In : Molecular Microbiology. 62, 3, p. 667-679 13 p.

Research output: Contribution to JournalArticleAcademic

Mycobacterium
Mycobacterium marinum
Mycobacterium smegmatis
Genes
Macrophages

Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.

van Bloois, D. W., Haan, G. J., de Gier, J-W., Oudega, B. & Luirink, S., 2006, In : Journal of Biological Chemistry. 14, 281

Research output: Contribution to JournalArticleAcademic

Open Access
File
Escherichia coli
Membrane Proteins
Protein Subunits
Capsid Proteins
Membranes

Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle.

Ullers, R. S., Houben, E. N. G., Oudega, B., Harms, N. & Luirink, S., 2006, In : Journal of Biological Chemistry. 281, 20, p. 13999-144005 7 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Signal Recognition Particle
Escherichia coli
Protein Sorting Signals
Anchors
Peptides
2005

Biogenesis of inner membrane proteins in Escherichia coli

Luirink, S., von Heijne, G., Houben, E. N. G. & de Gier, J-W., 2005, In : Annual Review of Microbiology. 59, p. 329-355 17 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Membrane Proteins
Escherichia coli
Membranes
Signal Recognition Particle
Protein Folding

Characterization of an iron-regulated alpha-enolase of Bacteroides fragilis

Sijbrandi, R., den Blaauwen, T., Tame, J. R. H., Oudega, B., Luirink, S. & Otto, B. R., 2005, In : Microbes and Infection. 7, p. 9-18 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacteroides fragilis
Phosphopyruvate Hydratase
Iron
Plasminogen
Proteins

Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli

Otto, B. R., Sijbrandi, R., Luirink, S., Oudega, B., Heddle, J. G., Mizutani, K., Park, S. Y. & Tame, J. R. H., 2005, In : Journal of Biological Chemistry. 280, p. 17339-17345 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli Proteins
Heme
Hemoglobins
Peptide Hydrolases
Crystal structure

Early encounters of a nascent membrane protein : specificity and timing of contacts inside and outside the ribosome

Houben, E. N. G., Zarivach, R., Brunner, J., Oudega, B. & Luirink, S., 2005, In : Journal of Cell Biology. 170, p. 27-35 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Ribosomes
Membrane Proteins
Signal Recognition Particle
Peptidyl Transferases
Molecular Probes

Evolution of mitochondrial oxa proteins from bacterial YidC: inherited and acquired functions of a conserved insertion machinery

Preuss, M., Ott, M., Funes, G., Luirink, S. & Herrmann, J. M., 2005, In : Journal of Biological Chemistry. 280, p. 13004-13011 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Mitochondria
Bacterial Proteins
Mitochondrial Proteins
Machinery
Ribosomes

Signal peptide hydrophobicity is critical for early stages in protein export by Bacillus subtilis

van Zanen, L. F., Houben, E. N. G., Meima, R. B., Tjalsma, H., Jongbloed, J. D. H., Westers, T. M., Oudega, B., Luirink, S., Dijl, J. M. & Quax, W. J., 2005, In : The FEBS Journal. 272, p. 4617-4630 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bacilli
Hydrophobicity
Protein Sorting Signals
Bacillus subtilis
Hydrophobic and Hydrophilic Interactions

The Sec-independent function of Escherichia coli YidC is evolutionary conserved and essential

van Bloois, D. W., Nagamori, S., Koningstein, G. M., Ullers, R. S., Preuss, M., Oudega, B., Harms, N., Kaback, H. R. & Luirink, S., 2005, In : Journal of Biological Chemistry. 280, p. 12996-13003 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli
Thylakoid Membrane Proteins
Membranes
Assays
Protein Transport
2004

F1F0 ATP synthase subunit c is targeted by SRP to YidC in the Escherichia coli inner membrane.

van Bloois, D. W., Haan, G. J., Gier de, J. W., Oudega, B. & Luirink, S., 2004, In : FEBS Letters. 576, p. 97-100 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Escherichia coli
Membrane Proteins
Membranes
F1F0-ATP synthase

SecB is a bona fide generalized chaperone in Escherichia coli

Ullers, R. S., Luirink, S., Harms, N., Schwager, F., Georgopoulos, C. & Genevaux, P., 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, p. 7583-7588 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Escherichia coli Proteins
Escherichia coli
Temperature
Ribosomes
Phenotype

SRP-mediated protein targeting: structure and function revisited.

Luirink, S. & Sinning, I., 2004, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. p. 17-35 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Targeting and translocation of the two lipoproteins in Escherichia coli via the SRP/Sec/YidC pathway.

Froderberg, L., Houben, E. N. G., Baars, L., Luirink, S. & Gier de, J. W., 2004, In : Journal of Biological Chemistry. 279, p. 31026-31032 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Escherichia coli
Lipoproteins
Bacteriocins
Peptidoglycan
Lipid Bilayers

The two membrane segments of leader peptidase partition one by one into the lipid bilayer via a Sec/YidC interface.

Houben, E. N. G., ten Hagen-Jongman ten, C. M., Brunner, J., Oudega, B. & Luirink, S., 2004, In : EMBO Reports. 5, p. 970-975 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Lipid bilayers
Lipid Bilayers
Membranes
Lipids
Molecular biology

Trigger factor interacts with the signal peptide of nascent Tat substrates but does not play a critical role in tat-mediated export.

Jong, W. S., ten Hagen-Jongman ten, C. M., Genevaux, P., Brunner, J., Oudega, B. & Luirink, S., 2004, In : European Journal of Biochemistry. 271, p. 4779-4787 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Protein Sorting Signals
Arginine
Substrates
Protein Transport
Ribosomes
2003

A conserved function of YidC in the biogenesis of respiratory chain complexes.

van der Laan, M., Urbanus, M. L., ten Hagen-Jongman ten, C. M., Nouwen, N., Oudega, B., Harms, N., Driessen, A. J. M. & Luirink, S., 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, p. 5801-5806 6 p.

Research output: Contribution to JournalArticleAcademic

Inosine Monophosphate
Electron Transport
Proton-Motive Force
Capsid Proteins
Bacteriophages

Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome

Ullers, R. S., Houben, E. N. G., Raine, A., ten Hagen-Jongman ten, C. M., Ehrenberg, M., Brunner, J., Oudega, B., Harms, N. & Luirink, S., 2003, In : Journal of Cell Biology. 161, p. 679-684 6 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Signal Recognition Particle
Ribosomes
Escherichia coli
Membrane Proteins
Protein Sorting Signals

Signal recognition particle (SRP)- mediated targeting and Sec-dependent translocation of an extracellular E. coli protein.

Sijbrandi, R., Urbanus, M. L., ten Hagen-Jongman ten, C. M., Bernstein, H. D., Oudega, B., Otto, B. R. & Luirink, S., 2003, In : Journal of Biological Chemistry. 278, p. 4654-4659 6 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Signal Recognition Particle
Escherichia coli Proteins
Hemoglobins
Peptide Hydrolases
Membranes

Targeting and insertion of heterologous membrane proteins in E. coli.

Raine, A., Ullers, R. S., Pavlov, M., Luirink, S., Wikberg, J. E. S. & Ehrenberg, M., 2003, In : Biochimie. 85, p. 659-668 9 p.

Research output: Contribution to JournalArticleAcademic

Proton Pumps
Escherichia coli
Membrane Proteins
Membranes
human MC4R protein

The ribosome and YidC: new insights into the biogenesis of Escherichia coli inner membrane proteins.

de Gier, J-W. & Luirink, S., 2003, In : EMBO Reports. 4, p. 939-943 5 p.

Research output: Contribution to JournalArticleAcademic

Ribosomes
Escherichia coli
Membrane Proteins
Signal Recognition Particle
Periplasm

Versatility of inner membrane protein biogenesis in Escherichia coli.

Froderberg, L., Houben, E. N. G., Samuleson, J. C., Chen, M., Park, S. K., Philips, G. J., Dalbey, R. E., Luirink, S. & de Gier, J-W., 2003, In : Molecular Microbiology. 47, p. 1015-1027 13 p.

Research output: Contribution to JournalArticleAcademic

Inosine Monophosphate
Membrane Proteins
Escherichia coli
Signal Recognition Particle
Membranes
2002

Defective translocation of a signal sequence mutant in a prlA4 suppressor strain of Escherichia coli.

Adams, H., Scottie, P. A., Luirink, S. & Tommassen, J., 2002, In : European Journal of Biochemistry. 269, p. 5572-5580 8 p.

Research output: Contribution to JournalArticleAcademic

Signal Recognition Particle
Protein Sorting Signals
Escherichia coli
Membrane Proteins
Endopeptidase K

Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis.

Otto, B. R., van Dooren, S. J. M., Dozois, C. M., Luirink, S. & Oudega, B., 2002, In : Infection and Immunity. 70, p. 5-10 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Bacteroides fragilis
Heme
Abscess
Intraabdominal Infections
Hemoglobins

Targeting, isertion and localization of E. coli YidC.

Urbanus, M. L., Froderberg, L., Drew, D., Bjork, P., de Gier, J-W., Brunner, J., Oudega, B. & Luirink, S., 2002, In : Journal of Biological Chemistry. 277, p. 12718-12723 5 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Escherichia coli
Membrane Proteins
Signal Recognition Particle
Poles
Membranes

The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli.

Adams, H., Scottie, P. A., Cock, H., Luirink, S. & Tommassen, J., 2002, In : European Journal of Biochemistry. 269, p. 5564-5571 7 p.

Research output: Contribution to JournalArticleAcademic

Signal Recognition Particle
Protein Sorting Signals
Glycine
Escherichia coli
Membrane Proteins

YidC and SecY mediate membrane insertion of a Type I transmembrane domain.

Houben, E. N. G., Urbanus, M. L., Van der laan, M., ten Hagen-Jongman ten, C. M., Driessen, A. J. M., Brunner, J., Oudega, B. & Luirink, S., 2002, In : Journal of Biological Chemistry. 277, p. 35880-35886 6 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Membrane Proteins
Membranes
Escherichia coli
Lipids
Ribosomes
2001

Biogenesis of inner membrane proteins in Escherichia coli

de Gier, J-W. & Luirink, S., 2001, In : Molecular Microbiology. 40, p. 314-322 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Membrane Proteins
Escherichia coli
Proteins
Membranes
E coli inner membrane protein

Biosynthesis of K88 fimbriae in Escherichia coli: interaction of tip-subunit FaeC with the periplasmic chaperone FaeE and the outer membrane usher FaeD.

Mol, O., Oudhuis, W. C., Oud, R. P. C., Sijbrandi, R., Luirink, S., Harms, N. & Oudega, B., 2001, In : Journal of Molecular Microbiology and Biotechnology. 3, p. 135-142 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY.

Herkovits, A. A., Seluanov, A., Rasjbaum, R., ten Hagen, C. M., Henrichs, T., Bochkareva, E. S., Philips, G. J., Probst, F. J., Nakae, T., Ehrmann, M., Luirink, S. & Bibi, E., 2001, In : EMBO Reports. 2, p. 1040-1046 6 p.

Research output: Contribution to JournalArticleAcademic

Membranes
Proteolysis
Escherichia coli
Catalytic Domain
Synchronization

Important role of the tetraloop region of 4,5 S RNA in SRP binding to its receptor FtsY.

Jagath, J. R., Matassova, N. B., de Leeuw, E., Warnecke, J. M., Lentzen, G., Rodina, M. V., Luirink, S. & Wintermeyer, W., 2001, In : RNA. 7, p. 293-301 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Signal Recognition Particle
RNA
Base Pairing
Hydroxyl Radical
Gels

Is Ffh required for export of secretory proteins.

Kim, J., Rusch, S., Luirink, S. & Kendall, D. A., 2001, In : FEBS Letters. 505, p. 245-248 3 p.

Research output: Contribution to JournalArticleAcademic

Signal Recognition Particle
Protein Sorting Signals
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Membrane Proteins

Purification of the autotransporter protein Hbp of Escherichia coli.

van Dooren, S. J. M., Tame, J. R. H., Luirink, S., Oudega, B. & Otto, B. R., 2001, In : FEMS Microbiology Letters. 205, p. 147-150 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Hemoglobins
Peptide Hydrolases
Escherichia coli
Proteins
Heme

Reconstitution of SecYEG-dependent membrane protein insertion: nacent FtsQ interacts with YidC in a SecYEG-dependent manner.

Van der laan, M., Houben, E. N. G., Nouwen, N., Luirink, S. & Driessen, A. J. M., 2001, In : EMBO Reports. 2, p. 519-523 4 p.

Research output: Contribution to JournalArticleAcademic

Sec-dependent membrane insertion: sequentail interaction of nascent FtsQ with SecY and YidC.

Urbanus, M. L., Scottie, P. A., Froderberg, L., Saaf, A., de Gier, J-W., Brunner, J., Samulelson, T., Dalbey, R. E., Oudega, B. & Luirink, S., 2001, In : EMBO Reports. 2, p. 524-529 5 p.

Research output: Contribution to JournalArticleAcademic

The early interaction of the outer membrane protein PhoE with the periplasmic chaperone Skp occurs at the cytoplasmic membrane.

Harms, N., Koningstein, G., Dontje, W., Muller, M., Oudega, B., Luirink, S. & Cock, H., 2001, In : Journal of Biological Chemistry. 276, p. 18804-18811 7 p.

Research output: Contribution to JournalArticleAcademic

Open Access
File
Membrane Proteins
Cell Membrane
Membranes
Proteins
Tetrahydrofolate Dehydrogenase

YidC/Oxalp/ALB3:evolutionary concerved mediators of membrane protein assembly

Luirink, S., Samuelson, T. & de Gier, J-W., 2001, In : FEBS Letters. 501, p. 1-5 4 p.

Research output: Contribution to JournalArticleAcademic

2000

Anionic phospholipids are involed in membrane association of the recognition particle receptor FtsY and stimulate its GTPase activity.

de Leeuw, E. P. H., te Kaat, K., Moser, C., Menestrina, G., Demel, R., Kruyff, B., Oudega, B., Luirink, S. & Sinning, I., 2000, In : EMBO Journal. 19, p. 531-541

Research output: Contribution to JournalArticleAcademicpeer-review

Nascent Lep insert into the Escherichia coli inner membrane in the vicinity of YidC, SecA.

Houben, E. N. G., Scotti, P. A., Valent, Q. A., Brunner, J., de Gier, J-W., Oudega, B. & Luirink, S., 2000, In : FEBS Letters. 476, p. 229-233

Research output: Contribution to JournalArticleAcademicpeer-review

Die casting inserts
Escherichia coli
Membranes
Membrane Proteins
Signal Recognition Particle