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Research Output 2004 2019

Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis

Pappa, I., Fedko, I. O., Mileva-Seitz, V. R., Hottenga, J. J., Bakermans-Kranenburg, M. J., Bartels, M., van Beijsterveldt, C. E. M., Jaddoe, V. W. V., Middeldorp, C. M., Rippe, R. C. A., Rivadeneira, F., Tiemeier, H., Verhulst, F. C., van IJzendoorn, M. H. & Boomsma, D. I., 2015, In : Journal of the American Academy of Child and Adolescent Psychiatry. 54, 9, p. 737-744 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Single Nucleotide Polymorphism
Genome
Phenotype
Genome-Wide Association Study
Child Behavior

Skewed X-inactivation is common in the general female population

Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Willemsen, G. & BIOS Consortium, Mar 2019, In : European Journal of Human Genetics. 27, 3, p. 455-465 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
X Chromosome Inactivation
X Chromosome
Population
Genes
Alleles

Smoking and caffeine consumption: a genetic analysis of their association

Treur, J. L., Taylor, A. E., Ware, J. J., Nivard, M. G., Neale, M. C., McMahon, G., Hottenga, J. J., Baselmans, B. M. L., Boomsma, D. I., Munafò, M. & Vink, J. M., 1 Jul 2017, In : Addiction Biology. 22, 4, p. 1090-1102

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Caffeine
Smoking
Coffee
Netherlands
Mendelian Randomization Analysis

Smoking initiation and persistence: First results for genome-wide association analyses in Dutch adults

Vink, J. M., Sullivan, P. F., Smit, J. A., Hoogendijk, W. J. G., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Penninx, B. W. J. H. & Boomsma, D. I., 2008.

Research output: Contribution to ConferencePosterOther research output

Smoking initiation and persistence: First results for genome-wide association analyses in Dutch adults.

Boomsma, D. I., Vink, J. M., Sullivan, P. F., Smit, J. H., Hoogendijk, W. J. G., Hottenga, J. J., Willemsen, G., de Geus, E. J. C. & Penninx, B. W. J. H., 2008, In : Behavior Genetics. 38, p. 615-616

Research output: Contribution to JournalMeeting AbstractOther research output

Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample

Peyrot, W., Middeldorp, C. M., Jansen, R., Smit, J. H., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Vink, J. M., Virding, S., Barragan, I., Ingelman-Sundberg, M., Sim, S. C., Boomsma, D. I. & Penninx, B. W. J. H., 2013, In : Journal of Affective Disorders. 146, 1, p. 91-99

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Haplotypes
Gene-Environment Interaction
Logistic Models
Serotonin Plasma Membrane Transport Proteins

Suggestive linkage on chromosome 2, 8, and 17 for Lifetime Major Depression

Middeldorp, C. M., Sullivan, P. F., Wray, N. R., Hottenga, J. J., de Geus, E. J. C., van den Berg, M., Montgomery, GW., Coventry, W. L., Statham, D. J., Andrews, G., Slagboom, P. E., Boomsma, D. I. & Martin, N. G., 2009, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 150B, 3, p. 352-358

Research output: Contribution to JournalArticleAcademicpeer-review

File
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 2
Major Depressive Disorder
Serotonin Plasma Membrane Transport Proteins

Testing familial transmission of smoking with two different research designs

Treur, J. L., Verweij, K. J. H., Abdellaoui, A., Fedko, I. O., de Zeeuw, E. L., Ehli, E. A., Davies, G. E., Hottenga, J. J., Willemsen, G., Boomsma, D. I. & Vink, J. M., 7 Jun 2018, In : Nicotine and Tobacco Research. 20, 7, p. 836-842 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Research Design
Smoking
Gene-Environment Interaction
Twin Studies
Netherlands

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~ 25 000 subjects

Peyrot, W., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A. & 9 othersRipke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Posthuma, D., Middeldorp, C. M. & Penninx, B. W. J. H., 2015, In : Molecular Psychiatry. 20, 6, p. 735-743 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Depression
Single Nucleotide Polymorphism
Genomics
Mental Disorders

The Contribution of the Functional IL6R Polymorphism rs2228145, eQTLs and Other Genome-Wide SNPs to the Heritability of Plasma sIL-6R Levels

van Dongen, J., Jansen, R., Smit, D. J. A., Hottenga, J. J., Mbarek, H., Willemsen, G., Kluft, C., Penninx, B. W. J. H., Ferreira, M. A., Boomsma, D. I. & de Geus, E. J. C., 2014, In : Behavior Genetics. 44, 4, p. 368-382 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

heritability
Single Nucleotide Polymorphism
polymorphism
genome
genetic polymorphism

The Dopaminergic Reward System and Leisure Time Exercise Behavior: A Candidate Allele Study

Huppertz, C., Bartels, M., Blokhuis, M. M., Dolan, C. V., de Moor, M. H. M., Abdellaoui, A., van Beijsterveldt, C. E. M., Ehli, E. A., Hottenga, J. J., Willemsen, G., Xiao, X., Scheet, P., Davies, G. E., Boomsma, D. I., Hudziak, J. J. & de Geus, E. J. C., 2014, In : Biomed research international. 2014, 9 p., 591717.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Minisatellite Repeats
Leisure Activities
Polymorphism
Reward
Nucleotides

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

EArly Genetics Lifecourse Epidemiology (EAGLE) consortium & Early Growth Genetics (EGG) Consortium, Mar 2019, In : European Journal of Epidemiology. 34, 3, p. 279-300

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Molecular Epidemiology
Sample Size
Genetic Research
Low Birth Weight Infant
Atopic Dermatitis

The effect of FTO rs9939609 on major depression differs across MDD subtypes

Milaneschi, Y., Lamers, F., Mbarek, H., Hottenga, J. J., Boomsma, D. I. & Penninx, B. W. J. H., 2014, In : Molecular Psychiatry. 19, 9, p. 960-962 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Thompson, P. M., Stein, J. L., Medland, S. E., Hibar, D. P., Arias-Vásquez, A., Renteria, M. E., Toro, R., Jahanshad, N., Schumann, G., Franke, B., Wright, M. J., Martin, N. G., Agartz, I., Lopez de Alda, M., Alhusaini, S., Boomsma, D. I., Brouwer, R. M., de Geus, E. J. C., den Braber, A., Fedko, I. O. & 22 othersHottenga, J. J., Hulshoff Pol, H. E., Montgomery, G. W., Penninx, B. W. J. H., Milaneschi, Y., Schnack, H. G., van t Ent, D., Westlye, L. T., Whalley, H. C., Whelan, C. D., White, T., Winkler, A. M., Wittfeld, K., Woldehawariat, G., Wolf, C., Zilles, D., Zwiers, M. P., Thalamuthu, A., Schofield, P. R., Freimer, N. B., Lawrence, N. S. & Drevets, W., 2014, In : Brain Imaging and Behavior. 8, 2, p. 153-182 30 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neuroimaging
Meta-Analysis
Genome-Wide Association Study
Brain
Attention Deficit Disorder with Hyperactivity

The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

Middeldorp, C. M., de Moor, M. H. M., McGrath, L. M., Gordon, S. D., Blackwood, D. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Nyholt, DR., Tanaka, T., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J. J., Distel, M. A., Uda, M., Sanna, S. & 41 othersSpinhoven, P., Hartman, C. A., Ripke, S., Sullivan, P. F., Realo, A., Allik, J., Heath, A. C., Pergadia, M. L., Agrawal, A., Lin, P., Grucza, R. A., Widen, E., Cousminer, D. L., Eriksson, J. G., Palotie, A., Barnett, J. H., Lee, P. H., Luciano, M., Tenesa, A., Davies, G., Lopez, L. M., Hansell, N. K., Medland, S. E., Ferrucci, L., Schlessinger, D., Montgomery, GW., Wright, M. J., Aulchenko, Y. S., Janssens, A. C. J. W., Oostra, B. A., Metspalu, A., Abecasis, G. R., Deary, I. J., Räikkönen, K., Bierut, L. J., Martin, N. G., Wray, N. R., van Duijn, C. M., Smoller, J. W., Penninx, B. W. J. H. & Boomsma, D. I., 2011, In : Translational Psychiatry. 1, e50.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Bipolar Disorder
Major Depressive Disorder
Personality
Depression

The Genetic Overlap Between Hair and Eye Color

Lin, B., Willemsen, G., Abdellaoui, A., Bartels, M., Ehli, E. A., Davies, G. E., Boomsma, D. I. & Hottenga, J. J., 2016, In : Twin Research and Human Genetics. 19, 6, p. 595-599

Research output: Contribution to JournalArticleAcademicpeer-review

Hair Color
Eye Color
Netherlands
Phenotype
Genome-Wide Association Study

The Genetics of Alcohol Dependence: Twin and SNP-Based Heritability, and Genome-Wide Association Study Based on AUDIT Scores

Mbarek, H., Milaneschi, Y., Fedko, I. O., Hottenga, J. J., de Moor, M. H. M., Jansen, R., Gelernter, J., Sherva, R., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H. & Vink, J. M., 2015, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 168, 8, p. 739-748 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Alcoholism
Single Nucleotide Polymorphism
Alcohols
Netherlands

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L. A., Kanoni, S., Jansen, R., Boomsma, D. I., Hottenga, J. J., Penninx, B. W. J. H., van Duijn, C. M., Wichmann, H. E., Palmer, C. N. A., Stefansson, K., Ridker, P. M., Loos, R. J. F. & 5 othersChakravarti, A., Deloukas, P., Morris, A. P., Newton-Cheh, C. & Munroe, P. B., 2016, In : Nature Genetics. 48, 10, p. 1171-1184

Research output: Contribution to JournalArticleAcademicpeer-review

Blood Pressure
Single Nucleotide Polymorphism
Kidney
Blood Vessels
Endothelial Cells

The Genome of the Netherlands: design, and project goals

Boomsma, D. I., Wijmenga, C., Slagboom, P. E., Swertz, M., Karssen, L. C., Abdellaoui, A., Ye, K., Guryev, V., Vermaat, M., Dijk, F., Francioli, L. C., Hottenga, J. J., Laros, J. F. J., Li, Q., Li., Y., Cao, H., Chen, R., Du, Y., Li, N., Cao, S. & 32 othersvan Setten, J., Menelaou, A., Pulit, S. L., Hehir-Kwa, J. Y., Beekman, M., Elbers, C. C., Byelas, H., de Craen, A. J., Deelen, P., Dijkstra, M., den Dunnen, J. T., de Knijff, P., Houwing-Duistermaat, J. J., Koval, V., Estrada, K., Hofman, A., Kanterakis, A., van Enckevort, D., Mai, H., Kattenberg, V. M., van Leeuwen, E. M., Neerincx, P. B. T., Oostra, B., Rivadeneira, F., Suchiman, H. E. D., Uitterlinden, A. G., Willemsen, G., Wolffenbuttel, B. H., Wang, J., Bakker, P. I. W., van Ommen, G. J. & van Duijn, C. M., 2014, In : European Journal of Human Genetics. 22, 2, p. 221-227 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Netherlands
Genome
Research
Phenotype
Geographic Locations

The impact of low-frequency and rare variants on lipid levels

Surakka, I., Horikoshi, M., Magi, R., Sarin, A., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hagg, S., Hottenga, J. J., Isaacs, A., Ladenvall, C., Beekman, M., Esko, T. & 66 othersRied, J. S., Nelson, C. P., Willenborg, C., Gustafsson, S., Westra, H., Blades, M., Craen, A. J. M., de Geus, E. J. C., Deelen, J., Grallert, H., Hamsten, A., Havulinna, A. S., Hengstenberg, C., Houwing-Duistermaat, J. J., Hypponen, E., Karssen, L. C., Lehtimaki, T., Lyssenko, V., Magnusson, P. K. E., Mihailov, E., Muller-Nurasyid, M., Mpindi, J., Pedersen, N. L., Penninx, B. W. J. H., Perola, M., Pers, T. H., Peters, A., Rung, J., Smit, J. H., Steinthorsdottir, V., Tobin, M. D., Tsernikova, N., van Leeuwen, E. M., Viikari, J. S., Willems, S. M., Willemsen, G., Schunkert, H., Erdmann, J., Samani, N. J., Kaprio, J., Lind, L., Gieger, C., Metspalu, A., Slagboom, P. E., Groop, L., van Duijn, C. M., Eriksson, J. G., Jula, A., Salomaa, V., Boomsma, D. I., Power, C., Raitakari, O. T., Ingelsson, E., Jarvelin, M., Thorsteinsdottir, U., Franke, L., Ikonen, E., Kallioniemi, O., Pietiainen, V., Lindgren, C. M., Stefansson, K., Palotie, A., McCarthy, M. I., Morris, A. P., Prokopenko, I. & Ripatti, S., 2015, In : Nature Genetics. 47, 6, p. 589-597

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Single Nucleotide Polymorphism
Lipids
Genome
Missense Mutation
LDL Cholesterol

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpelainen, T. O., Lu, Y., Magi, R., Mihailov, E., Pers, T. H., Rueeger, S., Teumer, A., Ehret, G. B., Ferreira, T., Heard-Costa, N. L., Karjalainen, J. & 418 othersLagou, V., Mahajan, A., Neinast, M. D., Prokopenko, I., Simino, J., Teslovich, T. M., Jansen, R., Westra, H., White, C. C., Absher, D., Ahluwalia, T. S., Ahmad, S., Albrecht, E., Alves, A. C., Bragg-Gresham, J. L., Craen, A. J. M., Bis, J. C., Bonnefond, A., Boucher, G., Cadby, G., Cheng, Y., Chiang, C. W. K., Delgado, G., Demirkan, A., Dueker, N., Eklund, N., Eiriksdottir, G., Eriksson, J., Feenstra, B., Fischer, K., Frau, F., Galesloot, T. E., Geller, F., Goel, A., Gorski, M., Grammer, T. B., Gustafsson, S., Haitjema, S., Hottenga, J. J., Huffman, J. E., Jackson, A. U., Jacobs, K. B., Johansson, A., Kaakinen, M., Kleber, M. E., Lahti, J., Leach, I. M., Lehne, B., Lo, K. S., Lorentzon, M., Luan, J., Madden, P. A. F., Mangino, M., McKnight, B., Medina-Gomez, C., Monda, K. L., Montasser, M. E., Mueller, G., Mueller-Nurasyid, M., Nolte, I. M., Panoutsopoulou, K., Pascoe, L., Paternoster, L., Rayner, N. W., Renstrom, F., Rizzi, F., Rose, L. M., Ryan, K. A., Salo, P., Sanna, S., Scharnagl, H., Shi, J., Smith, A. V., Southam, L., Stancakova, A., Steinthorsdottir, V., Strawbridge, R. J., Sung, Y. J., Tachmazidou, I., Tanaka, T., Thorleifsson, G., Trompet, S., Pervjakova, N., Tyrer, J. P., Vandenput, L., van der Laan, S. W., van der Velde, N., van Setten, J., van Vliet-Ostaptchouk, J. V., Verweij, N., Vlachopoulou, E., Waite, L. L., Wang, S. R., Wang, Z., Wild, S. H., Willenborg, C., Wilson, J. F., Wong, A., Yang, J., Yengo, L., Yerges-Armstrong, L. M., Yu, L., Zhang, W., Zhao, J. H., Andersson, E. A., Bakker, S. J. L., Baldassarre, D., Banasik, K., Barcella, M., Barlassina, C., Bellis, C., Benaglio, P., Blangero, J., Blueher, M., Bonnet, F., Bonnycastle, L. L., Boyd, H. A., Bruinenberg, M., Buchman, A. S., Campbell, H., Chen, Y. I., Chines, P. S., Claudi-Boehm, S., Cole, J., Collins, F. S., de Geus, E. J. C., de Groot, L. C. P. G. M., Dimitriou, M., Duan, J., Enroth, S., Eury, E., Farmaki, A., Forouhi, N. G., Friedrich, N., Gejman, P. V., Gigante, B., Glorioso, N., Go, A. S., Gottesman, O., Graessler, J., Grallert, H., Grarup, N., Gu, Y., Broer, L., van der Ham, A. C., Hansen, T., Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N., Hattersley, A. T., Heath, A. C., Henders, A. K., Hernandez, D., Hillege, H., Holmen, O., Hovingh, K. G., Hui, J., Husemoen, L. L., Hutri-Kahonen, N., Hysi, P. G., Illig, T., de Jager, P. L., Jalilzadeh, S., Jorgensen, T., Jukema, J. W., Juonala, M., Kanoni, S., Karaleftheri, M., Khaw, K. T., Kinnunen, L., Kittner, S. J., Koenig, W., Kolcic, I., Kovacs, P., Krarup, N. T., Kratzer, W., Krueger, J., Kuh, D., Kumari, M., Kyriakou, T., Langenberg, C., Lannfelt, L., Lanzani, C., Lotay, V., Launer, L. J., Leander, K., Lindstrom, J., Linneberg, A., Liu, Y., Lobbens, S., Luben, R., Lyssenko, V., Mannisto, S., Magnusson, P. K., McArdle, W. L., Menni, C., Merger, S., Milani, L., Montgomery, G. W., Morris, A. P., Narisu, N., Nelis, M., Ong, K. K., Palotie, A., Perusse, L., Pichler, I., Pilia, M. G., Pouta, A., Rheinberger, M., Ribel-Madsen, R., Richards, M., Rice, K. M., Rice, T. K., Rivolta, C., Salomaa, V., Sanders, A. R., Sarzynski, M. A., Scholtens, S., Scott, R. A., Scott, W. R., Sebert, S., Sengupta, S., Sennblad, B., Seufferlein, T., Silveira, A., Slagboom, P. E., Smit, J. H., Sparso, T. H., Stirrups, K., Stolk, R. P., Stringham, H. M., Swertz, M. A., Swift, A. J., Syvanen, A., Tan, S., Thorand, B., Toenjes, A., Tremblay, A., Tsafantakis, E., van der Most, P. J., Voelker, U., Vohl, M., Vonk, J. M., Waldenberger, M., Walker, R. W., Wennauer, R., Widen, E., Willemsen, G., Wilsgaard, T., Wright, A. F., Zillikens, M. C., van Dijk, S. C., van Schoor, N. M., Asselbergs, F. W., Bakker, P. I. W., Beckmann, J. S., Beilby, J., Bennett, D. A., Bergman, R. N., Bergmann, S., Boeger, C. A., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Bornstein, S. R., Bottinger, E. P., Bouchard, C., Chambers, J. C., Chanock, S. J., Chasman, D. I., Cucca, F., Cusi, D., Dedoussis, G., Erdmann, J., Eriksson, J. G., Evans, D. A., de Faire, U., Farrall, M., Ferrucci, L., Ford, I., Franke, L., Franks, P. W., Froguel, P., Gansevoort, R. T., Gieger, C., Gronberg, H., Gudnason, V., Gyllensten, U., Hall, P., Hamsten, A., van der Harst, P., Hayward, C., Heliovaara, M., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hofman, A., Hu, F., Huikuri, H. V., Hveem, K., James, A. L., Jordan, J. M., Jula, A., Kaehoenen, M., Kajantie, E., Kathiresan, S., Kiemeney, L. A. L. M., Kivimaki, M., Knekt, P. B., Koistinen, H. A., Kooner, J. S., Koskinen, S., Kuusisto, J., Maerz, W., Martin, N. G., Laakso, M., Lakka, T. A., Lehtimaki, T., Lettre, G., Levinson, D. F., Lind, L., Lokki, M., Mantyselka, P., Melbye, M., Metspalu, A., Mitchell, B. D., Moll, F. L., Murray, J. C., Musk, A. W., Nieminen, M. S., Njolstad, I., Ohlsson, C., Oldehinkel, A. J., Oostra, B. A., Palmer, L. J., Pankow, J. S., Pasterkamp, G., Pedersen, N. L., Pedersen, O., Penninx, B. W. J. H., Perola, M., Peters, A., Polasek, O., Pramstaller, P. P., Psaty, B. M., Qi, L., Quertermous, T., Raitakari, O. T., Rankinen, T., Rauramaa, R., Ridker, P. M., Rioux, J. D., Rivadeneira, F., Rotter, J. I., Rudan, I., den Ruijter, H. M., Saltevo, J., Sattar, N., Schunkert, H., Schwarz, P. E. H., Shuldiner, A. R., Sinisalo, J., Snieder, H., Sorensen, T. I. A., Spector, T. D., Staessen, J. A., Stefania, B., Thorsteinsdottir, U., Stumvoll, M., Tardif, J., Tremoli, E., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Verbeek, A. L. M., Vermeulen, S. H., Viikari, J. S., Vitart, V., Voelzke, H., Vollenweider, P., Waeber, G., Walker, M., Wallaschofski, H., Wareham, N. J., Watkins, H., Zeggini, E., Chakravarti, A., Clegg, D. J., Cupples, L. A., Gordon-Larsen, P., Jaquish, C. E., Rao, D. C., Abecasis, G. R., Assimes, T. L., Barroso, I., Berndt, S. I., Boehnke, M., Deloukas, P., Fox, C. S., Groop, L. C., Hunter, D. J., Ingelsson, E., Kaplan, R. C., McCarthy, M. I., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Hirschhorn, J. N., Lindgren, C. M., Heid, I. M., North, K. E., Borecki, I. B., Kutalik, Z. & Loos, R. J. F., 2015, In : PLoS Genetics. 11, 10, e1005378.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
waist-to-hip ratio
body shape
Waist-Hip Ratio
Genome-Wide Association Study
Body Size

The International Cannabis Consortium: What Did We Learn About The Genetics Of Cannabis Use

Verweij, K., Minica, C., Stringer, S., van der Most, P., Mbarek, H., Nivard, M., Abdellaoui, A., Hottenga, J-J., Martin, N., Boomsma, D., Gillespie, N., Derks, E. & Vink, J., 15 Aug 2017, In : European Neuropsychopharmacology. 27, p. S494-S495

Research output: Contribution to JournalArticleAcademicpeer-review

The Lin28/let-7 axis regulates glucose metabolism

Zhu, H., Shyh-Chang, N., Segre, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J. P., Kharas, M. G., Urbach, A., Thornton, J. E., Triboulet, R., Gregory, R. I., Hottenga, J. J., de Geus, E. J. C., Posthuma, D., Willemsen, G., Boomsma, D. I., Altshuler, D. & 1 othersDaley, G. Q., 2011, In : Cell. 147, 1, p. 81-94

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels

Neumann, A., Direk, N., Crawford, A. A., Mirza, S., Adams, H. H. H., Bolton, J., Hayward, C., Strachan, D. P., Payne, E. K., Smith, J. A., Milaneschi, Y., Penninx, B., Hottenga, J. J., de Geus, E., Oldehinkel, A. J., van der Most, P. J., de Rijke, Y., Walker, B. R. & Tiemeier, H., Nov 2017, In : Psychoneuroendocrinology. 85, p. 88-95 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Saliva
Single Nucleotide Polymorphism
Hydrocortisone
Genome-Wide Association Study
Linkage Disequilibrium
Open Access
Educational Status
Social Class
Netherlands
Genetic Structures
Netherlands
Research
Genetic Association Studies
Biocompatible Materials
Pedigree

The Netherlands Twin Register Axiom Biobank platform for GWAS

Hottenga, J. J., 2015.

Research output: Contribution to ConferencePosterOther research output

The Netherlands Twin Register Biobank: A resource for genetic epidemiological studies

Willemsen, G., de Geus, E. J. C., Bartels, M., van Beijsterveldt, C. E. M., Brooks, A. I., Estourgie-van Burk, G. F., Fugman, D. A., Hoekstra, C., Hottenga, J. J., Kluft, C., Meijer, P., Montgomery, GW., Rizzu, P., Sondervan, D., Smit, A. B., Spijker, S., Suchiman, H. E. D., Tischfield, J. A., Lehner, T., Slagboom, P. E. & 1 othersBoomsma, D. I., 2010, In : Twin Research and Human Genetics. 13, 3, p. 231-245

Research output: Contribution to JournalArticleAcademicpeer-review

Netherlands
Epidemiologic Studies
Personality
Life Style
Health

The Nigerian Twin and Sibling Registry: An Update

Hur, Y-M., Jeong, H-U., Kang, M. C., Ajose, F., Kim, J. W., Beck, J. J., Hottenga, J-J., Mbarek, H., Finnicum, C. T., Ehli, E. A., Martin, N. G., de Geus, E. J., Boomsma, D. I., Davies, G. E. & Bates, T., 3 Dec 2019, In : Twin research and human genetics : the official journal of the International Society for Twin Studies. p. 1-4 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Registries
Siblings
Birth Rate
Nigeria
Population

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Fall, T., Hägg, S., Mägi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A. P., Thorleifsson, G., Ladenvall, C., Kals, M., Kuningas, M., Draisma, H. H. M., Ried, J. S., van Zuydam, N. R., Huikari, V., Mangino, M., Sonestedt, E., Benyamin, B., Nelson, C. P., Rivera, N. V. & 105 othersKristiansson, K., Shen, H. Y., Havulinna, A. S., Dehghan, A., Donnelly, L. A., Kaakinen, M., Nuotio, M. L., Robertson, N., de Bruijn, R. F., Ikram, M. A., Amin, N., Balmforth, A. J., Braund, P. S., Doney, A. S. F., Döring, A., Elliott, P., Esko, T., Franco, O. H., Gretarsdottir, S., Hartikainen, A. L., Heikkilä, K., Herzig, K. H., Holm, H., Hottenga, J. J., Hyppönen, E., Illig, T., Isaacs, A., Isomaa, B., Karssen, L. C., Kettunen, J., Koenig, W., Kuulasmaa, K., Laatikainen, T., Laitinen, J., Lindgren, C. M., Lyssenko, V., Läärä, E., Rayner, N. W., Männistö, S., Pouta, A., Rathmann, W., Rivadeneira, F., Ruokonen, A., Savolainen, M. J., Sijbrands, E. J., Small, K. S., Smit, J. H., Steinthorsdottir, V., Syvänen, A. C., Taanila, A., Tobin, M. D., Uitterlinden, A. G., Willems, S. M., Willemsen, G., Witteman, J., Perola, M., Evans, A., Ferrières, J., Virtamo, J., Kee, F., Tregouet, D. A., Arveiler, D., Amouyel, P., Ferrario, M. M., Brambilla, P., Hall, A. S., Heath, A. C., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Whitfield, J. B., Jula, A., Knekt, P., Oostra, B. A., van Duijn, C. M., Penninx, B. W. J. H., Davey Smith, G., Kaprio, J., Samani, N. J., Gieger, C., Peters, A., Wichmann, H. E., Boomsma, D. I., de Geus, E. J. C., Tuomi, T., Power, C., Hammond, C. J., Spector, T. D., Lind, L., Orho-Melander, M., Palmer, C. N. A., Morris, A. D., Groop, L., Järvelin, M. R., Salomaa, V., Vartiainen, E., Hofman, A., Ripatti, S., Metspalu, A., Thorsteinsdottir, U., Stefansson, K., Pedersen, N. L., McCarthy, M. I., Ingelsson, E. & Prokopenko, I., 2013, In : PLoS Medicine. 10, 6, p. e1001474 e1001474.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mendelian Randomization Analysis
Adiposity
Body Mass Index
Random Allocation
Type 2 Diabetes Mellitus
Serotonin Plasma Membrane Transport Proteins
Depression
Genes
Meta-Analysis
Neuroticism

The vitamin D receptor gene is not strongly associated with stature: Results from The Netherlands Twin Register

Hottenga, J. J., Suchiman, E., Willemsen, G., Slagboom, P. E. & Boomsma, D. I., 2007, In : Behavior Genetics. 37, p. 763

Research output: Contribution to JournalMeeting AbstractOther research output

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Hottenga, J. J., de Geus, E. J. C., Martin, N. G., Peltonen, L., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Loos, S. A., Montgomery, GW., Ridker, P. M. & 9 othersSpector, T. D., Streeten, E. A., Stefansson, K., Thorsteinsdottir, U., Uitterlinden, A. G., Widen, E., Murabito, J. M., Ong, K. K. & Murray, A., 2010, In : Nature Genetics. 42, 12, p. 1077-1085

Research output: Contribution to JournalArticleAcademicpeer-review

Menarche
Genome-Wide Association Study
Meta-Analysis
Genes
Biological Phenomena

Trends in genome wide association results of multiple phenotypes

Hottenga, J. J., 2009.

Research output: Contribution to ConferencePosterOther research output

Twins, Tissue, and Time: An Assessment of SNPs and CNVs

Scheet, P., Ehli, E. A., Xiao, X., van Beijsterveldt, C. E. M., Abdellaoui, A., Althoff, R. R., Hottenga, J. J., Willemsen, G., Nelson, K. A., Huizenga, P. E., Hu, Y., Amos, C. I., Bartels, M., Groen-Blokhuis, M. M., de Geus, E. J. C., Hudziak, J. J., Davies, G. E. & Boomsma, D. I., 2012, In : Twin Research and Human Genetics. 15, 6, p. 737-745

Research output: Contribution to JournalArticleAcademicpeer-review

Cheek
Single Nucleotide Polymorphism
DNA
Genotype
Monozygotic Twins

Using a multivariate model to assess the interactive effects of demographics and lifestyle on the hematological profile

McArtor, D. B., Lin, B. D., Hottenga, J-J., Boomsma, D. I., Willemsen, G. & Lubke, G. H., 1 Jun 2017, In : Biomarkers in medicine. 11, 6, p. 427-438 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Biomarkers
Linear regression
Life Style
Linear Models
Demography

Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders

Verduijn, J., Milaneschi, Y., Peyrot, W. J., Hottenga, J. J., Abdellaoui, A., de Geus, E. J. C., Smit, J. H., Breen, G., Lewis, C. M., Boomsma, D. I., Beekman, A. T. F. & Penninx, B. W. J. H., 15 Feb 2017, In : Biological Psychiatry. 81, 4, p. 316-324 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Load
Major Depressive Disorder
Psychiatry
Schizophrenia
Bipolar Disorder

Using genetic methods to get insight into human complex traits

Lin, B., 2017, 206 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Freathy, R. M., Mook-Kanamori, D. O., Sovio, U., Prokopenko, I., Timpson, N. J., Berry, D. J., Warrington, N. M., Widen, E., Hottenga, J. J., Kaakinen, M., Lange, L. A., Bradfield, J. P., Kerkhof, M., Marsh, J. A., Mägi, R., Chen, C. M., Lyon, H. N., Kirin, M., Adair, L. S., Aulchenko, Y. S. & 63 othersBennett, A. J., Borja, J. B., Bouatia-Naji, N., Charoen, P., Coin, L. J. M., Cousminer, D. L., de Geus, E. J. C., Deloukas, P., Elliott, P., Evans, D. M., Froguel, P., Glaser, B., Groves, C. J., Hartikainen, A-L., Hassanali, N., Hirschhorn, J. N., Hofman, A., Holly, J. M. P., Hyppönen, E., Kanoni, S., Knight, B. A., Laitinen, J., Lindgren, C. M., McArdle, W. L., O'Reilly, P. F., Pennell, C. E., Postma, D. S., Pouta, A., Ramasamy, A., Rayner, N. W., Ring, S. M., Rivadeneira, F., Shields, B. M., Strachan, D. P., Surakka, I., Taanila, A., Tiesler, C., Uitterlinden, A. G., van Duijn, C. M., Wijga, A. H., Willemsen, G., Zhang, H., Zhao, J., Wilson, J. F., Steegers, E. A. P., Hattersley, A. T., Eriksson, J. G., Peltonen, L., Mohlke, K. L., Grant, S. F. A., Hakonarson, H., Koppelman, G. H., Dedoussis, G. V., Heinrich, J., Gillman, M. W., Palmer, L. J., Frayling, T. M., Boomsma, D. I., Smith, G. D., Power, C., Jaddoe, V. W. V., Jarvelin, M-R. & McCarthy, M. I., 2010, In : Nature Genetics. 42, 5, p. 430-435

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Fetal Weight
Fetal Development
Birth Weight
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism

Variants in MTNR1B influence fasting glucose levels

Prokopenko, I., Langenberg, C., Florez, J. C., Saxena, R., Soranzo, N., Thorleifsson, G., Loos, R. J. F., Manning, A. K., Jackson, A. U., Aulchenko, Y. S., Potter, S. C., Erdos, M. R., Sanna, S., Hottenga, J. J., Wheeler, E., Kaakinen, M., Lyssenko, V., Chen, W-M., Ahmadi, K., Beckmann, J. S. & 79 othersBergman, R. N., Bochud, M., Bonnycastle, L. L., Buchanan, T. A., Cao, A., Cervin, A., Coin, L., Collins, F. S., Crisponi, L., de Geus, E. J. C., Dehghan, A., Deloukas, P., Doney, A. S. F., Elliott, P., Freimer, N. B., Gateva, V., Herder, C., Hofman, A., Hughes, T. E., Hunt, S., Illig, T., Inouye, M., Isomaa, B., Johnson, T., Kong, A., Krestyaninova, M., Kuusisto, J., Laaks, M., Lim, N., Lindblad, U., Lindgren, C. M., McCann, O. T., Mohlke, K. L., Morris, A. D., Naitza, S., Orrù, M., Palmer, C. N. A., Pouta, A., Randall, J., Rathmann, W., Saramies, J., Scheet, P., Scott, L. J., Scuteri, A., Sharp, S., Sijbrands, E. J. G., Smit, J. H., Song, K., Steinthorsdottir, V., Stringham, H. M., Tuomi, T., Tuomilehto, J., Uitterlinden, A. G., Voight, B. F., Waterworth, D., Wichmann, H-E., Willemsen, G., Witteman, J. C. M., Yuan, X., Zha, J. H., Zeggini, E., Schlessinger, D., Sandhu, M., Boomsma, D. I., Uda, M., Spector, T. D., Penninx, B. W. J. H., Altshuler, D., Vollenweider, P., Jarvelin, M-R., Lakatta, E., Waeber, G., Fox, C. S., Peltonen, L., Groop, L. C., Mooser, V., Cupples, L. A., Thorsteinsdottir, U. & Abecasis, G. R., 2009, In : Nature Genetics. 41, 1, p. 77-81

Research output: Contribution to JournalArticleAcademicpeer-review

File
Melatonin MT2 Receptor
Fasting
Glucose
HapMap Project
Genetic Loci

Vitamin D receptor gene polymorphisms have negligible effect on human height.

Macgregor, S., Hottenga, J. J., Lind, P. A., Suchiman, E., Willemsen, G., Slagboom, P. E., Montgomery, GW., Martin, N. G., Visscher, P. M. & Boomsma, D. I., 2008, In : Twin Research and Human Genetics. 11, 5, p. 488-494

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Calcitriol Receptors
Meta-Analysis
Genes
Physiological Phenomena
Vitamin D

WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

Genome of the Netherlands Consortium, Abdellaoui, A., Hottenga, J. J., Kattenberg, M., Willemsen, G. & Boomsma, D. I., 10 Dec 2019, In : Scientific Reports. 9, 1, p. 18758

Research output: Contribution to JournalArticleAcademicpeer-review

Telomere
Genes
Fathers
Heritable Quantitative Trait
Maternal Inheritance