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Research Output 2004 2019

2015

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci

Rahmioglu, N., Macgregor, S., Drong, A. W., Hedman, A. K., Harris, H. R., Randall, J. C., Prokopenko, I., Hottenga, J. J., Boomsma, D. I., Nyholt, DR., Morris, A. P., Montgomery, G. W., Missmer, S. A., Lindgren, C. M. & Zondervan, K. T., 2015, In : Human Molecular Genetics. 24, 4, p. 1185-1199 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Endometriosis
Genome-Wide Association Study
Obesity
Genome
Body Mass Index

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., Paynter, N., Monda, K. L., Amin, N., Fischer, K., Renstrom, F., Ngwa, J. S., Huikari, V., Cavadino, A., Nolte, I. M., Teumer, A., Yu, K., Marques-Vidal, P., Rawal, R., Manichaikul, A., Wojczynski, M. K. & 134 othersVink, J. M., Zhao, J. H., Burlutsky, G., Lahti, J., Mikkilä, V., Lemaitre, R. N., Eriksson, J., Musani, S. K., Tanaka, T., Geller, F., Luan, J., Hui, J., Mägi, R., Dimitriou, M., Garcia, M. E., Ho, W. K., Wright, M. J., Rose, L. M., Magnusson, P. K. E., Pedersen, N. L., Couper, D., Oostra, B. A., Hofman, A., Ikram, M. A., Tiemeier, H., Uitterlinden, A. G., van Rooij, F. J. A., Barroso, I., Johansson, I., Xue, L., Kaakinen, M., Milani, L., Power, C., Snieder, H., Stolk, R. P., Baumeister, S. E., Biffar, R., Gu, F., Bastardot, F., Kutalik, Z., Jacobs, D. R., Forouhi, N. G., Mihailov, E., Lind, L., Lindgren, C., Michaëlsson, K., Morris, A., Jensen, M., Khaw, K. T., Luben, R. N., Wang, J. J., Männisto, S., Perälä, M. M., Kähönen, M., Lehtimäki, T., Viikari, J., Mozaffarian, D., Mukamal, K., Psaty, B. M., Döring, A., Heath, A. C., Montgomery, G. W., Dahmen, N., Carithers, T., Tucker, K. L., Ferrucci, L., Boyd, H. A., Melbye, M., Treur, J. L., Mellström, D., Hottenga, J. J., Prokopenko, I., Tönjes, A., Deloukas, P., Kanoni, S., Lorentzon, M., Houston, D. K., Liu, Y., Danesh, J., Rasheed, A., Mason, M. A., Zonderman, A. B., Franke, L., Kristal, B. S., Karjalainen, J., Reed, D. R., Westra, H. J., Evans, M. K., Saleheen, D., Harris, T. B., Dedoussis, G., Curhan, G., Stumvoll, M., Beilby, J., Pasquale, L. R., Feenstra, B., Bandinelli, S., Ordovas, J. M., Chan, A. T., Peters, U., Ohlsson, C., Gieger, C., Martin, N. G., Waldenberger, M., Siscovick, D. S., Raitakari, O., Eriksson, J. G., Mitchell, P., Hunter, D. J., Kraft, P., Rimm, E. B., Boomsma, D. I., Borecki, I. B., Loos, R. J. F., Wareham, N. J., Vollenweider, P., Caporaso, N., Grabe, H. J., Neuhouser, M. L., Wolffenbuttel, B. H. R., Hu, F. B., Hyppönen, E., Järvelin, M. R., Cupples, L. A., Franks, P. W., Ridker, P. M., van Duijn, C. M., Heiss, G., Metspalu, A., North, K. E., Ingelsson, E., Nettleton, J. A., van Dam, R. M. & Chasman, D. I., 2015, In : Molecular Psychiatry. 20, 5, p. 647-656 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Coffee
Meta-Analysis
Genome
Single Nucleotide Polymorphism
Caffeine

Genome-wide patterns and properties of de novo mutations in humans

Francioli, L. C., Polak, P. P., Koren, A., Menelaou, A., Chun, S., Renkens, I., van Duijn, C. M., Swertz, M. A., Wijmenga, C., van Ommen, G. J., Slagboom, P. E., Boomsma, D. I., Ye, K., Guryev, V., Arndt, P. F., Kloosterman, W. P., Bakker, P. I. W., Sunyaev, S. R., Dijk, F., Neerincx, P. B. T. & 68 othersPulit, S. L., Deelen, P., Elbers, C. C., Palamara, P. F., Pe'er, I., Abdellaoui, A., van Oven, M., Vermaat, M., Li, M., Laros, J. F. J., Stoneking, M., de Knijff, P., Kayser, M., Veldink, J. H., Van den Berg, L. H., Byelas, H., den Dunnen, J. T., Dijkstra, M., Amin, N., van der Velde, K. J., Hottenga, J. J., van Setten, J., van Leeuwen, E. M., Kanterakis, A., Kattenberg, V. M., Karssen, L. C., van Schaik, B. D. C., Bot, J., Nijman, I. J., van Enckevort, D., Mei, H., Koval, V., Estrada, K., Medina-Gomez, C., Lameijer, E. W., Moed, M. H., Hehir-Kwa, J. Y., Handsaker, R. E., McCarroll, S. A., Vuzman, D., Sohail, M., Hormozdiari, F., Marschall, T., Schönhuth, A., Beekman, M., de Craen, A. J., Suchiman, H. E. D., Hofman, A., Oostra, B., Isaacs, A., Rivadeneira, F., Uitterlinden, A. G., Willemsen, G., Platteel, M., Pitts, S. J., Potluri, S., Sundar, P., Cox, D. R., Li, Q., Li, Y., Du, Y., Chen, R., Cao, H., Li, N., Cao, S., Wang, J., Bovenberg, J. A. & Brandsma, M., 2015, In : Nature Genetics. 47, 7, p. 822-826 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mutation Rate
Genome
Mutation
Inborn Genetic Diseases
Pan troglodytes

Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset

Minica, C. C., Dolan, C. V., Hottenga, J. J., Pool, R., Fedko, I. O., Mbarek, H., Huppertz, C., Bartels, M., Boomsma, D. I. & Vink, J. M., 2015, In : Behavior Genetics. 45, 5, p. 503-513 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cannabis
heritability
Age of Onset
single nucleotide polymorphism
Single Nucleotide Polymorphism

Heritability and Genome-Wide Association Studies for Hair Color in a Dutch Twin Family Based Sample

Lin, B., Mbarek, H., Willemsen, G., Dolan, C. V., Fedko, I. O., Abdellaoui, A., de Geus, E. J. C., Boomsma, D. I. & Hottenga, J. J., 2015, In : Genes. 6, 3, p. 559-576 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Hair Color
Genome-Wide Association Study
Light
Single Nucleotide Polymorphism
Netherlands

Heritability of liver enzyme levels estimated from genome-wide SNP data

van Beek, J. H. D. A., Lubke, G. H., de Moor, M. H. M., Willemsen, G., de Geus, E. J. C., Hottenga, J. J., Walters, R. K., Smit, J. H., Penninx, B. W. J. H. & Boomsma, D. I., 2015, In : European Journal of Human Genetics. 23, 9, p. 1223-1228 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Single Nucleotide Polymorphism
Genome
Liver
Enzymes
Transferases

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

Shah, S., Bonder, M. J., Marioni, R. E., Zhu, Z., McRae, A. F., Zhernakova, A., Harris, S. E., Liewald, D. C. M., Henders, A. K., Mendelson, M. M., Liu, C., Joehanes, R., Liang, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Levy, D., Martin, N. G., Starr, J. M. & 7 othersWijmenga, C., Wray, N. R., Yang, J., Montgomery, G. W., Franke, L., Deary, I. J. & Visscher, P. M., 2015, In : American Journal of Human Genetics. 97, 1, p. 75-85 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Epigenomics
Body Mass Index
Methylation
Genome-Wide Association Study
DNA Methylation

In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons

Vaez, A., Jansen, R., Prins, B. P., Hottenga, J. J., de Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Nolte, I. M., Snieder, H. & Alizadeh, BZ., 2015, In : Circulation-cardiovascular genetics. 8, 3, p. 487-497 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Computer Simulation
C-Reactive Protein
Interferons
Single Nucleotide Polymorphism

Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait

Franic, S., Blokhuis, M. M., Dolan, C. V., Kattenberg, V. M., Pool, R., Xiao, X., Scheet, P., Ehli, E. A., Davies, G. E., van der Sluis, S., Abdellaoui, A., Hansell, N. K., Martin, N. G., Hudziak, J. J., van Beijsterveldt, C. E. M., Swagerman, S. C., Hulshoff Pol, H. E., de Geus, E. J. C., Bartels, M., Ropers, H-H. & 2 othersHottenga, J. J. & Boomsma, D. I., 2015, In : European Journal of Human Genetics. 23, 10, p. 1378-1383 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Multifactorial Inheritance
Intelligence
Genes
Medical Genetics
Single Nucleotide Polymorphism

Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

Maier, R., Moser, G., Chen, G. B., Ripke, S., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Coryell, W. H., Potash, J. B., Scheftner, W. A., Shi, J., Weissmann, M. M., Hultman, C. M., Landén, M., Levinson, D. F., Kendler, K. S., Smoller, J. W., Wray, N. R. & 1 othersLee, S. H., 2015, In : American Journal of Human Genetics. 96, 2, p. 283-294 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Bipolar Disorder
Psychiatry
Schizophrenia
Joints

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Day, F. R., Ruth, K. S., Thompson, D. J., Lunetta, K. L., Pervjakova, N., Chasman, D. I., Stolk, L., Finucane, H. K., Sulem, P., Bulik-Sullivan, B. K., Esko, T., Johnson, A. D., Elks, C. E., Franceschini, N., He, C., Altmaier, E., Brody, J. A., Franke, L. L., Huffman, J. E., Keller, M. F. & 221 othersMcArdle, P. F., Nutile, T., Porcu, E., Robino, A., Rose, L. M., Schick, U. M., Smith, J. A., Teumer, A., Traglia, M., Vuckovic, D., Yao, J., Zhao, W., Albrecht, E., Amin, N., Corre, T., Hottenga, J. J., Mangino, M., Smith, A. V., Tanaka, T., Abecasis, G. R., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C., Arndt, V., Arnold, A. M., Barbieri, C., Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bernstein, L., Bielinski, S. J., Blomqvist, C., Boerwinkle, E., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Borresen-Dale, A. L., Boutin, T. S., Brauch, H., Brenner, H., Brüning, T., Burwinkel, B., Campbell, A., Campbell, H., Chanock, S. J., Chapman, J. R., Ida Chen, Y. D., Chenevix-Trench, G., Couch, F. J., Coviello, A. D., Cox, A., Czene, K., Darabi, H., De Vivo, I., Demerath, E. W., Dennis, J., Devilee, P., Dörk, T., dos-Santos-Silva, I., Dunning, A. M., Eicher, J. D., Fasching, P. A., Faul, J. D., Figueroa, J., Flesch-Janys, D., Gandin, I., Garcia, M. E., García-Closas, M., Giles, G. G., Girotto, G. G., Goldberg, M. S., González-Neira, A., Goodarzi, M. O., Grove, M. L., Gudbjartsson, D. F., Guénel, P., Guo, X., Haiman, C. A., Hall, P., Hamann, U., Henderson, B. E., Hocking, L. J., Hofman, A., Homuth, G., Hooning, M. J., Hopper, J. L., Hu, F. B., Huang, J., Humphreys, K., Hunter, D. J., Jakubowska, A., Jones, S. E., Kabisch, M., Karasik, D., Knight, J. A., Kolcic, I., Kooperberg, C., Kosma, V. M., Kriebel, J., Kristensen, V., Lambrechts, D., Langenberg, C., Li, J., Li, X., Lindström, S., Liu, Y., Luan, J., Lubinski, J., Mägi, R., Mannermaa, A., Manz, J., Margolin, S., Marten, J., Martin, N. G., Masciullo, C., Meindl, A., Michailidou, K., Mihailov, E., Milani, L., Milne, R. L., Müller-Nurasyid, M., Nalls, M., Neale, B. M., Nevanlinna, H., Neven, P., Newman, A. B., Nordestgaard, B. G., Olson, J. E., Padmanabhan, S., Peterlongo, P., Peters, U., Petersmann, A., Peto, J., Pharoah, P. D. P., Pirastu, N. N., Pirie, A., Pistis, G., Polasek, O., Porteous, D., Psaty, B. M., Pylkäs, K., Radice, P., Raffel, L. J., Rivadeneira, F., Rudan, I., Rudolph, A., Ruggiero, D., Sala, C. F., Sanna, S., Sawyer, E. J., Schlessinger, D., Schmidt, M. K., Schmidt, F., Schmutzler, R. K., Schoemaker, M. J., Scott, R. A., Seynaeve, C. M., Simard, J., Sorice, R., Southey, M. C., Stöckl, D., Strauch, K., Swerdlow, A., Taylor, K. D., Thorsteinsdottir, U., Toland, A. E., Tomlinson, I., Truong, T., Tryggvadottir, L., Turner, S. T., Vozzi, D., Wang, Q., Wellons, M., Willemsen, G., Wilson, J. F., Winqvist, R., Wolffenbuttel, B. H. R., Wright, A. F., Yannoukakos, D., Zemunik, T., Zheng, W., Zygmunt, M., Bergmann, S., Boomsma, D. I., Buring, J. E., Ferrucci, L., Montgomery, G. W., Gudnason, V., Spector, T. D., van Duijn, C. M., Alizadeh, BZ., Ciullo, M., Crisponi, L., Easton, D. F., Gasparini, P. P., Gieger, C., Harris, T. B., Hayward, C., Kardia, S. L. R., Kraft, P., McKnight, B., Metspalu, A., Morrison, A. C., Reiner, A. P., Ridker, P. M., Rotter, J. I., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Völzke, H., Wareham, N. J., Weir, D. R., Yerges-Armstrong, L. M., Price, A. L., Stefansson, K., Visser, J. A., Ong, K. K., Chang-Claude, J., Murabito, J. M. M., Perry, J. R. B. & Murray, A., 2015, In : Nature Genetics. 47, 11, p. 1294-1303 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Menopause
DNA Repair
Breast Neoplasms
Mendelian Randomization Analysis
DNA Damage

Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence

Franic, S., Dolan, C. V., Broxholme, J., Hu, H., Zemojtel, T., Davies, G. E., Nelson, K. A., Ehli, E. A., Pool, R., Hottenga, J. J., Ropers, H-H. & Boomsma, D. I., 2015, In : Intelligence. 49, p. 10-22 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Multifactorial Inheritance
Intelligence
Intellectual Disability
Reference Values
Genes

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

de Moor, M. H. M., van den Berg, S. M., Verweij, C. J. H., Krueger, R. F., Luciano, M., Arias-Vasquez, A., Matteson, L. K., Derringer, J., Esko, T., Amin, N., Gordon, S. D., Hansell, N. K., Hart, A. B., Seppälä, I., Huffman, J. E., Konte, B., Lahti, J., Lee, M. Y., Miller, M., Nutile, T. & 98 othersTanaka, T., Teumer, A., Viktorin, A., Wedenoja, J., Abecasis, G. R., Adkins, D. E., Agrawal, A., Allik, J., Appel, K., Bigdeli, T. B., Busonero, F., Campbell, H., Costa, P. T., Davey Smith, G., Davies, G., de Wit, H., Ding, J., Engelhardt, B. E., Eriksson, J. G., Fedko, I. O., Ferrucci, L., Franke, B., Giegling, I., Grucza, R., Hartmann, A. M., Heath, A. C., Heinonen, K., Henders, A. K., Homuth, G., Hottenga, J. J., Iacono, W. G., Janzing, J., Jokela, M., Karlsson, R., Kemp, J. P., Kirkpatrick, M. G., Latvala, A., Lehtimäki, T., Liewald, D. C., Madden, P. A. F., Magri, C., Magnusson, P. K. E., Marten, J., Maschio, A., Medland, S. E., Mihailov, E., Milaneschi, Y., Montgomery, G. W., Nauck, M., Ouwens, K. G., Palotie, A., Pettersson, E., Polasek, O., Qian, Y., Pulkki-Råback, L., Raitakari, O. T., Realo, A., Rose, R. J., Ruggiero, D., Schmidt, C. O., Slutske, W. S., Sorice, R., Starr, J. M., St Pourcain, B., Sutin, A. R., Timpson, N. J., Trochet, H., Vermeulen, S., Vuoksimaa, E., Widén, E., Wouda, J., Wright, M. J., Zgaga, L., Porteous, D., Minelli, A., Palmer, A. A., Rujescu, D., Ciullo, M., Hayward, C., Rudan, I., Metspalu, A., Kaprio, J., Deary, I. J., Räikkönen, K., Wilson, J. F., Keltikangas-Järvinen, L., Bierut, L. J., Hettema, J. M., Grabe, H. J., van Duijn, C. M., Evans, D. M., Schlessinger, D., Pedersen, N. L., Terracciano, A., McGue, M., Penninx, B. W. J. H., Martin, N. G. & Boomsma, D. I., 2015, In : JAMA Psychiatry. 72, 7, p. 642-650 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Major Depressive Disorder
Meta-Analysis
Single Nucleotide Polymorphism
Genome

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bonnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C., Thyssen, J. P., den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., Marenholz, I. & 130 othersKalb, B., Pino-Yanes, M., Xu, C., Carstensen, L., Groen-Blokhuis, M. M., Venturini, C., Pennell, C. E., Barton, S. J., Levin, A. M., Curjuric, I., Bustamante, M., Kreiner-Moller, E., Lockett, G. A., Bacelis, J., Bunyavanich, S., Myers, R. A., Matanovic, A., Kumar, A., Tung, J. Y., Hirota, T., Kubo, M., McArdle, W. L., Henderson, A. J., Kemp, J. P., Zheng, J., Smith, G. D., Rueschendorf, F., Bauerfeind, A., Lee-Kirsch, M. A., Arnold, A., Homuth, G., Schmidt, C. O., Mangold, E., Cichon, S., Keil, T., Rodriguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Foelster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L. L., Grarup, N., de Jongste, J. C., Rivadeneira, F., Hofman, A., Jaddoe, V. W. V., Pasmans, S. G. M. A., Elbert, N. J., Uitterlinden, A. G., Marks, G. B., Thompson, P. J., Matheson, M. C., Robertson, C. F., Ried, J. S., Li, J., Zuo, X. B., Zheng, X. D., Yin, X. Y., Sun, L. D., McAleer, M. A., O'Regan, G. M., Fahy, C. M. R., Campbell, L. E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D. S., Feenstra, B., Geller, F., Hottenga, J. J., Middeldorp, C. M., Hysi, P., Bataille, V., Spector, T., Tiesler, C. M. T., Thiering, E., Pahukasahasram, B., Yang, J. J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C. L., Myhre, R., Nystad, W., Custovic, A., Weiss, S. T., Meyers, D. A., Soederhaell, C., Melen, E., Ober, C., Raby, B. A., Simpson, A., Jacobsson, B., Holloway, J. W., Bisgaard, H., Sunyer, J., Probst-Hensch, N. M., Williams, L. K., Godfrey, K. M., Wang, C. A., Boomsma, D. I., Melbye, M., Koppelman, G. H., Jarvis, D., McLean, W. H. I., Irvine, A. D., Zhang, X. J., Hakonarson, H., Gieger, C., Burchard, E. G., Martin, N. G., Duijts, L., Linneberg, A., Jarvelin, M., Noethen, M. M., Lau, S., Huebner, N., Lee, Y., Tamari, M., Hinds, D. A., Glass, D., Brown, S. J., Heinrich, J., Evans, D. M. & Weidinger, S., 2015, In : Nature Genetics. 47, 12, p. 1449-1456

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Atopic Dermatitis
Genetic Association Studies
Hispanic Americans
Skin Diseases

Multicohort analysis of the maternal age effect on recombination

Martin, H. C., Christ, R., Hussin, J. G., O'Connell, J., Gordon, S., Mbarek, H., Hottenga, J. J., McAloney, K., Willemsen, G., Gasparini, P., Pirastu, N., Montgomery, G. W., Navarro, P., Soranzo, N., Toniolo, D., Vitart, V., Wilson, J. F., Marchini, J., Boomsma, D. I., Martin, N. G. & 1 othersDonnelly, P., 2015, In : Nature Communications. 6, 10 p., 7846.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Maternal Age
Polymorphism
Genetic Recombination
Nucleotides
Cohort Effect

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

Gottlieb, D. J., Hek, K., Chen, T. H., Watson, N. F., Eiriksdottir, G., Byrne, E. M., Cornelis, M., Warby, S. C., Bandinelli, S., Cherkas, L., Evans, D. S., Grabe, H. J., Lahti, J., Li, M., Lehtimäki, T., Lumley, T., Marciante, K., Pérusse, L., Psaty, B. M., Robbins, J. & 66 othersTranah, G., Vink, J. M., Wilk, J. B., Stafford, J. M., Bellis, M., Biffar, R., Bouchard, C., Cade, B., Curhan, G. C., Eriksson, J. G., Ewert, R., Ferrucci, L., Fülöp, T., Gehrman, P. R., Goodloe, R., Harris, T. B., Heath, A. C., Hernandez, D., Hofman, A., Hottenga, J. J., Hunter, D. J., Jensen, M. K., Johnson, A. D., Kähönen, M., Kao, L., Kraft, P., Larkin, E. K., Lauderdale, D. S., Luik, A. I., Medici, M., Montgomery, G. W., Palotie, A., Patel, S. R., Pistis, G., Porcu, E., Quaye, L., Raitakari, O., Redline, S., Rimm, E. B., Rotter, J. I., Smith, A. V., Spector, T. D., Teumer, A., Uitterlinden, A. G., Vohl, M-C., Widén, E., Willemsen, G., Young, T., Zhang, X., Liu, Y., Blanger, J., Boomsma, D. I., Gudnason, V., Hu, F., Mangino, M., Martin, N. G., O'Connor, G. T., Stone, K. L., Tanaka, T., Viikari, J., Gharib, S. A., Punjabi, N. M., Räikkönen, K., Völzke, H., Mignot, E. & Tiemeier, H., 2015, In : Molecular Psychiatry. 20, 10, p. 1232-1239 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Sleep
Psychiatry
Alleles
Intergenic DNA

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

Power, R. A., Steinberg, S., Bjornsdottir, G., Rietveld, C. A., Abdellaoui, A., Nivard, M. M., Johannesson, M., Galesloot, T. E., Hottenga, J. J., Willemsen, G., Cesarini, D., Benjamin, D. J., Magnusson, P. K., Ullén, F., Tiemeier, H., Hofman, A., van Rooij, F. J., Walters, G. B., Sigurdsson, E., Thorgeirsson, T. E. & 9 othersIngason, A., Helgason, A., Kong, A., Kiemeney, L. A., Koellinger, P. D., Boomsma, D. I., Gudbjartsson, D., Stefansson, H. & Stefansson, K., 2015, In : Nature Neuroscience. 18, 7, p. 953-955

Research output: Contribution to JournalArticleAcademicpeer-review

Creativity
Bipolar Disorder
Psychotic Disorders
Schizophrenia

Population genetic differentiation of height and body mass index across Europe

Robinson, M. R., Hemani, G., Medina-Gomez, C., Mezzavilla, M., Esko, T., Shakhbazov, K., Powell, J. E., Vinkhuyzen, A. A., Berndt, S. I., Gustafsson, S., Justice, A. E., Kahali, B., Locke, A. E., Pers, T. H., Vedantam, S., Wood, A. R., van Rheenen, W., Andreassen, O. A., Gasparini, P., Metspalu, A. & 23 othersVan den Berg, L. H., Veldink, J. H., Rivadeneira, F., Werge, T. M., Abecasis, G. R., Boomsma, D. I., Chasman, D. I., de Geus, E. J. C., Frayling, T. M., Hirschhorn, J. N., Hottenga, J. J., Ingelsson, E., Loos, R. J. F., Magnusson, P. K. E., Martin, N. G., Montgomery, G. W., North, K. E., Pedersen, N. L., Spector, T. D., Speliotes, E. K., Goddard, M. E., Yang, J. & Visscher, P. M., 2015, In : Nature Genetics. 47, 11, p. 1357-1362 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Population Genetics
Body Mass Index
Phenotype
Population

Population-specific genotype imputations using minimac or IMPUTE2

van Leeuwen, E. M., Kanterakis, A., Deelen, P., Kattenberg, V. M., Slagboom, P. E., Bakker, P. I. W., Wijmenga, C., Swertz, M. A., Boomsma, D. I., van Duijn, C. M., Karssen, L. C. & Hottenga, J. J., 2015, In : Nature Protocols. 10, 9, p. 1285-1296 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Genes
Genotype
Guidelines
Netherlands

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

O’Dushlaine, C., Rossin, L., Lee, P. H., Duncan, L., Parikshak, N. N., Newhouse, S., Ripke, S., Neale, B. M., Purcell, S. M., Posthuma, D., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Krabbendam, A. C., Middeldorp, C. M., Penninx, B. W. J. H., Sergeant, J. A., Smit, J. H., Grootheest, G., Willemsen, G. & 2 othersHolmes, P. & Breen, G., 2015, In : Nature Neuroscience. 18, 2, p. 199-209 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Histones
Psychiatry
Post-Synaptic Density
Genomics

Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

Byrne, E. M., Boomsma, D. I., Martin, N. G., Penninx, B. W. J. H., de Geus, E. J. C., Hoogendijk, W. J. G., Hottenga, J. J., Middeldorp, C. M., Nyholt, DR., Smit, J. H., van den Oord, E. J., Grootheest, G., Willemsen, G., Zitman, F. G., Neale, B. M., Sullivan, P. F., Raheja, U. K., Stephens, S. H., Heath, A. C., Madden, P. A. F. & 11 othersVaswani, D., Nijjar, G. V., Ryan, K. A., Youssufi, H., Gehrman, P. R., Shuldiner, A. R., Montgomery, G. W., Wray, N. R., Nelson, E. C., Mitchell, B. D. & Postolache, T. T., 2015, In : Journal of Clinical Psychiatry. 76, 2, p. 128-134 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bipolar Disorder
Schizophrenia
Major Depressive Disorder
Genome-Wide Association Study
Single Nucleotide Polymorphism

Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis

Pappa, I., Fedko, I. O., Mileva-Seitz, V. R., Hottenga, J. J., Bakermans-Kranenburg, M. J., Bartels, M., van Beijsterveldt, C. E. M., Jaddoe, V. W. V., Middeldorp, C. M., Rippe, R. C. A., Rivadeneira, F., Tiemeier, H., Verhulst, F. C., van IJzendoorn, M. H. & Boomsma, D. I., 2015, In : Journal of the American Academy of Child and Adolescent Psychiatry. 54, 9, p. 737-744 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Single Nucleotide Polymorphism
Genome
Phenotype
Genome-Wide Association Study
Child Behavior

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~ 25 000 subjects

Peyrot, W., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A. & 9 othersRipke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Posthuma, D., Middeldorp, C. M. & Penninx, B. W. J. H., 2015, In : Molecular Psychiatry. 20, 6, p. 735-743 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Depression
Single Nucleotide Polymorphism
Genomics
Mental Disorders

The Genetics of Alcohol Dependence: Twin and SNP-Based Heritability, and Genome-Wide Association Study Based on AUDIT Scores

Mbarek, H., Milaneschi, Y., Fedko, I. O., Hottenga, J. J., de Moor, M. H. M., Jansen, R., Gelernter, J., Sherva, R., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H. & Vink, J. M., 2015, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 168, 8, p. 739-748 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Alcoholism
Single Nucleotide Polymorphism
Alcohols
Netherlands

The impact of low-frequency and rare variants on lipid levels

Surakka, I., Horikoshi, M., Magi, R., Sarin, A., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hagg, S., Hottenga, J. J., Isaacs, A., Ladenvall, C., Beekman, M., Esko, T. & 66 othersRied, J. S., Nelson, C. P., Willenborg, C., Gustafsson, S., Westra, H., Blades, M., Craen, A. J. M., de Geus, E. J. C., Deelen, J., Grallert, H., Hamsten, A., Havulinna, A. S., Hengstenberg, C., Houwing-Duistermaat, J. J., Hypponen, E., Karssen, L. C., Lehtimaki, T., Lyssenko, V., Magnusson, P. K. E., Mihailov, E., Muller-Nurasyid, M., Mpindi, J., Pedersen, N. L., Penninx, B. W. J. H., Perola, M., Pers, T. H., Peters, A., Rung, J., Smit, J. H., Steinthorsdottir, V., Tobin, M. D., Tsernikova, N., van Leeuwen, E. M., Viikari, J. S., Willems, S. M., Willemsen, G., Schunkert, H., Erdmann, J., Samani, N. J., Kaprio, J., Lind, L., Gieger, C., Metspalu, A., Slagboom, P. E., Groop, L., van Duijn, C. M., Eriksson, J. G., Jula, A., Salomaa, V., Boomsma, D. I., Power, C., Raitakari, O. T., Ingelsson, E., Jarvelin, M., Thorsteinsdottir, U., Franke, L., Ikonen, E., Kallioniemi, O., Pietiainen, V., Lindgren, C. M., Stefansson, K., Palotie, A., McCarthy, M. I., Morris, A. P., Prokopenko, I. & Ripatti, S., 2015, In : Nature Genetics. 47, 6, p. 589-597

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Single Nucleotide Polymorphism
Lipids
Genome
Missense Mutation
LDL Cholesterol

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpelainen, T. O., Lu, Y., Magi, R., Mihailov, E., Pers, T. H., Rueeger, S., Teumer, A., Ehret, G. B., Ferreira, T., Heard-Costa, N. L., Karjalainen, J. & 418 othersLagou, V., Mahajan, A., Neinast, M. D., Prokopenko, I., Simino, J., Teslovich, T. M., Jansen, R., Westra, H., White, C. C., Absher, D., Ahluwalia, T. S., Ahmad, S., Albrecht, E., Alves, A. C., Bragg-Gresham, J. L., Craen, A. J. M., Bis, J. C., Bonnefond, A., Boucher, G., Cadby, G., Cheng, Y., Chiang, C. W. K., Delgado, G., Demirkan, A., Dueker, N., Eklund, N., Eiriksdottir, G., Eriksson, J., Feenstra, B., Fischer, K., Frau, F., Galesloot, T. E., Geller, F., Goel, A., Gorski, M., Grammer, T. B., Gustafsson, S., Haitjema, S., Hottenga, J. J., Huffman, J. E., Jackson, A. U., Jacobs, K. B., Johansson, A., Kaakinen, M., Kleber, M. E., Lahti, J., Leach, I. M., Lehne, B., Lo, K. S., Lorentzon, M., Luan, J., Madden, P. A. F., Mangino, M., McKnight, B., Medina-Gomez, C., Monda, K. L., Montasser, M. E., Mueller, G., Mueller-Nurasyid, M., Nolte, I. M., Panoutsopoulou, K., Pascoe, L., Paternoster, L., Rayner, N. W., Renstrom, F., Rizzi, F., Rose, L. M., Ryan, K. A., Salo, P., Sanna, S., Scharnagl, H., Shi, J., Smith, A. V., Southam, L., Stancakova, A., Steinthorsdottir, V., Strawbridge, R. J., Sung, Y. J., Tachmazidou, I., Tanaka, T., Thorleifsson, G., Trompet, S., Pervjakova, N., Tyrer, J. P., Vandenput, L., van der Laan, S. W., van der Velde, N., van Setten, J., van Vliet-Ostaptchouk, J. V., Verweij, N., Vlachopoulou, E., Waite, L. L., Wang, S. R., Wang, Z., Wild, S. H., Willenborg, C., Wilson, J. F., Wong, A., Yang, J., Yengo, L., Yerges-Armstrong, L. M., Yu, L., Zhang, W., Zhao, J. H., Andersson, E. A., Bakker, S. J. L., Baldassarre, D., Banasik, K., Barcella, M., Barlassina, C., Bellis, C., Benaglio, P., Blangero, J., Blueher, M., Bonnet, F., Bonnycastle, L. L., Boyd, H. A., Bruinenberg, M., Buchman, A. S., Campbell, H., Chen, Y. I., Chines, P. S., Claudi-Boehm, S., Cole, J., Collins, F. S., de Geus, E. J. C., de Groot, L. C. P. G. M., Dimitriou, M., Duan, J., Enroth, S., Eury, E., Farmaki, A., Forouhi, N. G., Friedrich, N., Gejman, P. V., Gigante, B., Glorioso, N., Go, A. S., Gottesman, O., Graessler, J., Grallert, H., Grarup, N., Gu, Y., Broer, L., van der Ham, A. C., Hansen, T., Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N., Hattersley, A. T., Heath, A. C., Henders, A. K., Hernandez, D., Hillege, H., Holmen, O., Hovingh, K. G., Hui, J., Husemoen, L. L., Hutri-Kahonen, N., Hysi, P. G., Illig, T., de Jager, P. L., Jalilzadeh, S., Jorgensen, T., Jukema, J. W., Juonala, M., Kanoni, S., Karaleftheri, M., Khaw, K. T., Kinnunen, L., Kittner, S. J., Koenig, W., Kolcic, I., Kovacs, P., Krarup, N. T., Kratzer, W., Krueger, J., Kuh, D., Kumari, M., Kyriakou, T., Langenberg, C., Lannfelt, L., Lanzani, C., Lotay, V., Launer, L. J., Leander, K., Lindstrom, J., Linneberg, A., Liu, Y., Lobbens, S., Luben, R., Lyssenko, V., Mannisto, S., Magnusson, P. K., McArdle, W. L., Menni, C., Merger, S., Milani, L., Montgomery, G. W., Morris, A. P., Narisu, N., Nelis, M., Ong, K. K., Palotie, A., Perusse, L., Pichler, I., Pilia, M. G., Pouta, A., Rheinberger, M., Ribel-Madsen, R., Richards, M., Rice, K. M., Rice, T. K., Rivolta, C., Salomaa, V., Sanders, A. R., Sarzynski, M. A., Scholtens, S., Scott, R. A., Scott, W. R., Sebert, S., Sengupta, S., Sennblad, B., Seufferlein, T., Silveira, A., Slagboom, P. E., Smit, J. H., Sparso, T. H., Stirrups, K., Stolk, R. P., Stringham, H. M., Swertz, M. A., Swift, A. J., Syvanen, A., Tan, S., Thorand, B., Toenjes, A., Tremblay, A., Tsafantakis, E., van der Most, P. J., Voelker, U., Vohl, M., Vonk, J. M., Waldenberger, M., Walker, R. W., Wennauer, R., Widen, E., Willemsen, G., Wilsgaard, T., Wright, A. F., Zillikens, M. C., van Dijk, S. C., van Schoor, N. M., Asselbergs, F. W., Bakker, P. I. W., Beckmann, J. S., Beilby, J., Bennett, D. A., Bergman, R. N., Bergmann, S., Boeger, C. A., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Bornstein, S. R., Bottinger, E. P., Bouchard, C., Chambers, J. C., Chanock, S. J., Chasman, D. I., Cucca, F., Cusi, D., Dedoussis, G., Erdmann, J., Eriksson, J. G., Evans, D. A., de Faire, U., Farrall, M., Ferrucci, L., Ford, I., Franke, L., Franks, P. W., Froguel, P., Gansevoort, R. T., Gieger, C., Gronberg, H., Gudnason, V., Gyllensten, U., Hall, P., Hamsten, A., van der Harst, P., Hayward, C., Heliovaara, M., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hofman, A., Hu, F., Huikuri, H. V., Hveem, K., James, A. L., Jordan, J. M., Jula, A., Kaehoenen, M., Kajantie, E., Kathiresan, S., Kiemeney, L. A. L. M., Kivimaki, M., Knekt, P. B., Koistinen, H. A., Kooner, J. S., Koskinen, S., Kuusisto, J., Maerz, W., Martin, N. G., Laakso, M., Lakka, T. A., Lehtimaki, T., Lettre, G., Levinson, D. F., Lind, L., Lokki, M., Mantyselka, P., Melbye, M., Metspalu, A., Mitchell, B. D., Moll, F. L., Murray, J. C., Musk, A. W., Nieminen, M. S., Njolstad, I., Ohlsson, C., Oldehinkel, A. J., Oostra, B. A., Palmer, L. J., Pankow, J. S., Pasterkamp, G., Pedersen, N. L., Pedersen, O., Penninx, B. W. J. H., Perola, M., Peters, A., Polasek, O., Pramstaller, P. P., Psaty, B. M., Qi, L., Quertermous, T., Raitakari, O. T., Rankinen, T., Rauramaa, R., Ridker, P. M., Rioux, J. D., Rivadeneira, F., Rotter, J. I., Rudan, I., den Ruijter, H. M., Saltevo, J., Sattar, N., Schunkert, H., Schwarz, P. E. H., Shuldiner, A. R., Sinisalo, J., Snieder, H., Sorensen, T. I. A., Spector, T. D., Staessen, J. A., Stefania, B., Thorsteinsdottir, U., Stumvoll, M., Tardif, J., Tremoli, E., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Verbeek, A. L. M., Vermeulen, S. H., Viikari, J. S., Vitart, V., Voelzke, H., Vollenweider, P., Waeber, G., Walker, M., Wallaschofski, H., Wareham, N. J., Watkins, H., Zeggini, E., Chakravarti, A., Clegg, D. J., Cupples, L. A., Gordon-Larsen, P., Jaquish, C. E., Rao, D. C., Abecasis, G. R., Assimes, T. L., Barroso, I., Berndt, S. I., Boehnke, M., Deloukas, P., Fox, C. S., Groop, L. C., Hunter, D. J., Ingelsson, E., Kaplan, R. C., McCarthy, M. I., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Hirschhorn, J. N., Lindgren, C. M., Heid, I. M., North, K. E., Borecki, I. B., Kutalik, Z. & Loos, R. J. F., 2015, In : PLoS Genetics. 11, 10, e1005378.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
waist-to-hip ratio
body shape
Waist-Hip Ratio
Genome-Wide Association Study
Body Size

The Netherlands Twin Register Axiom Biobank platform for GWAS

Hottenga, J. J., 2015.

Research output: Contribution to ConferencePosterOther research output

2014

A recessive genetic model and runs of homozygosity in major depressive disorder

Power, R. A., Keller, M. C., Ripke, S., Abdellaoui, A., Wray, N. R., Sullivan, P. F., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Penninx, B. W. J. H., Willemsen, G. & Breen, G., 2014, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 165, 2, p. 157-166 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Genetic Models
Major Depressive Disorder
Genome
Schizophrenia

Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children

Blokhuis, M. M., Middeldorp, C. M., Kan, K. J., Abdellaoui, A., van Beijsterveldt, C. E. M., Ehli, E. A., Davies, G. E., Scheet, P., Xiao, X., Hudziak, J. J., Hottenga, J. J., Neale, B. M. & Boomsma, D. I., 2014, In : Journal of the American Academy of Child and Adolescent Psychiatry. 53, 10, p. 1123-1129 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Population
Impulsive Behavior

Behavior - Genetics

Abdellaoui, A., 2014, Amsterdam. 260 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

DNA: van structuur naar associatie

Hottenga, J. J., 2014, In : Quality Practice. Nascholingstijdschrift voor tandartsen. 9, 5

Research output: Contribution to JournalArticleProfessional

Effect of polygenic risk scores on depression in childhood trauma

Peyrot, W. J., Milaneschi, Y., Abdellaoui, A., Sullivan, P. F., Hottenga, J. J., Boomsma, D. I. & Penninx, B. W. J. H., 2014, In : British Journal of Psychiatry. 205, 2, p. 113-119

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Depression
Wounds and Injuries
Gene-Environment Interaction
Genomics

Further confirmation of the association between anxiety and CTNND2: replication in humans

Nivard, M. G., Mbarek, H., Hottenga, J. J., Smit, J. H., Penninx, B. W. J. H., Middeldorp, C. M. & Boomsma, D. I., 2014, In : Genes, Brain and Behavior. 13, 2, p. 195-201 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Anxiety
Agoraphobia
Catenins
Chromosome Mapping
Panic Disorder

Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders

Ligthart, R. S. L., Hottenga, J. J., Lewis, C. M., Farmer, A. E., Craig, I. W., Breen, G., Willemsen, G., Vink, J. M., Middeldorp, C. M., Byrne, E. M., Heath, A. C., Madden, P. A. F., Pergadia, M. L., Montgomery, G. W., Martin, N. G., Penninx, B. W. J. H., McGuffin, P., Boomsma, D. I. & Nyholt, DR., 2014, In : Human Genetics. 133, 2, p. 173-186 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Migraine Disorders
Depression
Genome-Wide Association Study
Berlin

Genome-wide analyses of borderline personality features

Lubke, G. H., Laurin, C., Amin, N., Hottenga, J. J., Willemsen, G., Grootheest, G., Abdellaoui, A., Karssen, L. C., Oostra, B. A., van Duijn, C. M., Penninx, B. W. J. H. & Boomsma, D. I., 2014, In : Molecular Psychiatry. 19, 8, p. 923-929 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Personality Assessment
Personality Inventory
Personality
Genome
Netherlands

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Deelen, J., Beekman, M., Uh, H. W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Gudbjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., van den Akker, E. B., Böhringer, S. & 67 othersHelmer, Q., Nelson, C. P., Saunders, G. I., Alver, M., Andersen-Ranberg, K., Breen, M. E., van der Breggen, R., Caliebe, A., Capri, M., Cevenini, E., Collerton, J. C., Dato, S., Davies, K., Ford, I., Gampe, J., Garagnani, P., de Geus, E. J. C., Harrow, J., van Heemst, D., Heijmans, B. T., Heinsen, F. A., Hottenga, J. J., Hofman, A., Jeune, B., Jonsson, P. V., Lathrop, M., Lechner, D., Martin-Ruiz, C., McNerlan, S. E., Mihailov, E., Montesanto, A., Mooijaart, S. P., Murphy, A., Nohr, E. A., Paternoster, L., Postmus, I., Rivadeneira, F., Ross, O. A., Salvioli, S., Sattar, N., Schreiber, S., Stefansson, H., Stott, D. J., Tiemeier, H., Uitterlinden, A. G., Westendorp, R. G. J., Willemsen, G., Samani, N. J., Galan, P., Sørensen, T. I. A., Boomsma, D. I., Jukema, J. W., Maeve Rea, I., Passarino, G., de Craen, A. J., Christensen, K., Nebel, A., Stefansson, K., Metspalu, A., Magnusson, P., Blanché, H., Christiansen, L., Kirkwood, T. B. L., van Duijn, C. M., Franceschi, C., Houwing-Duistermaat, J. J. & Slagboom, P. E., 2014, In : Human Molecular Genetics. 23, 16, p. 4420-4432 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Disease Susceptibility
Meta-Analysis
Chromosomes
Survival

Heritability and genomics of gene expression in peripheral blood

Wright, F. A., Sullivan, P. F., Brooks, A. I., Zou, F., Sun, W., Xia, K., Madar, V., Jansen, R., Chung, W., Zhou, Y. H., Abdellaoui, A., Batista, S., Butler, C., Chen, G., Chen, T. H., D’Ambrosio, D., Gallins, P., Ha, M. J., Hottenga, J. J., Huang, S. & 18 othersKattenberg, V. M., Kochar, J., Middeldorp, C. M., Qu, A., Shabalin, A., Tischfield, J., Todd, L., Tzeng, J. Y., Grootheest, G., Vink, J. M., Wang, Q., Wang, W., Willemsen, G., Smit, J. H., de Geus, E. J. C., Yin, Z., Penninx, B. W. J. H. & Boomsma, D. I., 2014, In : Nature Genetics. 46, 5, p. 430-437 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Quantitative Trait Loci
Genomics
Gene Expression
Genetic Transcription
Genes

Identifying Genetic Variants for Heart Rate Variability in the Acetylcholine Pathway

Riese, H., Munoz, L. M., Hartman, C. A., Ding, X., Su, S., Oldehinkel, A. J., van Room, A. M., van der Most, P. J., Lefrandt, J., Gansevoort, R. T., van der Harst, P., Verweij, N., Licht, C. M. M., Boomsma, D. I., Hottenga, J. J., Willemsen, G., Penninx, B. W. J. H., Nolte, I. M., de Geus, E. J. C., Wang, X. & 1 othersSnieder, H., 2014, In : PLoS ONE. 9, 11, 9 p., e112476.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
acetylcholine
Acetylcholine
heart rate
Heart Rate
Genes

Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'

Deelen, P., Menelaou, A., van Leeuwen, E. M., Kanterakis, A., Dijk, F., Medina-Gomez, C., Francioli, L. C., Hottenga, J. J., Karssen, L. C., Estrada, K., Kreiner-Møller, E., Rivadeneira, F., van Setten, J., Gutierrez-Achury, J., Westra, H. J., Franke, L., van Enckevort, D., Dijkstra, M., Byelas, H., van Duijn, C. M. & 3 othersBakker, P. I. W., Wijmenga, C. & Swertz, M., 2014, In : European Journal of Human Genetics. 22, 11, p. 1321-1326 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Netherlands
Genome
Population
Genotype
Genome-Wide Association Study

Multi-ethnic fine-mapping of 14 central adiposity loci

Liu, C. T., Buchkovich, M. L., Winkler, T. W., Heid, I. M., Hottenga, J. J., Boomsma, D. I., de Geus, E. J. C., Willemsen, G., Borecki, I. B., Fox, C. S., Mohlke, K. L., North, K. E. & Cupples, L. A., 2014, In : Human Molecular Genetics. 23, 17, p. 4738-4744 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Adiposity
Meta-Analysis
Waist-Hip Ratio
Anthropometry
Bayes Theorem

No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80607 Subjects

Baumert, J., Huang, J., McKnight, B., Sabater-Lleal, M., Steri, M., Chu, A. Y., Trompet, S., Lopez, L. M., Fornage, M., Teumer, A., Tang, W., Rudnicka, A. R., Mälarstig, A., Hottenga, J. J., Kavousi, M., Lahti, J., Tanaka, T., Hayward, C., Huffman, J. E., Morange, P. E. & 83 othersRose, L. M., Basu, S., Rumley, A., Stott, D. J., Buckley, B. M., de Craen, A. J., Sanna, S., Masala, M., Biffar, R., Homuth, G., Silveira, A., Sennblad, B., Goel, A., Watkins, H., Müller-Nurasyid, M., Rückerl, R., Taylor, K., Chen, M. H., de Geus, E. J. C., Hofman, A., Witteman, J. C. M., de Maat, M. P. M., Palotie, A., Davies, G. E., Siscovick, D. S., Kolcic, I., Wild, S. H., Song, J., McArdle, W. L., Ford, I., Sattar, N., Schlessinger, D., Grotevendt, A., Franzosi, M. G., Illig, T., Waldenberger, M., Lumley, T., Tofler, G. H., Willemsen, G., Uitterlinden, A. G., Rivadeneira, F., Räikkönen, K., Chasman, D. I., Folsom, A. R., Lowe, G. D., Westendorp, R. G. J., Slagboom, P. E., Cucca, F., Wallaschofski, H., Strawbridge, R. J., Seedorf, U., Koenig, W., Bis, J. C., Mukamal, K. J., van Dongen, J., Widen, E., Franco, O. H., Starr, J. M., Liu, K., Ferrucci, L., Polasek, O., Wilson, J. F., Oudot-Mellakh, T., Campbell, H., Navarro, P., Bandinelli, S., Eriksson, J., Boomsma, D. I., Dehghan, A., Clarke, R., Hamsten, A., Boerwinkle, E., Jukema, J. W., Naitza, S., Ridker, P. M., Völzke, H., Deary, I. J., Reiner, A. P., Trégouët, D. A., O'Donnell, C. J., Strachan, D. P., Peters, A. & Smith, N. L., 2014, In : PLoS ONE. 9, 12, 18 p., e111156.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
fibrinogen
Beam plasma interactions
Alcohol Drinking
Fibrinogen
body mass index

Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index

Hoggart, C. J., Venturini, G., Mangino, M., Gomez, F., Ascari, G., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Uitterlinden, A. G., van Duijn, C. M., Visscher, P. M., Rousson, V., Hirschhorn, J. N., Rivolta, C., Loos, R. J. F. & Kutali, Z., 2014, In : PLoS Genetics. 10, 7, 12 p., e1004508.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Perry, J. R. B., Day, F. R., Elks, C. E., Sulem, P., Thompson, D. J., Ferreira, T., He, C., Chasman, D. I., Esko, T., Thorleifsson, G., Albrecht, E., Ang, W. Q., Corre, T., Cousminer, D. L., Feenstra, B., Franceschini, N., Ganna, A., Johnson, A. D., Kjellqvist, S., Lunetta, K. L. & 178 othersMcMahon, G., Nolte, I. M., Paternoster, L., Porcu, E., Smith, A. V., Stolk, L., Teumer, A., Tsernikova, N., Tikkanen, E., Ulivi, S., Wagner, E. K., Amin, N., Bierut, L. J., Byrne, E. M., Hottenga, J. J., Koller, D. L., Mangino, M., Pers, T. H., Yerges-Armstrong, L. M., Zhao, J. H., Andrulis, I. L., Anton-Culver, H., Atsma, F., Bandinelli, S., Beckmann, M. W., Benitez, J., Blomqvist, C., Bojesen, S. E., Bolla, M. K., Bonanni, B., Brauch, H., Brenner, H., Buring, J. E., Chang-Claude, J., Chanock, S., Chen, J., Chenevix-Trench, G., Collee, J. M., Couch, F. J., Couper, D., Coviello, A. D., Cox, A., Czene, K., Pio d'Adamo, A., Smith, G. D., De Vivo, I., Demerath, E. W., Dennis, J., Devilee, P., Dieffenbach, A. K., Dunning, A. M., Eiriksdottir, G., Eriksson, J. G., Fasching, P. A., Ferrucci, L., Flesch-Janys, D., Flyger, H., Foroud, T., Franke, L., Garcia, M. E., Garcia-Closas, M., Geller, F., de Geus, E. J. C., Giles, G. G., Gudbjartsson, D. F., Gudnason, V., Guenel, P., Guo, S., Hall, P., Hamann, U., Haring, R., Hartman, C. A., Heath, A. C., Hofman, A., Hooning, M. J., Hopper, J. L., Hu, F. B., Hunter, D. J., Karasik, D., Kiel, D. P., Knight, J. A., Kosma, V. M., Kutalik, Z., Lai, S., Lambrechts, D., Lindblom, A., Mägi, R., Magnusson, P. K., Mannermaa, A., Martin, N. G., Masson, G., McArdle, P. F., McArdle, W. L., Melbye, M., Michailidou, K., Mihailov, E., Milani, L., Milne, R. L., Nevanlinna, H., Neven, P., Nohr, E. A., Oldehinkel, A. J., Oostra, B. A., Palotie, A., Peacock, M., Pedersen, N. L., Peterlongo, P., Peto, J., Pharoah, P. D. P., Postma, D. S., Pouta, A., Pylkäs, K., Radice, P., Ring, S., Rivadeneira, F., Robino, A., Rose, L. M., Rudolph, A., Salomaa, V., Sanna, S., Schlessinger, D., Schmidt, M. K., Southey, M. C., Sovio, U., Stampfer, M. J., Stöckl, D., Storniolo, A. M., Timpson, N. J., Tyrer, J., Visser, J. A., Vollenweider, P., Völzke, H., Waeber, G., Waldenberger, M., Wallaschofski, H., Wang, Q., Willemsen, G., Winqvist, R., Wolffenbuttel, B. H. R., Wright, M. J., Boomsma, D. I., Econs, M. J., Khaw, K. T., Loos, R. J. F., McCarthy, M. I., Montgomery, G. W., Rice, J. P., Streeten, E. A., Thorsteinsdottir, U., van Duijn, C. M., Alizadeh, BZ., Bergmann, S., Boerwinkle, E., Boyd, H. A., Crisponi, L., Gasparini, P., Gieger, C., Harris, T. B., Ingelsson, E., Järvelin, M. R., Kraft, P., Lawlor, D., Metspalu, A., Pennell, C. E., Ridker, P. M., Snieder, H., Sorensen, T. I. A., Spector, T. D., Strachan, D. P., Uitterlinden, A. G., Wareham, N. J., Widen, E., Zygmunt, M., Murray, A., Easton, D. F., Stefansson, K., Murabito, J. M. & Ong, K. K., 2014, In : Nature. 514, 7520, p. 92-97 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Menarche
Puberty
Aminobutyrates
Cytoplasmic and Nuclear Receptors
Rare Diseases

Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children

de Zeeuw, L. E. J., van Beijsterveldt, C. E. M., Glasner, T. J., Bartels, M., Ehli, E. A., Davies, G. E., Hudziak, J. J., Rietveld, C. A., Blokhuis, M. M., Hottenga, J. J., de Geus, E. J. C. & Boomsma, D. I., 2014, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 165, 6, p. 510-520 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Educational Status
Attention Deficit Disorder with Hyperactivity
Aptitude
Netherlands
Meta-Analysis

Quality control and conduct of genome-wide association meta-analyses

Winkler, T. W., Day, F. R., Croteau-Chonka, D. C., Wood, A. R., Locke, A. E., Mägi, R., Ferreira, T., Fall, T., Graff, M., Justice, A. E., Luan, J., Gustafsson, S., Randall, J. C., Vedantam, S., Workalemahu, T., Kilpeläinen, T. O., Scherag, A., Esko, T., Kutalik, Z., Heid, I. M. & 7 othersLoos, R. J. F., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Penninx, B. W. J. H. & Smit, J. H., 2014, In : Nature Protocols. 9, 5, p. 1192-1212 21 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Quality Control
Quality control
Meta-Analysis
Genes

Sex differences in the human peripheral blood transcriptome

Jansen, R., Batista, S., Brooks, A. I., Tischfield, J. A., Willemsen, G., Grootheest, G., Hottenga, J. J., Milaneschi, Y., Mbarek, H., Madar, V., Peyrot, W., Vink, J. M., Verweij, C. L., de Geus, E. J. C., Smit, J. H., Wright, F. A., Sullivan, P. F., Boomsma, D. I. & Penninx, B. W. J. H., 2014, In : BMC Genomics. 15, p. 33 12 p., 33.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Transcriptome
Sex Characteristics
Genes
Contraceptive Agents
Gene Expression

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility

Guigas, B., de Leeuw van Weenen, J., van Leeuwen, N., Bik-Simonis, A. M. C., van Haeften, T. W., Nijpels, G., Houwing-Duistermaat, J. J., Beekman, M., Deelen, J., Havekes, L. M., Penninx, B. W. J. H., Vogelzangs, N., van 't Riet, E., Dehghan, A., Hofman, A., Witteman, J. C., Uitterlinden, A. G., Grarup, N., Jørgensen, T., Witte, D. R. & 15 othersLauritzen, T., Hansen, T., Pedersen, O., Hottenga, J. J., Romijn, J. A., Diamant, M., Kramer, M. H. H., Heine, R. J., Willemsen, G., Dekker, J. M., Eekhoff, E. M. W., Pijl, H., de Geus, E. J. C., Slagboom, P. E. & 't Hart, L. M., 2014, In : Diabetic Medicine. 31, 8, p. 1001-1008 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Dopamine D2 Receptors
Dopamine Receptors
Type 2 Diabetes Mellitus
Insulin
Single Nucleotide Polymorphism

The Contribution of the Functional IL6R Polymorphism rs2228145, eQTLs and Other Genome-Wide SNPs to the Heritability of Plasma sIL-6R Levels

van Dongen, J., Jansen, R., Smit, D. J. A., Hottenga, J. J., Mbarek, H., Willemsen, G., Kluft, C., Penninx, B. W. J. H., Ferreira, M. A., Boomsma, D. I. & de Geus, E. J. C., 2014, In : Behavior Genetics. 44, 4, p. 368-382 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

heritability
Single Nucleotide Polymorphism
polymorphism
genome
genetic polymorphism

The Dopaminergic Reward System and Leisure Time Exercise Behavior: A Candidate Allele Study

Huppertz, C., Bartels, M., Blokhuis, M. M., Dolan, C. V., de Moor, M. H. M., Abdellaoui, A., van Beijsterveldt, C. E. M., Ehli, E. A., Hottenga, J. J., Willemsen, G., Xiao, X., Scheet, P., Davies, G. E., Boomsma, D. I., Hudziak, J. J. & de Geus, E. J. C., 2014, In : Biomed research international. 2014, 9 p., 591717.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Minisatellite Repeats
Leisure Activities
Polymorphism
Reward
Nucleotides

The effect of FTO rs9939609 on major depression differs across MDD subtypes

Milaneschi, Y., Lamers, F., Mbarek, H., Hottenga, J. J., Boomsma, D. I. & Penninx, B. W. J. H., 2014, In : Molecular Psychiatry. 19, 9, p. 960-962 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review