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Research Output 2004 2019

2011

ADHD in Dutch adults: heritability and linkage study

Savyuk, V., Hottenga, J. J., Slagboom, P. E., Distel, M. A., de Geus, E. J. C., Willemsen, G. & Boomsma, D. I., 2011, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 156, 3, p. 352-362

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Phenotype
Netherlands
Self Report
Siblings

A genome-wide association study for subjective wellbeing

Bartels, M., de Geus, E. J. C., Groen-Blokhuis, M. M., de Moor, M. H. M., van Beijsterveldt, C. E. M., Hottenga, J. J., Ehli, E. A., Davies, G., Xiang, X., Scheet, P., Hudziak, J. J. & Boomsma, D. I., 2011, In : Behavior Genetics. 41, 6, p. 892

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access
File

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

Surakka, I., Isaacs, A., Karssen, L. C., Laurila, P. P. P., Middelberg, R. P. S., Tikkanen, E., Ried, J. S., Lamina, C., Mangino, M., Igl, W., Hottenga, J. J., Lagou, V., van der Harst, P., Mateo Leach, I., Esko, T., Kutalik, Z., Wainwright, N. W., Struchalin, M. V., Sarin, A. P., Kangas, A. J. & 57 othersViikari, J. S., Perola, M., Rantanen, T., Petersen, A. K., Soininen, P., Johansson, Å., Soranzo, N., Heath, A. C., Papamarkou, T., Prokopenko, I., Tönjes, A., Kronenberg, F., Döring, A., Rivadeneira, F., Montgomery, GW., Whitfield, J. B., Kähönen, M., Lehtimäki, T., Freimer, N. B., Willemsen, G., de Geus, E. J. C., Palotie, A., Sandhu, M. S., Waterworth, D., Metspalu, A., Stumvoll, M., Uitterlinden, A. G., Navis, G., Wijmenga, C., Wolffenbuttel, B. H. R., Taskinen, M. R., Ala-Korpela, M., Kaprio, J., Kyvik, K. O., Boomsma, D. I., Pedersen, N. L., Gyllensten, U., Wilson, J. F., Rudan, I., Campbell, H., Pramstaller, P. P., Spector, T. D., Witteman, J. C. M., Eriksson, J. G., Salomaa, V., Oostra, B. A., Raitakari, O. T., Wichmann, H. E., Gieger, C., Järvelin, M. J., Martin, N. G., Hofman, A., McCarthy, M. I., Peltonen, L., van Duijn, C. M., Aulchenko, Y. S. & Ripatti, S., 2011, In : PLoS Genetics. 7, 10, e1002333.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
waist-to-hip ratio
Waist-Hip Ratio
genome
lipid
Cholesterol

CNVs & attention problems in MZ twin pairs

Abdellaoui, A., Elhi, E., Hottenga, J. J., Hudziak, J. J., Davies, G. & Boomsma, D. I., 2011.

Research output: Contribution to ConferencePosterOther research output

Genetic architecture of circulating lipid levels

Demirkan, A., Amin, A., Isaacs, A., Jarvelin, M-R., Whitfield, J. B., Wichmann, H-E., Ohm Kyvik, K., Rudan, I., Gieger, C., Hicks, A. A., Johansson, A., Hottenga, J. J., Smith, J. J., Wild, S. H., Pedersen, N. L., Willemsen, G., Mangino, M., Hayward, C., Uitterlinden, A. G., Hofman, A. & 26 othersWitteman, J., Montgomery, GW., Pietilainen, K. H., Rantanen, T., Kaprio, J., Döring, A., Pramstaller, P. P., Gyllensten, U., de Geus, E. J. C., Penninx, B. W. J. H., Wilson, J. F., Rivadeneira, F., Magnusson, P. K. E., Boomsma, D. I., Spector, T. D., Campbell, H., Hoehne, B., Martin, N. G., Oostra, B. A., McCarthy, M., Peltonen, L., Aulchenko, Y. S., Visscher, P. M., Ripatti, S., Janssens, A. C. J. W. & van Duijn, C. M., 2011, In : European Journal of Human Genetics. 19, 7, p. 813-819

Research output: Contribution to JournalArticleAcademicpeer-review

Lipids
Genome-Wide Association Study
Genome
LDL Cholesterol
HDL Cholesterol

Genetic risk profiles for depression and anxiety in adult and elderly cohorts

Demirkan, A., Penninx, B. W. J. H., Hek, K., Wray, N. R., Amin, N., Aulchenko, Y. S., van Dyck, R., de Geus, E. J. C., Hofman, A., Uitterlinden, A. G., Hottenga, J. J., Nolen, W. A., Oostra, B. A., Sullivan, P. F., Willemsen, G., Zitman, F. G., Tiemeier, H., Janssens, A. C. J. W., Boomsma, D. I., van Duijn, C. M. & 1 othersMiddeldorp, C. M., 2011, In : Molecular Psychiatry. 16, 7, p. 773-783

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Anxiety
Depression
Genome-Wide Association Study
Psychiatry
Inborn Genetic Diseases

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

Speliotes, E. K., Yerges-Armstrong, L. M., Wu, J., Hernaez, R., Kim, L. J., Palmer, C. D., Gudnason, V., Eiriksdottir, G., Garcia, M. E., Launer, L. J., Nalls, M. A., Clark, J. M., Mitchell, B. D., Shuldiner, A. R., Butler, J. L., Tomas, M., Hoffmann, U., Hwang, S. J., Massaro, J. M., O'Donnell, C. J. & 19 othersSahani, D. V., Salomaa, V., Schadt, E. E., Schwartz, S. M., Siscovick, D. S., Posthuma, D., Voight, B. F., Carr, J. J., Feitosa, M. F., Harris, T. B., Fox, C. S., Smith, A. V., Kao, W. H. L., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Hirschhorn, J. N. & Borecki, I. B., 2011, In : PLoS Genetics. 7, 3, e1001324.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Schumann, G., Coin, L. J. M., Lourdusamy, A., Charoen, P., Berger, K. H., Stacey, D., Desrivières, S., Aliev, F. A., Khan, A. A., Amin, N., Aulchenko, Y. S., Bakalkin, G., Bakker, S. J., Balkau, B., Beulens, J. W., Bilbao, A., de Boer, R. A., Beury, D., Bots, M. L., Breetvelt, E. J. & 80 othersCauchi, S., Cavalcanti-Proença, C., Chambers, J. C., Clarke, T. K., Dahmen, N., de Geus, E. J. C., Dick, D., Duccia, F., Easton, A., Edenberg, H. J., Esk, T., Fernández-Medarde, A., Foroud, T., Freimer, N. B., Girault, J. A., Grobbee, D. E., Guarreray, S., Gudbjartsson, D. F., Hartikainen, A-L., Heath, A. C., Hesselbrock, V., Hofman, A., Hottenga, J. J., Isohanni, M., Kaprio, J., Khaw, K. T., Kuehnel, B., Laitinen, J., Lobbens, S., Luan, J., Mangino, M., Maroteau, M., Oostra, B. A., O’Reilly, P. F., Penninx, B. W. J. H., Pouta, A., Prokopenko, I., Ricceri, F., Santos, E., Smit, J. H., Soranzo, N., Stumvoll, M., Surakka, I., Thorgeirsson, T. E., Thorsteinsdottir, U., Troakes, C., Tyrfingsson, T., Tönjes, A., Uiterwaal, C. S., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Staehlin, O., Vogelzangs, N., Vollenweider, P., Waeber, G., Wareham, N. J., Waterworth, D., Whitfield, J. B., Wichmann, H. E., Willemsen, G., Witteman, J. C., Martin, N. G., Metspalu, A., Scott, J., Spector, T. D., Loos, R. J., Boomsma, D. I., Mooser, V., Peltonen, L., Stefansson, K., van Duijn, C. M., Vineis, P., Sommer, W. H., Kooner, J. S., Spanagel, R., Heberlein, U. A., Numans, M. E., Jarvelin, M-R. & Elliott, P., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 7119-7124

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Association Studies
Autistic Disorder
Alcohol Drinking
Genome
Single Nucleotide Polymorphism

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Strawbridge, R. J., Dupuis, J., Prokopenko, I., Barker, A., Ahlqvist, E., Rybin, D., Petrie, J. R., Bouatia-Naji, N., Dimas, A. S., Nica, A., Wheeler, E., Chen, H., Voight, B. F., Taneera, J., Kanoni, S., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Forsen, T. J. & 25 othersClarke, R., Franzosi, M. G., Seedorf, U., Watkins, H., Froguel, P., Johnson, P., Deloukas, P., Collins, F. S., Laakso, M., Dermitzakis, E. T., Boehnke, M., McCarthy, M. I., Wareham, N. J., Groop, L., Pattou, F., Gloyn, A. L., Dedoussis, G. V., Lyssenko, V., Meigs, J. B., Barroso, I., Watanabe, R. M., Ingelsson, E., Langenberg, C., Hamsten, A. & Florez, J. C., 2011, In : Diabetes. 60, 10, p. 2624-2634

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Proinsulin
Type 2 Diabetes Mellitus
Fasting
Genome
Insulin

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Chambers, J. C., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., Holm, H., Sanna, S., Kavousi, M., Baumeister, S. E., Hottenga, J. J., Speliotes, E. K., de Geus, E. J. C., Martin, N. G., Montgomery, G. W., Penninx, B. W. J. H., Prokopenko, I., Spector, T. D., Uitterlinden, A. G., Willemsen, G. & 16 othersAbecasis, G. R., Boomsma, D. I., van Duijn, C. M., Snieder, H., Whitfield, J. B., Witteman, J. C. M., Fox, C. S., Ala-Korpela, M., Stefansson, K., Vollenweider, P., Völzke, H., Schadt, E. E., Scott, J., Jarvelin, M. R., Elliot, P. & Kooner, J. S., 2011, In : Nature Genetics. 43, 11, p. 1131-1140

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Liver
Enzymes
Liver Diseases

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Wain, L. V., Verwoert, G. C., O'Reilly, P. F., Shi, G., Johnson, T., Johnson, A. D., Bochud, M., Rice, K. M., Henneman, P., Smith, A. V., Ehret, G. B., Amin, N., Larson, M. G., Mooser, V., Hadley, D., Dörr, M., Bis, J. C., Aspelund, T., Esko, T., Janssens, A. C. & 42 othersZhao, J. H., Heath, S., Laan, M., Fu, J., Pistis, G., Luan, J., Arora, P., Hottenga, J. J., Rivadeneira, F., Sijbrands, E. J., Uitterlinden, A. G., Soranzo, N., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Spector, T. D., Snieder, H., Oostra, B. A., Metspalu, A., Launer, L., Rettig, R., Strachan, D. P., Beckmann, J. S., Witteman, J. C., Erdmann, J., van Dijk, K. W., Boerwinkle, E., Boehnke, M., Ridker, P. M., Jarvelin, M. R., Chakravarti, A., Abecasis, G. R., Gudnason, V., Newton-Cheh, C., Levy, D., Munroe, P. B., Psaty, B. M., Caulfield, M. J., Rao, D. C., Tobin, M. D., Elliott, P. & van Duijn, C. M., 2011, In : Nature Genetics. 43, 10, p. 1005-1012

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Arterial Pressure
Blood Pressure

Genome-wide complex trait analysis (gcta) for complex traits including major depressive disorder and smoking

Boomsma, D. I., Hottenga, J. J., Walters, R., Laurin, C., de Geus, E. J. C., Willemsen, G., Smit, J. H., Middeldorp, C. M., Penninx, B. W. J. H., Vink, J. M. & Lubke, G. H., 2011.

Research output: Contribution to ConferencePosterOther research output

Influence of Candidate Genes on Attention Problems in Children: A Longitudinal Study

van Beijsterveldt, C. E. M., Middeldorp, C. M., Slof-Op 't Landt, M. C. T., Bartels, M., Hottenga, J. J., Suchiman, H. E. D., Slagboom, P. E. & Boomsma, D. I., 2011, In : Behavior Genetics. 41, 1, p. 155-164

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
longitudinal studies
Longitudinal Studies
single nucleotide polymorphism
polymorphism
gene

LPAR1 and ITGA4 Regulate Peripheral Blood Monocyte Counts

Maugeri, N., Powell, J. E., 't Hoen, P. A. C., de Geus, E. J. C., Willemsen, G., Kattenberg, V. M., Henders, A. K., Wallace, L., Penninx, B. W. J. H., Hottenga, J. J., Medland, S. E., Savyuk, V., Martin, N. G., Visscher, P. M., van Ommen, G. J. B., Frazer, I. H., Boomsma, D. I., Montgomery, GW. & Ferreira, M. A. R., 2011, In : Human Mutation. 32, 8, p. 873-876

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder

Liu, Y., Blackwood, D. H., Caesar, S., de Geus, E. J. C., Farmer, A., Ferreira, M. A. R., Ferrier, I. N., Fraser, C., Gordon-Smith, K., Green, E. K., Grozeva, D., Gurling, H. M., Hamshere, M. L., Heutink, P., Holmans, P. A., Hoogendijk, W. J. G., Hottenga, J. J., Jones, L., Jones, I. R., Kirov, G. & 24 othersLin, D., McGuffin, P., Moskvina, V., Nolen, W. A., Perlis, R. H., Posthuma, D., Scolnick, E. M., Smit, A. B., Smit, J. H., Smoller, J. W., St Clair, D., van Dyck, R., Verhage, M., Willemsen, G., Young, A. H., Zandbelt, T., Boomsma, D. I., Craddock, N., O’Donovan, M. C., Owen, M. J., Penninx, B. W. J. H., Purcell, S., Sklar, P. & Sullivan, P. F., 2011, In : Molecular Psychiatry. 16, 1, p. 2-4

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of genome-wide association for migraine in six population-based European cohorts

Ligthart, R. S. L., de Vries, B., Smith, A. V., Arfan Ikram, M., Amin, N., Hottenga, J. J., Koelewijn, S. C., Kattenberg, V. M., de Moor, M. H. M., Janssens, A. J. W., Aulchenko, Y. S., Oostra, B. A., de Geus, E. J. C., Smit, J. H., Zitman, F. G., Uitterlinden, A. G., Hofman, A., Willemsen, G., Nyholt, DR., Montgomery, G. W. & 9 othersTerwindt, G. M., Gudnason, V., Penninx, B. W. J. H., Breteler, M., Ferrari, M. D., Launer, L. J., van Duijn, C. M., van den Maagdenberg, A. M. J. M. & Boomsma, D. I., 2011, In : European Journal of Human Genetics. 19, 8, p. 901-907

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Migraine Disorders
Meta-Analysis
Single Nucleotide Polymorphism
Genome
Population

Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with Excitement-Seeking

Terracciano, A., Esko, T., Sutin, A. R., de Moor, M. H. M., Meirelles, O., Zhu, G., Tanaka, T., Giegling, I., Nutile, T., Realo, A., Allik, J., Hansell, N. K., Wright, M. J., Montgomery, G. W., Willemsen, G., Hottenga, J. J., Friedl, M., Ruggiero, D., Sorice, R., Sanna, S. & 17 othersDeiana, B., Cucca, F., Krueger, R. F., Lahti, A., Luciano, M., Smoller, J. W., van Duijn, C. M., Abecasis, G. R., Boomsma, D. I., Ciullo, M., Costa, P. T., Ferrucci, L., Martin, N. G., Metspalu, A., Rujescu, D., Schlessinger, D. & Uda, M., 2011, In : Translational Psychiatry. 1, e49

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Unsafe Sex
Genome-Wide Association Study
Meta-Analysis
Personality Inventory
Impulsive Behavior

Meta-analysis of genome wide association studies on heart rate variability

Nolte, I., Tragante do Ó, V., Whitsel, E., Kerr, K., Penninx, B. W. J. H., Oldehinkel, A., Bis, J., Hottenga, J. J., Dierckx, B., Lefrandt, J., Magnani, J., Gieger, C., Riese, H., Heckbert, S., Snieder, H. & de Geus, E. J. C., 2011, In : Behavior Genetics. 41, 6, p. 927

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access
File

New gene functions in megakaryopoiesis and platelet formation

Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G., Serbanovic-Canic, J., Elling, U., Goodall, A. H., Labrune, Y., Hottenga, J. J., de Geus, E. J. C., Montgomery, GW., Visscher, P. M., Willemsen, G., Boomsma, D. I., Martin, N. G., Spector, T. D., Prokopenko, I., Stemple, D. & 8 othersToniolo, L., Wernisch, L., Sanna, S., Hicks, A. A., Rendon, A., Ferreira, M. A., Ouwehand, W. H. & Soranzo, N., 2011, In : Nature. 480, 7376, p. 201-208

Research output: Contribution to JournalArticleAcademicpeer-review

Blood Platelets
Genome-Wide Association Study
Blood Cells
Genes
Megakaryocytes

Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals

Kilpelaïnen, T. O., van den Hoed, M., Ong, K. K., Grøntved, A., Brage, S., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Jameson, K., Cooper, C., Khaw, K. T., Ekelund, U., Wareham, N. J. & Loos, R. J., 2011, In : American Journal of Clinical Nutrition. 93, 4, p. 851-860

Research output: Contribution to JournalArticleAcademicpeer-review

Qualitative and quantitative sex differences in genetic architecture for human phenotypes

Boomsma, D. I., Bartels, M., van Beijsterveldt, C. E. M., Distel, M. A., Smit, D. J. A., de Moor, M. H. M., Middeldorp, M., Ligthart, R. S. L., Willemsen, G., Hottenga, J. J., de Geus, E. J. C. & Vink, J. M., 2011, In : Behavior Genetics. 41, 6, p. 894-895

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access
File

The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

Middeldorp, C. M., de Moor, M. H. M., McGrath, L. M., Gordon, S. D., Blackwood, D. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Nyholt, DR., Tanaka, T., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J. J., Distel, M. A., Uda, M., Sanna, S. & 41 othersSpinhoven, P., Hartman, C. A., Ripke, S., Sullivan, P. F., Realo, A., Allik, J., Heath, A. C., Pergadia, M. L., Agrawal, A., Lin, P., Grucza, R. A., Widen, E., Cousminer, D. L., Eriksson, J. G., Palotie, A., Barnett, J. H., Lee, P. H., Luciano, M., Tenesa, A., Davies, G., Lopez, L. M., Hansell, N. K., Medland, S. E., Ferrucci, L., Schlessinger, D., Montgomery, GW., Wright, M. J., Aulchenko, Y. S., Janssens, A. C. J. W., Oostra, B. A., Metspalu, A., Abecasis, G. R., Deary, I. J., Räikkönen, K., Bierut, L. J., Martin, N. G., Wray, N. R., van Duijn, C. M., Smoller, J. W., Penninx, B. W. J. H. & Boomsma, D. I., 2011, In : Translational Psychiatry. 1, e50.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Bipolar Disorder
Major Depressive Disorder
Personality
Depression

The Lin28/let-7 axis regulates glucose metabolism

Zhu, H., Shyh-Chang, N., Segre, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J. P., Kharas, M. G., Urbach, A., Thornton, J. E., Triboulet, R., Gregory, R. I., Hottenga, J. J., de Geus, E. J. C., Posthuma, D., Willemsen, G., Boomsma, D. I., Altshuler, D. & 1 othersDaley, G. Q., 2011, In : Cell. 147, 1, p. 81-94

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2010

A genome-wide association study for self-rated health

Bartels, M., Vink, J. M., de Moor, M. H. M., Hottenga, J. J., de Geus, E. J. C., Smit, J. H., Willemsen, G., Penninx, B. W. J. H. & Boomsma, D. I., 2010, In : Behavior Genetics. 40, 6, p. 785

Research output: Contribution to JournalMeeting AbstractOther research output

A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations

Lind, P. A., Macgregor, S., Vink, J. M., Pergadia, M. L., Hansell, N., de Moor, M. H. M., Smit, A. B., Hottenga, J. J., Richter, M., Heath, A. C., Martin, N. G., Willemsen, G., de Geus, E. J. C., Vogelzangs, N., Penninx, B. W. J. H., Whitfield, J. B., Montgomery, GW., Boomsma, D. I. & Madden, P. A. F., 2010, In : Twin Research and Human Genetics. 13, 1, p. 10-29

Research output: Contribution to JournalArticleAcademicpeer-review

Tobacco Use Disorder
Alcoholism
Single Nucleotide Polymorphism
Tobacco Use
Gene Frequency

Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?

Middeldorp, C. M., Slof-Op 't Landt, M. C. T., Medland, S. E., van Beijsterveldt, C. E. M., Bartels, M., Willemsen, G., Hottenga, J. J., de Geus, E. J. C., Suchiman, H. E. D., Dolan, C. V., Neale, M. C., Slagboom, P. E. & Boomsma, D. I., 2010, In : Genes, Brain and Behavior. 9, 6, p. 808-816

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Anxiety
Depression
Single Nucleotide Polymorphism
Neurogenesis
Genes

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifson, G., Jackson, A. U., Lango Allen, H., Lindgren, C. M., Luan, J., Mägi, R., Hottenga, J. J., de Geus, E. J. C., Martin, N. G., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Uitterlinden, A. G., Zillikens, M. C., Visscher, P. M., Peltonen, L. & 11 othersvan Duijn, C. M., Thorsteinsdottir, U., Abecasis, G. R., Barroso, I., Boehnke, M., Stefansson, K., North, K. E., McCarthy, M. I., Hirschhorn, J. N., Ingelsson, E. & Loos, R. J. F., 2010, In : Nature Genetics. 42, 11, p. 937-948

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Body Mass Index
Obesity
Single Nucleotide Polymorphism
Genetic Loci
methanohexohydroisoindoline ethylguanidine hemisulfate

Associations between ADH glene variants and alcohol phenotypes in Dutch adults

van Beek, J. H. D. A., Willemsen, G., de Moor, M. H. M., Hottenga, J. J. & Boomsma, D. I., 2010, In : Twin Research and Human Genetics. 13, 1, p. 30-42

Research output: Contribution to JournalArticleAcademicpeer-review

File
Single Nucleotide Polymorphism
Alcohols
Phenotype
Alcohol Drinking
Multigene Family

Biological, clinical and population relevance of 95 loci for blood lipids

Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Willemsen, G., Uitterlinden, A. G., Penninx, B. W. J. H., Montgomery, GW., Martin, N. G., Hottenga, J. J., de Geus, E. J. C., Boomsma, D. I., van Duijn, C. M., Peltonen, L., Abecasis, G. R., Boehnke, M. & Kathiresan, S., 2010, In : Nature. 466, 7307, p. 707-713

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lipids
Population
Coronary Artery Disease
Lipoproteins
Genome

Genetic epidemiology of Attention Deficit Hyperactivity Disorder (ADHD Index) in adults

Boomsma, D. I., Savyuk, V., Hottenga, J. J., Distel, M. A., de Moor, M. H. M., Vink, J. M., Geels, L. M., van Beek, J. H. D. A., Bartels, M., de Geus, E. J. C. & Willemsen, G., 2010, In : PLoS ONE. 5, 5, p. e10621 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Molecular Epidemiology
Attention Deficit Disorder with Hyperactivity
epidemiology
heritability
Parents

Genome-wide association analysis identifies multiple loci related to resting heart rate

Eijgelsheim, M., Newton-Cheh, C., Sotoodehnia, N., Bakker, P. I. W., Müller, M., Morrison, A. C., Smith, A. V., Isaacs, A., Sanna, S., Dörr, M., Navarro, P., Fuchsberger, C., Nolte, I. M., de Geus, E. J. C., Estrada, K., Hwang, S. J., Bis, J. C., Rückert, I. M., Alonso, A., Launer, L. J. & 54 othersHottenga, J. J., Rivadeneira, F., Noseworthy, P. A., Rice, T. A., Perz, S., Arking, D. E., Spector, T. D., Kors, J. A., Aulchenko, Y. S., Tarasov, K. V., Homuth, G., Wild, S. H., Marroni, F., Gieger, C., Licht, C. M. M., Prineas, R. J., Hofman, A., Rotter, J. I., Hicks, A. A., Ernst, F., Najjar, S. S., Wright, A. F., Peters, A., Fox, E. R., Oostra, B. A., Kroemer, H. K., Couper, D., Völzke, H., Campbell, H., Meitinger, T., Uda, M., Witteman, J. C. M., Psaty, B. M., Wichmann, H-E., Harris, T. B., Kääb, S., Siscovick, D. S., Jamshidi, Y., Uitterlinden, A. G., Folsom, A. R., Larson, M. G., Wilson, J. F., Penninx, B. W. J. H., Snieder, H., Pramstaller, P. P., van Duijn, C. M., Lakatta, E. G., Felix, S. B., Gudnason, V., Pfeufer, A., Heckbert, S. R., Stricker, B. H. C., Boerwinkle, E. & O'Donnell, C. J., 2010, In : Human Molecular Genetics. 19, 19, p. 3885-3894

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Heart Rate
Meta-Analysis
Cardiovascular Diseases
Mortality

Genome-wide linkage and association study of ADHD in adults

Boomsma, D. I., Savyuk, V., Hottenga, J. J., de Geus, E. J. C. & Willemsen, G., 2010, In : Behavior Genetics. 40, 6, p. 788

Research output: Contribution to JournalMeeting AbstractOther research output

File
Happiness
Genome
Phenotype
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 1

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Lango Allen, H., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., van Ommen, G. J. B., Martin, N. G., Montgomery, GW., Boomsma, D. I., Penninx, B. W. J. H., van Duijn, C. M., Peltonen, L., Visscher, P. M., Uitterlinden, A. G., Abecasis, G. R., Stefansson, H. & 2 othersFrayling, T. M. & Hirschhorn, J. N., 2010, In : Nature. 467, 7317, p. 832-838

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Multifactorial Inheritance
Genes
Genome-Wide Association Study
Genetic Loci
Growth

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., Mägi, R., Workalemahu, T., White, C. C., Bouatia-Naji, N., Harris, T. B., Berndt, S. I., Ingelsson, E., Willer, C. J., Weedon, M. N., Luan, J., Vedantam, S. & 81 othersEsko, T., Kilpeläinen, T. O., Kutalik, Z., Li, S., Monda, K. L., Dixon, A. L., Holmes, C. C., Kaplan, L. M., Liang, L., Min, J. L., Moffatt, M. F., Molony, C., Nicholson, G., Schadt, E. E., Zondervan, K. T., Feitosa, M. F., Ferreira, T., Lango Allen, H., Weyant, R. J., Wheeler, E., Wood, A. R., Estrada, K., Goddard, M. E., Lettre, G., Mangino, M., Nyholt, DR., Purcell, S., Smith, A. V., Visscher, H. M., Yang, J., McCarroll, S. A., Nemesh, J., Voight, B. F., Absher, D., Amin, N., Aspelund, T., Coin, L., Glazer, N. L., Hayward, C., Heard-Costa, N. L., Hottenga, J. J., Johansson, A., Johnson, T., Kaakinen, M., Kapur, K., Ketkar, S., Knowles, J. W., Kraft, P., Kraja, A. T., Lamina, C., Leitzmann, M. F., McKnight, B., Morris, A. P., Ong, K. K., Perry, J. R. B., Peters, M. J., Polasek, O., Prokopenko, I., Rayner, N. W., Ripatti, S., Rivadeneira, F., Robertson, R., Sanna, S., Sovio, U., Surakka, I., Teumer, A., van Wingerden, K. M. C., Vitart, V., Zhao, J. H., Cavalcanti-Proença, C., Chines, P. S., Fisher, E., Kulzer, J. R., Lecoeur, C., Narisu, N., Sandholt, C., de Geus, E. J. C., Willemsen, G., Penninx, B. W. J. H., Mohlke, K. L. & Lindgren, C. M., 2010, In : Nature Genetics. 42, 11, p. 949-960

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Waist-Hip Ratio
Sex Characteristics
Meta-Analysis
Fats
Body Fat Distribution

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Hottenga, J. J., de Geus, E. J. C., Kaprio, J., Kyvik, K. O., Pedersen, N. L. & 29 othersPerola, M., Posthuma, D., Rivadeneira, F., Uitterlinden, A. G., Willems van Dijk, K., van Hoek, M., Vogelzangs, N., Willemsen, G., Witteman, J. C. M., Zillikens, M. C., Penninx, B. W. J. H., Boomsma, D. I., van Duijn, C. M., Aulchenko, Y. S., Waterworth, D., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L. C., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., 2010, In : Nature Genetics. 42, 2, p. 105-116

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genetic Loci
Type 2 Diabetes Mellitus
Fasting
Homeostasis
Glucose

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior

Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., Amin, N., Geller, F., Sulem, P., Rafnar, T., Esko, T., Walter, S., Gieger, C., Rawal, R., Mangino, M., Prokopenko, I., Magi, R., Keskitalo, K., Gudjonsdottir, I. H., Gretarsdottir, S., Stefansson, H., Thompson, J. R. & 74 othersAulchenko, Y. S., Nelis, M., Aben, K. K., Heijer, M., Dirksen, A., Ashraf, H., Soranzo, N., Valdes, A. M., Steves, C., Uitterlinden, A. G., Hofman, A., Tonjes, A., Kovacs, P., Hottenga, J. J., Willemsen, G., Vogelzangs, N., Doring, A., Dahmen, N., Nitz, B., Pergadia, M. L., Saez, B., De Diego, V., Lezcano, V., Garcia-Prats, M. D., Ripatti, S., Perola, M., Kettunen, J., Hartikainen, A. L., Pouta, A., Laitinen, J., Isohanni, M., Huei-Yi, S., Allen, M., Krestyaninova, M., Hall, A. S., Jones, G. T., van Rij, A. M., Mueller, T., Dieplinger, B., Haltmayer, M., Jonsson, S., Matthiasson, S. E., Oskarsson, H., Tyrfingsson, T., Kiemeney, L. A., Mayordomo, J. I., Lindholt, J. S., Pedersen, J. H., Franklin, W. A., de Wolf, H., Montgomery, GW., Heath, A. C., Martin, N. G., Madden, P. A. F., Giegling, I., Rujescu, D., Jarvelin, M. R., Salomaa, V., Stumvoll, M., Spector, T. D., Wichmann, H. E., Metspalu, A., Samani, N. J., Penninx, B. W. J. H., Oostra, B. A., Boomsma, D. I., Tiemeier, H., van Duijn, C. M., Kaprio, J., Gulcher, J. R., McCarthy, M. I., Peltonen, L., Thorsteinsdottir, U. & Stefansson, K., 2010, In : Nature Genetics. 42, 5, p. 448-453

Research output: Contribution to JournalArticleAcademicpeer-review

Smoking

The Netherlands Twin Register Biobank: A resource for genetic epidemiological studies

Willemsen, G., de Geus, E. J. C., Bartels, M., van Beijsterveldt, C. E. M., Brooks, A. I., Estourgie-van Burk, G. F., Fugman, D. A., Hoekstra, C., Hottenga, J. J., Kluft, C., Meijer, P., Montgomery, GW., Rizzu, P., Sondervan, D., Smit, A. B., Spijker, S., Suchiman, H. E. D., Tischfield, J. A., Lehner, T., Slagboom, P. E. & 1 othersBoomsma, D. I., 2010, In : Twin Research and Human Genetics. 13, 3, p. 231-245

Research output: Contribution to JournalArticleAcademicpeer-review

Netherlands
Epidemiologic Studies
Personality
Life Style
Health
Serotonin Plasma Membrane Transport Proteins
Depression
Genes
Meta-Analysis
Neuroticism

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Hottenga, J. J., de Geus, E. J. C., Martin, N. G., Peltonen, L., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Loos, S. A., Montgomery, GW., Ridker, P. M. & 9 othersSpector, T. D., Streeten, E. A., Stefansson, K., Thorsteinsdottir, U., Uitterlinden, A. G., Widen, E., Murabito, J. M., Ong, K. K. & Murray, A., 2010, In : Nature Genetics. 42, 12, p. 1077-1085

Research output: Contribution to JournalArticleAcademicpeer-review

Menarche
Genome-Wide Association Study
Meta-Analysis
Genes
Biological Phenomena

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Freathy, R. M., Mook-Kanamori, D. O., Sovio, U., Prokopenko, I., Timpson, N. J., Berry, D. J., Warrington, N. M., Widen, E., Hottenga, J. J., Kaakinen, M., Lange, L. A., Bradfield, J. P., Kerkhof, M., Marsh, J. A., Mägi, R., Chen, C. M., Lyon, H. N., Kirin, M., Adair, L. S., Aulchenko, Y. S. & 63 othersBennett, A. J., Borja, J. B., Bouatia-Naji, N., Charoen, P., Coin, L. J. M., Cousminer, D. L., de Geus, E. J. C., Deloukas, P., Elliott, P., Evans, D. M., Froguel, P., Glaser, B., Groves, C. J., Hartikainen, A-L., Hassanali, N., Hirschhorn, J. N., Hofman, A., Holly, J. M. P., Hyppönen, E., Kanoni, S., Knight, B. A., Laitinen, J., Lindgren, C. M., McArdle, W. L., O'Reilly, P. F., Pennell, C. E., Postma, D. S., Pouta, A., Ramasamy, A., Rayner, N. W., Ring, S. M., Rivadeneira, F., Shields, B. M., Strachan, D. P., Surakka, I., Taanila, A., Tiesler, C., Uitterlinden, A. G., van Duijn, C. M., Wijga, A. H., Willemsen, G., Zhang, H., Zhao, J., Wilson, J. F., Steegers, E. A. P., Hattersley, A. T., Eriksson, J. G., Peltonen, L., Mohlke, K. L., Grant, S. F. A., Hakonarson, H., Koppelman, G. H., Dedoussis, G. V., Heinrich, J., Gillman, M. W., Palmer, L. J., Frayling, T. M., Boomsma, D. I., Smith, G. D., Power, C., Jaddoe, V. W. V., Jarvelin, M-R. & McCarthy, M. I., 2010, In : Nature Genetics. 42, 5, p. 430-435

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Fetal Weight
Fetal Development
Birth Weight
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
2009

A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation

Estrada, K., Krawczak, M., Schreiber, S., van Duijn, K., Stolk, L., van Meurs, J. B. J., Liu, F., Penninx, B. W. J. H., Smit, J. H., Vogelzangs, N., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Lorentzon, M., von Eller-Eberstein, H., Lips, P. T. A. M., van Schoor, N. M., Pop, V., de Keijzer, J., Hofman, A. & 8 othersAulchenko, Y. S., Oostra, B. A., Ohlsson, C., Boomsma, D. I., Uitterlinden, A. G., van Duijn, C. M., Rivadeneira, F. F. & Kayser, M., 2009, In : Human Molecular Genetics. 18, 18, p. 3516-3524

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
C-Type Natriuretic Peptide
Body Height
Genome-Wide Association Study
Population
Single Nucleotide Polymorphism

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

Benyamin, B., Ferreira, M. A., Willemsen, G., Gordon, S., Middelberg, R. P. S., McEvoy, B. P., Hottenga, J. J., Henders, A. K., Campbell, MJ., Wallace, L., Frazer, I. H., Heath, A. C., de Geus, E. J. C., Nyholt, DR., Visscher, P. M., Penninx, B. W. J. H., Boomsma, D. I., Martin, N. G., Montgomery, GW. & Whitfield, J. B., 2009, In : Nature Genetics. 41, 11, p. 1173-1175

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Erythrocyte Volume
Iron
Erythrocyte Indices
Erythropoiesis
Genome-Wide Association Study

Genetic Factors Underlie Stability of Obsessive–Compulsive Symptoms

van Grootheest, D. S., Cath, D., Hottenga, J. J., Beekman, A. T. F. & Boomsma, D. I., 2009, In : Twin Research and Human Genetics. 12, 5, p. 411-419

Research output: Contribution to JournalArticleAcademicpeer-review

File
Compulsive Behavior
Obsessive Behavior
Dizygotic Twins
Monozygotic Twins
Netherlands

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo

Sullivan, P. F., de Geus, E. J. C., Willemsen, G., James, M. R., Smit, J. H., Zandbelt, T., Arolt, V., Baune, B. T., Blackwood, D., Cichon, S., Coventry, W. L., Domschke, K., Farmer, A., Fava, M., Gordon, S. D., He, Q., Heath, A. C., Heutink, P., Holsboer, F., Hoogendijk, W. J. G. & 29 othersHottenga, J. J., Hu, Y., Kohli, M., Lin, D., Lucae, S., MacIntyre, D. J., Maier, W., McGhee, K. A., McGuffin, P., Montgomery, GW., Muir, W. J., Nolen, W. A., Nöthen, M. M., Perlis, R. H., Pirlo, K., Posthuma, D., Rietschel, M., Rizzu, P., Schosser, A., Smit, A. B., Smoller, J. W., Tzeng, J. Y., van Dyck, R., Verhage, M., Zitman, F. G., Martin, N. G., Wray, N. R., Boomsma, D. I. & Penninx, B. W. J. H., 2009, In : Molecular Psychiatry. 14, 4, p. 359-375

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Major Depressive Disorder
Genome
Overlapping Genes
Proteins
Information Services

Genome-wide association study of attention problems and ADHD in adults

Boomsma, D. I., Hottenga, J. J., Distel, M. A., de Moor, M. H. M., de Geus, E. J. C. & Willemsen, G., 2009, In : Behavior Genetics. 39, p. 637

Research output: Contribution to JournalMeeting AbstractOther research output

Genome-wide association study of exercise behavior in dutch and american adults

De Moor, M. H. M., Liu, Y. J., Boomsma, D. I., Li, J., Hamilton, J. J., Hottenga, J. J., Levy, S., Liu, X. G., Pei, Y. F., Posthuma, D., Recker, R. R., Sullivan, P. F., Wang, L., Willemsen, G., Yan, H., De Geus, E. J. C. & Deng, H. W., Oct 2009, In : Medicine and Science in Sports and Exercise. 41, 10, p. 1887-1895 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Exercise
Genes
Leisure Activities
Genome

Genome-wide Association Study of Smoking Initiation and Current Smoking

Vink, J. M., Smit, A. B., de Geus, E. J. C., Sullivan, P. F., Willemsen, G., Hottenga, J. J., Smit, J. H., Hoogendijk, W. J. G., Zitman, F. G., Peltonen, L., Kaprio, J., Pedersen, N. L., Magnusson, P. K. E., Spector, T. D., Kyvik, K. O., Morley, K. I., Heath, A. C., Martin, N. G., Westendorp, R. G. J., Slagboom, P. E. & 8 othersTiemeier, H., Hofman, A., Uitterlinden, A. G., Aulchenko, Y. S., Amin, N., van Duijn, C., Penninx, B. W. J. H. & Boomsma, D. I., 2009, In : American Journal of Human Genetics. 84, 3, p. 367-379

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Smoking
Excitatory Amino Acid Transporter 2
Genes
Proteins

Geographical structure and differential natural selection amongst North European populations

McEvoy, B. P., Montgomery, GW., McRae, A. F., Ripatti, S., Perola, M., Spector, T. D., Cherkas, L. F., Ahmadi, K., Boomsma, D. I., Willemsen, G., Hottenga, J. J., Pedersen, N. L., Magnusson, P. K. E., Kyvik, K., Christensen, K., Kaprio, J., Heikkilä, K., Palotie, A., Widen, E., Muilu, J. & 7 othersSyvänen, A. C., Liljedahl, U., Hardiman, O., Cronin, S., Peltonen, L., Martin, N. G. & Visscher, P. M., 2009, In : Genome Research. 19, 5, p. 804-814

Research output: Contribution to JournalArticleAcademicpeer-review

File
Genetic Selection
HapMap Project
Population
Chromosome Mapping
Denmark

Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap–CEU populations

Pardo, L. M., Bochdanovits, Z., de Geus, E. J. C., Hottenga, J. J., Sullivan, P. F., Posthuma, D., Penninx, B. W. J. H., Boomsma, D. I. & Heutink, P., 2009, In : European Journal of Human Genetics. 17, 6, p. 802-810

Research output: Contribution to JournalArticleAcademicpeer-review

File
Linkage Disequilibrium
HapMap Project
Population
Genome-Wide Association Study
Single Nucleotide Polymorphism