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2015

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., Paynter, N., Monda, K. L., Amin, N., Fischer, K., Renstrom, F., Ngwa, J. S., Huikari, V., Cavadino, A., Nolte, I. M., Teumer, A., Yu, K., Marques-Vidal, P., Rawal, R., Manichaikul, A., Wojczynski, M. K. & 134 others, Vink, J. M., Zhao, J. H., Burlutsky, G., Lahti, J., Mikkilä, V., Lemaitre, R. N., Eriksson, J., Musani, S. K., Tanaka, T., Geller, F., Luan, J., Hui, J., Mägi, R., Dimitriou, M., Garcia, M. E., Ho, W. K., Wright, M. J., Rose, L. M., Magnusson, P. K. E., Pedersen, N. L., Couper, D., Oostra, B. A., Hofman, A., Ikram, M. A., Tiemeier, H., Uitterlinden, A. G., van Rooij, F. J. A., Barroso, I., Johansson, I., Xue, L., Kaakinen, M., Milani, L., Power, C., Snieder, H., Stolk, R. P., Baumeister, S. E., Biffar, R., Gu, F., Bastardot, F., Kutalik, Z., Jacobs, D. R., Forouhi, N. G., Mihailov, E., Lind, L., Lindgren, C., Michaëlsson, K., Morris, A., Jensen, M., Khaw, K. T., Luben, R. N., Wang, J. J., Männisto, S., Perälä, M. M., Kähönen, M., Lehtimäki, T., Viikari, J., Mozaffarian, D., Mukamal, K., Psaty, B. M., Döring, A., Heath, A. C., Montgomery, G. W., Dahmen, N., Carithers, T., Tucker, K. L., Ferrucci, L., Boyd, H. A., Melbye, M., Treur, J. L., Mellström, D., Hottenga, J. J., Prokopenko, I., Tönjes, A., Deloukas, P., Kanoni, S., Lorentzon, M., Houston, D. K., Liu, Y., Danesh, J., Rasheed, A., Mason, M. A., Zonderman, A. B., Franke, L., Kristal, B. S., Karjalainen, J., Reed, D. R., Westra, H. J., Evans, M. K., Saleheen, D., Harris, T. B., Dedoussis, G., Curhan, G., Stumvoll, M., Beilby, J., Pasquale, L. R., Feenstra, B., Bandinelli, S., Ordovas, J. M., Chan, A. T., Peters, U., Ohlsson, C., Gieger, C., Martin, N. G., Waldenberger, M., Siscovick, D. S., Raitakari, O., Eriksson, J. G., Mitchell, P., Hunter, D. J., Kraft, P., Rimm, E. B., Boomsma, D. I., Borecki, I. B., Loos, R. J. F., Wareham, N. J., Vollenweider, P., Caporaso, N., Grabe, H. J., Neuhouser, M. L., Wolffenbuttel, B. H. R., Hu, F. B., Hyppönen, E., Järvelin, M. R., Cupples, L. A., Franks, P. W., Ridker, P. M., van Duijn, C. M., Heiss, G., Metspalu, A., North, K. E., Ingelsson, E., Nettleton, J. A., van Dam, R. M. & Chasman, D. I., 2015, In : Molecular Psychiatry. 20, 5, p. 647-656 10 p.

Research output: Contribution to JournalArticle

Genome-wide patterns and properties of de novo mutations in humans

Francioli, L. C., Polak, P. P., Koren, A., Menelaou, A., Chun, S., Renkens, I., van Duijn, C. M., Swertz, M. A., Wijmenga, C., van Ommen, G. J., Slagboom, P. E., Boomsma, D. I., Ye, K., Guryev, V., Arndt, P. F., Kloosterman, W. P., Bakker, P. I. W., Sunyaev, S. R., Dijk, F., Neerincx, P. B. T. & 68 others, Pulit, S. L., Deelen, P., Elbers, C. C., Palamara, P. F., Pe'er, I., Abdellaoui, A., van Oven, M., Vermaat, M., Li, M., Laros, J. F. J., Stoneking, M., de Knijff, P., Kayser, M., Veldink, J. H., Van den Berg, L. H., Byelas, H., den Dunnen, J. T., Dijkstra, M., Amin, N., van der Velde, K. J., Hottenga, J. J., van Setten, J., van Leeuwen, E. M., Kanterakis, A., Kattenberg, V. M., Karssen, L. C., van Schaik, B. D. C., Bot, J., Nijman, I. J., van Enckevort, D., Mei, H., Koval, V., Estrada, K., Medina-Gomez, C., Lameijer, E. W., Moed, M. H., Hehir-Kwa, J. Y., Handsaker, R. E., McCarroll, S. A., Vuzman, D., Sohail, M., Hormozdiari, F., Marschall, T., Schönhuth, A., Beekman, M., de Craen, A. J., Suchiman, H. E. D., Hofman, A., Oostra, B., Isaacs, A., Rivadeneira, F., Uitterlinden, A. G., Willemsen, G., Platteel, M., Pitts, S. J., Potluri, S., Sundar, P., Cox, D. R., Li, Q., Li, Y., Du, Y., Chen, R., Cao, H., Li, N., Cao, S., Wang, J., Bovenberg, J. A. & Brandsma, M., 2015, In : Nature Genetics. 47, 7, p. 822-826 5 p.

Research output: Contribution to JournalArticle

Open Access

Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset

Minica, C. C., Dolan, C. V., Hottenga, J. J., Pool, R., Fedko, I. O., Mbarek, H., Huppertz, C., Bartels, M., Boomsma, D. I. & Vink, J. M., 2015, In : Behavior Genetics. 45, 5, p. 503-513 11 p.

Research output: Contribution to JournalArticle

Open Access
Open Access

Heritability of liver enzyme levels estimated from genome-wide SNP data

van Beek, J. H. D. A., Lubke, G. H., de Moor, M. H. M., Willemsen, G., de Geus, E. J. C., Hottenga, J. J., Walters, R. K., Smit, J. H., Penninx, B. W. J. H. & Boomsma, D. I., 2015, In : European Journal of Human Genetics. 23, 9, p. 1223-1228 6 p.

Research output: Contribution to JournalArticle

Open Access

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

Shah, S., Bonder, M. J., Marioni, R. E., Zhu, Z., McRae, A. F., Zhernakova, A., Harris, S. E., Liewald, D. C. M., Henders, A. K., Mendelson, M. M., Liu, C., Joehanes, R., Liang, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Levy, D., Martin, N. G., Starr, J. M. & 7 others, Wijmenga, C., Wray, N. R., Yang, J., Montgomery, G. W., Franke, L., Deary, I. J. & Visscher, P. M., 2015, In : American Journal of Human Genetics. 97, 1, p. 75-85 11 p.

Research output: Contribution to JournalArticle

Open Access

In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons

Vaez, A., Jansen, R., Prins, B. P., Hottenga, J. J., de Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Nolte, I. M., Snieder, H. & Alizadeh, BZ., 2015, In : Circulation-cardiovascular genetics. 8, 3, p. 487-497 11 p.

Research output: Contribution to JournalArticle

Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait

Franic, S., Blokhuis, M. M., Dolan, C. V., Kattenberg, V. M., Pool, R., Xiao, X., Scheet, P., Ehli, E. A., Davies, G. E., van der Sluis, S., Abdellaoui, A., Hansell, N. K., Martin, N. G., Hudziak, J. J., van Beijsterveldt, C. E. M., Swagerman, S. C., Hulshoff Pol, H. E., de Geus, E. J. C., Bartels, M., Ropers, H-H. & 2 others, Hottenga, J. J. & Boomsma, D. I., 2015, In : European Journal of Human Genetics. 23, 10, p. 1378-1383 6 p.

Research output: Contribution to JournalArticle

Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

Maier, R., Moser, G., Chen, G. B., Ripke, S., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Coryell, W. H., Potash, J. B., Scheftner, W. A., Shi, J., Weissmann, M. M., Hultman, C. M., Landén, M., Levinson, D. F., Kendler, K. S., Smoller, J. W., Wray, N. R. & 1 others, Lee, S. H., 2015, In : American Journal of Human Genetics. 96, 2, p. 283-294 12 p.

Research output: Contribution to JournalArticle

Open Access

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Day, F. R., Ruth, K. S., Thompson, D. J., Lunetta, K. L., Pervjakova, N., Chasman, D. I., Stolk, L., Finucane, H. K., Sulem, P., Bulik-Sullivan, B. K., Esko, T., Johnson, A. D., Elks, C. E., Franceschini, N., He, C., Altmaier, E., Brody, J. A., Franke, L. L., Huffman, J. E., Keller, M. F. & 221 others, McArdle, P. F., Nutile, T., Porcu, E., Robino, A., Rose, L. M., Schick, U. M., Smith, J. A., Teumer, A., Traglia, M., Vuckovic, D., Yao, J., Zhao, W., Albrecht, E., Amin, N., Corre, T., Hottenga, J. J., Mangino, M., Smith, A. V., Tanaka, T., Abecasis, G. R., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C., Arndt, V., Arnold, A. M., Barbieri, C., Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bernstein, L., Bielinski, S. J., Blomqvist, C., Boerwinkle, E., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Borresen-Dale, A. L., Boutin, T. S., Brauch, H., Brenner, H., Brüning, T., Burwinkel, B., Campbell, A., Campbell, H., Chanock, S. J., Chapman, J. R., Ida Chen, Y. D., Chenevix-Trench, G., Couch, F. J., Coviello, A. D., Cox, A., Czene, K., Darabi, H., De Vivo, I., Demerath, E. W., Dennis, J., Devilee, P., Dörk, T., dos-Santos-Silva, I., Dunning, A. M., Eicher, J. D., Fasching, P. A., Faul, J. D., Figueroa, J., Flesch-Janys, D., Gandin, I., Garcia, M. E., García-Closas, M., Giles, G. G., Girotto, G. G., Goldberg, M. S., González-Neira, A., Goodarzi, M. O., Grove, M. L., Gudbjartsson, D. F., Guénel, P., Guo, X., Haiman, C. A., Hall, P., Hamann, U., Henderson, B. E., Hocking, L. J., Hofman, A., Homuth, G., Hooning, M. J., Hopper, J. L., Hu, F. B., Huang, J., Humphreys, K., Hunter, D. J., Jakubowska, A., Jones, S. E., Kabisch, M., Karasik, D., Knight, J. A., Kolcic, I., Kooperberg, C., Kosma, V. M., Kriebel, J., Kristensen, V., Lambrechts, D., Langenberg, C., Li, J., Li, X., Lindström, S., Liu, Y., Luan, J., Lubinski, J., Mägi, R., Mannermaa, A., Manz, J., Margolin, S., Marten, J., Martin, N. G., Masciullo, C., Meindl, A., Michailidou, K., Mihailov, E., Milani, L., Milne, R. L., Müller-Nurasyid, M., Nalls, M., Neale, B. M., Nevanlinna, H., Neven, P., Newman, A. B., Nordestgaard, B. G., Olson, J. E., Padmanabhan, S., Peterlongo, P., Peters, U., Petersmann, A., Peto, J., Pharoah, P. D. P., Pirastu, N. N., Pirie, A., Pistis, G., Polasek, O., Porteous, D., Psaty, B. M., Pylkäs, K., Radice, P., Raffel, L. J., Rivadeneira, F., Rudan, I., Rudolph, A., Ruggiero, D., Sala, C. F., Sanna, S., Sawyer, E. J., Schlessinger, D., Schmidt, M. K., Schmidt, F., Schmutzler, R. K., Schoemaker, M. J., Scott, R. A., Seynaeve, C. M., Simard, J., Sorice, R., Southey, M. C., Stöckl, D., Strauch, K., Swerdlow, A., Taylor, K. D., Thorsteinsdottir, U., Toland, A. E., Tomlinson, I., Truong, T., Tryggvadottir, L., Turner, S. T., Vozzi, D., Wang, Q., Wellons, M., Willemsen, G., Wilson, J. F., Winqvist, R., Wolffenbuttel, B. H. R., Wright, A. F., Yannoukakos, D., Zemunik, T., Zheng, W., Zygmunt, M., Bergmann, S., Boomsma, D. I., Buring, J. E., Ferrucci, L., Montgomery, G. W., Gudnason, V., Spector, T. D., van Duijn, C. M., Alizadeh, BZ., Ciullo, M., Crisponi, L., Easton, D. F., Gasparini, P. P., Gieger, C., Harris, T. B., Hayward, C., Kardia, S. L. R., Kraft, P., McKnight, B., Metspalu, A., Morrison, A. C., Reiner, A. P., Ridker, P. M., Rotter, J. I., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Völzke, H., Wareham, N. J., Weir, D. R., Yerges-Armstrong, L. M., Price, A. L., Stefansson, K., Visser, J. A., Ong, K. K., Chang-Claude, J., Murabito, J. M. M., Perry, J. R. B. & Murray, A., 2015, In : Nature Genetics. 47, 11, p. 1294-1303 12 p.

Research output: Contribution to JournalArticle

Open Access

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

de Moor, M. H. M., van den Berg, S. M., Verweij, C. J. H., Krueger, R. F., Luciano, M., Arias-Vasquez, A., Matteson, L. K., Derringer, J., Esko, T., Amin, N., Gordon, S. D., Hansell, N. K., Hart, A. B., Seppälä, I., Huffman, J. E., Konte, B., Lahti, J., Lee, M. Y., Miller, M., Nutile, T. & 98 others, Tanaka, T., Teumer, A., Viktorin, A., Wedenoja, J., Abecasis, G. R., Adkins, D. E., Agrawal, A., Allik, J., Appel, K., Bigdeli, T. B., Busonero, F., Campbell, H., Costa, P. T., Davey Smith, G., Davies, G., de Wit, H., Ding, J., Engelhardt, B. E., Eriksson, J. G., Fedko, I. O., Ferrucci, L., Franke, B., Giegling, I., Grucza, R., Hartmann, A. M., Heath, A. C., Heinonen, K., Henders, A. K., Homuth, G., Hottenga, J. J., Iacono, W. G., Janzing, J., Jokela, M., Karlsson, R., Kemp, J. P., Kirkpatrick, M. G., Latvala, A., Lehtimäki, T., Liewald, D. C., Madden, P. A. F., Magri, C., Magnusson, P. K. E., Marten, J., Maschio, A., Medland, S. E., Mihailov, E., Milaneschi, Y., Montgomery, G. W., Nauck, M., Ouwens, K. G., Palotie, A., Pettersson, E., Polasek, O., Qian, Y., Pulkki-Råback, L., Raitakari, O. T., Realo, A., Rose, R. J., Ruggiero, D., Schmidt, C. O., Slutske, W. S., Sorice, R., Starr, J. M., St Pourcain, B., Sutin, A. R., Timpson, N. J., Trochet, H., Vermeulen, S., Vuoksimaa, E., Widén, E., Wouda, J., Wright, M. J., Zgaga, L., Porteous, D., Minelli, A., Palmer, A. A., Rujescu, D., Ciullo, M., Hayward, C., Rudan, I., Metspalu, A., Kaprio, J., Deary, I. J., Räikkönen, K., Wilson, J. F., Keltikangas-Järvinen, L., Bierut, L. J., Hettema, J. M., Grabe, H. J., van Duijn, C. M., Evans, D. M., Schlessinger, D., Pedersen, N. L., Terracciano, A., McGue, M., Penninx, B. W. J. H., Martin, N. G. & Boomsma, D. I., 2015, In : JAMA Psychiatry. 72, 7, p. 642-650 9 p.

Research output: Contribution to JournalArticle

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bonnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C., Thyssen, J. P., den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., Marenholz, I. & 130 others, Kalb, B., Pino-Yanes, M., Xu, C., Carstensen, L., Groen-Blokhuis, M. M., Venturini, C., Pennell, C. E., Barton, S. J., Levin, A. M., Curjuric, I., Bustamante, M., Kreiner-Moller, E., Lockett, G. A., Bacelis, J., Bunyavanich, S., Myers, R. A., Matanovic, A., Kumar, A., Tung, J. Y., Hirota, T., Kubo, M., McArdle, W. L., Henderson, A. J., Kemp, J. P., Zheng, J., Smith, G. D., Rueschendorf, F., Bauerfeind, A., Lee-Kirsch, M. A., Arnold, A., Homuth, G., Schmidt, C. O., Mangold, E., Cichon, S., Keil, T., Rodriguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Foelster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L. L., Grarup, N., de Jongste, J. C., Rivadeneira, F., Hofman, A., Jaddoe, V. W. V., Pasmans, S. G. M. A., Elbert, N. J., Uitterlinden, A. G., Marks, G. B., Thompson, P. J., Matheson, M. C., Robertson, C. F., Ried, J. S., Li, J., Zuo, X. B., Zheng, X. D., Yin, X. Y., Sun, L. D., McAleer, M. A., O'Regan, G. M., Fahy, C. M. R., Campbell, L. E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D. S., Feenstra, B., Geller, F., Hottenga, J. J., Middeldorp, C. M., Hysi, P., Bataille, V., Spector, T., Tiesler, C. M. T., Thiering, E., Pahukasahasram, B., Yang, J. J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C. L., Myhre, R., Nystad, W., Custovic, A., Weiss, S. T., Meyers, D. A., Soederhaell, C., Melen, E., Ober, C., Raby, B. A., Simpson, A., Jacobsson, B., Holloway, J. W., Bisgaard, H., Sunyer, J., Probst-Hensch, N. M., Williams, L. K., Godfrey, K. M., Wang, C. A., Boomsma, D. I., Melbye, M., Koppelman, G. H., Jarvis, D., McLean, W. H. I., Irvine, A. D., Zhang, X. J., Hakonarson, H., Gieger, C., Burchard, E. G., Martin, N. G., Duijts, L., Linneberg, A., Jarvelin, M., Noethen, M. M., Lau, S., Huebner, N., Lee, Y., Tamari, M., Hinds, D. A., Glass, D., Brown, S. J., Heinrich, J., Evans, D. M. & Weidinger, S., 2015, In : Nature Genetics. 47, 12, p. 1449-1456

Research output: Contribution to JournalArticle

Open Access

Multicohort analysis of the maternal age effect on recombination

Martin, H. C., Christ, R., Hussin, J. G., O'Connell, J., Gordon, S., Mbarek, H., Hottenga, J. J., McAloney, K., Willemsen, G., Gasparini, P., Pirastu, N., Montgomery, G. W., Navarro, P., Soranzo, N., Toniolo, D., Vitart, V., Wilson, J. F., Marchini, J., Boomsma, D. I., Martin, N. G. & 1 others, Donnelly, P., 2015, In : Nature Communications. 6, 10 p., 7846.

Research output: Contribution to JournalArticle

Open Access

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

Gottlieb, D. J., Hek, K., Chen, T. H., Watson, N. F., Eiriksdottir, G., Byrne, E. M., Cornelis, M., Warby, S. C., Bandinelli, S., Cherkas, L., Evans, D. S., Grabe, H. J., Lahti, J., Li, M., Lehtimäki, T., Lumley, T., Marciante, K., Pérusse, L., Psaty, B. M., Robbins, J. & 66 others, Tranah, G., Vink, J. M., Wilk, J. B., Stafford, J. M., Bellis, M., Biffar, R., Bouchard, C., Cade, B., Curhan, G. C., Eriksson, J. G., Ewert, R., Ferrucci, L., Fülöp, T., Gehrman, P. R., Goodloe, R., Harris, T. B., Heath, A. C., Hernandez, D., Hofman, A., Hottenga, J. J., Hunter, D. J., Jensen, M. K., Johnson, A. D., Kähönen, M., Kao, L., Kraft, P., Larkin, E. K., Lauderdale, D. S., Luik, A. I., Medici, M., Montgomery, G. W., Palotie, A., Patel, S. R., Pistis, G., Porcu, E., Quaye, L., Raitakari, O., Redline, S., Rimm, E. B., Rotter, J. I., Smith, A. V., Spector, T. D., Teumer, A., Uitterlinden, A. G., Vohl, M-C., Widén, E., Willemsen, G., Young, T., Zhang, X., Liu, Y., Blanger, J., Boomsma, D. I., Gudnason, V., Hu, F., Mangino, M., Martin, N. G., O'Connor, G. T., Stone, K. L., Tanaka, T., Viikari, J., Gharib, S. A., Punjabi, N. M., Räikkönen, K., Völzke, H., Mignot, E. & Tiemeier, H., 2015, In : Molecular Psychiatry. 20, 10, p. 1232-1239 8 p.

Research output: Contribution to JournalArticle

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

Power, R. A., Steinberg, S., Bjornsdottir, G., Rietveld, C. A., Abdellaoui, A., Nivard, M. G., Johannesson, M., Galesloot, T. E., Hottenga, J. J., Willemsen, G., Cesarini, D., Benjamin, D. J., Magnusson, P. K., Ullén, F., Tiemeier, H., Hofman, A., van Rooij, F. J., Walters, G. B., Sigurdsson, E., Thorgeirsson, T. E. & 9 others, Ingason, A., Helgason, A., Kong, A., Kiemeney, L. A., Koellinger, P. D., Boomsma, D. I., Gudbjartsson, D., Stefansson, H. & Stefansson, K., 2015, In : Nature Neuroscience. 18, 7, p. 953-955

Research output: Contribution to JournalArticle

Population genetic differentiation of height and body mass index across Europe

Robinson, M. R., Hemani, G., Medina-Gomez, C., Mezzavilla, M., Esko, T., Shakhbazov, K., Powell, J. E., Vinkhuyzen, A. A., Berndt, S. I., Gustafsson, S., Justice, A. E., Kahali, B., Locke, A. E., Pers, T. H., Vedantam, S., Wood, A. R., van Rheenen, W., Andreassen, O. A., Gasparini, P., Metspalu, A. & 23 others, Van den Berg, L. H., Veldink, J. H., Rivadeneira, F., Werge, T. M., Abecasis, G. R., Boomsma, D. I., Chasman, D. I., de Geus, E. J. C., Frayling, T. M., Hirschhorn, J. N., Hottenga, J. J., Ingelsson, E., Loos, R. J. F., Magnusson, P. K. E., Martin, N. G., Montgomery, G. W., North, K. E., Pedersen, N. L., Spector, T. D., Speliotes, E. K., Goddard, M. E., Yang, J. & Visscher, P. M., 2015, In : Nature Genetics. 47, 11, p. 1357-1362 6 p.

Research output: Contribution to JournalArticle

Population-specific genotype imputations using minimac or IMPUTE2

van Leeuwen, E. M., Kanterakis, A., Deelen, P., Kattenberg, V. M., Slagboom, P. E., Bakker, P. I. W., Wijmenga, C., Swertz, M. A., Boomsma, D. I., van Duijn, C. M., Karssen, L. C. & Hottenga, J. J., 2015, In : Nature Protocols. 10, 9, p. 1285-1296 12 p.

Research output: Contribution to JournalArticle

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

O’Dushlaine, C., Rossin, L., Lee, P. H., Duncan, L., Parikshak, N. N., Newhouse, S., Ripke, S., Neale, B. M., Purcell, S. M., Posthuma, D., Boomsma, D. I., de Geus, E. J. C., Hottenga, J. J., Krabbendam, A. C., Middeldorp, C. M., Penninx, B. W. J. H., Sergeant, J. A., Smit, J. H., Grootheest, G., Willemsen, G. & 2 others, Holmes, P. & Breen, G., 2015, In : Nature Neuroscience. 18, 2, p. 199-209 11 p.

Research output: Contribution to JournalArticle

Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

Byrne, E. M., Boomsma, D. I., Martin, N. G., Penninx, B. W. J. H., de Geus, E. J. C., Hoogendijk, W. J. G., Hottenga, J. J., Middeldorp, C. M., Nyholt, DR., Smit, J. H., van den Oord, E. J., Grootheest, G., Willemsen, G., Zitman, F. G., Neale, B. M., Sullivan, P. F., Raheja, U. K., Stephens, S. H., Heath, A. C., Madden, P. A. F. & 11 others, Vaswani, D., Nijjar, G. V., Ryan, K. A., Youssufi, H., Gehrman, P. R., Shuldiner, A. R., Montgomery, G. W., Wray, N. R., Nelson, E. C., Mitchell, B. D. & Postolache, T. T., 2015, In : Journal of Clinical Psychiatry. 76, 2, p. 128-134 7 p.

Research output: Contribution to JournalArticle

Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis

Pappa, I., Fedko, I. O., Mileva-Seitz, V. R., Hottenga, J. J., Bakermans-Kranenburg, M. J., Bartels, M., van Beijsterveldt, C. E. M., Jaddoe, V. W. V., Middeldorp, C. M., Rippe, R. C. A., Rivadeneira, F., Tiemeier, H., Verhulst, F. C., van IJzendoorn, M. H. & Boomsma, D. I., 2015, In : Journal of the American Academy of Child and Adolescent Psychiatry. 54, 9, p. 737-744 8 p.

Research output: Contribution to JournalArticle

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~ 25 000 subjects

Peyrot, W., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A. & 9 others, Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Posthuma, D., Middeldorp, C. M. & Penninx, B. W. J. H., 2015, In : Molecular Psychiatry. 20, 6, p. 735-743 9 p.

Research output: Contribution to JournalArticle

The Genetics of Alcohol Dependence: Twin and SNP-Based Heritability, and Genome-Wide Association Study Based on AUDIT Scores

Mbarek, H., Milaneschi, Y., Fedko, I. O., Hottenga, J. J., de Moor, M. H. M., Jansen, R., Gelernter, J., Sherva, R., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H. & Vink, J. M., 2015, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 168, 8, p. 739-748 10 p.

Research output: Contribution to JournalArticle

The impact of low-frequency and rare variants on lipid levels

Surakka, I., Horikoshi, M., Magi, R., Sarin, A., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hagg, S., Hottenga, J. J., Isaacs, A., Ladenvall, C., Beekman, M., Esko, T. & 66 others, Ried, J. S., Nelson, C. P., Willenborg, C., Gustafsson, S., Westra, H., Blades, M., Craen, A. J. M., de Geus, E. J. C., Deelen, J., Grallert, H., Hamsten, A., Havulinna, A. S., Hengstenberg, C., Houwing-Duistermaat, J. J., Hypponen, E., Karssen, L. C., Lehtimaki, T., Lyssenko, V., Magnusson, P. K. E., Mihailov, E., Muller-Nurasyid, M., Mpindi, J., Pedersen, N. L., Penninx, B. W. J. H., Perola, M., Pers, T. H., Peters, A., Rung, J., Smit, J. H., Steinthorsdottir, V., Tobin, M. D., Tsernikova, N., van Leeuwen, E. M., Viikari, J. S., Willems, S. M., Willemsen, G., Schunkert, H., Erdmann, J., Samani, N. J., Kaprio, J., Lind, L., Gieger, C., Metspalu, A., Slagboom, P. E., Groop, L., van Duijn, C. M., Eriksson, J. G., Jula, A., Salomaa, V., Boomsma, D. I., Power, C., Raitakari, O. T., Ingelsson, E., Jarvelin, M., Thorsteinsdottir, U., Franke, L., Ikonen, E., Kallioniemi, O., Pietiainen, V., Lindgren, C. M., Stefansson, K., Palotie, A., McCarthy, M. I., Morris, A. P., Prokopenko, I. & Ripatti, S., 2015, In : Nature Genetics. 47, 6, p. 589-597

Research output: Contribution to JournalArticle

Open Access

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpelainen, T. O., Lu, Y., Magi, R., Mihailov, E., Pers, T. H., Rueeger, S., Teumer, A., Ehret, G. B., Ferreira, T., Heard-Costa, N. L., Karjalainen, J. & 418 others, Lagou, V., Mahajan, A., Neinast, M. D., Prokopenko, I., Simino, J., Teslovich, T. M., Jansen, R., Westra, H., White, C. C., Absher, D., Ahluwalia, T. S., Ahmad, S., Albrecht, E., Alves, A. C., Bragg-Gresham, J. L., Craen, A. J. M., Bis, J. C., Bonnefond, A., Boucher, G., Cadby, G., Cheng, Y., Chiang, C. W. K., Delgado, G., Demirkan, A., Dueker, N., Eklund, N., Eiriksdottir, G., Eriksson, J., Feenstra, B., Fischer, K., Frau, F., Galesloot, T. E., Geller, F., Goel, A., Gorski, M., Grammer, T. B., Gustafsson, S., Haitjema, S., Hottenga, J. J., Huffman, J. E., Jackson, A. U., Jacobs, K. B., Johansson, A., Kaakinen, M., Kleber, M. E., Lahti, J., Leach, I. M., Lehne, B., Lo, K. S., Lorentzon, M., Luan, J., Madden, P. A. F., Mangino, M., McKnight, B., Medina-Gomez, C., Monda, K. L., Montasser, M. E., Mueller, G., Mueller-Nurasyid, M., Nolte, I. M., Panoutsopoulou, K., Pascoe, L., Paternoster, L., Rayner, N. W., Renstrom, F., Rizzi, F., Rose, L. M., Ryan, K. A., Salo, P., Sanna, S., Scharnagl, H., Shi, J., Smith, A. V., Southam, L., Stancakova, A., Steinthorsdottir, V., Strawbridge, R. J., Sung, Y. J., Tachmazidou, I., Tanaka, T., Thorleifsson, G., Trompet, S., Pervjakova, N., Tyrer, J. P., Vandenput, L., van der Laan, S. W., van der Velde, N., van Setten, J., van Vliet-Ostaptchouk, J. V., Verweij, N., Vlachopoulou, E., Waite, L. L., Wang, S. R., Wang, Z., Wild, S. H., Willenborg, C., Wilson, J. F., Wong, A., Yang, J., Yengo, L., Yerges-Armstrong, L. M., Yu, L., Zhang, W., Zhao, J. H., Andersson, E. A., Bakker, S. J. L., Baldassarre, D., Banasik, K., Barcella, M., Barlassina, C., Bellis, C., Benaglio, P., Blangero, J., Blueher, M., Bonnet, F., Bonnycastle, L. L., Boyd, H. A., Bruinenberg, M., Buchman, A. S., Campbell, H., Chen, Y. I., Chines, P. S., Claudi-Boehm, S., Cole, J., Collins, F. S., de Geus, E. J. C., de Groot, L. C. P. G. M., Dimitriou, M., Duan, J., Enroth, S., Eury, E., Farmaki, A., Forouhi, N. G., Friedrich, N., Gejman, P. V., Gigante, B., Glorioso, N., Go, A. S., Gottesman, O., Graessler, J., Grallert, H., Grarup, N., Gu, Y., Broer, L., van der Ham, A. C., Hansen, T., Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N., Hattersley, A. T., Heath, A. C., Henders, A. K., Hernandez, D., Hillege, H., Holmen, O., Hovingh, K. G., Hui, J., Husemoen, L. L., Hutri-Kahonen, N., Hysi, P. G., Illig, T., de Jager, P. L., Jalilzadeh, S., Jorgensen, T., Jukema, J. W., Juonala, M., Kanoni, S., Karaleftheri, M., Khaw, K. T., Kinnunen, L., Kittner, S. J., Koenig, W., Kolcic, I., Kovacs, P., Krarup, N. T., Kratzer, W., Krueger, J., Kuh, D., Kumari, M., Kyriakou, T., Langenberg, C., Lannfelt, L., Lanzani, C., Lotay, V., Launer, L. J., Leander, K., Lindstrom, J., Linneberg, A., Liu, Y., Lobbens, S., Luben, R., Lyssenko, V., Mannisto, S., Magnusson, P. K., McArdle, W. L., Menni, C., Merger, S., Milani, L., Montgomery, G. W., Morris, A. P., Narisu, N., Nelis, M., Ong, K. K., Palotie, A., Perusse, L., Pichler, I., Pilia, M. G., Pouta, A., Rheinberger, M., Ribel-Madsen, R., Richards, M., Rice, K. M., Rice, T. K., Rivolta, C., Salomaa, V., Sanders, A. R., Sarzynski, M. A., Scholtens, S., Scott, R. A., Scott, W. R., Sebert, S., Sengupta, S., Sennblad, B., Seufferlein, T., Silveira, A., Slagboom, P. E., Smit, J. H., Sparso, T. H., Stirrups, K., Stolk, R. P., Stringham, H. M., Swertz, M. A., Swift, A. J., Syvanen, A., Tan, S., Thorand, B., Toenjes, A., Tremblay, A., Tsafantakis, E., van der Most, P. J., Voelker, U., Vohl, M., Vonk, J. M., Waldenberger, M., Walker, R. W., Wennauer, R., Widen, E., Willemsen, G., Wilsgaard, T., Wright, A. F., Zillikens, M. C., van Dijk, S. C., van Schoor, N. M., Asselbergs, F. W., Bakker, P. I. W., Beckmann, J. S., Beilby, J., Bennett, D. A., Bergman, R. N., Bergmann, S., Boeger, C. A., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Bornstein, S. R., Bottinger, E. P., Bouchard, C., Chambers, J. C., Chanock, S. J., Chasman, D. I., Cucca, F., Cusi, D., Dedoussis, G., Erdmann, J., Eriksson, J. G., Evans, D. A., de Faire, U., Farrall, M., Ferrucci, L., Ford, I., Franke, L., Franks, P. W., Froguel, P., Gansevoort, R. T., Gieger, C., Gronberg, H., Gudnason, V., Gyllensten, U., Hall, P., Hamsten, A., van der Harst, P., Hayward, C., Heliovaara, M., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hofman, A., Hu, F., Huikuri, H. V., Hveem, K., James, A. L., Jordan, J. M., Jula, A., Kaehoenen, M., Kajantie, E., Kathiresan, S., Kiemeney, L. A. L. M., Kivimaki, M., Knekt, P. B., Koistinen, H. A., Kooner, J. S., Koskinen, S., Kuusisto, J., Maerz, W., Martin, N. G., Laakso, M., Lakka, T. A., Lehtimaki, T., Lettre, G., Levinson, D. F., Lind, L., Lokki, M., Mantyselka, P., Melbye, M., Metspalu, A., Mitchell, B. D., Moll, F. L., Murray, J. C., Musk, A. W., Nieminen, M. S., Njolstad, I., Ohlsson, C., Oldehinkel, A. J., Oostra, B. A., Palmer, L. J., Pankow, J. S., Pasterkamp, G., Pedersen, N. L., Pedersen, O., Penninx, B. W. J. H., Perola, M., Peters, A., Polasek, O., Pramstaller, P. P., Psaty, B. M., Qi, L., Quertermous, T., Raitakari, O. T., Rankinen, T., Rauramaa, R., Ridker, P. M., Rioux, J. D., Rivadeneira, F., Rotter, J. I., Rudan, I., den Ruijter, H. M., Saltevo, J., Sattar, N., Schunkert, H., Schwarz, P. E. H., Shuldiner, A. R., Sinisalo, J., Snieder, H., Sorensen, T. I. A., Spector, T. D., Staessen, J. A., Stefania, B., Thorsteinsdottir, U., Stumvoll, M., Tardif, J., Tremoli, E., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Verbeek, A. L. M., Vermeulen, S. H., Viikari, J. S., Vitart, V., Voelzke, H., Vollenweider, P., Waeber, G., Walker, M., Wallaschofski, H., Wareham, N. J., Watkins, H., Zeggini, E., Chakravarti, A., Clegg, D. J., Cupples, L. A., Gordon-Larsen, P., Jaquish, C. E., Rao, D. C., Abecasis, G. R., Assimes, T. L., Barroso, I., Berndt, S. I., Boehnke, M., Deloukas, P., Fox, C. S., Groop, L. C., Hunter, D. J., Ingelsson, E., Kaplan, R. C., McCarthy, M. I., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Hirschhorn, J. N., Lindgren, C. M., Heid, I. M., North, K. E., Borecki, I. B., Kutalik, Z. & Loos, R. J. F., 2015, In : PLoS Genetics. 11, 10, e1005378.

Research output: Contribution to JournalArticle

Open Access
2016

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

Middeldorp, C. M., Hammerschlag, A. R., Ouwens, K. G., Blokhuis, M. M., St. Pourcain, B., Greven, C. U., Pappa, I., Tiesler, C. M. T., Ang, W., Nolte, I. M., Vilor-Tejedor, N., Bacelis, J., Ebejer, J. L., Zhao, H., Davies, G. E., Ehli, E. A., Evans, D. M., Fedko, I. O., Guxens, M., Hottenga, J. J. & 31 others, Hudziak, J. J., Jugessur, A., Kemp, J. P., Krapohl, E., Martin, N. G., Murcia, M., Myhre, R., Ormel, J., Ring, S. M., Standl, M., Stergiakouli, E., Stoltenberg, C., Thiering, E., Timpson, N. J., Trzaskowski, M., van der Most, P. J., Wang, C., Nyholt, DR., Medland, S. E., Neale, B. M., Jacobsson, B., Sunyer, J., Hartman, C. A., Whitehouse, A. J. O., Pennell, C. E., Heinrich, J., Plomin, R., Davey Smith, G., Tiemeier, H., Posthuma, D. & Boomsma, D. I., 2016, In : Journal of the American Academy of Child and Adolescent Psychiatry. 55, 10, p. 896-905 10.

Research output: Contribution to JournalArticle

A meta-analysis of 120,246 individuals identifies 18 new loci for fibrinogen concentration

de Vries, P. S., Chasman, D. I., Sabater-Lleal, M., Chen, M. H., Huffman, J. E., Steri, M., Tang, W., Teumer, A., Marioni, R. E., Grossmann, V., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Cucca, F., Tracy, R., Watkins, H., Reiner, A. P., Folsom, A. R., Ridker, P. M. & 4 others, O'Donnell, C. J., Smith, N. L., Strachan, D. P. & Dehghan, A., 2016, In : Human Molecular Genetics. 25, 2, p. 358-370

Research output: Contribution to JournalArticle

Open Access

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Ried, J. S., Jeff, J. M., Chu, A. Y., Bragg-Gresham, J. L., van Dongen, J., Huffman, J. E., Ahluwalia, T. S., Cadby, G., Eklund, N., Eriksson, J., de Geus, E. J. C., Hottenga, J. J., Penninx, B. W. J. H., Willemsen, G., Boomsma, D. I., McCarthy, M. I., North, K. E., O'Connell, J. R., Schlessinger, D., Thorsteinsdottir, U. & 5 others, Strachan, D. P., Frayling, T. M., Hirschhorn, J. N., Müller-Nurasyid, M. & Loos, R. J. F., 2016, In : Nature Communications. 7, 13357.

Research output: Contribution to JournalArticle

Open Access

Associations between smoking and caffeine consumption in two European cohorts

Treur, J. L., Taylor, A. E., Ware, J. J., McMahon, G., Hottenga, J. J., Baselmans, B. M. L., Willemsen, G., Boomsma, D. I., Munafò, M. & Vink, J. M., 2016, In : Addiction. 111, 6, p. 1059-1068

Research output: Contribution to JournalArticle

Open Access

Blood lipids influence DNA methylation in circulating cells

Dekkers, K. F., van Iterson, M., Slieker, R. C., Moed, M. H., Bonder, M. J., van Galen, M., Mei, H., Zhernakova, D. V., Van den Berg, L. H., Deelen, J., van Dongen, J., van Heemst, D., Hofman, A., Hottenga, J. J., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., Tigchelaar, E. F., Uitterlinden, A. G., Willemsen, G. & 14 others, Zhernakova, A., Franke, L., 't Hoen, P. A. C., Jansen, R., van Meurs, J., Boomsma, D. I., van Duijn, C. M., van Greevenbroek, M. M. J., Veldink, J. H., Wijmenga, C., van Zwet, E. W., Slagboom, P. E., Jukema, J. W. & Heijmans, B. T., 2016, In : Genome Biology. 17, 138, p. 1-12

Research output: Contribution to JournalArticle

Open Access

Causes of variation in the neutrophil-lymphocyte and platelet-lymphocyte ratios: a twin-family study

Lin, B., Hottenga, J. J., Abdellaoui, A., Dolan, C. V., de Geus, E. J. C., Kluft, C., Boomsma, D. I. & Willemsen, G., 2016, In : Biomarkers in medicine. 10, 10, p. 1061-1072

Research output: Contribution to JournalArticle

Gene expression in major depressive disorder.

Jansen, R., Penninx, B. W. J. H., Madar, V., Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A. T. F., van der Wee, N., Smit, J. H., Brooks, A. I., Tischfield, J., Posthuma, D., Schoevers, R., Grootheest, G., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Wright, F. A., Zou, F. & 2 others, Sun, W. & Sullivan, P. F., 2016, In : Molecular Psychiatry. 21, p. 339 347 p.

Research output: Contribution to JournalArticle

Genetic and environmental influences interact with age and sex in shaping the human methylome

van Dongen, J., Nivard, M. G., Willemsen, G., Hottenga, J. J., Helmer, Q., Dolan, C. V., Ehli, E. A., Davies, G. E., van Iterson, M., Breeze, C. E., Beck, S., Pool, R., Suchiman, H. E. D., Jansen, R., van Meurs, J. B., Heijmans, B. T., Slagboom, P. E. & Boomsma, D. I., 2016, In : Nature Communications. 7, 11115, p. 1-13 11115.

Research output: Contribution to JournalArticle

Open Access

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight

Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., Wood, A. R., Horikoshi, M., Geller, F., Myhre, R., Bradfield, J. P., Kreiner-Møller, E., Huikari, V., Painter, J. N., Hottenga, J. J., Allard, C. & 44 others, Berry, D. J., Bouchard, L., Das, S., Evans, D. M., Hakonarson, H., Hayes, M. G., Heikkinen, J., Hofman, A., Knight, B., Lind, P. A., McCarthy, M. I., McMahon, G., Medland, S. E., Melbye, M., Morris, A. P., Nodzenski, M., Reichetzeder, C., Ring, S. M., Sebert, S., Sengpiel, V., Sørensen, T. I. A., Willemsen, G., de Geus, E. J. C., Martin, N. G., Spector, T. D., Power, C., Järvelin, M. R., Bisgaard, H., Grant, S. F. A., Nohr, E. A., Jaddoe, V. W., Jacobsson, B., Murray, J. C., Hocher, B., Hattersley, A. T., Scholtens, D. M., Davey Smith, G., Hivert, M. F., Felix, J. F., Hyppönen, E., Lowe, W. L., Frayling, T. M., Lawlor, D. A. & Freathy, R. M., 2016, In : JAMA. 315, 11, p. 1129-1140

Research output: Contribution to JournalArticle

Open Access

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Franke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., Arias-Vasquez, A., Smoller, J. W., Nichols, T. E., Neale, M. C., McIntosh, A. M., Lee, P., McMahon, F. J., Meyer-Lindenberg, A., Mattheisen, M., Andreassen, O. A., Gruber, O., Sachdev, P. S., Roiz-Santiañez, R., Saykin, A. J. & 20 others, Ehrlich, S., Mather, K. A., Turner, J. A., Schwarz, E., Thalamuthu, A., Yao, Y., Ho, Y. Y. W., Martin, N. G., Wright, M. J., den Braber, A., Fedko, I. O., Hottenga, J. J., van t Ent, D., Boomsma, D. I., de Geus, E. J. C., O'Donovan, M. C., Thompson, P. M., Neale, B. M., Medland, S. E. & Sullivan, P. F., 2016, In : Nature Neuroscience. 19, 3, p. 420-431

Research output: Contribution to JournalArticle

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Okbay, A., Baselmans, B. M. L., de Neve, J. E., Turley, P., Nivard, M. G., Fontana, M. A., Meddens, S. F. W., Karlsson Linnér, R., Rietveld, C. A., Derringer, J., de Vlaming, R., Minica, C. C., Hottenga, J. J., Vinkhuyzen, A. A. E., Boomsma, D. I., de Geus, E. J. C., Medland, S. E., Meyer, M. N., Pickrell, J. K., Esko, T. & 6 others, Krueger, R. F., Beauchamp, J., Koellinger, P. D., Benjamin, D. J., Bartels, M. & Cesarini, D., 2016, In : Nature Genetics. 48, 6, p. 624-633

Research output: Contribution to JournalArticle

Genetic variants in RBFOX3 are associated with sleep latency

Amin, N., Allebrandt, K. V., Spek, A., Müller-Myhsok, B., Hek, K., Teder-Laving, M., Hayward, C., Esko, T., van Mill, J. G., Mbarek, H., Watson, N. F., Melville, S. A., Del Greco, M. F., Byrne, E. M., Oole, E., Kolcic, I., Chen, T., Evans, D. S., Coresh, J., Vogelzangs, N. & 55 others, Karjalainen, J., Willemsen, G., Gharib, S. A., Zgaga, L., Mihailov, E., Stone, K. L., Campbell, H., Brouwer, R. W. W., Demirkan, A., Isaacs, A., Dogas, Z., Marciante, K., Campbell, S., Borovecki, F., Luik, A. I., Li, M., Hottenga, J. J., Huffman, J. E., van den Hout, M. C. G. N., Cummings, S. R., Aulchenko, Y. S., Gehrman, P. R., Uitterlinden, A. G., Wichmann, H. E., Müller-Nurasyid, M., Fehrmann, R. S. N., Montgomery, G. W., Hofman, A., Hong, W., Kao, L., Oostra, B. A., Wright, A. F., Vink, J. M., Wilson, J. F., Pramstaller, P. P., Hicks, A. A., Polasek, O., Punjabi, N. M., Redline, S., Psaty, B. M., Heath, A. C., Merrow, M., Tranah, G. J., Gottlieb, D. J., Boomsma, D. I., Martin, N. G., Rudan, I., Tiemeier, H., van Ijcken, W. F. J., Penninx, B. W. J. H., Metspalu, A., Meitinger, T., Franke, L., Roenneberg, T. & van Duijn, C. M., 2016, In : European Journal of Human Genetics. 24, 10, p. 1488-1495

Research output: Contribution to JournalArticle

Genetic variants linked to education predict longevity.

Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Okbay, A., Fischer, K., Adams, M. J., Hill, W. D., Davies, G., Abdellaoui, A., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Nagy, R., Amador, C., Läll, K., Metspalu, A., Liewald, D. C., Campbell, A., Wilson, J. F. & 6 others, Hayward, C., Esko, T., Porteous, D. J., Gale, C. R., Deary, I. J. & de Vlaming, R., 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, p. 13366-13371 47.

Research output: Contribution to JournalArticle

Open Access

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Felix, J. F., Bradfield, J. P., Monnereau, C., van der Valk, R. J. P., Stergiakouli, E., Chesi, A., Gaillard, R., Feenstra, B., Thiering, E., Kreiner-Møller, E., Blokhuis, M. M., Horikoshi, M., Hottenga, J. J., Middeldorp, C. M., Uitterlinden, A. G., Plomin, R., Boomsma, D. I., Heinrich, J., Melbye, M., Rivadeneira, F. & 7 others, Hakonarson, H., Ring, S. M., Davey Smith, G., Sørensen, T. I. A., Timpson, N. J., Grant, S. F. A. & Jaddoe, V. W. V., 2016, In : Human Molecular Genetics. 25, 2, p. 389-403

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Genome-wide associations for birth weight and correlations with adult disease

Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J., Feenstra, B., van Zuydam, N. R., Gaulton, K. J., Grarup, N., Hottenga, J. J., Rahmioglu, N., Nyholt, DR., van Beijsterveldt, C. E. M., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Frayling, T. M., Davey Smith, G., Morris, A. P. & 7 others, Ong, K. K., Felix, J. F., Timpson, N. J., Perry, J. R. B., Evans, D. M., McCarthy, M. I. & Freathy, R. M., 2016, In : Nature. 538, 7624, p. 248-252

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Genome-wide association study identifies 74 loci associated with educational attainment

Okbay, A., Beauchamp, J., Fontana, M. A., Lee, J. J., Pers, T. H., Rietveld, C. A., Turley, P., Chen, G. B., Emilsson, V., Meddens, S. F. W., de Vlaming, R., Abdellaoui, A., Peyrot, W., Vinkhuyzen, A. A. E., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Laibson, D., Medland, S. E. & 8 others, Meyer, M. N., Yang, J., Johannesson, M., Visscher, P. M., Esko, T., Koellinger, P. D., Cesarini, D. & Benjamin, D. J., 2016, In : Nature. 533, 7604, p. 539-542

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Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Stringer, S., Minică, C. C., Verweij, K. J. H., Mbarek, H., Bernard, M., Derringer, J., van Eijk, K. R., Isen, J. D., Loukola, A., Maciejewski, D. F., Mihailov, E., van der Most, P. J., Sánchez-Mora, C., Roos, L., Sherva, R., Walters, R., Ware, J. J., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T. & 60 others, Brown, S. A., Bruinenberg, M., Casas, M., Esko, T., Garcia-Martinez, I., Gordon, S. D. S., Harris, J. M., Hartman, C. A., Henders, A. K., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Huizink, A. C., Irons, D. E., Kahn, R. S., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Lubke, G. H., Madden, P. A. F., Mägi, R., McGue, M. K., Medland, S. E., Meeus, W. H. J., Miller, M. B., Montgomery, G. W., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Qaiser, B., Quaye, L., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, M. J., Koot, H. M., Paus, T., Hewitt, J. K., Ribasés, M., Kaprio, J., Boks, M. P. M., Snieder, H., Spector, T., Munafò, M. R., Metspalu, A., Gelernter, J., Boomsma, D. I., Iacono, W. G., Martin, N. G., Gillespie, N. A., Derks, E. M. & Vink, J. M., 29 Mar 2016, In : Translational Psychiatry. 6, p. e769

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Open Access

Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2

Ware, J. J., Chen, X., Vink, J. M., Loukola, A., Minica, C. C., Pool, R., Milaneschi, Y., Mangino, M., Menni, C., Chen, J., Peterson, R. E., Auro, K., Lyytikäinen, L. P., Wedenoja, J., Stiby, A. I., Hemani, G., Willemsen, G., Hottenga, J. J., Korhonen, T., Heliövaara, M. & 18 others, Perola, M., Rose, R. J., Paternoster, L., Timpson, N., Wassenaar, C. A., Zhu, A. Z. X., Davey Smith, G., Raitakari, O. T., Lehtimäki, T., Kähönen, M., Koskinen, S., Spector, T. D., Penninx, B. W. J. H., Salomaa, V., Boomsma, D. I., Tyndale, R. F., Kaprio, J. & Munafò, M., 2016, In : Scientific Reports. 6, 20092, 20092.

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Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Kettunen, J., Demirkan, A., Würtz, P., Draisma, H. H. M., Haller, T., Rawal, R., Vaarhorst, A. A. M., Kangas, A. J., Lyytikäinen, L. P., Pirinen, M., Pool, R., Sarin, A-P., Soininen, P., Tukiainen, T., Wang, Q., Tiainen, M., Tynkkynen, T., Amin, N., Zeller, T., Beekman, M. & 30 others, Deelen, J., Willems van Dijk, K., Esko, T., Hottenga, J. J., van Leeuwen, E. M., Lehtimäki, T., Mihailov, E., Rose, R. J., de Craen, A. J., Gieger, C., Kähönen, M., Perola, M., Blankenberg, S., Savolainen, M. J., Verhoeven, A., Viikari, J., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Eriksson, J., Jula, A., Järvelin, M. R., Kaprio, J., Metspalu, A., Raitakari, O., Salomaa, V., Slagboom, P. E., Waldenberger, M., Ripatti, S. & Ala-Korpela, M., 2016, In : Nature Communications. 7, 11122.

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Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

Spjuth, O., Krestyaninova, M., Hastings, J., Shen, H. Y., Heikkinen, J., Waldenberger, M., Langhammer, A., Ladenvall, C., Esko, T., Persson, M. Å., Heggland, J., Dietrich, J., Ose, S., Gieger, C., Ried, J. S., Peters, A., Fortier, I., de Geus, E. J. C., Klovins, J., Zaharenko, L. & 16 others, Willemsen, G., Hottenga, J. J., Litton, J. E., Karvanen, J., Boomsma, D. I., Groop, L., Rung, J., Palmgren, J., Pedersen, N. L., McCarthy, M. I., van Duijn, C. M., Hveem, K., Metspalu, A., Ripatti, S., Prokopenko, I. & Harris, J. R., 2016, In : European Journal of Human Genetics. 24, 4, p. 521-528

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Open Access

Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility

Mbarek, H., Steinberg, S., Nyholt, DR., Gordon, S. D., Miller, M. B., McRae, A. F., Hottenga, J. J., Day, F. R., Willemsen, G., de Geus, E. J. C., Davies, G. E., Martin, H. C., Penninx, B. W. J. H., Jansen, R., McAloney, K., Vink, J. M., Kaprio, J., Plomin, R., Spector, T. D., Magnusson, P. K. & 17 others, Reversade, B., Harris, R. A., Aagaard, K., Kristjansson, R. P., Olafsson, I., Eyjolfsson, G. I., Sigurdardottir, O., Iacono, W. G., Lambalk, C. B., Montgomery, G. W., McGue, M., Ong, K. K., Perry, J. R. B., Martin, N. G., Stefansson, H., Stefansson, K. & Boomsma, D. I., 2016, In : American Journal of Human Genetics. 98, 5, p. 898-908

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KLB is associated with alcohol drinking, and its gene product B-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O'Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S. R., Hottenga, J. J., Mbarek, H., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Bakalkin, G., Evangelou, E., Liu, Y., Rice, K. M., Desrivieres, S. & 5 others, Kliewer, S. A., Mangelsdorf, D. J., Müller, C. P., Levy, D. & Elliott, P., 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14372-14377

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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., Farh, K. H., Cuenca-Leon, E., Muona, M., Furlotte, N. A., Kurth, T., Ingason, A., McMahon, G., Ligthart, L., Terwindt, G. M., Kallela, M., Freilinger, T., Ran, C., Gordon, S. G., Stam, A. H. & 88 others, Steinberg, S., Borck, G., Koiranen, M., Quaye, L., Adams, H. H. H., Lehtimäki, T., Sarin, A. P., Wedenoja, J., Hinds, D. A., Buring, J. E., Schürks, M., Ridker, P. M., Gudlaug Hrafnsdottir, M., Stefansson, H., Ring, S. M., Hottenga, J. J., Penninx, B. W. J. H., Färkkilä, M., Artto, V., Kaunisto, M. A., Vepsäläinen, S., Malik, R., Heath, A. C., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Kurki, M. I., Kals, M., Mägi, R., Pärn, K., Hämaläinen, E., Huang, H., Byrnes, A. E., Franke, L., Huang, J., Stergiakouli, E., Lee, P. H., Sandor, C., Webber, C., Cader, Z., Müller-Myhsok, B., Schreiber, S., Meitinger, T., Eriksson, J. G., Salomaa, V., Heikkilä, K., Loehrer, A. G., Uitterlinden, A. G., Hofman, A., van Duijn, C. M., Cherkas, L., Pedersen, L., Stubhaug, A., Nielsen, C. S., Männikkö, M., Mihailov, E., Milani, L., Göbel, H., Esserlind, A. L., Francke Christensen, A., Folkmann Hansen, T., Werge, T., Kaprio, J., Aromaa, A., Raitakari, O., Ikram, M. A., Spector, T. D., Järvelin, M. R., Metspalu, A., Kubisch, C., Strachan, D. P., Ferrari, M. D., Belin, A. C., Dichgans, M., Wessman, M., van den Maagdenberg, A. M. J. M., Zwart, J. A., Boomsma, D. I., Davey Smith, G., Stefansson, K., Eriksson, N., Daly, M. J., Neale, B. M., Olesen, J., Chasman, D. I., Nyholt, DR., Palotie, A. & Posthuma, D., 2016, In : Nature Genetics. 48, 8, p. 856-866

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