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2013

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt, S. I., Gustafsson, S., Mägi, R., Ganna, A., Wheeler, E., Feitosa, M. F., Justice, A. E., Monda, K. L., Croteau-Chonka, D. C., Day, F. R., Esko, T., Fall, T., Ferreira, T., Gentilini, D., Jackson, A. U., Luan, J., Randall, J. C., Vedantam, S., Willer, C. J., Winkler, T. W. & 302 othersWood, A. R., Workalemahu, T., Hu, Y. J., Lee, S. H., Liang, L., Lin, D-Y., Min, J. L., Neale, B., Thorleifsson, G., Yang, J., Albrecht, E., Amin, N., Bragg-Gresham, J. L., Cadby, G., den Heijer, M., Eklund, N., Fischer, K., Goel, A., Hottenga, J. J., Huffman, J. E., Jarick, I., Johansson, A., Johnson, T., Kanoni, S., Kleber, M. E., König, I. R., Kristiansson, K., Kutalik, Z., Lamina, C., Lecoeur, C., Li, G., Mangino, M., McArdle, W. L., Medina-Gomez, C., Müller-Nurasyid, M., Ngwa, J. S., Nolte, I. M., Paternoster, L., Pechlivanis, S., Perola, M., Peters, M. J., Preuss, M., Rose, L. M., Shi, J., Shungin, D., Smith, A. V., Strawbridge, R. J., Surakka, I., Teumer, A., Trip, M. D., Tyrer, J., van Vliet-Ostaptchouk, J. V., Vandenput, L., Waite, L. L., Zhao, J. H., Absher, D., Asselbergs, F. W., Atalay, M., Attwood, A. P., Balmforth, A. J., Basart, H., Beilby, J., Bonnycastle, L. L., Brambilla, P., Bruinenberg, M., Campbell, H., Chasman, D. I., Chines, P. S., Collins, F. S., Connell, J. M. C., Cookson, W. O., de Faire, U., de Vegt, F., Dei, M., Dimitriou, M., Edkins, S., Estrada, K., Evans, D. M., Farrall, M., Ferrario, M. M., Ferrières, J., Franke, L., Frau, F., Gejman, P. V., Grallert, H., Grönberg, H., Gudnason, V., Hall, A. S., Hall, P., Hartikainen, A. L., Hayward, C., Heard-Costa, N. L., Heath, A. C., Hebebrand, J., Homuth, G., Hu, F. B., Hunt, S. E., Hyppönen, E., Iribarren, C., Jacobs, K. B., Jansson, J. O., Jula, A., Kähönen, M., Kathiresan, S., Kee, F., Khaw, K. T., Kivimäki, M., Koenig, W., Kraja, A. T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Laitinen, J., Lakka, T. A., Langenberg, C., Launer, L. J., Lind, L., Lindström, J., Liu, J., Liuzzi, A., Lokki, M. L., Lorentzon, M., Madden, P. A., Magnusson, P. K. E., Manunta, P., Marek, D., März, W., Mateo Leach, I., McKnight, B., Medland, S. E., Mihailov, E., Milani, L., Montgomery, G. W., Mooser, V., Mühleisen, T. W., Munroe, P. B., Musk, A. W., Narisu, N., Navis, G., Nicholson, G., Nohr, E. A., Ong, K. K., Oostra, B. A., Palmer, C. N. A., Palotie, A., Peden, J. F., Pedersen, N. L., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Prokopenko, I., Pütter, C., Radhakrishnan, A., Raitakari, O. T., Rendon, A., Rivadeneira, F., Rudan, I., Saaristo, T. E., Sambrook, J. G., Sanders, A. R., Sanna, S., Saramies, J., Schipf, S., Schreiber, S., Schunkert, H., Shin, S. Y., Signorini, S., Sinisalo, J., Skrobek, B., Soranzo, N., Stancakova, A., Stark, K., Stephens, J. C., Stirrups, K., Stolk, R. P., Stumvoll, M., Swift, A. J., Theodoraki, E. V., Thorand, B., Tregouet, D. A., Tremoli, E., van der Klauw, M. M., van Meurs, J. B., Vermeulen, S. H., Viikari, J., Virtamo, J., Vitart, V., Waeber, G., Wang, Z., Widén, E., Wild, S. H., Willemsen, G., Winkelmann, B. R., Witteman, J. C., Wolfenbuttel, B. H. R., Wong, A., Wright, A. F., Zillikens, M. C., Amouyel, P., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Caulfield, M. J., Chanock, S. J., Cupples, L. A., Cusi, D., Dedoussis, G. V., Erdmann, J., Eriksson, J. G., Franks, P. W., Froguel, P., Gieger, C., Gyllensten, U., Hamsten, A., Harris, T. B., Hengstenberg, C., Hicks, A. A., Hingorani, A. D., Hinney, A., Hofman, A., Hovingh, K. G., Hveem, K., Illig, T., Järvelin, M. R., Jöckel, K. H., Keinanen-Kiukaanniemie, S., Kiemeney, L. A., Kuh, D., Laakso, M., Lehtimäki, T., Levinson, D. F., Martin, N. G., Metspalu, A., Morris, A. D., Nieminen, M. S., Njolstad, I., Ohlsson, C., Oldehinkel, A. J., Ouwehand, W. H., Palmer, L. J., Penninx, B. W. J. H., Power, C., Province, M. A., Psaty, B. M., Qi, L., Rauramaa, R., Ridker, P. M., Ripatti, S., Salomaa, V., Samani, N. J., Snieder, H., Sorensen, T. I. A., Spector, T. D., Stefansson, K., Tönjes, A., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., van der Harst, P., Vollenweider, P., Wallaschofski, H., Wareham, N. J., Watkins, H., Wichmann, H. E., Wilson, J. F., Abecasis, G. R., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T. M., Groop, L. C., Haritunian, T., Heid, I. M., Hunter, D. J., Kaplan, R. C., Karpe, F., Moffat, M. F., Mohlke, K. L., O'Connell, J. R., Pawitan, Y., Schadt, E. E., Schlessinger, D., Steinthorsdottir, V., Strachan, D. P., Thorsteinsdottir, U., van Duijn, C. M., Visscher, P. M., Di Blasio, A. M., Hirschhorn, J. N., Lindgren, C. M., Morris, A. P., Meyre, D., Scherag, A., McCarthy, M. I., Speliotes, E. K., North, K. E., Loos, R. J. & Ingelsson, E., 2013, In : Nature Genetics. 45, 5, p. 501-512

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Meta-Analysis
Obesity
Genome
Waist-Hip Ratio
Genetic Structures

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S. E., Todt, U., McArdle, W. L., Quaye, L., Koiranen, M., Ikram, M. A., Lehtimäki, T., Stam, A. H., Ligthart, R. S. L., Wedenoja, J. & 75 othersDunham, I., Neale, B. M., Palta, P., Hamalainen, E., Schürks, M., Rose, L. M., Buring, J. E., Ridker, P. M., Steinberg, S., Stefansson, H., Jakobsson, F., Lawlor, D. A., Evans, D. M., Ring, S. M., Färkkilä, M., Artto, V., Kaunisto, M. A., Freilinger, T., Schoenen, J., Frants, R. R., Pelzer, N., Weller, C. M., Zielman, R., Heath, A. C., Madden, P. A. F., Montgomery, G. W., Martin, N. G., Borck, G., Göbel, H., Heinze, A., Heinze-Kuhn, K., Williams, F. M., Hartikainen, A-L., Pouta, A., van den Ende, J., Uitterlinden, A. G., Hofman, A., Amin, N., Hottenga, J. J., Vink, J. M., Heikkilä, K., Alexander, M., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Wichmann, H. E., Aromaa, A., Eriksson, J. G., Traynor, B. J., Trabzuni, D., Rossin, E., Lage, K., Jacobs, S. B., Gibbs, J. R., Birney, E., Kaprio, J., Penninx, B. W. J. H., Boomsma, D. I., van Duijn, C. M., Raitakari, O., Jarvelin, M-R., Zwart, J. A., Cherkas, L., Strachan, D. P., Kubisch, C., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Dichgans, M., Wessman, M., Smith, G. D., Stefansson, K., Daly, M. J., Nyholt, DR., Chasman, D. I. & Palotie, A., 2013, In : Nature Genetics. 45, 8, p. 912-917

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Migraine Disorders
Meta-Analysis
Genome
Population Control
Genome-Wide Association Study

GWAS of 126559 Individuals Identifies Genetic Variants Associated with Educational Attainment

Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., Westra, H. J., Shakhbazov, K., Abdellaoui, A., Agrawal, A., Albrecht, E., Alizadeh, BZ., Amin, N., Barnard, J., Baumeister, S. E., Benke, K. S., Bielak, L. F., Boatman, J. A., Boyle, P. A., Davies, G. & 182 othersde Leeuw, C. A., Eklund, N., Evans, D. S., Fehrmann, R. S., Fischer, K., Gieger, C., Gjessing, H. K., Hägg, S., Harris, J. R., Hayward, C., Holzapfel, C., Ibrahim-Verbaas, C. A., Ingelsson, E., Jacobsson, B., Joshi, P. K., Jugessur, A., Kaakinen, M., Kanoni, S., Karjalainen, J., Kolcic, I., Kristiansson, K., Kutalik, Z., Lahti, J., Lee, S. H., Lin, P., Lind, P. A., Liu, Y., Lohman, K., Loitfelder, M., McMahon, G., Vidal, P. M., Meirelles, O., Milani, L., Myhre, R., Nuotio, M. L., Oldmeadow, C. J., Petrovic, K. E., Peyrot, W. J., Polasek, O., Quaye, L., Reinmaa, E., Rice, J. P., Rizzi, T. S., Schmidt, H., Schmidt, R., Smith, A. V., Smith, J. A., Tanaka, T., Terracciano, A., van der Loos, M. J., Vitart, V., Völzke, H., Wellmann, J., Yu, L., Zhao, W., Allik, J., Attia, J. R., Bandinelli, S., Bastardot, F., Beauchamp, J., Bennett, D. A., Berger, K., Bierut, L. J., Boomsma, D. I., Bültmann, U., Campbell, H., Chabris, C. F., Cherkas, L., Chung, M. K., Cucca, F., de Andrade, M., Jager, P. L., de Neve, J. E., Deary, I. J., Dedoussis, G. V., Deloukas, P., Dimitriou, M., Eiriksdottir, G., Elderson, M. F., Eriksson, J. G., Evans, D. M., Faul, J. D., Ferrucci, L., Garcia, M. E., Grönberg, H., Gudnason, V., Hall, P., Harris, J. M., Harris, T. B., Hastie, N. D., Heath, A. C., Hernandez, D. G., Hoffmann, W., Hofman, A., Holle, R., Holliday, E. G., Hottenga, J. J., Iacono, W. G., Illig, T., Järvelin, M. R., Kähönen, M., Kaprio, J., Kirkpatrick, R. M., Kowgier, M., Latvala, A., Launer, L. J., Lawlor, D. A., Lehtimäki, T., Li, J., Lichtenstein, P., Lichtner, P., Liewald, D. C., Madden, P. A. F., Magnusson, P. K. E., Mäkinen, T. E., Masala, M., McGue, M., Metspalu, A., Mielck, A., Miller, M. B., Montgomery, G. W., Mukherjee, S., Nyholt, DR., Oostra, B. A., Palmer, L. J., Palotie, A., Penninx, B. W. J. H., Perola, M., Peyser, P. A., Preisig, M., Räikkönen, K., Raitakari, O. T., Realo, A., Ring, S. M., Ripatti, S., Rivadeneira, F., Rudan, I., Rustichini, A., Salomaa, V., Sarin, A. P., Schlessinger, D., Scott, R. J., Snieder, H., St Pourcain, B., Starr, J. M., Sul, J. H., Surakka, I., Svento, R., Teumer, A., Tiemeier, H., van Rooij, F. J., Wagoner, D. R., Vartiainen, E., Viikari, J., Vollenweider, P., Vonk, J. M., Waeber, G., Weir, D. R., Wichmann, H. E., Widen, E., Willemsen, G., Wilson, J. F., Wright, A. F., Conley, D., Davey Smith, G., Franke, L., Groenen, P. J. F., Johannesson, M., Kardia, S., Krueger, R. F., Laibson, D., Martin, N. G., Meyer, M. N., Posthuma, D., Thurik, A. R., Timpson, N. J., Uitterlinden, A. G., van Duijn, C. M., Visscher, P. M., Benjamin, D. J., Cesarini, D. & Koellinger, P. D., 2013, In : Science. 340, 6139, p. 1467-1471

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Single Nucleotide Polymorphism
Genome

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

den Hoed, M. A. H., Eijgelsheim, M., Esko, T., Brundel, B. J., Peal, D. S., Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E., Westra, H. J., Johnson, T., Isaacs, A., Yang, L., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., Bochud, M. & 248 othersBoucher, G., Cornelis, M. C., Gudbjartsson, D. F., Hadley, D., van der Harst, P., Hayward, C., den Heijer, M., Igl, W., Jackson, A. U., Kutalik, Z., Luan, J., Kemp, J. P., Kristiansson, K., Ladenvall, C., Lorentzon, M., Montasser, M. E., Njajou, O. T., O'Reilly, P. F., Padmanabhan, S., St Pourcain, B., Rankinen, T., Salo, P., Tanaka, T., Timpson, N. J., Vitart, V., Waite, L., Wheeler, W., Zhang, W., Draisma, H. H. M., Feitosa, M. F., Kerr, K. F., Lind, P. A., Mihailov, E., Onland-Moret, N. C., Song, C., Weedon, M. N., Xie, W., Yengo, L., Absher, D., Albert, C. M., Alonso, A., Arking, D. E., de Bakker, P. I., Balkau, B., Barlassina, C., Benaglio, P., Bis, J. C., Bouatia-Naji, N., Brage, S., Chanock, S. J., Chines, P. S., Chung, M., Darbar, D., Dina, C., Dörr, M., Elliott, P., Felix, S. B., Fischer, K., Fuchsberger, C., de Geus, E. J. C., Goyette, P., Gudnason, V., Harris, T. B., Hartikainen, A. L., Havulinna, A. S., Heckbert, S. R., Hicks, A. A., Hofman, A., Holewijn, S., Hoogstra-Berends, F., Hottenga, J. J., Jensen, M. K., Johansson, A., Junttila, J., Kääb, S., Kanon, B., Ketkar, S., Khaw, K. T., Knowles, J. W., Kooner, A. S., Kors, J. A., Kumari, M., Milani, L., Laiho, P., Lakatta, E. G., Langenberg, C., Leusink, M., Liu, Y., Luben, R. N., Lunetta, K. L., Lynch, S. N., Markus, M. R., Marques-Vidal, P., Mateo Leach, I., McArdle, W. L., McCarroll, S. A., Medland, S. E., Miller, K. A., Montgomery, G. W., Morrison, A. C., Müller-Nurasyid, M., Navarro, P., Nelis, M., O'Connell, J. R., O'Donnell, C. J., Ong, K. K., Newman, A. B., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Psaty, B. M., Rao, D. C., Ring, S. M., Rossin, E. J., Rudan, D., Sanna, S., Scott, R. A., Sehmi, J. S., Sharp, S., Shin, J. T., Singleton, A. B., Smith, A. V., Soranzo, N., Spector, T. D., Stewart, C., Stringham, H. M., Tarasov, K. V., Uitterlinden, A. G., Vandenput, L., Hwang, S. J., Whitfield, J. B., Wijmenga, C., Wild, S. H., Willemsen, G., Wilson, J. F., Witteman, J. C., Wong, A., Wong, Q., Jamshidi, Y., Zitting, P., Boer, J. M., Boomsma, D. I., Borecki, I. B., van Duijn, C. M., Ekelund, U., Forouhi, N. G., Froguel, P., Hingorani, A. D., Ingelsson, E., Kivimaki, M., Kronmal, R. A., Kuh, D., Lind, L., Martin, N. G., Oostra, B. A., Pedersen, N. L., Quertermous, T., Rotter, J. I., van der Schouw, Y. T., Verschuren, W. M., Walker, M., Albanes, D., Arnar, D. O., Assimes, T. L., Bandinelli, S., Boehnke, M., de Boer, R. A., Bouchard, C., Caulfield, W. L., Chambers, J. C., Curhan, G., Cusi, D., Eriksson, J., Ferrucci, L., van Gilst, W. H., Glorioso, N., de Graaf, J., Groop, L., Gyllensten, U., Hsueh, W. C., Hu, F. B., Huikuri, H. V., Hunter, D. J., Iribarren, C., Isomaa, B., Järvelin, M. R., Jula, A., Kähönen, M., Kiemeney, L. A., van der Klauw, M. M., Kooner, J. S., Kraft, P., Iacoviello, L., Lehtimäki, T., Lokki, M. L., Mitchell, B. D., Navis, G., Nieminen, M. S., Ohlsson, C., Poulter, N. R., Qi, L., Raitakari, O. T., Rimm, E. B., Rioux, J. D., Rizzi, F., Rudan, I., Salomaa, V., Sever, P. S., Shields, D. C., Shuldiner, A. R., Sinisalo, J., Stanton, A. V., Stolk, R. P., Strachan, D. P., Tardif, J. C., Thorsteinsdottir, U., Tuomilehto, J., van Veldhuisen, D. J., Virtamo, J., Viikari, J., Vollenweider, P., Waeber, G., Widen, E., Cho, Y. S., Olsen, J. V., Visscher, P. M., Willer, C. J., Franke, L., Erdmann, J., Thompson, J. R., Pfeufer, A., Sotoodehnia, N., Newton-Cheh, C., Ellinor, P. T., Stricker, B. H. C., Metspalu, A., Perola, M., Beckmann, J. S., Smith, G. D., Stefansson, K., Wareham, N. J., Munroe, P. B., Sibon, O. C. M., Milan, D. J., Snieder, H., Samani, N. J. & Loos, R. J., 2013, In : Nature Genetics. 45, 6, p. 621-631

Research output: Contribution to JournalArticleAcademicpeer-review

Heart Rate
Sick Sinus Syndrome
Genome-Wide Association Study
Sudden Cardiac Death
Dilated Cardiomyopathy

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

Smoller, J. W., Ripke, S., Lee, P. H., Neale, B., Nurnberger, J. I., Santangelo, S., Sullivan, P. F., Perlis, R. H., Purcell, S. M., Fanous, A., Neale, M. C., Rietschel, M., Schulze, T. G., Thapar, A., Anney, R., Buitelaar, J. K., Farone, S. V., Hoogendijk, W. J. G., Levinson, D. F., Lesch, K. P. & 291 othersRiley, B., Schachar, R., Sonuga-Barke, E. J., Absher, D., Agartz, I., Akil, H., Amin, F., Andreassen, O. A., Anjorin, A., Arking, D., Asherson, P., Azevedo, M. H., Backlund, L., Badner, J. A., Banaschewski, T., Barchas, J. D., Barnes, M. R., Bass, N., Bauer, M. C. R., Bellivier, F., Bergen, S. E., Berrettini, W., Bettecken, T., Biederman, J., Binder, E. B., Black, D. W., Blackwood, D. H., Bloss, C. S., Boehnke, M., Boomsma, D. I., Breen, G., Breuer, R., Buccola, N. G., Bunner, W. E., Burmeister, M., Buxbaum, J. D., Byerley, W. F., Sian, C., Cantor, R. M., Chakravarti, A., Chambert, K., Chicon, S., Cloniger, C. R., Collier, D. A., Cook, E., Coon, H., Corvin, A., Coryell, W. H., Craig, D. W., Craig, I. W., Curtis, D., Czamara, D., Daly, M., Datta, S., Day, R., de Geus, E. J. C., Degenhardt, F., Devlin, B., Srdjan, D., Doyle, A. E., Duan, J., Dudbridge, F., Edenberg, H. J., Elkin, A., Etain, B., Farmer, A. E., Ferreira, M. A. R., Ferrier, I. N., Flickinger, M., Foroud, T., Frank, J., Franke, B., Fraser, C., Freedman, R., Freimer, N. B., Friedl, M., Frisén, L., Gejman, P. V., Georgieva, L., Gershon, E. S., Giegling, I., Gill, M., Gordon, S. D., Gordon-Smith, K., Green, E. K., Greenwood, T. A., Gross, M., Grozeva, D., Guan, W., Gurling, H., Gustafsson, O., Hakonarson, H., Hamilton, S. P., Hamshere, M. L., Hansen, T. F., Hartmann, A. M., Hautzinger, M., Heath, A. C., Henders, A. K., Herms, S., Hickie, I. B., Hipolito, M., Hoefels, S., Holmans, P. A., Holsboer, F., Hottenga, J. J., Hultman, C. M., Ingason, A., Ising, M., Jamain, S., Jones, E. G., Jones, L., Jones, I., Jung-Ying, T., Kahler, A., Kandaswamy, R., Keller, M. C., Kelsoe, J., Kennedy, J. L., Kenny, E., Kim, Y., Kirov, G. K., Knowles, J. A., Kohli, M. A., Koller, D. L., Konte, B., Korszun, A., Krasucki, R., Kuntsi, J., Phoenix, K., Landén, M., Langstrom, N., Lathrop, M., Lawrence, J., Lawson, W. B., Leboyer, M., Lencz, T., Lewis, C. M., Li, J., Lichtenstein, P., Lieberman, J. A., Lin, D., Liu, C., Lohoff, F. W., Loo, S. K., Lucae, S., MacIntyre, D. J., Madden, P. A. F., Magnusson, P., Mahon, P. B., Maier, W., Malhotra, A. K., Mattheisen, M., Matthews, K., Mattingsdal, M., McCarroll, S., McGhee, K. A., McGough, J. J., McGrath, P. J., McGuffin, P., McInnis, M. G., McIntosh, A., McKinney, R., McClean, A. W., McMahon, F. J., McQuillin, A., Medeiros, H., Medland, S. E., Meier, S., Melle, I., Meng, F., Middeldorp, C. M., Middleton, L., Vihra, M., Mitchell, P. B., Montgomery, G. W., Moran, J., Morken, G., Morris, D. W., Moskvina, V., Mowry, B. J., Muglia, P., Mühleisen, T. W., Muir, W. J., Müller-Myhsok, B., Myers, R. M., Nelson, S. F., Nievergelt, C. M., Nikolovq, I., Nimgaonkar, V. L., Nolen, W. A., Nöthen, M. M., Nwulia, E. A., Nyholt, DR., O'Donovan, M. C., O'Dushlaine, C., Oades, R. D., Olincy, A., Olsen, L., Ophoff, R. A., Osby, U., Óskarsson, H., Owen, M. J., Palotie, A., Pato, M. T., Pato, C. N., Penninx, B. W. J. H., Pergadia, M. L., Petursson, H., Pickard, B. S., Pimm, J., Piven, J., Porgeirsson, P., Posthuma, D., Potash, J. B., Propping, J., Puri, V., Quested, D., Quinn, E. M., Rasmussen, H. B., Raychaudhuri, S., Rehnström, K., Reif, A., Rice, J., Rossin, L., Rothenberger, A., Rouleau, G., Ruderfer, D., Rujescu, D., Sanders, A. R., Schalling, M., Schatzberg, A. F., Scheftner, W. A., Schellenberg, G. D., Schofield, P. R., Schork, N. J., Schumacher, J., Schwarz, M. M., Scolnick, E., Scott, L. J., Shi, J., Shillling, P. D., Shyn, S. I., Sigurdsson, E., Silverman, J. M., Sklar, P., Slager, S. L., Smalley, S. L., Smit, J. H., Smith, E. N., Sonuga-Barke, E., St Clair, D., State, M., Stefansson, K., Stefansson, H., Steffans, M., Steinberg, S., Steinhausen, H. C., Strauss, J., Strohmaier, J., Stroup, T. S., Sutcliffe, J., Szatmari, P., Szelinger, S., Thirumalai, S., Thompson, R. C., Tozzi, F., Treutlein, J., Uhr, M., van den Oord, E. J., Grootheest, G., Vieland, V., Vincent, J. B., Visscher, P. M., Watson, S. J., Weissman, M. M., Werge, T., Wienker, T. F., Willemsen, G., Williamson, R., Witt, S. H., Wray, N. R., Wright, A., Xu, W., Young, A. H., Zammit, S., Zandi, P. P., Zhang, P., Zitman, F. G., Zöllner, S. & Kendler, K. S., 2013, In : Lancet. 381, 9875, p. 1371-1379

Research output: Contribution to JournalArticleAcademicpeer-review

Identification of seven loci affecting mean telomere length and their association with disease

Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., Surakka, I., Broer, L., Nyholt, DR., Mateo Leach, I., Salo, P., Hägg, S., Matthews, M. K., Palmen, J., Norata, G. D., O'Reilly, P. F., Saleheen, D. & 79 othersAmin, N., Balmforth, A. J., Beekman, M., de Boer, R. A., Böhringer, S., Braund, P. S., Burton, P. R., de Craen, A. J., Denniff, M., Dong, Y., Douroudis, K., Dubinina, E., Eriksson, J. G., Garlaschelli, K., Guo, D., Hartikainen, A. L., Henders, A. K., Houwing-Duistermaat, J. J., Kananen, L., Karssen, L. C., Kettunen, J., Klopp, N., Lagou, V., van Leeuwen, E., Madden, P. A., Mägi, R., Magnusson, P. K. E., Männistö, S., McCarthy, M. I., Medland, S. E., Mihailov, E., Montgomery, G. W., Oostra, B. A., Palotie, A., Peters, A., Pollard, H., Pouta, A., Prokopenko, I., Ripatti, S., Salomaa, V., Suchiman, H. E. D., Valdes, A. M., Verweij, N., Viñuela, A., Wang, X., Wichmann, H. E., Widen, E., Willemsen, G., Wright, M. J., Xia, K., Xiao, X., van Veldhuisen, D. J., Catapano, A. L., Tobin, M. D., Hall, A. S., Blakemore, A. I. F., van Gilst, W. H., Zhu, H., Erdmann, J., Reilly, M. P., Kathiresan, S., Schunkert, H., Talmud, P. J., Pedersen, N. L., Perola, M., Ouwehand, W., Kaprio, J., Martin, N. G., van Duijn, C. M., Hovatta, I., Gieger, C., Metspalu, A., Boomsma, D. I., Järvelin, M. R., Slagboom, P. E., Thompson, J. R., Spector, T. D., van der Harst, P. & Samani, N. J., 2013, In : Nature Genetics. 45, 4, p. 422-427

Research output: Contribution to JournalArticleAcademicpeer-review

Telomere
Leukocytes
Coronary Artery Disease
Idiopathic Pulmonary Fibrosis
Single Nucleotide Polymorphism

Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs

Hemani, G., Yang, J., Vinkhuyzen, A. A. E., Powell, J. E., Willemsen, G., Hottenga, J. J., Abdellaoui, A., Mangino, M., Valdes, A. M., Medland, S. E., Madden, P. A. F., Heath, A. C., Henders, A. K., Nyholt, DR., de Geus, E. J. C., Magnusson, P. K. E., Ingelsson, E., Montgomery, G. W., Spector, T. D., Boomsma, D. I. & 3 othersPedersen, N. L., Martin, N. G. & Visscher, P. M., 2013, In : American Journal of Human Genetics. 93, 5, p. 865-875

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Siblings
Body Mass Index
Multifactorial Inheritance
Genome-Wide Association Study
Nuclear Family

Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci

Paul, D. S., Albers, C. A., Rendon, A., Voss, K., Stephens, J., Akkerman, J. W., Algra, A., Al-Hussani, A., Allayee, H., Anni, F., Asselbergs, F. W., Attwood, A., Balkau, B., Bandinelli, S., Bastardot, F., Basu, S., Baumeister, S. E., Beckmann, J., Benyamin, B., Biino, G. & 219 othersBis, J. C., Bomba, L., Bonnefond, A., Boomsma, D. I., Bradley, J. R., Cambien, F., Ciullo, M., Cookson, W. O., Cucca, F., Cvejic, A., d'Adamo, A. P., Danesh, J., Danjou, F., Das, D., Davies, G., de Bakker, P. I., de Boer, R. A., de Geus, E. J. C., Deary, I. J., Dedoussis, G. V., Dimitriou, M., Dina, C., Döring, A., Elling, U., Ellinghaus, D., Elliott, P., Engström, G., Erdmann, J., Esko, T., Evans, D. M., Eyjolfsson, G. I., Falchi, M., Feng, W. W., Ferreira, M. A., Ferrucci, L., Fischer, K., Folsom, A. R., Fortina, P., Franke, A., Franke, L., Frazer, I. H., Froguel, P., Galanello, R., Ganesh, S., Garner, S. F., Gasparini, P., Genser, B., Gibson, Q. D., Gieger, C., Girotto, G., Glazer, N. L., Gögele, M., Goodall, A. H., Greinacher, A., Gudbjartsson, D. F., Hammond, C. J., Harris, S. E., Hartiala, J., Hartikainen, A. L., Hazen, S. L., Heckbert, S. R., Hedblad, B., Hengstenberg, C., Hersch, M., Hicks, A. A., Holm, H., Hottenga, J. J., Illig, T., Järvelin, M. R., Jolley, J., Jupe, S., Kähönen, M., Kamatani, N., Kanoni, S., Kema, I. P., Kemp, J. P., Khadake, J., Khaw, K. T., Kleber, M. E., Kooner, J. S., Kovacs, P., Kühnel, B., Kyrtsonis, M. C., Labrune, Y., Lagou, V., Langenberg, C., Lehtimäki, T., Li, X., Liang, L., Lloyd-Jones, H., Loos, R. J., Lopez, L. M., Lumley, T., Lyytikäinen, L. P., Maerz, W., Mägi, R., Mangino, M., Martin, N. G., Maschio, A., Mateo Leach, I., McKnight, B., Meacham, S., Medland, S. E., Meisinger, C., Melander, O., Memari, Y., Metspalu, A., Miller, K., Mitchell, B. D., Moffatt, M. F., Montgomery, G. W., Moore, C., Murgia, F., Nakamura, Y., Nauck, M., Navis, G., Nolte, I. M., Nöthlings, U., Nutile, T., Okada, Y., Olafsson, I., Onundarson, P. T., O'Reilly, P. F., Parracciani, D., Parsa, A., Penninger, J. M., Penninx, B. W. J. H., Pirastu, M., Pirastu, N., Pistis, G., Porcu, E., Portas, L., Porteous, D. J., Pouta, A., Pramstaller, P. P., Prokopenko, I., Psaty, B. M., Pullat, J., Radhakrishnan, A., Raitakari, O., Ramirez-Solis, R., Ried, J. S., Ring, S. M., Robino, A., Rotter, J. I., Ruggiero, D., Ruokonen, A., Sala, C., Saluments, A., Samani, N. J., Sambrook, J., Sanna, S., Schlessinger, D., Schmidt, C. O., Schreiber, S., Schunkert, H., Scott, J., Sehmi, J., Serbanovic-Canic, J., Shin, S. Y., Shuldiner, A. R., Sladek, R., Smit, J. H., Smith, G. D., Smith, J. G., Smith, N. L., Snieder, H., Sorice, R., Spector, T. D., Starr, J. M., Stefansson, K., Stemple, D., Stumvoll, M., Sulem, P., Takahashi, A., Tan, S. T., Tanaka, T., Tang, C., Tang, W., Tang, W. H., Taylor, K., Tenesa, A., Teumer, A., Thein, S., Thorsteinsdottir, U., Toniolo, D., Tönjes, A., Traglia, M., Uda, M., Ulivi, S., van der Schoot, E., van Gilst, W. H., van Pelt, L. J., van Veldhuisen, D. J., Verweij, N., Visscher, P. M., Völker, U., Vollenweider, P., Wareham, N. J., Wernisch, L., Westra, H. J., Whitfield, J. B., Wichmann, H. E., Wiggins, K. L., Willemsen, G., Winkelmann, B. R., Wirnsberger, G., Wolffenbuttel, B. H., Yang, J., Yang, T. P., Zhang, J. H., Zhao, J. H., Zitting, P., Zwaginga, JJ., van der Harst, P., Chambers, J. C., Soranzo, N., Ouwehand, W. H. & Deloukas, P., 2013, In : Genome Research. 23, 7, p. 1130-1141

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chromatin
Blood Platelets
Quantitative Trait Loci
Histone Code
Erythrocytes

Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics

Hu, Y. J., Berndt, S. I., Gustafsson, S., Ganna, A., Hirschhorn, J. N., North, K. E., Ingelsson, E., Lin, D-Y., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H. & van Duijn, C. M., 2013, In : American Journal of Human Genetics. 93, 2, p. 236-248

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Meta-Analysis
Genes
Genome-Wide Association Study
Software
Databases

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

Sabater-Lleal, M., Huang, J., Chasman, D. I., Naitza, S., Dehghan, A., Johnson, A. D., Teumer, A., Reiner, A. P., Folkersen, L., Basu, S., Rudnicka, A. R., Trompet, S., Mälarstig, A., Baumert, J., Bis, J. C., Guo, X., Hottenga, J. J., Shin, S. Y., Lopez, L. M., Lahti, J. & 125 othersTanaka, T., Yanek, L. R., Oudot-Mellakh, T., Wilson, J. F., Navarro, P., Huffman, J. E., Zemunik, T., Redline, S., Mehra, R., Pulanic, D., Rudan, I., Wright, A. F., Kolcic, I., Polasek, O., Wild, S. H., Campbell, H., Curb, J. D., Wallace, R., Liu, S., Eaton, C. B., Becker, D. M., Becker, L. C., Bandinelli, S., Räikkönen, K., Widén, E., Palotie, A., Fornage, M., Green, D., Gross, M., Davies, G. E., Harris, S. E., Liewald, D. C., Starr, J. M., Williams, F. M., Grant, P. J., Spector, T. D., Strawbridge, R. J., Silveira, A., Sennblad, B., Rivadeneira, F., Uitterlinden, A. G., Franco, O. H., Hofman, A., van Dongen, J., Willemsen, G., Boomsma, D. I., Yao, J., Swords Jenny, N., Haritunians, T., McKnight, B., Lumley, T., Taylor, K. D., Rotter, J. I., Psaty, B. M., Peters, A., Gieger, C., Illig, T., Grotevendt, A., Homuth, G., Völzke, H., Kocher, T., Goel, A., Franzosi, M. G., Seedorf, U., Clarke, R., Steri, M., Tarasov, K. V., Sanna, S., Schlessinger, D., Stott, D. J., Sattar, N., Buckley, B. M., Rumley, A., Lowe, G. D., McArdle, W. L., Chen, M. H., Tofler, G. H., Song, J., Boerwinkle, E., Folsom, A. R., Rose, L. M., Franco-Cereceda, A., Teichert, M., Ikram, M. A., Mosley, T. H., Bevan, S., Dichgans, M., Rothwell, P. M., Sudlow, C. L., Hopewell, J. C., Chambers, J. C., Saleheen, D., Kooner, J. S., Danesh, J., Nelson, C. P., Erdmann, J., Reilly, M. P., Kathiresan, S., Schunkert, H., Morange, P. E., Ferrucci, L., Eriksson, J. G., Jacobs, D., Deary, I. J., Soranzo, N., Witteman, J. C., de Geus, E. J. C., Tracy, R. P., Hayward, C., Koenig, W., Cucca, F., Jukema, J. W., Eriksson, P., Seshadri, S., Markus, H. S., Watkins, H., Samani, N. J., Wallaschofski, H., Smith, N. L., Tregouet, D. A., Ridker, P. M., Tang, W., Strachan, D. P., Hamsten, A. & O'Donnell, C. J., 2013, In : Circulation. 128, 12, p. 1310-1324

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Fibrinogen
Meta-Analysis
Cardiovascular Diseases
Coronary Artery Disease

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D. O., Sovio, U., Taal, H. R., Hennig, B. J., Bradfield, J. P., St Pourcain, B., Evans, D. M., Charoen, P., Kaakinen, M., Cousminer, D. L., Lehtimäki, T., Kreiner-Møller, E., Warrington, N. M., Bustamante, M., Feenstra, B., Berry, D. J., Thiering, E., Pfab, T. & 128 othersBarton, S. J., Shields, B. M., Kerkhof, M., Leeuwen, E. M., Fulford, A. J., Kutalik, Z., Zhao, J. H., van den Hoed, M., Mahajan, A., Lindi, V., Goh, L. K., Hottenga, J. J., Wu, Y., Raitakari, O. T., Harder, M. N., Meirhaeghe, A., Ntalla, I., Salem, R. M., Jameson, K. A., Zhou, K., Monies, D. M., Lagou, V., Kirin, M., Heikkinen, J., Adair, L. S., Alkuraya, F. S., Al-Odaib, A., Amouyel, P., Andersson, E. A., Bennett, A. J., Blakemore, A. I. F., Buxton, J. L., Dallongeville, J., Das, S., de Geus, E. J. C., Estivill, X., Flexeder, C., Froguel, P., Geller, F., Godfrey, K. M., Gottrand, F., Groves, C. J., Hansen, T., Hirschhorn, J. N., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Hyppönen, E., Inskip, H. M., Isaacs, A., Jørgensen, T., Kanaka-Gantenbein, C., Kemp, J. P., Kiess, W., Kilpeläinen, T. O., Klopp, N., Knight, B. A., Kuzawa, C. W., McMahon, G., Newnham, J. P., Niinikoski, H., Oostra, B. A., Pedersen, L., Postma, D. S., Ring, S. M., Rivadeneira, F., Robertson, N. R., Sebert, S., Simell, O., Slowinski, T., Tiesler, C. M. T., Tönjes, A., Vaag, A. A., Viikari, J. S., Vink, J. M., Vissing, N. H., Wareham, N. J., Willemsen, G., Witte, D. R., Zhang, H., Zhao, J., Wilson, J. F., Stumvoll, M., Prentice, A. M., Meyer, B. F., Pearson, E. R., Boreham, C. A., Cooper, C., Gillman, M. W., Dedoussis, G. V., Moreno, L. A., Pedersen, O., Saarinen, M., Mohlke, K. L., Boomsma, D. I., Saw, S. M., Lakka, T. A., Körner, A., Loos, R. J., Ong, K. K., Vollenweider, P., van Duijn, C. M., Koppelman, G. H., Hattersley, A. T., Holloway, J. W., Hocher, B., Heinrich, J., Power, C., Melbye, M., Guxens, M., Pennell, C. E., Bønnelykke, K., Bisgaard, H., Eriksson, J. G., Widén, E., Hakonarson, H., Uitterlinden, A. G., Pouta, A., Lawlor, D. A., Smith, G. D., Frayling, T. M., McCarthy, M. I., Grant, S. F., Jaddoe, V. W., Järvelin, M. R., Timpson, N. J., Prokopenko, I. & Freathy, R. M., 2013, In : Nature Genetics. 45, 1, p. 76-82

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Birth Weight
Genome-Wide Association Study
Growth
Type 2 Diabetes Mellitus
Fetal Development

Population structure, migration, and diversifying selection in the Netherlands

Abdellaoui, A., Hottenga, J. J., de Knijff, P., Nivard, M. G., Xiao, X., Scheet, P., Brooks, A., Ehli, E. A., Hu, Y., Davies, G. E., Hudziak, J. J., Sullivan, P. F., van Beijsterveldt, C. E. M., Willemsen, G., de Geus, E. J. C., Penninx, B. W. J. H. & Boomsma, D. I., 2013, In : European Journal of Human Genetics. 21, 11, p. 1277-1285

Research output: Contribution to JournalArticleAcademicpeer-review

Geography
Netherlands
Linkage Disequilibrium
Single Nucleotide Polymorphism
Population

Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions

Amin, N., Hottenga, J. J., Hansell, N. K., Janssens, A. C. J. W., de Moor, M. H. M., Madden, P. A. F., Zorkoltseva, I. V., Penninx, B. W. J. H., Terracciano, A., Uda, M., Tanaka, T., Esko, T., Realo, A., Ferrucci, L., Luciano, M., Davies, G., Metspalu, A., Abecasis, G. R., Deary, I. J., Raikkonen, K. & 19 othersBierut, L. J., Costa, P. T., Savyuk, V., Zhu, G., Kirichenko, A. V., Isaacs, A., Aulchenko, Y. S., Willemsen, G., Heath, A. C., Pergadia, M. L., Medland, S. E., Axenovich, T. I., de Geus, E. J. C., Montgomery, G. W., Wright, M. J., Oostra, B. A., Martin, N. G., Boomsma, D. I. & van Duijn, C. M., 2013, In : European Journal of Human Genetics. 21, 8, p. 876-882

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Personality
Meta-Analysis
Genome
Chromosomes

Sex-stratified Genome-wide Association Studies Including 270000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Randall, J. C., Winkler, T. W., Kutalik, Z., Berndt, S. I., Jackson, A. U., Monda, K. L., Kilpeläinen, T. O., Esko, T., Mägi, R., Li, S., Workalemahu, T., Feitosa, M. F., Croteau-Chonka, D. C., Day, F. R., Fall, T., Ferreira, T., Gustafsson, S., Locke, A. E., Mathieson, I., Scherag, A. & 244 othersVedantam, S., Wood, A. R., Liang, L., Steinthorsdottir, V., Thorleifsson, G., Dermitzakis, E. T., Dimas, A. S., Karpe, F., Min, J. L., Nicholson, G., Clegg, D. J., Person, T., Krohn, J. P., Bauer, S., Buechler, C., Eisinger, K., Bonnefond, A., Froguel, P., Hottenga, J. J., Prokopenko, I., Waite, L. L., Harris, T. B., Smith, A. V., Shuldiner, A. R., McArdle, W. L., Caulfield, M. J., Munroe, P. B., Grönberg, H., Chen, Y. D., Li, G., Beckmann, J. S., Johnson, T., Thorsteinsdottir, U., Teder-Laving, M., Khaw, K. T., Wareham, N. J., Zhao, J. H., Amin, N., Oostra, B. A., Kraja, A. T., Province, M. A., Cupples, L. A., Heard-Costa, N. L., Kaprio, J., Ripatti, S., Surakka, I., Collins, F. S., Saramies, J., Tuomilehto, J., Jula, A., Salomaa, V., Erdmann, J., Hengstenberg, C., Loley, C., Schunkert, H., Lamina, C., Wichmann, H. E., Albrecht, E., Gieger, C., Hicks, A. A., Johansson, A., Pramstaller, P. P., Kathiresan, S., Speliotes, E. K., Penninx, B. W. J. H., Hartikainen, A. L., Järvelin, M. R., Gyllensten, U., Boomsma, D. I., Campbell, H., Wilson, J. F., Chanock, S. J., Farrall, M., Goel, A., Medina-Gomez, C., Rivadeneira, F., Estrada, K., Uitterlinden, A. G., Hofman, A., Zillikens, M. C., den Heijer, M., Kiemeney, L. A., Maschio, A., Hall, P., Tyrer, J., Teumer, A., Völzke, H., Kovacs, P., Tönjes, A., Mangino, M., Spector, T. D., Hayward, C., Rudan, I., Hall, A. S., Samani, N. J., Attwood, A. P., Sambrook, J. G., Hung, J., Palmer, L. J., Lokki, M. L., Sinisalo, J., Boucher, G., Huikuri, H. V., Lorentzon, M., Ohlsson, C., Eklund, N., Eriksson, J. G., Barlassina, C., Rivolta, C., Nolte, I. M., Snieder, H., van der Klauw, M. M., van Vliet-Ostaptchouk, J. V., Gejman, P. V., Shi, J., Jacobs, K. B., Wang, Z., Bakker, S. J., Mateo Leach, I., Navis, G., van der Harst, P., Martin, N. G., Medland, S. E., Montgomery, G. W., Yang, J., Chasman, D. I., Ridker, P. M., Rose, L. M., Lehtimäki, T., Raitakari, O., Absher, D., Iribarren, C., Basart, H., Hovingh, K. G., Hyppönen, E., Power, C., Anderson, D., Beilby, J. P., Hui, J., Jolley, J., Sager, H., Bornstein, S. R., Schwarz, P. E., Kristiansson, K., Perola, M., Lindström, J., Swift, A. J., Uusitupa, M., Atalay, M., Lakka, T. A., Rauramaa, R., Bolton, J. L., Fowkes, G., Fraser, R. M., Price, J. F., Fischer, K., Krjuta Kov, K., Metspalu, A., Mihailov, E., Langenberg, C., Luan, J., Ong, K. K., Chines, P. S., Keinanen-Kiukaanniemie, S., Saaristo, T. E., Edkins, S., Franks, P. W., Hallmans, G., Shungin, D., Morris, A. D., Palmer, C. N. A., Erbel, R., Moebus, S., Nöthen, M. M., Pechlivanis, S., Hveem, K., Narisu, N., Hamsten, A., Humphries, S. E., Strawbridge, R. J., Tremoli, E., Grallert, H., Thorand, B., Illig, T., Koenig, W., Müller-Nurasyid, M., Peters, A., Boehm, B. O., Kleber, M. E., März, W., Winkelmann, B. R., Kuusisto, J., Laakso, M., Arveiler, D., Cesana, G., Kuulasmaa, K., Virtamo, J., Yarnell, J. W., Kuh, D., Wong, A., Lind, L., de Faire, U., Gigante, B., Magnusson, P. K. E., Pedersen, N. L., Dedoussis, G., Dimitriou, M., Kolovou, G., Kanoni, S., Stirrups, K., Bonnycastle, L. L., Njolstad, I., Wilsgaard, T., Ganna, A., Rehnberg, E., Hingorani, A. D., Kivimaki, M., Kumari, M., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T. M., Groop, L. C., Haritunians, T., Hunter, D., Ingelsson, E., Kaplan, R., Mohlke, K. L., O'Connell, J. R., Schlessinger, D., Strachan, D. P., Stefansson, K., van Duijn, C. M., Abecasis, G. R., McCarthy, M. I., Hirschhorn, J. N., Qi, L., Loos, R. J., Lindgren, C. M., North, K. E. & Heid, I. M., 2013, In : PLoS Genetics. 9, 6, p. e1003500 e1003500.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genetic Loci
Genome-Wide Association Study
sexual dimorphism
gender differences
Sex Characteristics

Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample

Peyrot, W., Middeldorp, C. M., Jansen, R., Smit, J. H., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Vink, J. M., Virding, S., Barragan, I., Ingelman-Sundberg, M., Sim, S. C., Boomsma, D. I. & Penninx, B. W. J. H., 2013, In : Journal of Affective Disorders. 146, 1, p. 91-99

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Major Depressive Disorder
Haplotypes
Gene-Environment Interaction
Logistic Models
Serotonin Plasma Membrane Transport Proteins

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Fall, T., Hägg, S., Mägi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A. P., Thorleifsson, G., Ladenvall, C., Kals, M., Kuningas, M., Draisma, H. H. M., Ried, J. S., van Zuydam, N. R., Huikari, V., Mangino, M., Sonestedt, E., Benyamin, B., Nelson, C. P., Rivera, N. V. & 105 othersKristiansson, K., Shen, H. Y., Havulinna, A. S., Dehghan, A., Donnelly, L. A., Kaakinen, M., Nuotio, M. L., Robertson, N., de Bruijn, R. F., Ikram, M. A., Amin, N., Balmforth, A. J., Braund, P. S., Doney, A. S. F., Döring, A., Elliott, P., Esko, T., Franco, O. H., Gretarsdottir, S., Hartikainen, A. L., Heikkilä, K., Herzig, K. H., Holm, H., Hottenga, J. J., Hyppönen, E., Illig, T., Isaacs, A., Isomaa, B., Karssen, L. C., Kettunen, J., Koenig, W., Kuulasmaa, K., Laatikainen, T., Laitinen, J., Lindgren, C. M., Lyssenko, V., Läärä, E., Rayner, N. W., Männistö, S., Pouta, A., Rathmann, W., Rivadeneira, F., Ruokonen, A., Savolainen, M. J., Sijbrands, E. J., Small, K. S., Smit, J. H., Steinthorsdottir, V., Syvänen, A. C., Taanila, A., Tobin, M. D., Uitterlinden, A. G., Willems, S. M., Willemsen, G., Witteman, J., Perola, M., Evans, A., Ferrières, J., Virtamo, J., Kee, F., Tregouet, D. A., Arveiler, D., Amouyel, P., Ferrario, M. M., Brambilla, P., Hall, A. S., Heath, A. C., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Whitfield, J. B., Jula, A., Knekt, P., Oostra, B. A., van Duijn, C. M., Penninx, B. W. J. H., Davey Smith, G., Kaprio, J., Samani, N. J., Gieger, C., Peters, A., Wichmann, H. E., Boomsma, D. I., de Geus, E. J. C., Tuomi, T., Power, C., Hammond, C. J., Spector, T. D., Lind, L., Orho-Melander, M., Palmer, C. N. A., Morris, A. D., Groop, L., Järvelin, M. R., Salomaa, V., Vartiainen, E., Hofman, A., Ripatti, S., Metspalu, A., Thorsteinsdottir, U., Stefansson, K., Pedersen, N. L., McCarthy, M. I., Ingelsson, E. & Prokopenko, I., 2013, In : PLoS Medicine. 10, 6, p. e1001474 e1001474.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Mendelian Randomization Analysis
Adiposity
Body Mass Index
Random Allocation
Type 2 Diabetes Mellitus
2012

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Manning, A. K., Hivert, M. F., Scott, R. A., Grimsby, J. L., Bouatia-Naji, N., Chen, H., Rybin, D., Liu, C. T., Bielak, L. F., Prokopenko, I., Amin, N., Barnes, D., Cadby, G., Hottenga, J. J., Ingelsson, E., Boomsma, D. I., de Geus, E. J. C., Penninx, B. W. J. H., Willemsen, G., Wilson, J. F. & 14 othersWitteman, J. C. M., Wright, A. F., Yaghootkar, H., Zelenika, D., Zemunik, T., Zgaga, L., Wareham, N. J., McCarthy, M. I., Barroso, I., Watanabe, R. M., Florez, J. C., Dupuis, J., Meigs, J. B. & Langenberg, C., 2012, In : Nature Genetics. 44, 6, p. 659-669

Research output: Contribution to JournalArticleAcademicpeer-review

Insulin Resistance
Fasting
Body Mass Index
Genome
Insulin

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., Sandy An, S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M. & 11 othersDivers, J., Shriner, D., Adeyemo, A., Rotimi, C. N., Ng, M. C. Y., Langefeld, C. D., Freedman, B. I., Bowden, D. W., Posthuma, D., Penninx, B. W. J. H. & Sladek, R., 2012, In : PLoS ONE. 7, 1, p. e29202 e29202.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
African Americans
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site

Nürnberg, S. T., Rendon, A., Smethurst, P. A., Paul, D. S., Voss, K., Thon, J. N., Lloyd-Jones, H., Sambrook, J. G., Tijssen, M. R., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Italiano Jr, J. E., Deloukas, P., Gottgens, B., Soranzo, N. & Ouwehand, W. H., 2012, In : Blood. 120, 24, p. 4859-4868

Research output: Contribution to JournalArticleAcademicpeer-review

Megakaryocytes
Genome-Wide Association Study
Platelets
Blood Platelets
Binding Sites

Common variants at 12q14 and 12q24 are associated with hippocampal volume

Bis, J. C., DeCarli, C. S., Vernon Smith, A., van der Lijn, F., Crivello, F., Fornage, M., Debette, S., Shulman, J. M., Schmidt, H., Srikanth, V., Schuur, M., Yu, L., Choi, S., Sigurdsson, S., Verhaaren, B. F. J., DeStefano, A. L., Lambert, J. C., Jack, C. R. . J., Struchalin, M., Stankovich, J. & 64 othersIbrahim-Verbaas, C. A., Fleischman, D., Zijdenbos, A., den Heijer, T., Mazoyer, B., Coker, L. H., Enzinger, C., Danoy, P., Amin, N., Arfanakis, K., van Buchem, M. A., de Bruijn, R. F. A. G., Beiser, A., Dufouil, C., Huang, J., Cavalieri, M., Thomson, R., Niessen, W. J., Chibnik, L. B., Gislason, G. K., Hofman, A., Pikula, A., Amouyel, P., Freeman, K. B., Phan, T. G., Oostra, B. A., Stein, J. L., Medland, S. E., Vasquez, A. A., Hibar, D. P., Wright, M. J., Franke, B., Martin, N. G., Thompson, P. M., Hottenga, J. J., Boomsma, D. I., Nalls, M. A., Uitterlinden, A. G., Au, R., Elbaz, A., Beare, R. J., van Swieten, J. C., Lopez, O. L., Harris, T. B., Chouraki, V., Breteler, M. M. B., de Jager, P. L., Becker, J. T., Vernooij, M. W., Knopman, D., Fazekas, F., Wolf, P. A., van der Lugt, A., Gudnason, V., Longstreth, J. W. T., Brown, M. A., Bennett, D. A., van Duijn, C. M., Mosley, T. H., Schmidt, R., Tzourio, C., Launer, L. J., Arfan Ikram, M. & Seshadri, S., 2012, In : Nature Genetics. 44, 5, p. 545-551

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Single Nucleotide Polymorphism
Dementia
Alzheimer Disease
vascular factor

Common variants at 12q15 and 12q24 are associated with infant head circumference

Taal, H. R., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, D. O., van Beijsterveldt, C. E. M., Groen-Blokhuis, M. M., Hottenga, J. J., Middeldorp, C. M., Willemsen, G., Boomsma, D. I., Hakonarson, H., Smith, G. D., Heinrich, J., Jarvelin, M-R. & Jaddoe, V. W. V., 2012, In : Nature Genetics. 44, 5, p. 532-538

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Meta-Analysis
Chromosomes
Head
Parturition

Common variants at 6q22 and 17q21 are associated with intracranial volume

Arfan Ikram, M., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Taal, H. R., Mook-Kanamori, D. O., Coker, L. H., Longstreth, J. W. T., Niessen, W. J., DeStefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., Rivadeneira, F. & 43 othersUitterlinden, A. G., Knopman, D. S., Hartikainen, A-L., Pennell, C. E., Thiering, E., Steegers, E. A. P., Hakonarson, H., Heinrich, J., Palmer, L. J., Jarvelin, M-R., McCarthy, M. I., Grant, S. F. A., St Pourcain, B., Timpson, N. J., Smith, G. D., Sovio, U., van Beijsterveldt, C. E. M., Groen-Blokhuis, M. M., Hottenga, J. J., Middeldorp, C. M., Nivard, M. G., Willemsen, G., Boomsma, D. I., Nalls, M. A., Au, R., Hofman, A., Gudnason, H., van der Lugt, A., Harris, T. B., Meeks, W. M., Vernooij, M. W., van Buchem, M. A., Catellier, D., Jaddoe, V. W. V., Gudnason, V., Windham, B. G., Wolf, P. A., van Duijn, C. M., Mosley, T. H., Schmidt, H., Launer, L. J., Breteler, M. M. B. & DeCarli, C. S., 2012, In : Nature Genetics. 44, 5, p. 539-544

Research output: Contribution to JournalArticleAcademicpeer-review

Brain
Independent Living
Biological Phenomena
Genome-Wide Association Study
Genome

De novo and inherited CNVs in MZ twin pairs selected for discordance and concordance on Attention Problems

Ehli, E. A., Abdellaoui, A., Hu, Y., Hottenga, J. J., Kattenberg, V. M., van Beijsterveldt, C. E. M., Bartels, M., Althoff, R. R., Xiao, X., Scheet, P., de Geus, E. J. C., Hudziak, J. J., Boomsma, D. I. & Davies, G. E., 2012, In : European Journal of Human Genetics. 20, 10, p. 1037-1043

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Monozygotic Twins
Genes
Gene Dosage
Parents
Genome

Estimating the Genetic Variance of Major Depressive Disorder Due to All Single Nucleotide Polymorphisms

Lubke, G. H., Hottenga, J. J., Walters, R., Laurin, C., de Geus, E. J. C., Willemsen, G., Smit, J. H., Middeldorp, C. M., Penninx, B. W. J. H., Vink, J. M. & Boomsma, D. I., 2012, In : Biological Psychiatry. 72, 8, p. 707-709

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Single Nucleotide Polymorphism
Twin Studies
Genome-Wide Association Study
Genome

FTO genotype is associated with phenotypic variability of body mass index

Yang, J., Loos, R. J., Powell, J. E., Medland, S. E., Speliotes, E. K., Chasman, D. I., Rose, L. M., Thorleifsson, G., Steinthorsdottir, V., Mägi, R., Waite, L., Smith, A. V., Yerges-Armstrong, L. M., Monda, K. L., Hadley, D., Mahajan, A., Li, G., Kapur, K., Vitart, V., Huffman, J. E. & 151 othersWang, S. R., Palmer, C., Esko, T., Fischer, K., Zhao, J. H., Demirkan, A., Isaacs, A., Feitosa, M. F., Luan, J., Heard-Costa, N. L., White, C., Jackson, A. U., Preuss, M., Ziegler, A., Eriksson, J., Kutalik, Z., Frau, F., Nolte, I. M., van Vliet-Ostaptchouk, J. V., Hottenga, J. J., Jacobs, K. B., Verweij, N., Goel, A., Medina-Gomez, C., Estrada, K., Bragg-Gresham, J. L., Sanna, S., Sidore, C., Tyrer, J., Teumer, A., Prokopenko, I., Mangino, M., Lindgren, C. M., Assimes, T. L., Shuldiner, A. R., Hui, J., Beilby, J. P., McArdle, W. L., Hall, P., Haritunians, T., Zgaga, L., Kolcic, I., Polasek, O., Zemunik, T., Oostra, B. A., Junttila, M. J., Grönberg, H., Schreiber, S., Peters, A., Hicks, A. A., Stephens, J., Foad, N. S., Laitinen, J., Pouta, A., Kaakinen, M., Willemsen, G., Vink, J. M., Wild, S. H., Navis, G., Asselbergs, F. W., Homuth, G., John, U., Iribarren, C., Harris, T., Launer, L. J., Gudnason, V., O'Connell, J. R., Boerwinkle, E., Cadby, G., Palmer, L. J., James, A. L., Musk, A. W., Ingelsson, E., Psaty, B. M., Beckmann, J. S., Waeber, G., Vollenweider, P., Hayward, C., Wright, A. F., Rudan, I., Groop, L. C., Metspalu, A., Thee Khaw, K., van Duijn, C. M., Borecki, I. B., Province, M. A., Wareham, N. J., Tardif, J. C., Huikuri, H. V., Cupples, L. A., Atwood, L. D., Fox, C. S., Boehnke, M., Collins, F. S., Mohlke, K. L., Erdmann, J., Schunkert, H., Hengstenberg, C., Stark, K., Lorentzon, M., Ohlsson, C., Cusi, D., Staessen, J. A., van der Klauw, M. M., Pramstaller, P. P., Kathiresan, S., Jolley, D. J., Ripatti, S., Jarvelin, M-R., de Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Wilson, J. F., Campbell, H., Chanock, S. J., van der Harst, P., Hamsten, A., Watkins, H., Hofman, A., Witteman, J. C., Zillikens, M. C., Uitterlinden, A. G., Rivadeneira, F., Kiemeney, L. A., Vermeulen, S. H., Abecasis, G. R., Schlessinger, D., Schipf, S., Stumvoll, M., Tönjes, A., Spector, T. D., North, K. E., Lettre, G., McCarthy, M. I., Berndt, S. I., Heath, A. C., Madden, P. A. F., Nyholt, DR., Montgomery, G. W., Martin, N. G., McKnight, B., Strachan, D. P., Hill, W. G., Snieder, H., Ridker, P. M., Thorsteinsdottir, U., Stefansson, K., Frayling, T. M., Hirschhorn, J. N., Goddard, M. E. & Visscher, P. M., 2012, In : Nature. 490, 7419, p. 267-272

Research output: Contribution to JournalArticleAcademicpeer-review

Body Mass Index
Genotype
Single Nucleotide Polymorphism
Obesity
Genome-Wide Association Study

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women

Fox, C. S., Liu, Y., White, C. C., Feitosa, M., Smith, A. V., Heard-Costa, N., Lohman, K., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Johnson, A. D., Foster, M. C., Greenawalt, D. M., Griffin, P., Ding, J., Newman, A. B., Tylavsky, F., Miljkovic, I., Kritchevsky, S. B. & 9 othersLauner, L., Garcia, M., Eiriksdottir, G., Posthuma, D., Carr, J. J., Gudnason, V., Harris, T. B., Cupples, L. A. & Borecki, I. B., 2012, In : PLoS Genetics. 8, 5, p. e1002695 e1002695.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
visceral fat
Intra-Abdominal Fat
Subcutaneous Fat
adipose tissue
fat

Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned

Wray, N. R., Pergadia, M. L., Blackwood, D. H., Penninx, B. W. J. H., Gordon, S. D., Nyholt, DR., Ripke, S., MacIntyre, D. J., McGhee, K. A., Maclean, A. W., Smit, J. H., Hottenga, J. J., Willemsen, G., Middeldorp, C. M., de Geus, E. J. C., Lewis, C. M., McGuffin, P., Hickie, I. B., van den Oord, E. J. C. G., Liu, J. Z. & 12 othersMacgregor, S., McEvoy, B. P., Byrne, E. M., Medland, S. E., Statham, D. J., Henders, A. K., Heath, A. C., Montgomery, G. W., Martin, N. G., Boomsma, D. I., Madden, P. A. F. & Sullivan, P. F., 2012, In : Molecular Psychiatry. 17, 1, p. 36-48

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Major Depressive Disorder
Meta-Analysis
Single Nucleotide Polymorphism
Galanin

Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States

Luciano, M., Huffman, J. E., Arias-Vasquez, A., Vinkhuyzen, A. A. E., Middeldorp, C. M., Giegling, I., Payton, A., Davies, G. E., Zgaga, L., Janzing, J. G., Ke, X. Y., Galesloot, T., Hartmann, A. M., Ollier, W., Tenesa, A., Hayward, C., Verhagen, M., Montgomery, G. W., Hottenga, J. J., Konte, B. & 24 othersStarr, J. M., Vitart, V., Vos, P. E., Madden, P. A. F., Willemsen, G., Konnerth, H., Horan, M. A., Porteous, D. J., Campbell, H., Vermeulen, S. H., Heath, A. C., Wright, A., Polasek, O., Kovacevic, S. B., Hastie, N., Franke, B., Boomsma, D. I., Martin, N. G., Rujescu, D., Wilson, J. F., Buitelaar, J., Pendleton, N., Rudan, I. & Deary, I. J., 2012, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 159B, 6, p. 684-695

Research output: Contribution to JournalArticleAcademicpeer-review

Single Nucleotide Polymorphism
Personality
Genome
Psychology
Genes

Genome-wide meta-analysis of common variant differences between men and women

Boraska, V., Jeroncic, A., Colonna, V., Southam, L., Nyholt, DR., Rayner, N. W., Perry, J. R. B., Toniolo, D., Albrecht, E., Ang, W., Bandinelli, S., Barbalic, M., Barroso, I., Beckmann, J. S., Biffar, R., Boomsma, D. I., Campbell, H., Corre, T., Erdmann, J., Esko, T. & 107 othersFischer, K., Franceschini, N., Frayling, T. M., Girotto, G., Gonzalez, J. R., Harris, T. B., Heath, A. C., Heid, I. M., Hoffmann, W., Hofman, A., Horikoshi, M., Zhao, J. H., Jackson, A. U., Hottenga, J. J., Jula, A., Kähönen, M., Khaw, K. T., Kiemeney, L. A., Klopp, N., Kutalik, Z., Lagou, V., Launer, L. J., Lehtimäki, T., Lemire, M., Lokki, M. L., Loley, C., Luan, J. A., Mangino, M., Mateo Leach, I., Medland, S. E., Mihailov, E., Montgomery, G. W., Navis, G., Newnham, J., Nieminen, M. S., Palotie, A., Panoutsopoulou, K., Peters, A., Pirastu, N., Polasek, O., Rehnström, K., Ripatti, S., Ritchie, G. R. S., Rivadeneira, F., Robino, A., Samani, N. J., Shin, S. Y., Sinisalo, J., Smit, J. H., Soranzo, N., Stolk, L., Swinkels, D. W., Tanaka, T., Teumer, A., Tönjes, A., Traglia, M., Tuomilehto, J., Valsesia, A., van Gilst, W. H., van Meurs, J. B. J., Vernon Smith, A., Viikari, J., Vink, J. M., Waeber, G., Warrington, N. M., Widen, E., Willemsen, G., Wright, A. F., Zanke, B. W., Zgaga, L., Boehnke, M., Pio d'Adamo, A., de Geus, E. J. C., Demerath, E. W., den Heijer, M., Eriksson, J. G., Ferrucci, L., Gieger, C., Gudnason, V., Hayward, C., Hengstenberg, C., Hudson, T. J., Järvelin, M. J., Kogevinas, M., Loos, R. J. F., Martin, N. G., Metspalu, A., Pennell, C. E., Penninx, B. W. J. H., Perola, M., Raitakari, O., Salomaa, V., Schreiber, S., Schunkert, H., Spector, T. D., Stumvoll, M., Uitterlinden, A. G., Ulivi, S., van der Harst, P., Vollenweider, P., Völzke, H., Wareham, N. J., Wichmann, H. E., Wilson, J. F., Rudan, I., Xue, Y. & Zeggini, E., 2012, In : Human Molecular Genetics. 21, 21, p. 4805-4815

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Sex Ratio
Meta-Analysis
Gene Frequency
Genome
Parturition

Identification of common variants associated with human hippocampal and intracranial volumes

Stein, J. L., Medland, S. E., Arias-Vasquez, A., Hibar, D. P., Senstad, R. E., Winkler, A. M., Toro, R., Appel, K., Bartecek, R., Bergmann, O., Hottenga, J. J., Boomsma, D. I., Montgomery, G. W., de Geus, E. J. C., Hulshoff Pol, H. E., Kahn, R. S., Penninx, B. W. J. H., Sämann, P. G., Saykin, A. J., Schumann, G. & 7 othersSmoller, J. W., Wardlaw, J. M., Weale, M. E., Martin, N. G., Franke, B., Wright, M. J. & Thompson, P. M., 2012, In : Nature Genetics. 44, 5, p. 552-561

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Temporal Lobe Epilepsy
Genome-Wide Association Study
Brain
Neuroimaging
Cognition

Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers

Hartz, S. M., Short, S. E., Saccone, N. L., Culverhouse, R., Chen, L., Schwantes-An, T. H., Coon, H., Han, Y., Stephens, S. H., Sun, J., Chen, X., Ducci, F., Dueker, N., Franceschini, N., Frank, J., Geller, F., Gubjartsson, D., Hansel, N. N., Jiang, C., Keskitalo-Vuokko, K. & 132 othersLiu, Z., Lyytikäinen, L. P., Michel, M., Rawal, R., Rosenberger, A., Scheet, P., Shaffer, J. R., Teumer, A., Thompson, J. R., Vink, J. M., Vogelzangs, N., Wenzlaff, A. S., Wheeler, W., Xiao, X., Yang, B. Z., Aggen, S. H., Balmforth, A. J., Baumeister, S. E., Beaty, T., Bennett, S., Bergen, A. W., Boyd, H. A., Broms, U., Campbell, H., Chatterjee, N., Chen, J., Cheng, Y. C., Cichon, S., Couper, D., Cucca, F., Dick, D. M., Foroud, T., Furberg, H., Giegling, I., Gu, F., Hall, A. S., Hällfors, J., Han, S., Hartmann, A. M., Hayward, C., Heikkilä, K., Hewitt, J. K., Hottenga, J. J., Jensen, M. K., Jousilahti, P., Kaakinen, M., Kittner, S. J., Konte, B., Korhonen, T., Landi, M. T., Laatikainen, T., Leppert, M., Levy, S. M., Mathias, R. A., McNeil, D. W., Medland, S. E., Montgomery, G. W., Muley, T., Murray, T., Nauck, M., North, K., Pergadia, M. L., Polasek, O., Ramos, E. M., Ripatti, S., Risch, A., Ruczinski, I., Rudan, I., Salomaa, V., Schlessinger, D., Styrkársdóttir, U., Terracciano, A., Uda, M., Willemsen, G., Wu, X., Abecasis, G. R., Barnes, K., Bickeböller, H., Boerwinkle, E., Boomsma, D. I., Caporaso, N., Duan, J., Edenberg, H. J., Francks, C., Gejman, P. V., Gelernter, J., Grabe, H. J., Hops, H., Jarvelin, M. R., Viikari, J., Kähönen, M., Kendler, K. S., Lehtimäki, T., Levinson, D. F., Marazita, M. L., Marchini, J., Melbye, M., Mitchell, B. D., Murray, J. C., Nöthen, M. M., Penninx, B. W. J. H., Raitakari, O., Rietschel, M., Rujescu, D., Samani, N. J., Sanders, A. R., Schwartz, A. G., Shete, S., Shi, J., Spitz, M., Stefansson, K., Swan, G. E., Thorgeirsson, T. E., Völzke, H., Wei, Q., Wichmann, H. E., Amos, C. I., Breslau, N., Cannon, D. S., Ehringer, M., Grucza, R. A., Hatsukami, D., Heath, A. C., Johnson, E. O., Kaprio, J., Madden, P., Martin, N. G., Stevens, V. L., Stitzel, J. A., Weiss, R. B., Kraft, P. & Bierut, L. J., 2012, In : Archives of General Psychiatry. 69, 8, p. 854-860

Research output: Contribution to JournalArticleAcademicpeer-review

Age of Onset
Tobacco Products
Smoking
Alleles
Odds Ratio

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Scott, R. A., Lagou, V., Welch, R. P., Wheeler, E., Montasser, M. E., Luan, J., Mägi, R., Strawbridge, R. J., Rehnberg, E., Gustafsson, S., Kanoni, S., Rasmussen-Torvik, L. J., Yengo, L., Lecoeur, C., Shungin, D., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Penninx, B. W. J. H., van Duijn, C. M. & 17 othersBoomsma, D. I., Mohlke, K. L., Balkau, B., Froguel, P., Pouta, A., Jarvelin, M-R., Wareham, N. J., Bouatia-Naji, N., McCarthy, M. I., Franks, P. W., Meigs, J. B., Teslovich, T. M., Florez, J. C., Langenberg, C., Ingelsson, E., Prokopenko, I. & Barroso, I., 2012, In : Nature Genetics. 44, 9, p. 991-1005

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Type 2 Diabetes Mellitus
Insulin Resistance
Meta-Analysis
Fasting

Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations

Middelberg, R. P. S., Benyamin, B., de Moor, M. H. M., Warrington, N. M., Gordon, S., Henders, A. K., Medland, S. E., Nyholt, DR., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Beilin, L. J., Mori, T. A., Wright, M. J., Heath, A. C., Madden, P. A. F., Boomsma, D. I., Pennell, C. E., Montgomery, G. W., Martin, N. G. & 1 othersWhitfield, J. B., 2012, In : Human Molecular Genetics. 21, 2, p. 446-455

Research output: Contribution to JournalArticleAcademicpeer-review

Transferases
Single Nucleotide Polymorphism
Intergenic DNA
Chromosomes, Human, Pair 1
Genome-Wide Association Study

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Stolk, L., Perry, J. R. B., Chasman, D. I., He, C., Mangino, M., Sulem, P., Barbalic, M., Broer, L., Byrne, E. M., Ernst, F., Esko, T., Franceschini, N., Gudbjartsson, D. F., Hottenga, J. J., Kraft, P., McArdle, P. F., Porcu, E., Shin, S. Y., Smith, A. V., van Wingerden, S. & 34 othersZhai, G., Zhuang, W. V., Albrecht, E., Alizadeh, BZ., Aspelund, T., de Geus, E. J. C., Vink, J. M., Willemsen, G., Boomsma, D. I., Crisponi, L., Demerath, E. W., Gudnason, V., Harris, T. B., Hu, F. B., Hunter, D. J., Launer, L. J., Metspalu, A., Montgomery, G. W., Oostra, B. A., Ridker, P. M., Sanna, S., Schlessinger, D., Spector, T. D., Stefansson, K., Streeten, E. A., Thorsteinsdottir, U., Uda, M., Uitterlinden, A. G., van Duijn, C. M., Völzke, H., Murray, A., Murabito, J. M., Visser, J. A. & Lunetta, K. L., 2012, In : Nature Genetics. 44, 3, p. 260-268

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Menopause
DNA Repair
Meta-Analysis
Genome-Wide Association Study
Interleukin-11

Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes

Webb, B. T., Guo, A. Y., Maher, B. S., Zhao, Z., van den Oord, E. J., Kendler, K. S., Riley, B. P., Gillespie, N. A., Prescott, C. A., Middeldorp, C. M., Willemsen, G., de Geus, E. J. C., Hottenga, J. J., Boomsma, D. I., Slagboom, P. E., Wray, N. R., Montgomery, G. W., Martin, N. G., Wright, M. J., Heath, A. C. & 15 othersMadden, P. A. F., Gelernter, J., Knowles, J. A., Hamilton, S. P., Weissman, M. M., Fyer, A. J., Huezo-Diaz, P., McGuffin, P., Farmer, A., Craig, I. W., Lewis, C., Sham, P., Crowe, R. R., Flint, J. & Hettema, J. M., 2012, In : European Journal of Human Genetics. 20, 10, p. 1078-1084

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-Analysis
Anxiety
Genome
Phenotype
Anxiety Disorders

Meta-analysis of genome-wide association studies for personality

de Moor, M. H. M., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Toshiko, T., Penninx, B. W. J. H., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J. J., Distel, M. A., Uda, M., Sanna, S., Spinhoven, P., Hartman, C. A., Sullivan, P. F., Realo, A. & 37 othersAllik, J., Heath, A. C., Pergadia, M. L., Agrawal, A., Lin, P., Grucza, R. A., Nutile, T., Ciullo, M., Rujescu, D., Giegling, I., Konte, B., Widen, E., Cousminer, D. L., Eriksson, J. G., Palotie, A., Peltonen, L., Luciano, M., Tenesa, A., Davies, G., Lopez, L. M., Hansell, N. K., Medland, S. E., Ferrucci, L., Schlessinger, D., Montgomery, G. W., Wright, M. J., Aulchenko, Y. S., Janssens, A. C. J. W., Oostra, B. A., Metspalu, A., Abecasis, G. R., Deary, I. J., Räikkönen, K., Bierut, L. J., Martin, N. G., van Duijn, C. M. & Boomsma, D. I., 2012, In : Molecular Psychiatry. 17, 3, p. 337-349

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Personality
Meta-Analysis
Single Nucleotide Polymorphism
Genome

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

Paternoster, L., Standl, M., Chen, C. M., Ramasamy, A., Bønnelykke, K., Duijts, L., Ferreira, M. A., Couto Alves, A., Thyssen, J. P., Albrecht, E., Baurecht, H., Feenstra, B., Sleiman, P. M. A., Hysi, P., Warrington, N. M., Curjuric, I., Myhre, R., Curtin, J. A., Groen-Blokhuis, M. M., Kerkhof, M. & 71 othersSääf, A., Franke, A., Ellinghaus, D., Fölster-Holst, R., Dermitzakis, E., Montgomery, S. B., Prokisch, H., Heim, K., Hartikainen, A-L., Pouta, A., Pekkanen, J., Blakemore, A. I. F., Buxton, J. L., Kaakinen, M., Duffy, DL., Madden, P. A. F., Heath, A. C., Montgomery, G. W., Thompson, P. J., Matheson, M. C., Le Souëf, P., St Pourcain, B., Davey Smith, G., Henderson, J., Kemp, J. P., Timpson, N. J., Deloukas, P., Ring, S. M., Wichmann, H-E., Müller-Nurasyid, M., Novak, N., Klopp, N., Rodríguez, E., McArdle, W., Linneberg, A., Menné, T., Nohr, E. A., Hofman, A., Uitterlinden, A. G., van Duijn, C. M., Rivadeneira, F., de Jongste, J. C., van der Valk, R. J. P., Wjst, M., Jogi, R., Geller, F., Boyd, H. A., Murray, J. C., Kim, C., Mentch, F., March, M., Mangino, M., Spector, T. D., Bataille, V., Pennell, C. E., Holt, P. G., Sly, P., Tiesler, C. M. T., Hottenga, J. J., Boomsma, D. I., Hakonarson, H., Melbye, M., Ljarvis, D., Jaddoe, V. W. V., Gieger, C., Strachan, D. P., Martin, N. G., Jarvelin, M-R., Heinrich, J., Evans, D. M. & Weidinger, S., 2012, In : Nature Genetics. 44, 2, p. 187-192

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Atopic Dermatitis
Meta-Analysis
Skin Diseases
Single Nucleotide Polymorphism

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Dastani, Z., Hivert, M. F., Timpson, N. J., Perry, J. R., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L. P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S. & 101 othersPankow, J. S., Uh, H. W., Wu, Y., Bidulescu, A., Rasmussen-Torvik, L. J., Greenwood, C. M., Ladouceur, M., Grimsby, J., Manning, A. K., Liu, C. T., Kooner, J., Mooser, V. E., Vollenweider, P., Kapur, K. A., Chambers, J., Wareham, N. J., Langenberg, C., Frants, R., Willems van Dijk, K., Oostra, B. A., Willems, S. M., Lamina, C., Winkler, T. W., Psaty, B. M., Tracy, R. P., Brody, J., Chen, I., Viikari, J., Kähönen, M., Pramstaller, P. P., Evans, D. M., St Pourcain, B., Sattar, N., Wood, A. R., Bandinelli, S., Carlson, O. D., Egan, J. M., Böhringer, S., van Heemst, D., Kedenko, L., Kristiansson, K., Nuotio, M. L., Loo, B. M., Harris, T., Garcia, M., Kanaya, A., Haun, M., Klopp, N., Wichmann, H. E., Deloukas, P., Katsareli, E., Couper, D. J., Duncan, B. B., Kloppenburg, M., Adair, L. S., Borja, J. B., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Wilson, J. G., Musani, G., Guo, X., Johnson, T., Semple, R., Teslovich, T. M., Allison, M. A., Redline, S., Buxbaum, S. G., Mohlke, K. L., Meulenbelt, I., Ballantyne, C. M., Dedoussis, G. V., Hu, F. B., Liu, Y., Paulweber, B., Spector, T. D., Slagboom, P. E., Ferrucci, L., Jula, A., Perola, M., Raitakari, O., Florez, J. C., Salomaa, V., Eriksson, J. G., Frayling, T. M., Hicks, A. A., Lehtimäki, T., Smith, G. D., Siscovick, D. S., Kronenberg, F., van Duijn, C. M., Loos, R. J., Waterworth, D., Meigs, J. B., Dupuis, J., Richards, J. B., Posthuma, D., Penninx, B. W. J. H., Vogelzangs, N. & Kathiresan, S., 2012, In : PLoS Genetics. 8, 3, p. e1002607 e1002607.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
adiponectin
diabetes
Adiponectin
meta-analysis
noninsulin-dependent diabetes mellitus

Seventy-five genetic loci influencing the human red blood cell

van der Harst, P., Zhang, W., Mateo Leach, I., Rendon, A., Verweij, N., Sehmi, J., Paul, D. S., Elling, U., Allayee, H., Li, X., Radhakrishnan, A., Tan, S. T., Voss, K., Weichenberger, C. X., Albers, C. A., Al-Hussani, A., Asselbergs, F. W., Ciullo, M., Danjou, F., Dina, C. & 175 othersEsko, T., Evans, D. M., Franke, L., Gögele, M., Hartiala, J., Hersch, M., Holm, H., Hottenga, J. J., Kanoni, S., Kleber, M. E., Lagou, V., Langenberg, C., Lopez, L. M., Lyytikäinen, L. P., Melander, O., Murgia, F., Nolte, I. M., O'Reilly, P. F., Padmanabhan, S., Parsa, A., Pirastu, N., Porcu, E., Portas, L., Prokopenko, I., Ried, J. S., Shin, S. Y., Tang, C. S., Teumer, A., Traglia, M., Ulivi, S., Westra, H. J., Yang, J., Zhao, J. H., Anni, F., Abdellaoui, A., Attwood, A., Balkau, B., Bandinelli, S., Bastardot, F., Benyamin, B., Boehm, B. O., Cookson, W. O., Das, D., de Bakker, P. I., de Boer, R. A., de Geus, E. J. C., de Moor, M. H. M., Dimitriou, M., Domingues, F. S., Döring, A., Engström, G., Eyjolfsson, G. I., Ferrucci, L., Fischer, K., Galanello, R., Garner, S. F., Genser, B., Gibson, Q. D., Girotto, G., Gudbjartsson, D. F., Harris, S. E., Hartikainen, A. L., Hastie, C. E., Hedblad, B., Illig, T., Jolley, J., Kähönen, M., Kema, I. P., Kemp, J. P., Liang, L., Lloyd-Jones, H., Loos, R. J., Meacham, S., Medland, S. E., Meisinger, C., Memari, Y., Mihailov, E., Miller, K., Moffatt, M. F., Nauck, M., Novatchkova, M., Nutile, T., Olafsson, I., Onundarson, P. T., Parracciani, D., Penninx, B. W. J. H., Perseu, L., Piga, A., Pisits, G., Pouta, A., Puc, U., Raitakari, O., Ring, S. M., Robino, A., Ruggiero, D., Ruokonen, A., Saint-Pierre, A., Sala, C., Salumets, A., Sambrook, J., Schepers, H., Schmidt, C. O., Silljé, H. H., Sladek, R., Smit, J. H., Starr, J. M., Stephens, J., Sulem, P., Tanaka, T., Thorsteinsdottir, U., Tragante, V., van Gilst, W. H., van Pelt, L. J., van Veldhuisen, D. J., Völker, U., Whitfield, J. B., Willemsen, G., Winkelmann, B. R., Wirnsberger, G., Algra, A., Cucca, F., d'Adamo, A. P., Danesh, J., Deary, I. J., Dominiczak, A. F., Elliott, P., Fortina, P., Froguel, P., Gasparini, P., Greinacher, A., Hazen, S. L., Jarvelin, M-R., Khaw, K. T., Lehtimäki, T., Maerz, W., Martin, N. G., Metspalu, A., Mitchell, B. D., Montgomery, G. W., Moore, C., Navis, G., Pirastu, M., Pramstaller, P. P., Ramirez-Solis, R., Schadt, E., Scott, J., Shuldiner, A. R., Smith, G. D., Smith, J. G., Snieder, H., Sorice, R., Spector, T. D., Stefansson, K., Stumvoll, M., Tang, W. H., Toniolo, D., Tönjes, A., Visscher, P. M., Vollenweider, P., Wareham, N. J., Wolffenbuttel, B. H. R., Boomsma, D. I., Beckmann, J. S., Dedoussis, G. V., Deloukas, P., Ferreira, M. A., Sanna, S., Uda, M., Hicks, A. A., Penninger, J. M., Gieger, C., Kooner, J. S., Ouwehand, W. H., Soranzo, N. & Chambers, J. C., 2012, In : Nature. 492, 7429, p. 369-375

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Loci
Erythrocytes
Genome-Wide Association Study
Anemia
Hemoglobins

Sex Differences in Genetic Architecture of Complex Phenotypes?

Vink, J. M., Bartels, M., van Beijsterveldt, C. E. M., van Dongen, J., van Beek, J. H. D. A., Distel, M. A., de Moor, M. H. M., Smit, D. J. A., Minica, C. C., Ligthart, R. S. L., Geels, L. M., Abdellaoui, A., Middeldorp, C. M., Hottenga, J. J., Willemsen, G., de Geus, E. J. C. & Boomsma, D. I., 2012, In : PLoS ONE. 7, 12, e47371.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
gender differences
Sex Characteristics
Genes
Phenotype
phenotype

Twins, Tissue, and Time: An Assessment of SNPs and CNVs

Scheet, P., Ehli, E. A., Xiao, X., van Beijsterveldt, C. E. M., Abdellaoui, A., Althoff, R. R., Hottenga, J. J., Willemsen, G., Nelson, K. A., Huizenga, P. E., Hu, Y., Amos, C. I., Bartels, M., Groen-Blokhuis, M. M., de Geus, E. J. C., Hudziak, J. J., Davies, G. E. & Boomsma, D. I., 2012, In : Twin Research and Human Genetics. 15, 6, p. 737-745

Research output: Contribution to JournalArticleAcademicpeer-review

Cheek
Single Nucleotide Polymorphism
DNA
Genotype
Monozygotic Twins
2011

ADHD in Dutch adults: heritability and linkage study

Savyuk, V., Hottenga, J. J., Slagboom, P. E., Distel, M. A., de Geus, E. J. C., Willemsen, G. & Boomsma, D. I., 2011, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 156, 3, p. 352-362

Research output: Contribution to JournalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Phenotype
Netherlands
Self Report
Siblings

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

Surakka, I., Isaacs, A., Karssen, L. C., Laurila, P. P. P., Middelberg, R. P. S., Tikkanen, E., Ried, J. S., Lamina, C., Mangino, M., Igl, W., Hottenga, J. J., Lagou, V., van der Harst, P., Mateo Leach, I., Esko, T., Kutalik, Z., Wainwright, N. W., Struchalin, M. V., Sarin, A. P., Kangas, A. J. & 57 othersViikari, J. S., Perola, M., Rantanen, T., Petersen, A. K., Soininen, P., Johansson, Å., Soranzo, N., Heath, A. C., Papamarkou, T., Prokopenko, I., Tönjes, A., Kronenberg, F., Döring, A., Rivadeneira, F., Montgomery, GW., Whitfield, J. B., Kähönen, M., Lehtimäki, T., Freimer, N. B., Willemsen, G., de Geus, E. J. C., Palotie, A., Sandhu, M. S., Waterworth, D., Metspalu, A., Stumvoll, M., Uitterlinden, A. G., Navis, G., Wijmenga, C., Wolffenbuttel, B. H. R., Taskinen, M. R., Ala-Korpela, M., Kaprio, J., Kyvik, K. O., Boomsma, D. I., Pedersen, N. L., Gyllensten, U., Wilson, J. F., Rudan, I., Campbell, H., Pramstaller, P. P., Spector, T. D., Witteman, J. C. M., Eriksson, J. G., Salomaa, V., Oostra, B. A., Raitakari, O. T., Wichmann, H. E., Gieger, C., Järvelin, M. J., Martin, N. G., Hofman, A., McCarthy, M. I., Peltonen, L., van Duijn, C. M., Aulchenko, Y. S. & Ripatti, S., 2011, In : PLoS Genetics. 7, 10, e1002333.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
waist-to-hip ratio
Waist-Hip Ratio
genome
lipid
Cholesterol

Genetic architecture of circulating lipid levels

Demirkan, A., Amin, A., Isaacs, A., Jarvelin, M-R., Whitfield, J. B., Wichmann, H-E., Ohm Kyvik, K., Rudan, I., Gieger, C., Hicks, A. A., Johansson, A., Hottenga, J. J., Smith, J. J., Wild, S. H., Pedersen, N. L., Willemsen, G., Mangino, M., Hayward, C., Uitterlinden, A. G., Hofman, A. & 26 othersWitteman, J., Montgomery, GW., Pietilainen, K. H., Rantanen, T., Kaprio, J., Döring, A., Pramstaller, P. P., Gyllensten, U., de Geus, E. J. C., Penninx, B. W. J. H., Wilson, J. F., Rivadeneira, F., Magnusson, P. K. E., Boomsma, D. I., Spector, T. D., Campbell, H., Hoehne, B., Martin, N. G., Oostra, B. A., McCarthy, M., Peltonen, L., Aulchenko, Y. S., Visscher, P. M., Ripatti, S., Janssens, A. C. J. W. & van Duijn, C. M., 2011, In : European Journal of Human Genetics. 19, 7, p. 813-819

Research output: Contribution to JournalArticleAcademicpeer-review

Lipids
Genome-Wide Association Study
Genome
LDL Cholesterol
HDL Cholesterol

Genetic risk profiles for depression and anxiety in adult and elderly cohorts

Demirkan, A., Penninx, B. W. J. H., Hek, K., Wray, N. R., Amin, N., Aulchenko, Y. S., van Dyck, R., de Geus, E. J. C., Hofman, A., Uitterlinden, A. G., Hottenga, J. J., Nolen, W. A., Oostra, B. A., Sullivan, P. F., Willemsen, G., Zitman, F. G., Tiemeier, H., Janssens, A. C. J. W., Boomsma, D. I., van Duijn, C. M. & 1 othersMiddeldorp, C. M., 2011, In : Molecular Psychiatry. 16, 7, p. 773-783

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Anxiety
Depression
Genome-Wide Association Study
Psychiatry
Inborn Genetic Diseases

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

Speliotes, E. K., Yerges-Armstrong, L. M., Wu, J., Hernaez, R., Kim, L. J., Palmer, C. D., Gudnason, V., Eiriksdottir, G., Garcia, M. E., Launer, L. J., Nalls, M. A., Clark, J. M., Mitchell, B. D., Shuldiner, A. R., Butler, J. L., Tomas, M., Hoffmann, U., Hwang, S. J., Massaro, J. M., O'Donnell, C. J. & 19 othersSahani, D. V., Salomaa, V., Schadt, E. E., Schwartz, S. M., Siscovick, D. S., Posthuma, D., Voight, B. F., Carr, J. J., Feitosa, M. F., Harris, T. B., Fox, C. S., Smith, A. V., Kao, W. H. L., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Hirschhorn, J. N. & Borecki, I. B., 2011, In : PLoS Genetics. 7, 3, e1001324.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Schumann, G., Coin, L. J. M., Lourdusamy, A., Charoen, P., Berger, K. H., Stacey, D., Desrivières, S., Aliev, F. A., Khan, A. A., Amin, N., Aulchenko, Y. S., Bakalkin, G., Bakker, S. J., Balkau, B., Beulens, J. W., Bilbao, A., de Boer, R. A., Beury, D., Bots, M. L., Breetvelt, E. J. & 80 othersCauchi, S., Cavalcanti-Proença, C., Chambers, J. C., Clarke, T. K., Dahmen, N., de Geus, E. J. C., Dick, D., Duccia, F., Easton, A., Edenberg, H. J., Esk, T., Fernández-Medarde, A., Foroud, T., Freimer, N. B., Girault, J. A., Grobbee, D. E., Guarreray, S., Gudbjartsson, D. F., Hartikainen, A-L., Heath, A. C., Hesselbrock, V., Hofman, A., Hottenga, J. J., Isohanni, M., Kaprio, J., Khaw, K. T., Kuehnel, B., Laitinen, J., Lobbens, S., Luan, J., Mangino, M., Maroteau, M., Oostra, B. A., O’Reilly, P. F., Penninx, B. W. J. H., Pouta, A., Prokopenko, I., Ricceri, F., Santos, E., Smit, J. H., Soranzo, N., Stumvoll, M., Surakka, I., Thorgeirsson, T. E., Thorsteinsdottir, U., Troakes, C., Tyrfingsson, T., Tönjes, A., Uiterwaal, C. S., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Staehlin, O., Vogelzangs, N., Vollenweider, P., Waeber, G., Wareham, N. J., Waterworth, D., Whitfield, J. B., Wichmann, H. E., Willemsen, G., Witteman, J. C., Martin, N. G., Metspalu, A., Scott, J., Spector, T. D., Loos, R. J., Boomsma, D. I., Mooser, V., Peltonen, L., Stefansson, K., van Duijn, C. M., Vineis, P., Sommer, W. H., Kooner, J. S., Spanagel, R., Heberlein, U. A., Numans, M. E., Jarvelin, M-R. & Elliott, P., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 7119-7124

Research output: Contribution to JournalArticleAcademicpeer-review

Genetic Association Studies
Autistic Disorder
Alcohol Drinking
Genome
Single Nucleotide Polymorphism

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Strawbridge, R. J., Dupuis, J., Prokopenko, I., Barker, A., Ahlqvist, E., Rybin, D., Petrie, J. R., Bouatia-Naji, N., Dimas, A. S., Nica, A., Wheeler, E., Chen, H., Voight, B. F., Taneera, J., Kanoni, S., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Forsen, T. J. & 25 othersClarke, R., Franzosi, M. G., Seedorf, U., Watkins, H., Froguel, P., Johnson, P., Deloukas, P., Collins, F. S., Laakso, M., Dermitzakis, E. T., Boehnke, M., McCarthy, M. I., Wareham, N. J., Groop, L., Pattou, F., Gloyn, A. L., Dedoussis, G. V., Lyssenko, V., Meigs, J. B., Barroso, I., Watanabe, R. M., Ingelsson, E., Langenberg, C., Hamsten, A. & Florez, J. C., 2011, In : Diabetes. 60, 10, p. 2624-2634

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Proinsulin
Type 2 Diabetes Mellitus
Fasting
Genome
Insulin

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Chambers, J. C., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., Holm, H., Sanna, S., Kavousi, M., Baumeister, S. E., Hottenga, J. J., Speliotes, E. K., de Geus, E. J. C., Martin, N. G., Montgomery, G. W., Penninx, B. W. J. H., Prokopenko, I., Spector, T. D., Uitterlinden, A. G., Willemsen, G. & 16 othersAbecasis, G. R., Boomsma, D. I., van Duijn, C. M., Snieder, H., Whitfield, J. B., Witteman, J. C. M., Fox, C. S., Ala-Korpela, M., Stefansson, K., Vollenweider, P., Völzke, H., Schadt, E. E., Scott, J., Jarvelin, M. R., Elliot, P. & Kooner, J. S., 2011, In : Nature Genetics. 43, 11, p. 1131-1140

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Liver
Enzymes
Liver Diseases

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Wain, L. V., Verwoert, G. C., O'Reilly, P. F., Shi, G., Johnson, T., Johnson, A. D., Bochud, M., Rice, K. M., Henneman, P., Smith, A. V., Ehret, G. B., Amin, N., Larson, M. G., Mooser, V., Hadley, D., Dörr, M., Bis, J. C., Aspelund, T., Esko, T., Janssens, A. C. & 42 othersZhao, J. H., Heath, S., Laan, M., Fu, J., Pistis, G., Luan, J., Arora, P., Hottenga, J. J., Rivadeneira, F., Sijbrands, E. J., Uitterlinden, A. G., Soranzo, N., de Geus, E. J. C., Willemsen, G., Boomsma, D. I., Spector, T. D., Snieder, H., Oostra, B. A., Metspalu, A., Launer, L., Rettig, R., Strachan, D. P., Beckmann, J. S., Witteman, J. C., Erdmann, J., van Dijk, K. W., Boerwinkle, E., Boehnke, M., Ridker, P. M., Jarvelin, M. R., Chakravarti, A., Abecasis, G. R., Gudnason, V., Newton-Cheh, C., Levy, D., Munroe, P. B., Psaty, B. M., Caulfield, M. J., Rao, D. C., Tobin, M. D., Elliott, P. & van Duijn, C. M., 2011, In : Nature Genetics. 43, 10, p. 1005-1012

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Arterial Pressure
Blood Pressure