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Research Output 2004 2019

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2016

Causes of variation in the neutrophil-lymphocyte and platelet-lymphocyte ratios: a twin-family study

Lin, B., Hottenga, J. J., Abdellaoui, A., Dolan, C. V., de Geus, E. J. C., Kluft, C., Boomsma, D. I. & Willemsen, G., 2016, In : Biomarkers in medicine. 10, 10, p. 1061-1072

Research output: Contribution to JournalArticleAcademicpeer-review

Twin Studies
Lymphocytes
Platelets
Neutrophils
Blood Platelets

Detection of gene-environment interaction in pedigree data using genome-wide genotypes

Nivard, M. G., Middeldorp, C. M., Lubke, G. H., Hottenga, J. J., Abdellaoui, A., Boomsma, D. I. & Dolan, C. V., 2016, In : European Journal of Human Genetics. 24, 12, p. 1803-1809

Research output: Contribution to JournalArticleAcademicpeer-review

Gene-Environment Interaction
Pedigree
Single Nucleotide Polymorphism
Body Mass Index
Genotype

Gene expression in major depressive disorder.

Jansen, R., Penninx, B. W. J. H., Madar, V., Xia, K., Milaneschi, Y., Hottenga, J. J., Hammerschlag, A. R., Beekman, A. T. F., van der Wee, N., Smit, J. H., Brooks, A. I., Tischfield, J., Posthuma, D., Schoevers, R., Grootheest, G., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Wright, F. A., Zou, F. & 2 othersSun, W. & Sullivan, P. F., 2016, In : Molecular Psychiatry. 21, p. 339 347 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Gene Expression
Multigene Family
Natural Killer Cells
Interleukin-6

Genetic and environmental influences interact with age and sex in shaping the human methylome

van Dongen, J., Nivard, M. G., Willemsen, G., Hottenga, J. J., Helmer, Q., Dolan, C. V., Ehli, E. A., Davies, G. E., van Iterson, M., Breeze, C. E., Beck, S., Pool, R., Suchiman, H. E. D., Jansen, R., van Meurs, J. B., Heijmans, B. T., Slagboom, P. E. & Boomsma, D. I., 2016, In : Nature Communications. 7, 11115, p. 1-13 11115.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
methylation
genome
Methylation
Genes
Genome

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight

Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., Wood, A. R., Horikoshi, M., Geller, F., Myhre, R., Bradfield, J. P., Kreiner-Møller, E., Huikari, V., Painter, J. N., Hottenga, J. J., Allard, C. & 44 othersBerry, D. J., Bouchard, L., Das, S., Evans, D. M., Hakonarson, H., Hayes, M. G., Heikkinen, J., Hofman, A., Knight, B., Lind, P. A., McCarthy, M. I., McMahon, G., Medland, S. E., Melbye, M., Morris, A. P., Nodzenski, M., Reichetzeder, C., Ring, S. M., Sebert, S., Sengpiel, V., Sørensen, T. I. A., Willemsen, G., de Geus, E. J. C., Martin, N. G., Spector, T. D., Power, C., Järvelin, M. R., Bisgaard, H., Grant, S. F. A., Nohr, E. A., Jaddoe, V. W., Jacobsson, B., Murray, J. C., Hocher, B., Hattersley, A. T., Scholtens, D. M., Davey Smith, G., Hivert, M. F., Felix, J. F., Hyppönen, E., Lowe, W. L., Frayling, T. M., Lawlor, D. A. & Freathy, R. M., 2016, In : JAMA. 315, 11, p. 1129-1140

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Birth Weight
Obesity
Mothers
Body Mass Index
Blood Pressure

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Franke, B., Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., Arias-Vasquez, A., Smoller, J. W., Nichols, T. E., Neale, M. C., McIntosh, A. M., Lee, P., McMahon, F. J., Meyer-Lindenberg, A., Mattheisen, M., Andreassen, O. A., Gruber, O., Sachdev, P. S., Roiz-Santiañez, R., Saykin, A. J. & 20 othersEhrlich, S., Mather, K. A., Turner, J. A., Schwarz, E., Thalamuthu, A., Yao, Y., Ho, Y. Y. W., Martin, N. G., Wright, M. J., den Braber, A., Fedko, I. O., Hottenga, J. J., van t Ent, D., Boomsma, D. I., de Geus, E. J. C., O'Donovan, M. C., Thompson, P. M., Neale, B. M., Medland, S. E. & Sullivan, P. F., 2016, In : Nature Neuroscience. 19, 3, p. 420-431

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Okbay, A., Baselmans, B. M. L., de Neve, J. E., Turley, P., Nivard, M. G., Fontana, M. A., Meddens, S. F. W., Karlsson Linnér, R., Rietveld, C. A., Derringer, J., de Vlaming, R., Minica, C. C., Hottenga, J. J., Vinkhuyzen, A. A. E., Boomsma, D. I., de Geus, E. J. C., Medland, S. E., Meyer, M. N., Pickrell, J. K., Esko, T. & 6 othersKrueger, R. F., Beauchamp, J., Koellinger, P. D., Benjamin, D. J., Bartels, M. & Cesarini, D., 2016, In : Nature Genetics. 48, 6, p. 624-633

Research output: Contribution to JournalArticleAcademicpeer-review

Genome
Depression
Phenotype
Genome-Wide Association Study
Sample Size

Genetic variants in RBFOX3 are associated with sleep latency

Amin, N., Allebrandt, K. V., Spek, A., Müller-Myhsok, B., Hek, K., Teder-Laving, M., Hayward, C., Esko, T., van Mill, J. G., Mbarek, H., Watson, N. F., Melville, S. A., Del Greco, M. F., Byrne, E. M., Oole, E., Kolcic, I., Chen, T., Evans, D. S., Coresh, J., Vogelzangs, N. & 55 othersKarjalainen, J., Willemsen, G., Gharib, S. A., Zgaga, L., Mihailov, E., Stone, K. L., Campbell, H., Brouwer, R. W. W., Demirkan, A., Isaacs, A., Dogas, Z., Marciante, K., Campbell, S., Borovecki, F., Luik, A. I., Li, M., Hottenga, J. J., Huffman, J. E., van den Hout, M. C. G. N., Cummings, S. R., Aulchenko, Y. S., Gehrman, P. R., Uitterlinden, A. G., Wichmann, H. E., Müller-Nurasyid, M., Fehrmann, R. S. N., Montgomery, G. W., Hofman, A., Hong, W., Kao, L., Oostra, B. A., Wright, A. F., Vink, J. M., Wilson, J. F., Pramstaller, P. P., Hicks, A. A., Polasek, O., Punjabi, N. M., Redline, S., Psaty, B. M., Heath, A. C., Merrow, M., Tranah, G. J., Gottlieb, D. J., Boomsma, D. I., Martin, N. G., Rudan, I., Tiemeier, H., van Ijcken, W. F. J., Penninx, B. W. J. H., Metspalu, A., Meitinger, T., Franke, L., Roenneberg, T. & van Duijn, C. M., 2016, In : European Journal of Human Genetics. 24, 10, p. 1488-1495

Research output: Contribution to JournalArticleAcademicpeer-review

Sleep
Genes
Genome-Wide Association Study
Single Nucleotide Polymorphism
Meta-Analysis

Genetic variants linked to education predict longevity.

Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Okbay, A., Fischer, K., Adams, M. J., Hill, W. D., Davies, G., Abdellaoui, A., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Nagy, R., Amador, C., Läll, K., Metspalu, A., Liewald, D. C., Campbell, A., Wilson, J. F. & 6 othersHayward, C., Esko, T., Porteous, D. J., Gale, C. R., Deary, I. J. & de Vlaming, R., 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, p. 13366-13371 47.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Felix, J. F., Bradfield, J. P., Monnereau, C., van der Valk, R. J. P., Stergiakouli, E., Chesi, A., Gaillard, R., Feenstra, B., Thiering, E., Kreiner-Møller, E., Blokhuis, M. M., Horikoshi, M., Hottenga, J. J., Middeldorp, C. M., Uitterlinden, A. G., Plomin, R., Boomsma, D. I., Heinrich, J., Melbye, M., Rivadeneira, F. & 7 othersHakonarson, H., Ring, S. M., Davey Smith, G., Sørensen, T. I. A., Timpson, N. J., Grant, S. F. A. & Jaddoe, V. W. V., 2016, In : Human Molecular Genetics. 25, 2, p. 389-403

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-wide associations for birth weight and correlations with adult disease

Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J., Feenstra, B., van Zuydam, N. R., Gaulton, K. J., Grarup, N., Hottenga, J. J., Rahmioglu, N., Nyholt, DR., van Beijsterveldt, C. E. M., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Frayling, T. M., Davey Smith, G., Morris, A. P. & 7 othersOng, K. K., Felix, J. F., Timpson, N. J., Perry, J. R. B., Evans, D. M., McCarthy, M. I. & Freathy, R. M., 2016, In : Nature. 538, 7624, p. 248-252

Research output: Contribution to JournalArticleAcademicpeer-review

Birth Weight
Genome
Genome-Wide Association Study
Metabolic Diseases
Type 2 Diabetes Mellitus

Genome-wide association study identifies 74 loci associated with educational attainment

Okbay, A., Beauchamp, J., Fontana, M. A., Lee, J. J., Pers, T. H., Rietveld, C. A., Turley, P., Chen, G. B., Emilsson, V., Meddens, S. F. W., de Vlaming, R., Abdellaoui, A., Peyrot, W., Vinkhuyzen, A. A. E., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Laibson, D., Medland, S. E. & 8 othersMeyer, M. N., Yang, J., Johannesson, M., Visscher, P. M., Esko, T., Koellinger, P. D., Cesarini, D. & Benjamin, D. J., 2016, In : Nature. 533, 7604, p. 539-542

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Phenotype
Proxy
Cognition
Single Nucleotide Polymorphism

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Stringer, S., Minică, C. C., Verweij, K. J. H., Mbarek, H., Bernard, M., Derringer, J., van Eijk, K. R., Isen, J. D., Loukola, A., Maciejewski, D. F., Mihailov, E., van der Most, P. J., Sánchez-Mora, C., Roos, L., Sherva, R., Walters, R., Ware, J. J., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T. & 60 othersBrown, S. A., Bruinenberg, M., Casas, M., Esko, T., Garcia-Martinez, I., Gordon, S. D. S., Harris, J. M., Hartman, C. A., Henders, A. K., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Huizink, A. C., Irons, D. E., Kahn, R. S., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Lubke, G. H., Madden, P. A. F., Mägi, R., McGue, M. K., Medland, S. E., Meeus, W. H. J., Miller, M. B., Montgomery, G. W., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Qaiser, B., Quaye, L., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, M. J., Koot, H. M., Paus, T., Hewitt, J. K., Ribasés, M., Kaprio, J., Boks, M. P. M., Snieder, H., Spector, T., Munafò, M. R., Metspalu, A., Gelernter, J., Boomsma, D. I., Iacono, W. G., Martin, N. G., Gillespie, N. A., Derks, E. M. & Vink, J. M., 29 Mar 2016, In : Translational Psychiatry. 6, p. e769

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Cannabis
Single Nucleotide Polymorphism
Genome
Genes

Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2

Ware, J. J., Chen, X., Vink, J. M., Loukola, A., Minica, C. C., Pool, R., Milaneschi, Y., Mangino, M., Menni, C., Chen, J., Peterson, R. E., Auro, K., Lyytikäinen, L. P., Wedenoja, J., Stiby, A. I., Hemani, G., Willemsen, G., Hottenga, J. J., Korhonen, T., Heliövaara, M. & 18 othersPerola, M., Rose, R. J., Paternoster, L., Timpson, N., Wassenaar, C. A., Zhu, A. Z. X., Davey Smith, G., Raitakari, O. T., Lehtimäki, T., Kähönen, M., Koskinen, S., Spector, T. D., Penninx, B. W. J. H., Salomaa, V., Boomsma, D. I., Tyndale, R. F., Kaprio, J. & Munafò, M., 2016, In : Scientific Reports. 6, 20092, 20092.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cotinine
Genome-Wide Association Study
Tobacco Products
Meta-Analysis
Nicotine

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Kettunen, J., Demirkan, A., Würtz, P., Draisma, H. H. M., Haller, T., Rawal, R., Vaarhorst, A. A. M., Kangas, A. J., Lyytikäinen, L. P., Pirinen, M., Pool, R., Sarin, A-P., Soininen, P., Tukiainen, T., Wang, Q., Tiainen, M., Tynkkynen, T., Amin, N., Zeller, T., Beekman, M. & 30 othersDeelen, J., Willems van Dijk, K., Esko, T., Hottenga, J. J., van Leeuwen, E. M., Lehtimäki, T., Mihailov, E., Rose, R. J., de Craen, A. J., Gieger, C., Kähönen, M., Perola, M., Blankenberg, S., Savolainen, M. J., Verhoeven, A., Viikari, J., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Eriksson, J., Jula, A., Järvelin, M. R., Kaprio, J., Metspalu, A., Raitakari, O., Salomaa, V., Slagboom, P. E., Waldenberger, M., Ripatti, S. & Ala-Korpela, M., 2016, In : Nature Communications. 7, 11122.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
lipoproteins
Lipoprotein(a)
genome
metabolites
Genome-Wide Association Study

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

Spjuth, O., Krestyaninova, M., Hastings, J., Shen, H. Y., Heikkinen, J., Waldenberger, M., Langhammer, A., Ladenvall, C., Esko, T., Persson, M. Å., Heggland, J., Dietrich, J., Ose, S., Gieger, C., Ried, J. S., Peters, A., Fortier, I., de Geus, E. J. C., Klovins, J., Zaharenko, L. & 16 othersWillemsen, G., Hottenga, J. J., Litton, J. E., Karvanen, J., Boomsma, D. I., Groop, L., Rung, J., Palmgren, J., Pedersen, N. L., McCarthy, M. I., van Duijn, C. M., Hveem, K., Metspalu, A., Ripatti, S., Prokopenko, I. & Harris, J. R., 2016, In : European Journal of Human Genetics. 24, 4, p. 521-528

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Privacy
Blood Vessels
Molecular Epidemiology
Vocabulary
Research

Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility

Mbarek, H., Steinberg, S., Nyholt, DR., Gordon, S. D., Miller, M. B., McRae, A. F., Hottenga, J. J., Day, F. R., Willemsen, G., de Geus, E. J. C., Davies, G. E., Martin, H. C., Penninx, B. W. J. H., Jansen, R., McAloney, K., Vink, J. M., Kaprio, J., Plomin, R., Spector, T. D., Magnusson, P. K. & 17 othersReversade, B., Harris, R. A., Aagaard, K., Kristjansson, R. P., Olafsson, I., Eyjolfsson, G. I., Sigurdardottir, O., Iacono, W. G., Lambalk, C. B., Montgomery, G. W., McGue, M., Ong, K. K., Perry, J. R. B., Martin, N. G., Stefansson, H., Stefansson, K. & Boomsma, D. I., 2016, In : American Journal of Human Genetics. 98, 5, p. 898-908

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Fertility
Mothers
Dizygotic Twins
Genome-Wide Association Study
Single Nucleotide Polymorphism

KLB is associated with alcohol drinking, and its gene product B-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O'Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S. R., Hottenga, J. J., Mbarek, H., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Bakalkin, G., Evangelou, E., Liu, Y., Rice, K. M., Desrivieres, S. & 5 othersKliewer, S. A., Mangelsdorf, D. J., Müller, C. P., Levy, D. & Elliott, P., 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14372-14377

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., Farh, K. H., Cuenca-Leon, E., Muona, M., Furlotte, N. A., Kurth, T., Ingason, A., McMahon, G., Ligthart, R. S. L., Terwindt, G. M., Kallela, M., Freilinger, T., Ran, C., Gordon, S. G., Stam, A. H. & 88 othersSteinberg, S., Borck, G., Koiranen, M., Quaye, L., Adams, H. H. H., Lehtimäki, T., Sarin, A. P., Wedenoja, J., Hinds, D. A., Buring, J. E., Schürks, M., Ridker, P. M., Gudlaug Hrafnsdottir, M., Stefansson, H., Ring, S. M., Hottenga, J. J., Penninx, B. W. J. H., Färkkilä, M., Artto, V., Kaunisto, M. A., Vepsäläinen, S., Malik, R., Heath, A. C., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Kurki, M. I., Kals, M., Mägi, R., Pärn, K., Hämaläinen, E., Huang, H., Byrnes, A. E., Franke, L., Huang, J., Stergiakouli, E., Lee, P. H., Sandor, C., Webber, C., Cader, Z., Müller-Myhsok, B., Schreiber, S., Meitinger, T., Eriksson, J. G., Salomaa, V., Heikkilä, K., Loehrer, A. G., Uitterlinden, A. G., Hofman, A., van Duijn, C. M., Cherkas, L., Pedersen, L., Stubhaug, A., Nielsen, C. S., Männikkö, M., Mihailov, E., Milani, L., Göbel, H., Esserlind, A. L., Francke Christensen, A., Folkmann Hansen, T., Werge, T., Kaprio, J., Aromaa, A., Raitakari, O., Ikram, M. A., Spector, T. D., Järvelin, M. R., Metspalu, A., Kubisch, C., Strachan, D. P., Ferrari, M. D., Belin, A. C., Dichgans, M., Wessman, M., van den Maagdenberg, A. M. J. M., Zwart, J. A., Boomsma, D. I., Davey Smith, G., Stefansson, K., Eriksson, N., Daly, M. J., Neale, B. M., Olesen, J., Chasman, D. I., Nyholt, DR., Palotie, A. & Posthuma, D., 2016, In : Nature Genetics. 48, 8, p. 856-866

Research output: Contribution to JournalArticleAcademicpeer-review

Migraine Disorders
Meta-Analysis
Genome-Wide Association Study
Nervous System Diseases
Vascular Diseases

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

van den Berg, S. M., de Moor, M. H. M., Verweij, C. J. H., Krueger, R. F., Luciano, M., Vasquez, A. A., Matteson, L. K., Derringer, J., Esko, T., Amin, N., Gordon, S. D., Hansell, N. K., Hart, A. B., Seppälä, I., Huffman, J. E., Konte, B., Lahti, J., Miller, M., Nutile, T., Tanaka, T. & 95 othersTeumer, A., Viktorin, A., Wedenoja, J., Abdellaoui, A., Abecasis, G. R., Adkins, D. E., Agrawal, A., Allik, J., Appel, K., Bigdeli, T. B., Busonero, F., Campbell, H., Costa, P. T., Davey Smith, G., Davies, G., de Wit, H., Ding, J., Engelhardt, B. E., Eriksson, J. G., Fedko, I. O., Ferrucci, L., Franke, B., Giegling, I., Grucza, R., Hartmann, A. M., Heath, A. C., Heinonen, K., Henders, A. K., Homuth, G., Hottenga, J. J., Iacono, W. G., Janzing, J., Jokela, M., Karlsson, R., Kemp, J. P., Kirkpatrick, M. G., Latvala, A., Lehtimäki, T., Liewald, D. C., Madden, P. A. F., Magri, C., Magnusson, P. K. E., Marten, J., Maschio, A., Mbarek, H., Medland, S. E., Mihailov, E., Milaneschi, Y., Montgomery, G. W., Nauck, M., Nivard, M. G., Ouwens, K. G., Palotie, A., Pettersson, E., Polasek, O., Qian, Y., Pulkki-Raback, L., Raitakari, O. T., Realo, A., Rose, R. J., Ruggiero, D., Schmidt, C. O., Slutske, W. S., Sorice, R., Starr, J. M., St Pourcain, B., Sutin, A. R., Timpson, N. J., Trochet, H., Zgaga, L., Porteous, D., Minelli, A., Palmer, A. A., Rujescu, D., Ciullo, M., Hayward, C., Rudan, I., Metspalu, A., Kaprio, J., Deary, I. J., Räikkönen, K., Wilson, J. F., Keltikangas-Järvinen, L., Bierut, L. J., Hettema, J. M., Grabe, H. J., Penninx, B. W. J. H., van Duijn, C. M., Evans, D. M., Schlessinger, D., Pedersen, N. L., Terracciano, A., McGue, M., Martin, N. G. & Boomsma, D. I., 2016, In : Behavior Genetics. 46, 2, p. 170-182

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
meta-analysis
Personality
Meta-Analysis
genome

Meta-analysis of genome-wide association studies of anxiety disorders

Otowa, T., Hek, K., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T. B., Aggen, S. H., Adkins, D. E., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., van der Auwera, S. V., Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J. J., Direk, N. & 26 othersHofman, A., Uitterlinden, A. G., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F., Pergadia, M. L., van der Most, P. J., Nolte, I. M., van Oort, F. V. A., Hartman, C. A., Oldehinkel, A. J., Preisig, M., Grabe, H. J., Middeldorp, C. M., Penninx, B. W. J. H., Boomsma, D. I., Martin, N. G., Montgomery, G. W., Maher, B. S., van den Oord, E. J., Wray, N. R., Tiemeier, H. & Hettema, J. M., 2016, In : Molecular Psychiatry. 21, 10, p. 1391-1399

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Anxiety Disorders
Meta-Analysis
Phenotype
Genome

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Adams, H. H. H., Hibar, D. P., Chouraki, V., Stein, J. L., Nyquist, P. A., Renteria, M. E., Trompet, S., Arias Vazquez, A., Seshadri, S., Desrivieres, S., den Braber, A., Boomsma, D. I., de Geus, E. J. C., Fedko, I. O., Hottenga, J. J., Hulshoff Pol, H. E., Penninx, B. W. J. H., de Craen, A. J., Wright, M. J., Launer, L. J. & 8 othersSchumann, G., van t Ent, D., Fornage, M., Franke, B., Debette, S., Medland, S. E., Arfan Ikram, M. & Thompson, P. M., 2016, In : Nature Neuroscience. 19, 12, p. 1569-1582

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Loci
Genome
Genome-Wide Association Study
Phosphatidylinositol 3-Kinases
Cognition

Obsessive–compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs

den Braber, A., Rodrigues Zilhao Nogueira, N., Fedko, I. O., Hottenga, J. J., Pool, R., Smit, D. J. A., Cath, D. C. & Boomsma, D. I., 2016, In : Translational Psychiatry. 6, e731

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Personality Polygenes, Positive Affect, and Life Satisfaction.

Weiss, A., Baselmans, B. M. L., Hofer, E., Yang, J., Okbay, A., Lind, P. A., Miller, M. B., Nolte, I. M., Zhao, W., Hagenaars, S. P., Hottenga, J. J., Matteson, L. K., Snieder, H., Faul, J. D., Hartman, C. A., Boyle, P. A., Tiemeier, H., Mosing, M. A., Pattie, A., Davies, G. & 26 othersLiewald, D. C., Schmidt, R., Jager, P. L., Heath, A. C., Jokela, M., Starr, J. M., Oldehinkel, A. J., Johannesson, M., Cesarini, D., Hofman, A., Harris, S. E., Smith, J. A., Keltikangas-Järvinen, L., Pulkki-Råback, L., Schmidt, H., Smith, J., Iacono, W. G., McGue, M., Bennett, D. A., Pedersen, N. L., Magnusson, P. K. E., Deary, I. J., Martin, N. G., Boomsma, D. I., Bartels, M. & Luciano, M., 2016, In : Twin Research and Human Genetics. 19, p. 407-417 5.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Personality
Equipment and Supplies
Genome
Personality Inventory
Genetic Research

Polygenic dissection of major depression clinical heterogeneity

Milaneschi, Y., Winkelman, F., Peyrot, W., Abdellaoui, A., Willemsen, G., Hottenga, J. J., Jansen, R., Mbarek, H., Dehghan, A., Lu, C., Boomsma, D. I. & Penninx, B. W. J. H., 2016, In : Molecular Psychiatry. 21, 4, p. 516-522

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Dissection
Depression
Psychiatry
Odds Ratio

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

Ricano-Ponce, I., Zhernakova, D. V., Deelen, P., Luo, O., Li, X., Isaacs, A., Karjalainen, J., Di. Tommaso, J., Borek, Z. A., Zorro, M. M., Gutierrez-Achury, J., Uitterlinden, A. G., Hofman, A., van Meurs, J., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Neteaf, M. G., Jonkers, I. H. & 7 othersWithoff, S., van Duijn, C. M., Li, Y., Ruan, Y., Franke, L., Wijmenga, C. & Kumar, V., 2016, In : Journal of Autoimmunity. 68, p. 62-74

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

The Genetic Overlap Between Hair and Eye Color

Lin, B., Willemsen, G., Abdellaoui, A., Bartels, M., Ehli, E. A., Davies, G. E., Boomsma, D. I. & Hottenga, J. J., 2016, In : Twin Research and Human Genetics. 19, 6, p. 595-599

Research output: Contribution to JournalArticleAcademicpeer-review

Hair Color
Eye Color
Netherlands
Phenotype
Genome-Wide Association Study

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L. A., Kanoni, S., Jansen, R., Boomsma, D. I., Hottenga, J. J., Penninx, B. W. J. H., van Duijn, C. M., Wichmann, H. E., Palmer, C. N. A., Stefansson, K., Ridker, P. M., Loos, R. J. F. & 5 othersChakravarti, A., Deloukas, P., Morris, A. P., Newton-Cheh, C. & Munroe, P. B., 2016, In : Nature Genetics. 48, 10, p. 1171-1184

Research output: Contribution to JournalArticleAcademicpeer-review

Blood Pressure
Single Nucleotide Polymorphism
Kidney
Blood Vessels
Endothelial Cells
2015

CNV Concordance in 1,097 MZ Twin Pairs

Abdellaoui, A., Ehli, E. A., Hottenga, J. J., Weber, Z., Mbarek, H., Willemsen, G., van Beijsterveldt, C. E. M., Brooks, A., Hudziak, J. J., Sullivan, P. F., de Geus, E. J. C., Davies, G. E. & Boomsma, D. I., 2015, In : Twin Research and Human Genetics. 18, 1, p. 1-12 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Monozygotic Twins
Cheek
DNA
Epithelium
Overlapping Genes

Common genetic variants influence human subcortical brain structures

Hibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., Andersson, M., Aribisala, B. S., Armstrong, N. J., Bernard, M., Bohlken, M. M., Biks, M. P., Bralten, J., Brown, A. A., Chakravarty, M. M., Chen, Q., Ching, C. R. K. & 267 othersCuellar-Partida, G., den Braber, A., Giddaluru, S., Goldman, A. L., Grimm, O., Guadalupe, T., Hass, J., Woldehawariat, G., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Olde Loohuis, L. M., Luciano, M., Macare, C., Mather, K. A., Mattheisen, M., Milaneschi, Y., Nho, K., Papmeyer, M., Ramasamy, A., Risacher, S. L., Roiz-Santiañez, R., Rose, E. J., Salami, A., Sämann, P. G., Schmaal, L., Schork, A. J., Shin, J., Strike, L. T., Teumer, A., Donkelaar, M. M. J., van Eijk, K. R., Walters, R. K., Westlye, L. T., Welan, C. D., Winkler, A. M., Zwiers, M. P., Alhusaini, S., Athanasiu, L., Ehrlich, S., Hakobjan, M. M. H., Hartberg, C. B., Haukvik, U. K., Heister, A. J. G. A. M., Hoehn, D., Kasperaviciute, D., Liewald, D. C. M., Lopez, L. M., Makkinje, R. R., Matarin, M., Naber, M. A. M., Reese McKay, D., Needham, M., Nugent, A. C., Pütz, B., Royle, N. A., Shen, L., Sprooten, E., Trabzuni, D., van der Marel, S. S. L., van Hulzen, K. J. E., Walton, E., Wolf, C., Almasy, L., Ames, D., Arepalli, S., Assareh, A. A., Bastin, M. E., Brodaty, H., Bulayeva, K. B., Carless, M. A., Cichon, S., Corvin, A., Curran, J. E., Czisch, M., de Zubicaray, G. I., Dillman, A., Duggirala, R., Dyer, T. D., Erk, S., Fedko, I. O., Ferrucci, L., Foroud, T. M., Fox, P. T., Fukunaga, M., Gibbs, J. R., Göring, H. H. H., Green, R. C., Guelfi, S., Hansell, N. K., Hartman, C. A., Hegenscheid, K., Heinz, A., Hernandez, D. G., Heslenfeld, D. J., Hoekstra, P. J., Holsboer, F., Homuth, G., Hottenga, J. J., Ikeda, M., Jack, C. R. . J., Jenkinson, M., Johnson, R., Kanai, R., Keil, M., Kent, J. W. J., Kochunov, P., Kwok, J. B., Lawrie, S. M., Liu, X., Longo, D. L., McMahon, K. L., Meisenzahl, E., Melle, I., Mohnke, S., Montgomery, G. W., Mostert, J. C., Mühleisen, T. W., Nalls, M. A., Nichols, T. E., Nilsson, L. G., Nöthen, M. M., Ohi, K., Olvera, R. L., Perez-Iglesias, R., Pike, G. B., Potkin, S. G., Reinvang, I., Reppermund, S., Rietschel, M., Romanczuk-Seiferth, N., Rosen, G. D., Rujescu, D., Schnell, K., Schofield, P. R., Smith, C., Steen, V. M., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Valdés Hernández, M. C., van t Ent, D., van der Brug, M., van der Wee, N. J. A., van Tol, M. J., Veltman, D. J., Wassink, T. H., Westmann, E., Zielke, R. H., Zonderman, A. B., Ashbrook, D. G., Hager, R., Lu, L., McMahon, F. J., Morris, D. W., Williams, R. W., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Cahn, W., Calhoun, V. D., Cavalleri, G. L., Crespo-Facorro, B., Dale, A. M., Davies, G. E., Delanty, N., Depondt, C., Djurovic, S., Drevets, W. C., Espeseth, T., Gollub, R. L., Ho, B. C., Hoffmann, W., Hosten, N., Kahn, R. S., Le Hellard, S., Meyer-Lindenberg, A., Müller-Myhsok, B., Nauck, M., Nyberg, L., Pandolfo, M., Penninx, B. W. J. H., Roffman, J. L., Sisodiya, SM., Smoller, J. W., van Bokhoven, H., van Haren, N. E. M., Völzke, H., Walter, H., Weiner, M. W., Wen, W., White, T., Agartz, I., Andreassen, O. A., Blangero, J., Boomsma, D. I., Brouwer, R. M., Cannon, D. M., Cookson, M. R., de Geus, E. J. C., Deary, I. J., Donohoe, G., Fernandez, G., Fisher, S. E., Francks, C., Glahn, D. C., Grabe, H. J., Gruber, O., Hardy, J., Hashimoto, R., Hulshoff Pol, H. E., Jönsson, E. G., Kloszewska, I., Lovestone, S., Mattay, V. S., Mecocci, P., McDonald, C., McIntosh, A. M., Ophoff, R. A., Paus, T., Pausova, Z., Ryten, M., Sachdev, P. S., Saykin, A. J., Simmons, A., Singleton, A., Soininen, H., Wardlaw, J. M., Weale, M. E., Weinberger, D. R., Adams, H. H. H., Launer, L. J., Seiler, S., Schmidt, R., Chauhan, G., Satizabal, C. L., Becker, J. T., Yanek, L., van der Lee, S. J., Ebling, M., Fischl, B., Longstreth, J. W. T., Greve, D., Schmidt, H., Nyquist, P., Vinke, L. N., van Duijn, C. M., Xue, L., Mazoyer, B., Bis, J. C., Gudnason, V., Seshadri, S., Arfan Ikram, M., Martin, N. G., Wright, M. J., Schumann, G., Franke, B., Thompson, P. M. & Medland, S. E., 2015, In : Nature. 520, 7546, p. 224-229 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Putamen
Brain
Developmental Genes
Transport Vesicles
Caudate Nucleus

Directional dominance on stature and cognition in diverse human populations

Joshi, P. K., Esko, T., Mattsson, H., Eklund, N., Gandin, I., Nutile, T., Jackson, A. U., Schurmann, C., Smith, A. V., Zhang, W., Okada, Y., Stancáková, A., Faul, J. D., Zhao, W., Bartz, T. M., Pina Concas, M., Franceschini, N., Enroth, S., Vitart, V., Trompet, S. & 338 othersGuo, X., Chasman, D. I., O'Connel, J. R., Corre, T., Nongmaithem, S. S., Chen, Y., Mangino, M., Ruggiero, D., Traglia, M., Farmaki, A-E., Kacprowski, T., Bjonnes, A., Spek, A., Wu, Y., Giri, A. K., Yanek, L. R., Wang, L., Hofer, E., Rietveld, C. A., McLeod, O., Cornelis, M. C., Pattaro, C., Verweij, N., Baumbach, C., Abdellaoui, A., Warren, H. R., Vuckovic, D., Mei, H., Bouchard, C., Perry, J. R. B., Cappellani, S., Mirza, S. S., Benton, M. C., Broeckel, U., Medland, S. E., Lind, P. A., Malerba, G., Drong, A., Yengo, L., Bielak, L. F., Zhi, D., van der Most, P. J., Shriner, D., Mägi, R., Hemani, G., Karaderi, T., Wang, Z., Liu, T., Demuth, I., Zhao, J. H., Meng, W., Lataniotis, L., van der Laan, S. W., Brafdfield, J. P., Wood, A. R., Bonnefond, A., Ahluwalia, T. S., Hall, L. M., Salvi, E., Yazar, S., Carstensen, L., de Haan, H. G., Abney, M., Afzal, U., Allison, M. A., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Barr, R. G., Baumeister, S. E., Benjamin, D. J., Bergmann, S., Boerwinkle, E., Bottinger, E. P., Campbell, A., Chakravarti, A., Chan, Y., Chanock, S. J., Chen, C., Chen, Y. D. I., Colins, F. S., Connell, J., Correa, A., Cupples, L. A., Davey Smith, G., Davies, G., Dörr, M., Ehret, G., Ellis, S. B., Feenstra, B., Feitosa, M. F., Ford, I., Fox, C. S., Frayling, T. M., Friedrich, N., Geller, F., Gillham-Nasenya, I., Gottesman, O., Graff, M., Grodstein, F., Gu, C., Haley, C., Hammond, C. J., Harris, S. E., Harris, T. B., Hastie, N. D., Heard-Costa, N. L., Heikkilä, K., Hocking, L. J., Homuth, G., Hottenga, J. J., Huang, J., Huffman, J. E., Hysi, P. G., Arfan Ikram, M., Ingelsson, E., Joensuu, A., Johansson, A., Jousilahti, P., Jukema, J. W., Kähönen, M., Kamatani, Y., Kanoni, S., Kerr, S. M., Khan, N. M., Koellinger, P., Koistinen, H. A., Kooner, M. K., Kubo, M., Kuusisto, J., Lahti, J., Launer, L. J., Lea, R. A., Lehne, B., Lehtimäki, T., Liewald, D. C. M., Lind, L., Loh, M., Lokki, M. L., London, S. J., Loomis, S. J., Loukola, A., Lu, Y., Lumley, T., Lundqvist, A., Männistö, S., Marques-Vidal, P., Masciullo, C., Matchan, A., Mathias, R. A., Matsuda, K., Meigs, J. B., Meisinger, C., Meitinger, T., Menni, C., Mentch, F. D., Mihailov, E., Milani, L., Montasser, M. E., Montgomery, G. W., Morrison, A., Myers, R. H., Nadukuru, R., Navarro, P., Nelis, M., Nieminen, M. S., Nolte, I. M., O'Connor, G. T., Ogunniyi, A., Padmanabhan, S., Palmas, W. R., Pankow, J. S., Patarcic, I., Pavani, F., Peyser, P. A., Pietilainen, K. H., Poulter, N., Prokopenko, I., Ralhan, S., Redmond, P., Rich, S. S., Rissanen, H., Robino, A., Rose, L. M., Rose, R., Sala, C., Salako, B., Salomaa, V., Sarin, A-P., Saxena, R., Schmidt, H., Scott, L. J., Scott, W. R., Sennblad, B., Seshadri, S., Sever, P., Shrestha, S., Smith, B. H., Smith, J. A., Soranzo, N., Sotoodehnia, N., Southam, L., Stanton, A. V., Stathopoulou, M. G., Strauch, K., Strawbridge, R. J., Suderman, M. J., Tandon, N., Tang, S. T., Taylor, K. D., Tayo, B. O., Töglhofer, A. M., Tomaszewski, M., Tsernikova, N., Tuomilehto, J., Uitterlinden, A. G., Vaidya, D., Hylckama Vlieg, A., van Setten, J., Vasankari, T., Vedantam, S., Vlachopoulou, E., Vozzi, D., Vuoksimaa, E., Waldenberger, M., Ware, E. B., Wentworth-Shields, W., Whitfield, J. B., Wild, S., Willemsen, G., Yajnik, C. S., Yao, J., Zaza, G., Zhu, X., Salem, R. M., Melbye, M., Bisgaard, H., Samani, N. J., Cusi, D., Mackey, D. A., Cooper, R. S., Froguel, P., Pasterkamp, G., Grant, S. F. A., Hakonarson, H., Ferrucci, L., Scott, R. A., Morris, A. D., Palmer, C. N. A., Dedoussis, G., Deloukas, P., Bertram, L., Lindenberger, U., Berndt, S. I., Lindgren, C. M., Timpson, N. J., Tönjes, A., Munroe, P. B., Sorensen, T. I. A., Rotimi, C. N., Arnett, D. K., Oldehinkel, A. J., Kardia, S. L. R., Balkau, B., Gambaro, G., Morris, A. P., Eriksson, J. G., Wright, M. J., Martin, N. G., Hunt, S. C., Starr, J. M., Deary, I. J., Griffiths, L. R., Tiemeier, H., Pirastu, N., Kaprio, J., Wareham, N. J., Pérusse, L., Wilson, J. G., Girotto, G., Caulfield, M. J., Raitakari, O., Boomsma, D. I., Gieger, C., van der Harst, P., Hicks, A. A., Kraft, P., Sinisalo, J., Knekt, P., Johannesson, M., Magnusson, P. K. E., Hamsten, A., Schmidt, R., Borecki, I. B., Vartiainen, E., Becker, D. M., Bharadwaj, D., Mohlke, K. L., Boehnke, M., van Duijn, C. M., Sanghera, D. K., Teumer, A., Zeggini, E., Metspalu, A., Gasparini, P., Ulivi, S., Ober, C., Toniolo, D., Rudan, I., Porteous, D. J., Ciullo, M., Spector, T. D., Hayward, C., Dupuis, J., Loos, R. J. F., Wright, A. F., Chandak, G. R., Vollenweider, P., Shuldiner, A. R., Ridker, P. M., Rotter, J. I., Sattar, N., Gyllensten, U., North, K. E., Pirastu, M., Psaty, B. M., Weir, D. R., Laakso, M., Gudnason, V., Takahashi, A., Chambers, J. C., Kooner, J. S., Strachan, D. P., Campbell, H., Hirschhorn, J. N., Perola, M., Polasek, O. & Wilson, J. F., 2015, In : Nature. 523, 7561, p. 459-462 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cognition
Aptitude
Inbreeding
Forced Expiratory Volume
Population

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High- Density Imputation

Horikoshi, M., Mägi, R., van de Bunt, M., Surakka, I., Sarin, A-P., Mahajan, A., Marullo, L., Thorleifsson, G., Hägg, S., Hottenga, J. J., Ladenvall, C., Ried, J. S., Winkler, T. W., Willems, S. M., Pervjakova, N., Esko, T., Beekman, M., Nelson, C. P., Willenborg, C., Wiltshire, S. & 62 othersFerreira, T., Fernandez, J., Gaulton, K. J., Steinthorsdottir, V., Hamsten, A., Magnusson, P. K. E., Willemsen, G., Milaneschi, Y., Robertson, N. R., Groves, C. J., Bennett, A. J., Lehtimäki, T., Viikari, J. S., Rung, J., Lyssenko, V., Perola, M., Heid, I. M., Herder, C., Grallert, H., Müller-Nurasyid, M., Roden, M., Hypponen, E., Isaacs, A., van Leeuwen, E. M., Karssen, L. C., Mihailov, E., Houwing-Duistermaat, J. J., de Craen, A. J., Deelen, J., Havulinna, A. S., Blades, M., Hengstenberg, C., Erdmann, J., Schunkert, H., Kaprio, J., Tobin, M. D., Samani, N. J., Lind, L., Salomaa, V., Lindgren, C. M., Slagboom, P. E., Metspalu, A., van Duijn, C. M., Eriksson, J. G., Peters, A., Gieger, C., Jula, A., Groop, L., Raitakari, O. T., Power, C., Penninx, B. W. J. H., de Geus, E. J. C., Smit, J. H., Boomsma, D. I., Pedersen, N. L., Ingelsson, E., Thorsteinsdottir, U., Stefansson, K., Ripatti, S., Prokopenko, I., McCarthy, M. I. & Morris, A. P., 2015, In : PLoS Genetics. 11, 7, 24 p., e1005230.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
obesity
Genome-Wide Association Study
genome
Obesity
Genome

Educational Attainment Influences Levels of Homozygosity through Migration and Assortative Mating

Abdellaoui, A., Hottenga, J. J., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Ehli, E. A., Davies, G. E., Brooks, A., Sullivan, P. F., Penninx, B. W. J. H., de Geus, E. J. C. & Boomsma, D. I., 2015, In : PLoS ONE. 10, 3, 14 p., e0118935.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
assortative mating
homozygosity
ancestry
spouses
Education

Estimation of Genetic Relationships Between Individuals Across Cohorts and Platforms: Application to Childhood Height

Fedko, I. O., Hottenga, J. J., Medina-Gomez, C., Pappa, I., van Beijsterveldt, C. E. M., Ehli, E. A., Davies, G. E., Rivadeneira, F., Tiemeier, H., Swertz, M. A., Middeldorp, C. M., Bartels, M. & Boomsma, D. I., 2015, In : Behavior Genetics. 45, 5, p. 514-528 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
childhood
single nucleotide polymorphism
genetic relationships
Single Nucleotide Polymorphism
polymorphism

Genetic Analyses Benefit From Using Less Heterogeneous Phenotypes: An Illustration With the Hospital Anxiety and Depression Scale (HADS)

Laurin, C. A., Hottenga, J. J., Willemsen, G., Boomsma, D. I. & Lubke, G. H., 2015, In : Genetic Epidemiology. 39, 4, p. 317-324 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Anxiety
Depression
Phenotype
Genome-Wide Association Study
Single Nucleotide Polymorphism

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., Altmann, A., Trümbach, D., Wurst, W., Mehta, D., Uhr, M., Klengel, T., Erhardt, A., Carey, C. E., Drabant Conley, E., Boomsma, D. I. & 10 othersPenninx, B. W. J. H., de Geus, E. J. C., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Smit, J. H., Ruepp, A., Müller-Myhsok, B., Hariri, A. & Binder, E. B., 2015, In : Neuron. 86, p. 1189-1202 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Transcriptome
Psychiatry
Glucocorticoid Receptors
Brain
Endophenotypes

Genetic studies of body mass index yield new insights for obesity biology

Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., Powell, C., Vedantam, S., Buchkovich, M. L., Yang, J., Croteau-Chonka, D. C., Esko, T., Fall, T., Ferreira, T., Gustafsson, S., Kutalik, Z., Luan, J., Maegi, R., Randall, J. C., Winkler, T. W. & 461 othersWood, A. R., Workalemahu, T., Faul, J. D., Smith, J. A., Zhao, J. H., Zhao, W., Chen, J., Fehrmann, R., Hedman, A. K., Karjalainen, J., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bolton, J. L., Bragg-Gresham, L., Buyske, S., Demirkan, A., Deng, G., Ehret, G. B., Feenstra, B., Feitosa, M. F., Fischer, K., Goel, A., Gong, J., Jackson, A. U., Kanoni, S., Kleber, M. E., Kristiansson, K., Lim, U., Lotay, V., Mangino, M., Leach, I. M., Medina-Gomez, C., Medland, S. E., Nalls, M. A., Palmer, C. D., Pasko, D., Pechlivanis, S., Peters, MJ., Prokopenko, I., Shungin, D., Stancakova, A., Strawbridge, R. J., Sung, Y. J., Teumer, A., Trompet, S., van der Laan, S. W., van Settee, J., Van Vliet-Ostaptchouk, J. V., Wang, Z., Yengo, L., Zhang, W., Isaacs, A., Albrecht, E., Arnlov, J., Arscott, G. M., Attwood, A. P., Bandinelli, S., Barrett, A., Bas, I. N., Bellis, C., Bennett, A. J., Berne, C., Blagieva, R., Blueher, M., Bohringer, S., Bonnycastle, L. L., Boettcher, Y., Boyd, H. A., Bruinenberg, M., Caspersen, I. H., Chen, Y. I., Clarke, R., Daw, E. W., de Craen, A. J. M., Delgado, G., Dimitriou, M., Doney, A. S. F., Eklund, N., Estrada, K., Eury, E., Folkersen, L., Fraser, R. M., Garcia, M. E., Geller, F., Giedraitis, V., Gigante, B., Go, A. S., Golay, A., Goodall, A. H., Gordon, S. D., Gorski, M., Grabe, H., Grallert, H., Grammer, T. B., Graessler, J., Gronberg, H., Groves, C. J., Gusto, G., Haessler, J., Hall, P., Haller, T., Hallmans, G., Hartman, C. A., Hassinen, M., Hayward, C., Heard-Costa, N. L., Helmer, Q., Hengstenberg, C., Holmen, O., Hottenga, J. J., James, A. L., Jeff, J. M., Johansson, A., Jolley, J., Juliusdottir, T., Kinnunen, L., Koenig, W., Koskenvuo, M., Kratzer, W., Laitinen, J., Lamina, C., Leander, K., Lee, N. R., Lichtner, P., Lind, L., Lindstrom, J., Lo, K. S., Lobbens, S., Lorbeer, R., Lu, Y., Mach, F., Magnusson, P. K. E., Mahajan, A., McArdle, W. L., McLachlan, S., Menni, C., Merger, S., Mihailov, E., Milani, L., Moayyeri, A., Monda, K. L., Morken, M. A., Mulas, A., Mueller, G., Mueller-Nurasyid, M., Musk, A. W., Nagaraja, R., Noethen, M. M., Nolte, I. M., Pilz, S., Rayner, N. W., Renstrom, F., Rettig, R., Ried, J. S., Ripke, S., Robertson, N. R., Rose, L. M., Sanna, S., Scharnagl, H., Scholtens, S., Schumacher, F. R., Scott, W. R., Seufferlein, T., Shi, J., Smith, A. V., Smolonska, J., Stanton, A. V., Steinthorsdottir, V., Stirrups, K., Stringham, H. M., Sundstrom, J., Swertz, M. A., Swift, A. J., Syvanen, A., Tan, S., Tayo, B. O., Thorand, B., Thorleifsson, G., Tyrer, J. P., Uh, H., Vandenput, L., Verhulst, F. C., Vermeulen, S. H., Verweij, N., Vonk, J. M., Waite, L. L., Warren, H. R., Waterworth, D., Weedon, M. N., Wilkens, L. R., Willenborg, C., Wilsgaard, T., Wojczynski, M. K., Wong, A., Wrightl, A. F., Zhang, Q., Brennan, E. P., Choi, M., Dastani, Z., Drong, A. W., Eriksson, P., Franco-Cereceda, A., Gadin, J. R., Gharavi, A. G., Goddard, M. E., Handsaker, R. E., Huang, J., Karpe, F., Kathiresan, S., Keildson, S., Kiryluk, K., Kubo, M., Lee, J., Liang, L., Lifton, R. P., Ma, B., McCarroll, S. A., McKnight, A. J., Min, J. L., Moffatt, M. F., Montgomery, G. W., Murabito, J. M., Nicholson, G., Nyholt, DR., Okada, Y., Perry, J. R. B., Dorajoo, R., Reinmaa, E., Salem, R. M., Sandholm, N., Scott, R. A., Stolk, L., Takahashi, A., Tanaka, T., van 't Hooft, F. M., Vinkhuyzen, A. A. E., Westra, H., Zheng, W., Zondervan, K. T., Heath, A. C., Arveiler, D., Bakker, S. J. L., Beilby, J., Bergman, R. N., Blangero, J., Bovet, P., Campbell, H., Caulfield, M. J., Cesana, G., Chakravarti, A., Chasman, D. I., Chines, P. S., Collins, F. S., Crawford, D. C., Cupples, L. A., Cusi, D., Danesh, J., de Faire, U., den Ruijter, H. M., Dominiczak, A. F., Erbel, R., Erdmann, J., Eriksson, J. G., Farrall, M., Felix, S. B., Ferrannini, E., Ferrieres, J., Ford, I., Forouhi, N. G., Forrester, T., Franco, O. H., Gansevoort, R. T., Gejman, P. V., Gieger, C., Gottesman, O., Gudnason, V., Gyllensten, U., Hall, A. S., Harris, T. B., Hattersley, A. T., Hicks, A. A., Hindorff, L. A., Hingorani, A. D., Hofman, A., Homuth, G., Hovingh, G. K., Humphries, S. E., Hunt, S. C., Hypponen, E., Illig, T., Jacobs, K. B., Jarvelin, M., Joeckel, K., Johansen, B., Jousilahti, P., Jukema, J. W., Jula, A. M., Kaprio, J., Kastelein, J. J. P., Keinanen-Kiukaanniemi, S. M., Kiemeney, L. A., Knekt, P., Kooner, J. S., Kooperberg, C., Kovacs, P., Kraja, A. T., Kumari, M., Kuusisto, J., Lakka, T. A., Langenberg, C., Le Marchand, L., Lehtimaki, T., Lyssenko, V., Mannisto, S., Marette, A., Matise, T. C., McKenzie, C. A., McKnight, B., Moll, F. L., Morris, A. D., Morris, A. P., Murray, J. C., Nelis, M., Ohlsson, C., Oldehinkel, A. J., Ong, K. K., Madden, P. A. F., Pasterkamp, G., Peden, J. F., Peters, A., Postma, D. S., Pramstaller, P. P., Price, J. F., Qi, L., Raitakari, O. T., Rankinen, T., Rao, D. C., Rice, T. K., Ridker, P. M., Rioux, J. D., Ritchie, M. D., Rudan, I., Salomaa, V., Samani, N. J., Saramines, J., Sarzynski, M. A., Schunkert, H., Schwarz, P. E. H., Sever, P., Shuldiner, A. R., Sinisalo, J., Stolk, R. P., Strauch, K., Toenjes, A., Tregouet, D., Tremblay, A., Tremoli, E., Virtamo, J., Vohl, M., Voelker, U., Waeber, G., Willemsen, G., Witteman, J. C., Zillikens, M. C., Adair, L. S., Amouyel, P., Asselbergs, F. W., Assimes, T. L., Bochud, M., Boehm, B. O., Boerwinkle, E., Bornstein, S. R., Bottinger, E. P., Bouchard, C., Cauchi, S., Chambers, J. C., Chanock, S. J., Cooper, R. S., de Bakker, P. I. W., Dedoussis, G., Ferrucci, L., Franks, P. W., Froguel, P., Groop, L. C., Haiman, C. A., Hamsten, A., Hui, J., Hunter, D. J., Hveem, K., Kaplan, R. C., Kivimaki, M., Kuh, D., Laakso, M., Liu, Y., Martin, N. G., Maerz, W., Melbve, M., Metspalu, A., Moebus, S., Munroe, P. B., Njolstad, I., Oostra, B. A., Palmer, C. N. A., Pedersen, N. L., Perola, M., Perusse, L., Peters, U., Power, C., Quertermous, T., Rauramaa, R., Rivadeneira, F., Saaristo, T. E., Saleheen, D., Sattar, N., Schadt, E. E., Schlessinger, D., Slagboom, P. E., Snieder, H., Spector, T. D., Thorsteinsdottir, U. R., Stumvoll, M., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., van der Harst, P., Walker, M., Wallaschofski, H., Wareham, N. J., Watkins, H., Weir, D. R., Wichmann, H., Wilson, J. F., Zanen, P., Borecki, I. B., Deloukas, P., Fox, C. S., Heid, I. M., O'Connell, J. R., Strachan, D. P., Stefansson, K., van Duijri, C. M., Abecasis, G. R., Franke, L., Frayling, T. M., McCarthy, M. I., Visscher, P. M., Scherag, A., Willer, C. J., Boehnke, M., Mohlke, K. L., Lindgren, C. M., Beckmann, J. S., Barroso, I., North, K. E., Ingelsson, E., Hirschhorn, J. N., Loos, R. J. F. & Speliotes, E. K., 2015, In : Nature. 518, 7538, p. 197-206

Research output: Contribution to JournalArticleAcademicpeer-review

Body Mass Index
Obesity
Genome-Wide Association Study
Adiposity
Meta-Analysis

Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

van Leeuwen, E. M., Karssen, L. C., Deelen, J., Isaacs, A., Medina-Gomez, C., Mbarek, H., Kanterakis, A., Trompet, S., Postmus, I., Verweij, N., van Enckevort, D., Huffman, J. E., White, C. C., Feitosa, M. F., Bartz, T. M., Manichaikul, A., Joshi, P. K., Peloso, G. M., Deelen, P., Dijk, F. & 52 othersWillemsen, G., de Geus, E. J. C., Milaneschi, Y., Penninx, B. W. J. H., Francioli, L. C., Menelaou, A., Pulit, S. L., Rivadeneira, F., Hofman, A., Oostra, B. A., Franco, O. H., Mateo Leach, I., Beekman, M., de Craen, A. J., Uh, H. W., Trochet, H., Hocking, L. J., Porteous, D. J., Sattar, N., Packard, C. J., Buckley, B. M., Brody, J. A., Bis, J. C., Rotter, J. I., Mychaleckyj, J. C., Campbell, H., Duan, Q., Lange, L. A., Wilson, J. F., Hayward, C., Polasek, O., Vitart, V., Rudan, I., Wright, A. F., Rich, S. S., Psaty, B. M., Borecki, I. B., Kearney, P. M., Stott, D. J., Cupples, L. A., Jukema, J. W., van der Harst, P., Sijbrands, E. J., Hottenga, J. J., Uitterlinden, A. G., Swertz, M. A., van Ommen, G. J. B., Bakker, P. I. W., Slagboom, P. E., Boomsma, D. I., Wijmenga, C. & van Duijn, C. M., 2015, In : Nature Communications. 6, p. 6065 6 p., 6065.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
genome
Netherlands
cholesterol
Blood
Genes

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Draisma, H. H. M., Pool, R., Kobl, M., Jansen, R., Petersen, A. K., Vaarhorst, A. A. M., Yet, I., Haller, T., Demirkan, A., Esko, T., Zhu, G., Böhringer, S., Beekman, M., van Klinken, J. B., Römisch-Margl, W., Prehn, C., Adamski, J., de Craen, A. J., van Leeuwen, E. M., Amin, N. & 28 othersDharuri, H., Westra, H. J., Franke, L., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Henders, A. K., Montgomery, G. W., Nyholt, DR., Whitfield, J. B., Penninx, B. W. J. H., Spector, T. D., Metspalu, A., Slagboom, P. E., Willems van Dijk, K., 't Hoen, P. A. C., Strauch, K., Martin, N. G., van Ommen, G. J. B., Illig, T., Bell, J. T., Mangino, M., Suhre, K., McCarthy, M. I., Gieger, C., Isaacs, A., van Duijn, C. M. & Boomsma, D. I., 2015, In : Nature Communications. 6, p. 7208 9 p., 7208.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
genome
metabolites
Genome-Wide Association Study
Metabolites
blood

Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder

Jacobsen, K. K., Nievergelt, C. M., Zayats, T., Greenwood, T. A., Anttila, V., Akiskal, H. S., Ligthart, R. S. L., Hottenga, J. J., Vink, J. M., Penninx, B. W. J. H., Boomsma, D. I., Haavik, J., Fasmer, O. B., Kelsoe, J. R., Johansson, S. & Oedegaard, K. J., 2015, In : Journal of Affective Disorders. 172, p. 453-461 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Migraine Disorders
Bipolar Disorder
Genome

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci

Rahmioglu, N., Macgregor, S., Drong, A. W., Hedman, A. K., Harris, H. R., Randall, J. C., Prokopenko, I., Hottenga, J. J., Boomsma, D. I., Nyholt, DR., Morris, A. P., Montgomery, G. W., Missmer, S. A., Lindgren, C. M. & Zondervan, K. T., 2015, In : Human Molecular Genetics. 24, 4, p. 1185-1199 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Endometriosis
Genome-Wide Association Study
Obesity
Genome
Body Mass Index

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., Paynter, N., Monda, K. L., Amin, N., Fischer, K., Renstrom, F., Ngwa, J. S., Huikari, V., Cavadino, A., Nolte, I. M., Teumer, A., Yu, K., Marques-Vidal, P., Rawal, R., Manichaikul, A., Wojczynski, M. K. & 134 othersVink, J. M., Zhao, J. H., Burlutsky, G., Lahti, J., Mikkilä, V., Lemaitre, R. N., Eriksson, J., Musani, S. K., Tanaka, T., Geller, F., Luan, J., Hui, J., Mägi, R., Dimitriou, M., Garcia, M. E., Ho, W. K., Wright, M. J., Rose, L. M., Magnusson, P. K. E., Pedersen, N. L., Couper, D., Oostra, B. A., Hofman, A., Ikram, M. A., Tiemeier, H., Uitterlinden, A. G., van Rooij, F. J. A., Barroso, I., Johansson, I., Xue, L., Kaakinen, M., Milani, L., Power, C., Snieder, H., Stolk, R. P., Baumeister, S. E., Biffar, R., Gu, F., Bastardot, F., Kutalik, Z., Jacobs, D. R., Forouhi, N. G., Mihailov, E., Lind, L., Lindgren, C., Michaëlsson, K., Morris, A., Jensen, M., Khaw, K. T., Luben, R. N., Wang, J. J., Männisto, S., Perälä, M. M., Kähönen, M., Lehtimäki, T., Viikari, J., Mozaffarian, D., Mukamal, K., Psaty, B. M., Döring, A., Heath, A. C., Montgomery, G. W., Dahmen, N., Carithers, T., Tucker, K. L., Ferrucci, L., Boyd, H. A., Melbye, M., Treur, J. L., Mellström, D., Hottenga, J. J., Prokopenko, I., Tönjes, A., Deloukas, P., Kanoni, S., Lorentzon, M., Houston, D. K., Liu, Y., Danesh, J., Rasheed, A., Mason, M. A., Zonderman, A. B., Franke, L., Kristal, B. S., Karjalainen, J., Reed, D. R., Westra, H. J., Evans, M. K., Saleheen, D., Harris, T. B., Dedoussis, G., Curhan, G., Stumvoll, M., Beilby, J., Pasquale, L. R., Feenstra, B., Bandinelli, S., Ordovas, J. M., Chan, A. T., Peters, U., Ohlsson, C., Gieger, C., Martin, N. G., Waldenberger, M., Siscovick, D. S., Raitakari, O., Eriksson, J. G., Mitchell, P., Hunter, D. J., Kraft, P., Rimm, E. B., Boomsma, D. I., Borecki, I. B., Loos, R. J. F., Wareham, N. J., Vollenweider, P., Caporaso, N., Grabe, H. J., Neuhouser, M. L., Wolffenbuttel, B. H. R., Hu, F. B., Hyppönen, E., Järvelin, M. R., Cupples, L. A., Franks, P. W., Ridker, P. M., van Duijn, C. M., Heiss, G., Metspalu, A., North, K. E., Ingelsson, E., Nettleton, J. A., van Dam, R. M. & Chasman, D. I., 2015, In : Molecular Psychiatry. 20, 5, p. 647-656 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Coffee
Meta-Analysis
Genome
Single Nucleotide Polymorphism
Caffeine

Genome-wide patterns and properties of de novo mutations in humans

Francioli, L. C., Polak, P. P., Koren, A., Menelaou, A., Chun, S., Renkens, I., van Duijn, C. M., Swertz, M. A., Wijmenga, C., van Ommen, G. J., Slagboom, P. E., Boomsma, D. I., Ye, K., Guryev, V., Arndt, P. F., Kloosterman, W. P., Bakker, P. I. W., Sunyaev, S. R., Dijk, F., Neerincx, P. B. T. & 68 othersPulit, S. L., Deelen, P., Elbers, C. C., Palamara, P. F., Pe'er, I., Abdellaoui, A., van Oven, M., Vermaat, M., Li, M., Laros, J. F. J., Stoneking, M., de Knijff, P., Kayser, M., Veldink, J. H., Van den Berg, L. H., Byelas, H., den Dunnen, J. T., Dijkstra, M., Amin, N., van der Velde, K. J., Hottenga, J. J., van Setten, J., van Leeuwen, E. M., Kanterakis, A., Kattenberg, V. M., Karssen, L. C., van Schaik, B. D. C., Bot, J., Nijman, I. J., van Enckevort, D., Mei, H., Koval, V., Estrada, K., Medina-Gomez, C., Lameijer, E. W., Moed, M. H., Hehir-Kwa, J. Y., Handsaker, R. E., McCarroll, S. A., Vuzman, D., Sohail, M., Hormozdiari, F., Marschall, T., Schönhuth, A., Beekman, M., de Craen, A. J., Suchiman, H. E. D., Hofman, A., Oostra, B., Isaacs, A., Rivadeneira, F., Uitterlinden, A. G., Willemsen, G., Platteel, M., Pitts, S. J., Potluri, S., Sundar, P., Cox, D. R., Li, Q., Li, Y., Du, Y., Chen, R., Cao, H., Li, N., Cao, S., Wang, J., Bovenberg, J. A. & Brandsma, M., 2015, In : Nature Genetics. 47, 7, p. 822-826 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mutation Rate
Genome
Mutation
Inborn Genetic Diseases
Pan troglodytes

Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset

Minica, C. C., Dolan, C. V., Hottenga, J. J., Pool, R., Fedko, I. O., Mbarek, H., Huppertz, C., Bartels, M., Boomsma, D. I. & Vink, J. M., 2015, In : Behavior Genetics. 45, 5, p. 503-513 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cannabis
heritability
Age of Onset
single nucleotide polymorphism
Single Nucleotide Polymorphism

Heritability and Genome-Wide Association Studies for Hair Color in a Dutch Twin Family Based Sample

Lin, B., Mbarek, H., Willemsen, G., Dolan, C. V., Fedko, I. O., Abdellaoui, A., de Geus, E. J. C., Boomsma, D. I. & Hottenga, J. J., 2015, In : Genes. 6, 3, p. 559-576 18 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Hair Color
Genome-Wide Association Study
Light
Single Nucleotide Polymorphism
Netherlands

Heritability of liver enzyme levels estimated from genome-wide SNP data

van Beek, J. H. D. A., Lubke, G. H., de Moor, M. H. M., Willemsen, G., de Geus, E. J. C., Hottenga, J. J., Walters, R. K., Smit, J. H., Penninx, B. W. J. H. & Boomsma, D. I., 2015, In : European Journal of Human Genetics. 23, 9, p. 1223-1228 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Single Nucleotide Polymorphism
Genome
Liver
Enzymes
Transferases

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

Shah, S., Bonder, M. J., Marioni, R. E., Zhu, Z., McRae, A. F., Zhernakova, A., Harris, S. E., Liewald, D. C. M., Henders, A. K., Mendelson, M. M., Liu, C., Joehanes, R., Liang, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Levy, D., Martin, N. G., Starr, J. M. & 7 othersWijmenga, C., Wray, N. R., Yang, J., Montgomery, G. W., Franke, L., Deary, I. J. & Visscher, P. M., 2015, In : American Journal of Human Genetics. 97, 1, p. 75-85 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Epigenomics
Body Mass Index
Methylation
Genome-Wide Association Study
DNA Methylation

In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons

Vaez, A., Jansen, R., Prins, B. P., Hottenga, J. J., de Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Nolte, I. M., Snieder, H. & Alizadeh, BZ., 2015, In : Circulation-cardiovascular genetics. 8, 3, p. 487-497 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Computer Simulation
C-Reactive Protein
Interferons
Single Nucleotide Polymorphism

Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait

Franic, S., Blokhuis, M. M., Dolan, C. V., Kattenberg, V. M., Pool, R., Xiao, X., Scheet, P., Ehli, E. A., Davies, G. E., van der Sluis, S., Abdellaoui, A., Hansell, N. K., Martin, N. G., Hudziak, J. J., van Beijsterveldt, C. E. M., Swagerman, S. C., Hulshoff Pol, H. E., de Geus, E. J. C., Bartels, M., Ropers, H-H. & 2 othersHottenga, J. J. & Boomsma, D. I., 2015, In : European Journal of Human Genetics. 23, 10, p. 1378-1383 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Multifactorial Inheritance
Intelligence
Genes
Medical Genetics
Single Nucleotide Polymorphism