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Research Output 2004 2020

Article

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Fall, T., Hägg, S., Mägi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A. P., Thorleifsson, G., Ladenvall, C., Kals, M., Kuningas, M., Draisma, H. H. M., Ried, J. S., van Zuydam, N. R., Huikari, V., Mangino, M., Sonestedt, E., Benyamin, B., Nelson, C. P., Rivera, N. V. & 105 othersKristiansson, K., Shen, H. Y., Havulinna, A. S., Dehghan, A., Donnelly, L. A., Kaakinen, M., Nuotio, M. L., Robertson, N., de Bruijn, R. F., Ikram, M. A., Amin, N., Balmforth, A. J., Braund, P. S., Doney, A. S. F., Döring, A., Elliott, P., Esko, T., Franco, O. H., Gretarsdottir, S., Hartikainen, A. L., Heikkilä, K., Herzig, K. H., Holm, H., Hottenga, J. J., Hyppönen, E., Illig, T., Isaacs, A., Isomaa, B., Karssen, L. C., Kettunen, J., Koenig, W., Kuulasmaa, K., Laatikainen, T., Laitinen, J., Lindgren, C. M., Lyssenko, V., Läärä, E., Rayner, N. W., Männistö, S., Pouta, A., Rathmann, W., Rivadeneira, F., Ruokonen, A., Savolainen, M. J., Sijbrands, E. J., Small, K. S., Smit, J. H., Steinthorsdottir, V., Syvänen, A. C., Taanila, A., Tobin, M. D., Uitterlinden, A. G., Willems, S. M., Willemsen, G., Witteman, J., Perola, M., Evans, A., Ferrières, J., Virtamo, J., Kee, F., Tregouet, D. A., Arveiler, D., Amouyel, P., Ferrario, M. M., Brambilla, P., Hall, A. S., Heath, A. C., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Whitfield, J. B., Jula, A., Knekt, P., Oostra, B. A., van Duijn, C. M., Penninx, B. W. J. H., Davey Smith, G., Kaprio, J., Samani, N. J., Gieger, C., Peters, A., Wichmann, H. E., Boomsma, D. I., de Geus, E. J. C., Tuomi, T., Power, C., Hammond, C. J., Spector, T. D., Lind, L., Orho-Melander, M., Palmer, C. N. A., Morris, A. D., Groop, L., Järvelin, M. R., Salomaa, V., Vartiainen, E., Hofman, A., Ripatti, S., Metspalu, A., Thorsteinsdottir, U., Stefansson, K., Pedersen, N. L., McCarthy, M. I., Ingelsson, E. & Prokopenko, I., 2013, In : PLoS Medicine. 10, 6, p. e1001474 e1001474.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mendelian Randomization Analysis
Adiposity
Body Mass Index
Random Allocation
Type 2 Diabetes Mellitus
Serotonin Plasma Membrane Transport Proteins
Depression
Genes
Meta-Analysis
Neuroticism

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Hottenga, J. J., de Geus, E. J. C., Martin, N. G., Peltonen, L., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Loos, S. A., Montgomery, GW., Ridker, P. M. & 9 othersSpector, T. D., Streeten, E. A., Stefansson, K., Thorsteinsdottir, U., Uitterlinden, A. G., Widen, E., Murabito, J. M., Ong, K. K. & Murray, A., 2010, In : Nature Genetics. 42, 12, p. 1077-1085

Research output: Contribution to JournalArticleAcademicpeer-review

Menarche
Genome-Wide Association Study
Meta-Analysis
Genes
Biological Phenomena

Twins, Tissue, and Time: An Assessment of SNPs and CNVs

Scheet, P., Ehli, E. A., Xiao, X., van Beijsterveldt, C. E. M., Abdellaoui, A., Althoff, R. R., Hottenga, J. J., Willemsen, G., Nelson, K. A., Huizenga, P. E., Hu, Y., Amos, C. I., Bartels, M., Groen-Blokhuis, M. M., de Geus, E. J. C., Hudziak, J. J., Davies, G. E. & Boomsma, D. I., 2012, In : Twin Research and Human Genetics. 15, 6, p. 737-745

Research output: Contribution to JournalArticleAcademicpeer-review

Cheek
Single Nucleotide Polymorphism
DNA
Genotype
Monozygotic Twins

Using a multivariate model to assess the interactive effects of demographics and lifestyle on the hematological profile

McArtor, D. B., Lin, B. D., Hottenga, J-J., Boomsma, D. I., Willemsen, G. & Lubke, G. H., 1 Jun 2017, In : Biomarkers in medicine. 11, 6, p. 427-438 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Biomarkers
Linear regression
Life Style
Linear Models
Demography

Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders

Verduijn, J., Milaneschi, Y., Peyrot, W. J., Hottenga, J. J., Abdellaoui, A., de Geus, E. J. C., Smit, J. H., Breen, G., Lewis, C. M., Boomsma, D. I., Beekman, A. T. F. & Penninx, B. W. J. H., 15 Feb 2017, In : Biological Psychiatry. 81, 4, p. 316-324 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Load
Major Depressive Disorder
Psychiatry
Schizophrenia
Bipolar Disorder

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Freathy, R. M., Mook-Kanamori, D. O., Sovio, U., Prokopenko, I., Timpson, N. J., Berry, D. J., Warrington, N. M., Widen, E., Hottenga, J. J., Kaakinen, M., Lange, L. A., Bradfield, J. P., Kerkhof, M., Marsh, J. A., Mägi, R., Chen, C. M., Lyon, H. N., Kirin, M., Adair, L. S., Aulchenko, Y. S. & 63 othersBennett, A. J., Borja, J. B., Bouatia-Naji, N., Charoen, P., Coin, L. J. M., Cousminer, D. L., de Geus, E. J. C., Deloukas, P., Elliott, P., Evans, D. M., Froguel, P., Glaser, B., Groves, C. J., Hartikainen, A-L., Hassanali, N., Hirschhorn, J. N., Hofman, A., Holly, J. M. P., Hyppönen, E., Kanoni, S., Knight, B. A., Laitinen, J., Lindgren, C. M., McArdle, W. L., O'Reilly, P. F., Pennell, C. E., Postma, D. S., Pouta, A., Ramasamy, A., Rayner, N. W., Ring, S. M., Rivadeneira, F., Shields, B. M., Strachan, D. P., Surakka, I., Taanila, A., Tiesler, C., Uitterlinden, A. G., van Duijn, C. M., Wijga, A. H., Willemsen, G., Zhang, H., Zhao, J., Wilson, J. F., Steegers, E. A. P., Hattersley, A. T., Eriksson, J. G., Peltonen, L., Mohlke, K. L., Grant, S. F. A., Hakonarson, H., Koppelman, G. H., Dedoussis, G. V., Heinrich, J., Gillman, M. W., Palmer, L. J., Frayling, T. M., Boomsma, D. I., Smith, G. D., Power, C., Jaddoe, V. W. V., Jarvelin, M-R. & McCarthy, M. I., 2010, In : Nature Genetics. 42, 5, p. 430-435

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Fetal Weight
Fetal Development
Birth Weight
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism

Variants in MTNR1B influence fasting glucose levels

Prokopenko, I., Langenberg, C., Florez, J. C., Saxena, R., Soranzo, N., Thorleifsson, G., Loos, R. J. F., Manning, A. K., Jackson, A. U., Aulchenko, Y. S., Potter, S. C., Erdos, M. R., Sanna, S., Hottenga, J. J., Wheeler, E., Kaakinen, M., Lyssenko, V., Chen, W-M., Ahmadi, K., Beckmann, J. S. & 79 othersBergman, R. N., Bochud, M., Bonnycastle, L. L., Buchanan, T. A., Cao, A., Cervin, A., Coin, L., Collins, F. S., Crisponi, L., de Geus, E. J. C., Dehghan, A., Deloukas, P., Doney, A. S. F., Elliott, P., Freimer, N. B., Gateva, V., Herder, C., Hofman, A., Hughes, T. E., Hunt, S., Illig, T., Inouye, M., Isomaa, B., Johnson, T., Kong, A., Krestyaninova, M., Kuusisto, J., Laaks, M., Lim, N., Lindblad, U., Lindgren, C. M., McCann, O. T., Mohlke, K. L., Morris, A. D., Naitza, S., Orrù, M., Palmer, C. N. A., Pouta, A., Randall, J., Rathmann, W., Saramies, J., Scheet, P., Scott, L. J., Scuteri, A., Sharp, S., Sijbrands, E. J. G., Smit, J. H., Song, K., Steinthorsdottir, V., Stringham, H. M., Tuomi, T., Tuomilehto, J., Uitterlinden, A. G., Voight, B. F., Waterworth, D., Wichmann, H-E., Willemsen, G., Witteman, J. C. M., Yuan, X., Zha, J. H., Zeggini, E., Schlessinger, D., Sandhu, M., Boomsma, D. I., Uda, M., Spector, T. D., Penninx, B. W. J. H., Altshuler, D., Vollenweider, P., Jarvelin, M-R., Lakatta, E., Waeber, G., Fox, C. S., Peltonen, L., Groop, L. C., Mooser, V., Cupples, L. A., Thorsteinsdottir, U. & Abecasis, G. R., 2009, In : Nature Genetics. 41, 1, p. 77-81

Research output: Contribution to JournalArticleAcademicpeer-review

File
Melatonin MT2 Receptor
Fasting
Glucose
HapMap Project
Genetic Loci

Vitamin D receptor gene polymorphisms have negligible effect on human height.

Macgregor, S., Hottenga, J. J., Lind, P. A., Suchiman, E., Willemsen, G., Slagboom, P. E., Montgomery, GW., Martin, N. G., Visscher, P. M. & Boomsma, D. I., 2008, In : Twin Research and Human Genetics. 11, 5, p. 488-494

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Calcitriol Receptors
Meta-Analysis
Genes
Physiological Phenomena
Vitamin D

WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

Genome of the Netherlands Consortium, Abdellaoui, A., Hottenga, J. J., Kattenberg, M., Willemsen, G. & Boomsma, D. I., 10 Dec 2019, In : Scientific Reports. 9, 1, p. 18758

Research output: Contribution to JournalArticleAcademicpeer-review

Telomere
Genes
Fathers
Heritable Quantitative Trait
Maternal Inheritance
Comment / Letter to the editor
Erratum

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program, Dec 2018, In : Nature Genetics. 50, 12, p. 1755-1755 1 p.

Research output: Contribution to JournalErratumAcademic

Letter

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

23Andme Research Team & HUNT All-In Psychiatry, Feb 2019, In : Nature Genetics. 51, 2, p. 237-244 8 p.

Research output: Contribution to JournalLetterAcademicpeer-review

Tobacco Use
Alcohols
Tobacco Use Cessation
Genetic Association Studies
Synaptic Transmission
Meeting Abstract

A genome-wide association study for self-rated health

Bartels, M., Vink, J. M., de Moor, M. H. M., Hottenga, J. J., de Geus, E. J. C., Smit, J. H., Willemsen, G., Penninx, B. W. J. H. & Boomsma, D. I., 2010, In : Behavior Genetics. 40, 6, p. 785

Research output: Contribution to JournalMeeting AbstractOther research output

A genome-wide association study for subjective wellbeing

Bartels, M., de Geus, E. J. C., Groen-Blokhuis, M. M., de Moor, M. H. M., van Beijsterveldt, C. E. M., Hottenga, J. J., Ehli, E. A., Davies, G., Xiang, X., Scheet, P., Hudziak, J. J. & Boomsma, D. I., 2011, In : Behavior Genetics. 41, 6, p. 892

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access
File

A genome-wide linkage scan for wellbeing.

Bartels, M., de Moor, M. H. M., Willemsen, G., Hottenga, J. J., Posthuma, D., Hudziak, J., Boomsma, D. I. & de Geus, E. J. C., 2008, In : Behavior Genetics. 38, p. 614-615

Research output: Contribution to JournalMeeting AbstractOther research output

Assortative mating for obsessive-compulsive behavior in a population-based sample.

van Grootheest, D. S., van den Berg, S. M., Hottenga, J. J., Cath, D. C. & Boomsma, D. I., 2006, In : American Journal of Human Genetics. 141B, p. 739

Research output: Contribution to JournalMeeting AbstractOther research output

Can the comorbidity of physical inactivity and cardiovascular risk factors help us find genes?

de Geus, E. J. C., Willemsen, A. H. M., Posthuma, D., Hottenga, J. J., Kupper, H. M., Stubbe, J. H., Vink, J. M. & Boomsma, D. I., 2004, In : Twin Research. 7, 6, p. 682

Research output: Contribution to JournalMeeting AbstractOther research output

Genetic association tests of RGS genes on chromosome 1q for depression and correlated traits in the Netherlands Twin-family Study of Anxious Depression (NETSAD)

Boomsma, D. I., Beem, A. L., Willemsen, A. H. M., Hottenga, J. J., de Geus, J. C. N., Middeldorp, C. M., Sullivan, P. F., Suchiman, E., Lakenberg, N. & Slagboom, P. E., 2005, In : Behavior Genetics. 35, 6, p. 794-795

Research output: Contribution to JournalMeeting AbstractOther research output

Genetic contribution to blood pressure: heritability and linkage results from Dutch twin and sibling pairs.

Hottenga, J. J., de Geus, E. J. C., Willemsen, A. H. M., Snieder, H., Kupper, H. M., van den Berg, M., Beem, A. L., Heijmans, B. T., Beekman, M., Slagboom, P. E., Posthuma, D. & Boomsma, D. I., 2004, In : Genetic Epidemiology. 27, 3, p. 275

Research output: Contribution to JournalMeeting AbstractOther research output

Genome-wide association study of attention problems and ADHD in adults

Boomsma, D. I., Hottenga, J. J., Distel, M. A., de Moor, M. H. M., de Geus, E. J. C. & Willemsen, G., 2009, In : Behavior Genetics. 39, p. 637

Research output: Contribution to JournalMeeting AbstractOther research output

Genome-wide linkage and association study of ADHD in adults

Boomsma, D. I., Savyuk, V., Hottenga, J. J., de Geus, E. J. C. & Willemsen, G., 2010, In : Behavior Genetics. 40, 6, p. 788

Research output: Contribution to JournalMeeting AbstractOther research output

Genome-wide pleiotropy of adult aggression and blood metabolites

Hagenbeek, F. A., Nivard, M. G., Pool, R., van Dongen, J., Hottenga, J. J., Abdellaoui, A., Willemsen, G., Vink, J. M., Ligthart, R. S. L., Harms, A., Hankemeier, T., Bartels, M. & Boomsma, D. I., 2016, In : Behavior Genetics. 46, 6, p. 772-816

Research output: Contribution to JournalMeeting AbstractOther research output

Heritability of head size in Dutch and Australian twin families at ages 5–50 years

Boomsma, D. I., Bartels, M., van Beijsterveldt, C. E. M., Luciano, M., de Geus, E. J. C., Posthuma, D., Hottenga, J. J., Hoekstra, R. A., van Burk-Estourgie, G. F., Delemarre-van de Waal, H. A. & Martin, N. G., 2007, In : Behavior Genetics. 37, p. 740-741

Research output: Contribution to JournalMeeting AbstractOther research output

Is PLXNA2 a candidate gene for childhood and adult anxiety and depression?

Boomsma, D. I., Middeldorp, C. M., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., Bartels, M., Hudziak, J., Slof-Op 't Landt, M. C. T., Meulenbelt, I., Suchiman, E. & Slagboom, P. E., 2007, In : American Journal of Human Genetics.

Research output: Contribution to JournalMeeting AbstractOther research output

Meta-analysis of genome-wide association results in >10.000 individuals for the big five personality traits

de Moor, M. H. M., Boomsma, D. I., de Geus, E. J. C., Willemsen, G., Hottenga, J. J., Distel, M. A., Abecasis, G. R., Terracciano, A., McCrae, R. R., Costa, P. T., Hartman, C. A., Spinhoven, P., Penninx, B. W. J. H., Esko, T., Allik, J., Realo, A., Metspalu, A., Hansell, N., Medland, S. E., Wray, N. R. & 7 othersWright, M. J., Martin, N. G., Amin, N., Aulchenko, Y. S., Janssens, A., Oostra, B. A. & van Duijn, C. M., 2009, In : Behavior Genetics. 39, p. 643

Research output: Contribution to JournalMeeting AbstractOther research output

Meta-analysis of genome wide association studies on heart rate variability

Nolte, I., Tragante do Ó, V., Whitsel, E., Kerr, K., Penninx, B. W. J. H., Oldehinkel, A., Bis, J., Hottenga, J. J., Dierckx, B., Lefrandt, J., Magnani, J., Gieger, C., Riese, H., Heckbert, S., Snieder, H. & de Geus, E. J. C., 2011, In : Behavior Genetics. 41, 6, p. 927

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access
File

Multivariate and repeated measure GWAS of aggression phenotypes

Nivard, M., Middeldorp, C., Hottenga, J-J., Fedko, I., Ehli, E. A., Davies, G., van Beijsterveldt, C., Bartels, M. & Boomsma, D., Nov 2016, In : Behavior Genetics. 46, 6, p. 798-799

Research output: Contribution to JournalMeeting AbstractOther research output

Qualitative and quantitative sex differences in genetic architecture for human phenotypes

Boomsma, D. I., Bartels, M., van Beijsterveldt, C. E. M., Distel, M. A., Smit, D. J. A., de Moor, M. H. M., Middeldorp, M., Ligthart, R. S. L., Willemsen, G., Hottenga, J. J., de Geus, E. J. C. & Vink, J. M., 2011, In : Behavior Genetics. 41, 6, p. 894-895

Research output: Contribution to JournalMeeting AbstractOther research output

Open Access
File

Significant linkage on chromosome 14 for anxiety.

Middeldorp, C. M., Hottenga, J. J., Slagboom, P. E., Sullivan, P. F., Beem, A. L., Willemsen, G. & Boomsma, D. I., 2006, In : American Journal of Human Genetics. 141B, p. 725

Research output: Contribution to JournalMeeting AbstractOther research output

Smoking initiation and persistence: First results for genome-wide association analyses in Dutch adults.

Boomsma, D. I., Vink, J. M., Sullivan, P. F., Smit, J. H., Hoogendijk, W. J. G., Hottenga, J. J., Willemsen, G., de Geus, E. J. C. & Penninx, B. W. J. H., 2008, In : Behavior Genetics. 38, p. 615-616

Research output: Contribution to JournalMeeting AbstractOther research output

The vitamin D receptor gene is not strongly associated with stature: Results from The Netherlands Twin Register

Hottenga, J. J., Suchiman, E., Willemsen, G., Slagboom, P. E. & Boomsma, D. I., 2007, In : Behavior Genetics. 37, p. 763

Research output: Contribution to JournalMeeting AbstractOther research output

PhD Thesis - Research VU, graduation VU

Behavior - Genetics

Abdellaoui, A., 2014, Amsterdam. 260 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Computational approaches in genetics with a focus on GoNL and twin studies

Fedko, I. O., 2016

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
Twin Studies

Using genetic methods to get insight into human complex traits

Lin, B., 2017, 206 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
Poster

Clustering of subjects on subsets of SNPs

Meulman, J. J., de Geus, E. J. C., Willemsen, G., Hottenga, J. J., Sullivan, P. F., Smit, J. H., Penninx, B. W. J. H. & Boomsma, D. I., 2008.

Research output: Contribution to ConferencePosterOther research output

CNVs & attention problems in MZ twin pairs

Abdellaoui, A., Elhi, E., Hottenga, J. J., Hudziak, J. J., Davies, G. & Boomsma, D. I., 2011.

Research output: Contribution to ConferencePosterOther research output

Collaborative projects making use of the MDD – GAIN data

Hottenga, J. J., Willemsen, G., Vink, J. M., Posthuma, D., de Moor, M. H. M., Ligthart, R. S. L., Smit, D. J. A., de Geus, E. J. C. & Boomsma, D. I., 2008.

Research output: Contribution to ConferencePosterOther research output

Design and implementation of a customized genotyping array for imputation-based genome-wide association studies: the Avera-NTR Global Screening Array

Beck, J. J., Ehli, E. A., مبارك, ., Kallsen, N., Peyton, S., Abdellaoui, A., Fedko, I. O., Willemsen, G., de Geus, E., Boomsma, D. I., Davies, G. E. & Hottenga, J. J., 6 Mar 2017.

Research output: Contribution to ConferencePosterOther research output

Open Access

Genome Wide Association analysis for Borderline Personality Disorder Characteristics

Hottenga, J. J., Distel, M. A., Willemsen, G., Trull, T. J., Sullivan, P. F., de Geus, E. J. C. & Boomsma, D. I., 2008.

Research output: Contribution to ConferencePosterOther research output

Genome-wide complex trait analysis (gcta) for complex traits including major depressive disorder and smoking

Boomsma, D. I., Hottenga, J. J., Walters, R., Laurin, C., de Geus, E. J. C., Willemsen, G., Smit, J. H., Middeldorp, C. M., Penninx, B. W. J. H., Vink, J. M. & Lubke, G. H., 2011.

Research output: Contribution to ConferencePosterOther research output

Heritability and stability of resting blood pressure

Hottenga, J. J., 2005.

Research output: Contribution to ConferencePosterOther research output

Smoking initiation and persistence: First results for genome-wide association analyses in Dutch adults

Vink, J. M., Sullivan, P. F., Smit, J. A., Hoogendijk, W. J. G., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Penninx, B. W. J. H. & Boomsma, D. I., 2008.

Research output: Contribution to ConferencePosterOther research output

The Netherlands Twin Register Axiom Biobank platform for GWAS

Hottenga, J. J., 2015.

Research output: Contribution to ConferencePosterOther research output

Trends in genome wide association results of multiple phenotypes

Hottenga, J. J., 2009.

Research output: Contribution to ConferencePosterOther research output