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Research Output 2004 2019

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Article
2011

LPAR1 and ITGA4 Regulate Peripheral Blood Monocyte Counts

Maugeri, N., Powell, J. E., 't Hoen, P. A. C., de Geus, E. J. C., Willemsen, G., Kattenberg, V. M., Henders, A. K., Wallace, L., Penninx, B. W. J. H., Hottenga, J. J., Medland, S. E., Savyuk, V., Martin, N. G., Visscher, P. M., van Ommen, G. J. B., Frazer, I. H., Boomsma, D. I., Montgomery, GW. & Ferreira, M. A. R., 2011, In : Human Mutation. 32, 8, p. 873-876

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder

Liu, Y., Blackwood, D. H., Caesar, S., de Geus, E. J. C., Farmer, A., Ferreira, M. A. R., Ferrier, I. N., Fraser, C., Gordon-Smith, K., Green, E. K., Grozeva, D., Gurling, H. M., Hamshere, M. L., Heutink, P., Holmans, P. A., Hoogendijk, W. J. G., Hottenga, J. J., Jones, L., Jones, I. R., Kirov, G. & 24 othersLin, D., McGuffin, P., Moskvina, V., Nolen, W. A., Perlis, R. H., Posthuma, D., Scolnick, E. M., Smit, A. B., Smit, J. H., Smoller, J. W., St Clair, D., van Dyck, R., Verhage, M., Willemsen, G., Young, A. H., Zandbelt, T., Boomsma, D. I., Craddock, N., O’Donovan, M. C., Owen, M. J., Penninx, B. W. J. H., Purcell, S., Sklar, P. & Sullivan, P. F., 2011, In : Molecular Psychiatry. 16, 1, p. 2-4

Research output: Contribution to JournalArticleAcademicpeer-review

Meta-analysis of genome-wide association for migraine in six population-based European cohorts

Ligthart, R. S. L., de Vries, B., Smith, A. V., Arfan Ikram, M., Amin, N., Hottenga, J. J., Koelewijn, S. C., Kattenberg, V. M., de Moor, M. H. M., Janssens, A. J. W., Aulchenko, Y. S., Oostra, B. A., de Geus, E. J. C., Smit, J. H., Zitman, F. G., Uitterlinden, A. G., Hofman, A., Willemsen, G., Nyholt, DR., Montgomery, G. W. & 9 othersTerwindt, G. M., Gudnason, V., Penninx, B. W. J. H., Breteler, M., Ferrari, M. D., Launer, L. J., van Duijn, C. M., van den Maagdenberg, A. M. J. M. & Boomsma, D. I., 2011, In : European Journal of Human Genetics. 19, 8, p. 901-907

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Migraine Disorders
Meta-Analysis
Single Nucleotide Polymorphism
Genome
Population

Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with Excitement-Seeking

Terracciano, A., Esko, T., Sutin, A. R., de Moor, M. H. M., Meirelles, O., Zhu, G., Tanaka, T., Giegling, I., Nutile, T., Realo, A., Allik, J., Hansell, N. K., Wright, M. J., Montgomery, G. W., Willemsen, G., Hottenga, J. J., Friedl, M., Ruggiero, D., Sorice, R., Sanna, S. & 17 othersDeiana, B., Cucca, F., Krueger, R. F., Lahti, A., Luciano, M., Smoller, J. W., van Duijn, C. M., Abecasis, G. R., Boomsma, D. I., Ciullo, M., Costa, P. T., Ferrucci, L., Martin, N. G., Metspalu, A., Rujescu, D., Schlessinger, D. & Uda, M., 2011, In : Translational Psychiatry. 1, e49

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Unsafe Sex
Genome-Wide Association Study
Meta-Analysis
Personality Inventory
Impulsive Behavior

New gene functions in megakaryopoiesis and platelet formation

Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G., Serbanovic-Canic, J., Elling, U., Goodall, A. H., Labrune, Y., Hottenga, J. J., de Geus, E. J. C., Montgomery, GW., Visscher, P. M., Willemsen, G., Boomsma, D. I., Martin, N. G., Spector, T. D., Prokopenko, I., Stemple, D. & 8 othersToniolo, L., Wernisch, L., Sanna, S., Hicks, A. A., Rendon, A., Ferreira, M. A., Ouwehand, W. H. & Soranzo, N., 2011, In : Nature. 480, 7376, p. 201-208

Research output: Contribution to JournalArticleAcademicpeer-review

Blood Platelets
Genome-Wide Association Study
Blood Cells
Genes
Megakaryocytes

Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals

Kilpelaïnen, T. O., van den Hoed, M., Ong, K. K., Grøntved, A., Brage, S., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Boomsma, D. I., Jameson, K., Cooper, C., Khaw, K. T., Ekelund, U., Wareham, N. J. & Loos, R. J., 2011, In : American Journal of Clinical Nutrition. 93, 4, p. 851-860

Research output: Contribution to JournalArticleAcademicpeer-review

The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

Middeldorp, C. M., de Moor, M. H. M., McGrath, L. M., Gordon, S. D., Blackwood, D. H., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Nyholt, DR., Tanaka, T., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J. J., Distel, M. A., Uda, M., Sanna, S. & 41 othersSpinhoven, P., Hartman, C. A., Ripke, S., Sullivan, P. F., Realo, A., Allik, J., Heath, A. C., Pergadia, M. L., Agrawal, A., Lin, P., Grucza, R. A., Widen, E., Cousminer, D. L., Eriksson, J. G., Palotie, A., Barnett, J. H., Lee, P. H., Luciano, M., Tenesa, A., Davies, G., Lopez, L. M., Hansell, N. K., Medland, S. E., Ferrucci, L., Schlessinger, D., Montgomery, GW., Wright, M. J., Aulchenko, Y. S., Janssens, A. C. J. W., Oostra, B. A., Metspalu, A., Abecasis, G. R., Deary, I. J., Räikkönen, K., Bierut, L. J., Martin, N. G., Wray, N. R., van Duijn, C. M., Smoller, J. W., Penninx, B. W. J. H. & Boomsma, D. I., 2011, In : Translational Psychiatry. 1, e50.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Bipolar Disorder
Major Depressive Disorder
Personality
Depression

The Lin28/let-7 axis regulates glucose metabolism

Zhu, H., Shyh-Chang, N., Segre, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J. P., Kharas, M. G., Urbach, A., Thornton, J. E., Triboulet, R., Gregory, R. I., Hottenga, J. J., de Geus, E. J. C., Posthuma, D., Willemsen, G., Boomsma, D. I., Altshuler, D. & 1 othersDaley, G. Q., 2011, In : Cell. 147, 1, p. 81-94

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2010

A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations

Lind, P. A., Macgregor, S., Vink, J. M., Pergadia, M. L., Hansell, N., de Moor, M. H. M., Smit, A. B., Hottenga, J. J., Richter, M., Heath, A. C., Martin, N. G., Willemsen, G., de Geus, E. J. C., Vogelzangs, N., Penninx, B. W. J. H., Whitfield, J. B., Montgomery, GW., Boomsma, D. I. & Madden, P. A. F., 2010, In : Twin Research and Human Genetics. 13, 1, p. 10-29

Research output: Contribution to JournalArticleAcademicpeer-review

Tobacco Use Disorder
Alcoholism
Single Nucleotide Polymorphism
Tobacco Use
Gene Frequency

Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?

Middeldorp, C. M., Slof-Op 't Landt, M. C. T., Medland, S. E., van Beijsterveldt, C. E. M., Bartels, M., Willemsen, G., Hottenga, J. J., de Geus, E. J. C., Suchiman, H. E. D., Dolan, C. V., Neale, M. C., Slagboom, P. E. & Boomsma, D. I., 2010, In : Genes, Brain and Behavior. 9, 6, p. 808-816

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Anxiety
Depression
Single Nucleotide Polymorphism
Neurogenesis
Genes

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifson, G., Jackson, A. U., Lango Allen, H., Lindgren, C. M., Luan, J., Mägi, R., Hottenga, J. J., de Geus, E. J. C., Martin, N. G., Willemsen, G., Boomsma, D. I., Penninx, B. W. J. H., Uitterlinden, A. G., Zillikens, M. C., Visscher, P. M., Peltonen, L. & 11 othersvan Duijn, C. M., Thorsteinsdottir, U., Abecasis, G. R., Barroso, I., Boehnke, M., Stefansson, K., North, K. E., McCarthy, M. I., Hirschhorn, J. N., Ingelsson, E. & Loos, R. J. F., 2010, In : Nature Genetics. 42, 11, p. 937-948

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Body Mass Index
Obesity
Single Nucleotide Polymorphism
Genetic Loci
methanohexohydroisoindoline ethylguanidine hemisulfate

Associations between ADH glene variants and alcohol phenotypes in Dutch adults

van Beek, J. H. D. A., Willemsen, G., de Moor, M. H. M., Hottenga, J. J. & Boomsma, D. I., 2010, In : Twin Research and Human Genetics. 13, 1, p. 30-42

Research output: Contribution to JournalArticleAcademicpeer-review

File
Single Nucleotide Polymorphism
Alcohols
Phenotype
Alcohol Drinking
Multigene Family

Biological, clinical and population relevance of 95 loci for blood lipids

Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Willemsen, G., Uitterlinden, A. G., Penninx, B. W. J. H., Montgomery, GW., Martin, N. G., Hottenga, J. J., de Geus, E. J. C., Boomsma, D. I., van Duijn, C. M., Peltonen, L., Abecasis, G. R., Boehnke, M. & Kathiresan, S., 2010, In : Nature. 466, 7307, p. 707-713

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Lipids
Population
Coronary Artery Disease
Lipoproteins
Genome

Genetic epidemiology of Attention Deficit Hyperactivity Disorder (ADHD Index) in adults

Boomsma, D. I., Savyuk, V., Hottenga, J. J., Distel, M. A., de Moor, M. H. M., Vink, J. M., Geels, L. M., van Beek, J. H. D. A., Bartels, M., de Geus, E. J. C. & Willemsen, G., 2010, In : PLoS ONE. 5, 5, p. e10621 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Molecular Epidemiology
Attention Deficit Disorder with Hyperactivity
epidemiology
heritability
Parents

Genome-wide association analysis identifies multiple loci related to resting heart rate

Eijgelsheim, M., Newton-Cheh, C., Sotoodehnia, N., Bakker, P. I. W., Müller, M., Morrison, A. C., Smith, A. V., Isaacs, A., Sanna, S., Dörr, M., Navarro, P., Fuchsberger, C., Nolte, I. M., de Geus, E. J. C., Estrada, K., Hwang, S. J., Bis, J. C., Rückert, I. M., Alonso, A., Launer, L. J. & 54 othersHottenga, J. J., Rivadeneira, F., Noseworthy, P. A., Rice, T. A., Perz, S., Arking, D. E., Spector, T. D., Kors, J. A., Aulchenko, Y. S., Tarasov, K. V., Homuth, G., Wild, S. H., Marroni, F., Gieger, C., Licht, C. M. M., Prineas, R. J., Hofman, A., Rotter, J. I., Hicks, A. A., Ernst, F., Najjar, S. S., Wright, A. F., Peters, A., Fox, E. R., Oostra, B. A., Kroemer, H. K., Couper, D., Völzke, H., Campbell, H., Meitinger, T., Uda, M., Witteman, J. C. M., Psaty, B. M., Wichmann, H-E., Harris, T. B., Kääb, S., Siscovick, D. S., Jamshidi, Y., Uitterlinden, A. G., Folsom, A. R., Larson, M. G., Wilson, J. F., Penninx, B. W. J. H., Snieder, H., Pramstaller, P. P., van Duijn, C. M., Lakatta, E. G., Felix, S. B., Gudnason, V., Pfeufer, A., Heckbert, S. R., Stricker, B. H. C., Boerwinkle, E. & O'Donnell, C. J., 2010, In : Human Molecular Genetics. 19, 19, p. 3885-3894

Research output: Contribution to JournalArticleAcademicpeer-review

Genome-Wide Association Study
Heart Rate
Meta-Analysis
Cardiovascular Diseases
Mortality
File
Happiness
Genome
Phenotype
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 1

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Lango Allen, H., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Hottenga, J. J., de Geus, E. J. C., Willemsen, G., van Ommen, G. J. B., Martin, N. G., Montgomery, GW., Boomsma, D. I., Penninx, B. W. J. H., van Duijn, C. M., Peltonen, L., Visscher, P. M., Uitterlinden, A. G., Abecasis, G. R., Stefansson, H. & 2 othersFrayling, T. M. & Hirschhorn, J. N., 2010, In : Nature. 467, 7317, p. 832-838

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Multifactorial Inheritance
Genes
Genome-Wide Association Study
Genetic Loci
Growth

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., Mägi, R., Workalemahu, T., White, C. C., Bouatia-Naji, N., Harris, T. B., Berndt, S. I., Ingelsson, E., Willer, C. J., Weedon, M. N., Luan, J., Vedantam, S. & 81 othersEsko, T., Kilpeläinen, T. O., Kutalik, Z., Li, S., Monda, K. L., Dixon, A. L., Holmes, C. C., Kaplan, L. M., Liang, L., Min, J. L., Moffatt, M. F., Molony, C., Nicholson, G., Schadt, E. E., Zondervan, K. T., Feitosa, M. F., Ferreira, T., Lango Allen, H., Weyant, R. J., Wheeler, E., Wood, A. R., Estrada, K., Goddard, M. E., Lettre, G., Mangino, M., Nyholt, DR., Purcell, S., Smith, A. V., Visscher, H. M., Yang, J., McCarroll, S. A., Nemesh, J., Voight, B. F., Absher, D., Amin, N., Aspelund, T., Coin, L., Glazer, N. L., Hayward, C., Heard-Costa, N. L., Hottenga, J. J., Johansson, A., Johnson, T., Kaakinen, M., Kapur, K., Ketkar, S., Knowles, J. W., Kraft, P., Kraja, A. T., Lamina, C., Leitzmann, M. F., McKnight, B., Morris, A. P., Ong, K. K., Perry, J. R. B., Peters, M. J., Polasek, O., Prokopenko, I., Rayner, N. W., Ripatti, S., Rivadeneira, F., Robertson, R., Sanna, S., Sovio, U., Surakka, I., Teumer, A., van Wingerden, K. M. C., Vitart, V., Zhao, J. H., Cavalcanti-Proença, C., Chines, P. S., Fisher, E., Kulzer, J. R., Lecoeur, C., Narisu, N., Sandholt, C., de Geus, E. J. C., Willemsen, G., Penninx, B. W. J. H., Mohlke, K. L. & Lindgren, C. M., 2010, In : Nature Genetics. 42, 11, p. 949-960

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Waist-Hip Ratio
Sex Characteristics
Meta-Analysis
Fats
Body Fat Distribution

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Hottenga, J. J., de Geus, E. J. C., Kaprio, J., Kyvik, K. O., Pedersen, N. L. & 29 othersPerola, M., Posthuma, D., Rivadeneira, F., Uitterlinden, A. G., Willems van Dijk, K., van Hoek, M., Vogelzangs, N., Willemsen, G., Witteman, J. C. M., Zillikens, M. C., Penninx, B. W. J. H., Boomsma, D. I., van Duijn, C. M., Aulchenko, Y. S., Waterworth, D., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L. C., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., 2010, In : Nature Genetics. 42, 2, p. 105-116

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genetic Loci
Type 2 Diabetes Mellitus
Fasting
Homeostasis
Glucose

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior

Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., Amin, N., Geller, F., Sulem, P., Rafnar, T., Esko, T., Walter, S., Gieger, C., Rawal, R., Mangino, M., Prokopenko, I., Magi, R., Keskitalo, K., Gudjonsdottir, I. H., Gretarsdottir, S., Stefansson, H., Thompson, J. R. & 74 othersAulchenko, Y. S., Nelis, M., Aben, K. K., Heijer, M., Dirksen, A., Ashraf, H., Soranzo, N., Valdes, A. M., Steves, C., Uitterlinden, A. G., Hofman, A., Tonjes, A., Kovacs, P., Hottenga, J. J., Willemsen, G., Vogelzangs, N., Doring, A., Dahmen, N., Nitz, B., Pergadia, M. L., Saez, B., De Diego, V., Lezcano, V., Garcia-Prats, M. D., Ripatti, S., Perola, M., Kettunen, J., Hartikainen, A. L., Pouta, A., Laitinen, J., Isohanni, M., Huei-Yi, S., Allen, M., Krestyaninova, M., Hall, A. S., Jones, G. T., van Rij, A. M., Mueller, T., Dieplinger, B., Haltmayer, M., Jonsson, S., Matthiasson, S. E., Oskarsson, H., Tyrfingsson, T., Kiemeney, L. A., Mayordomo, J. I., Lindholt, J. S., Pedersen, J. H., Franklin, W. A., de Wolf, H., Montgomery, GW., Heath, A. C., Martin, N. G., Madden, P. A. F., Giegling, I., Rujescu, D., Jarvelin, M. R., Salomaa, V., Stumvoll, M., Spector, T. D., Wichmann, H. E., Metspalu, A., Samani, N. J., Penninx, B. W. J. H., Oostra, B. A., Boomsma, D. I., Tiemeier, H., van Duijn, C. M., Kaprio, J., Gulcher, J. R., McCarthy, M. I., Peltonen, L., Thorsteinsdottir, U. & Stefansson, K., 2010, In : Nature Genetics. 42, 5, p. 448-453

Research output: Contribution to JournalArticleAcademicpeer-review

Smoking

The Netherlands Twin Register Biobank: A resource for genetic epidemiological studies

Willemsen, G., de Geus, E. J. C., Bartels, M., van Beijsterveldt, C. E. M., Brooks, A. I., Estourgie-van Burk, G. F., Fugman, D. A., Hoekstra, C., Hottenga, J. J., Kluft, C., Meijer, P., Montgomery, GW., Rizzu, P., Sondervan, D., Smit, A. B., Spijker, S., Suchiman, H. E. D., Tischfield, J. A., Lehner, T., Slagboom, P. E. & 1 othersBoomsma, D. I., 2010, In : Twin Research and Human Genetics. 13, 3, p. 231-245

Research output: Contribution to JournalArticleAcademicpeer-review

Netherlands
Epidemiologic Studies
Personality
Life Style
Health
Serotonin Plasma Membrane Transport Proteins
Depression
Genes
Meta-Analysis
Neuroticism

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Hottenga, J. J., de Geus, E. J. C., Martin, N. G., Peltonen, L., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Loos, S. A., Montgomery, GW., Ridker, P. M. & 9 othersSpector, T. D., Streeten, E. A., Stefansson, K., Thorsteinsdottir, U., Uitterlinden, A. G., Widen, E., Murabito, J. M., Ong, K. K. & Murray, A., 2010, In : Nature Genetics. 42, 12, p. 1077-1085

Research output: Contribution to JournalArticleAcademicpeer-review

Menarche
Genome-Wide Association Study
Meta-Analysis
Genes
Biological Phenomena

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Freathy, R. M., Mook-Kanamori, D. O., Sovio, U., Prokopenko, I., Timpson, N. J., Berry, D. J., Warrington, N. M., Widen, E., Hottenga, J. J., Kaakinen, M., Lange, L. A., Bradfield, J. P., Kerkhof, M., Marsh, J. A., Mägi, R., Chen, C. M., Lyon, H. N., Kirin, M., Adair, L. S., Aulchenko, Y. S. & 63 othersBennett, A. J., Borja, J. B., Bouatia-Naji, N., Charoen, P., Coin, L. J. M., Cousminer, D. L., de Geus, E. J. C., Deloukas, P., Elliott, P., Evans, D. M., Froguel, P., Glaser, B., Groves, C. J., Hartikainen, A-L., Hassanali, N., Hirschhorn, J. N., Hofman, A., Holly, J. M. P., Hyppönen, E., Kanoni, S., Knight, B. A., Laitinen, J., Lindgren, C. M., McArdle, W. L., O'Reilly, P. F., Pennell, C. E., Postma, D. S., Pouta, A., Ramasamy, A., Rayner, N. W., Ring, S. M., Rivadeneira, F., Shields, B. M., Strachan, D. P., Surakka, I., Taanila, A., Tiesler, C., Uitterlinden, A. G., van Duijn, C. M., Wijga, A. H., Willemsen, G., Zhang, H., Zhao, J., Wilson, J. F., Steegers, E. A. P., Hattersley, A. T., Eriksson, J. G., Peltonen, L., Mohlke, K. L., Grant, S. F. A., Hakonarson, H., Koppelman, G. H., Dedoussis, G. V., Heinrich, J., Gillman, M. W., Palmer, L. J., Frayling, T. M., Boomsma, D. I., Smith, G. D., Power, C., Jaddoe, V. W. V., Jarvelin, M-R. & McCarthy, M. I., 2010, In : Nature Genetics. 42, 5, p. 430-435

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Fetal Weight
Fetal Development
Birth Weight
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
2009

A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation

Estrada, K., Krawczak, M., Schreiber, S., van Duijn, K., Stolk, L., van Meurs, J. B. J., Liu, F., Penninx, B. W. J. H., Smit, J. H., Vogelzangs, N., Hottenga, J. J., Willemsen, G., de Geus, E. J. C., Lorentzon, M., von Eller-Eberstein, H., Lips, P. T. A. M., van Schoor, N. M., Pop, V., de Keijzer, J., Hofman, A. & 8 othersAulchenko, Y. S., Oostra, B. A., Ohlsson, C., Boomsma, D. I., Uitterlinden, A. G., van Duijn, C. M., Rivadeneira, F. F. & Kayser, M., 2009, In : Human Molecular Genetics. 18, 18, p. 3516-3524

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
C-Type Natriuretic Peptide
Body Height
Genome-Wide Association Study
Population
Single Nucleotide Polymorphism

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

Benyamin, B., Ferreira, M. A., Willemsen, G., Gordon, S., Middelberg, R. P. S., McEvoy, B. P., Hottenga, J. J., Henders, A. K., Campbell, MJ., Wallace, L., Frazer, I. H., Heath, A. C., de Geus, E. J. C., Nyholt, DR., Visscher, P. M., Penninx, B. W. J. H., Boomsma, D. I., Martin, N. G., Montgomery, GW. & Whitfield, J. B., 2009, In : Nature Genetics. 41, 11, p. 1173-1175

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Erythrocyte Volume
Iron
Erythrocyte Indices
Erythropoiesis
Genome-Wide Association Study

Genetic Factors Underlie Stability of Obsessive–Compulsive Symptoms

van Grootheest, D. S., Cath, D., Hottenga, J. J., Beekman, A. T. F. & Boomsma, D. I., 2009, In : Twin Research and Human Genetics. 12, 5, p. 411-419

Research output: Contribution to JournalArticleAcademicpeer-review

File
Compulsive Behavior
Obsessive Behavior
Dizygotic Twins
Monozygotic Twins
Netherlands

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo

Sullivan, P. F., de Geus, E. J. C., Willemsen, G., James, M. R., Smit, J. H., Zandbelt, T., Arolt, V., Baune, B. T., Blackwood, D., Cichon, S., Coventry, W. L., Domschke, K., Farmer, A., Fava, M., Gordon, S. D., He, Q., Heath, A. C., Heutink, P., Holsboer, F., Hoogendijk, W. J. G. & 29 othersHottenga, J. J., Hu, Y., Kohli, M., Lin, D., Lucae, S., MacIntyre, D. J., Maier, W., McGhee, K. A., McGuffin, P., Montgomery, GW., Muir, W. J., Nolen, W. A., Nöthen, M. M., Perlis, R. H., Pirlo, K., Posthuma, D., Rietschel, M., Rizzu, P., Schosser, A., Smit, A. B., Smoller, J. W., Tzeng, J. Y., van Dyck, R., Verhage, M., Zitman, F. G., Martin, N. G., Wray, N. R., Boomsma, D. I. & Penninx, B. W. J. H., 2009, In : Molecular Psychiatry. 14, 4, p. 359-375

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Major Depressive Disorder
Genome
Overlapping Genes
Proteins
Information Services

Genome-wide association study of exercise behavior in dutch and american adults

De Moor, M. H. M., Liu, Y. J., Boomsma, D. I., Li, J., Hamilton, J. J., Hottenga, J. J., Levy, S., Liu, X. G., Pei, Y. F., Posthuma, D., Recker, R. R., Sullivan, P. F., Wang, L., Willemsen, G., Yan, H., De Geus, E. J. C. & Deng, H. W., Oct 2009, In : Medicine and Science in Sports and Exercise. 41, 10, p. 1887-1895 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Exercise
Genes
Leisure Activities
Genome

Genome-wide Association Study of Smoking Initiation and Current Smoking

Vink, J. M., Smit, A. B., de Geus, E. J. C., Sullivan, P. F., Willemsen, G., Hottenga, J. J., Smit, J. H., Hoogendijk, W. J. G., Zitman, F. G., Peltonen, L., Kaprio, J., Pedersen, N. L., Magnusson, P. K. E., Spector, T. D., Kyvik, K. O., Morley, K. I., Heath, A. C., Martin, N. G., Westendorp, R. G. J., Slagboom, P. E. & 8 othersTiemeier, H., Hofman, A., Uitterlinden, A. G., Aulchenko, Y. S., Amin, N., van Duijn, C., Penninx, B. W. J. H. & Boomsma, D. I., 2009, In : American Journal of Human Genetics. 84, 3, p. 367-379

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Smoking
Excitatory Amino Acid Transporter 2
Genes
Proteins

Geographical structure and differential natural selection amongst North European populations

McEvoy, B. P., Montgomery, GW., McRae, A. F., Ripatti, S., Perola, M., Spector, T. D., Cherkas, L. F., Ahmadi, K., Boomsma, D. I., Willemsen, G., Hottenga, J. J., Pedersen, N. L., Magnusson, P. K. E., Kyvik, K., Christensen, K., Kaprio, J., Heikkilä, K., Palotie, A., Widen, E., Muilu, J. & 7 othersSyvänen, A. C., Liljedahl, U., Hardiman, O., Cronin, S., Peltonen, L., Martin, N. G. & Visscher, P. M., 2009, In : Genome Research. 19, 5, p. 804-814

Research output: Contribution to JournalArticleAcademicpeer-review

File
Genetic Selection
HapMap Project
Population
Chromosome Mapping
Denmark

Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap–CEU populations

Pardo, L. M., Bochdanovits, Z., de Geus, E. J. C., Hottenga, J. J., Sullivan, P. F., Posthuma, D., Penninx, B. W. J. H., Boomsma, D. I. & Heutink, P., 2009, In : European Journal of Human Genetics. 17, 6, p. 802-810

Research output: Contribution to JournalArticleAcademicpeer-review

File
Linkage Disequilibrium
HapMap Project
Population
Genome-Wide Association Study
Single Nucleotide Polymorphism

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

Aulchenko, Y. S., Ripatti, S., Lindqvist, I., Boomsma, D. I., Heid, I. M., Pramstaller, P. P., Penninx, B. W. J. H., Janssen, A. C. J. W., Wilson, J. F., Spector, T., Martin, N. G., Pedersen, N. L., Kyvik, K. O., Kaprio, J., Hofman, A., Freimer, N. B., Jarvelin, M-R., Gyllensten, U., Campbell, H., Rudan, I. & 37 othersJohansson, A., Marroni, F., Hayward, C., Vitart, V., Jonasson, I., Pattar, C., Wright, A., Hastie, N., Pichler, I., Hicks, A. A., Falchi, M., Willemsen, G., Hottenga, J. J., de Geus, E. J. C., Montgomery, GW., Whitfield, J., Magnusson, P., Saharinen, J., Perola, M., Silander, K., Isaacs, A., Sijbrands, E. J. G., Uitterlinden, A. G., Witteman, J. C. M., Oostra, B. A., Elliott, P., Ruokonen, A., Sabatti, C., Gieger, C., Meitinger, T., Kronenberg, F., Döring, A., Wichmann, H-E., Smit, J. H., McCarthy, M. I., van Duijn, C. M. & Peltonen, L., 2009, In : Nature Genetics. 41, 1, p. 47-55

Research output: Contribution to JournalArticleAcademicpeer-review

File
Genome-Wide Association Study
Coronary Disease
Scandinavian and Nordic Countries
Lipids
LDL Cholesterol

Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci

Kettunen, J., Perola, M., Martin, N. G., Cornes, B. K., Wilson, S. G., Montgomery, GW., Benyamin, B., Harris, J. R., Boomsma, D. I., Willemsen, G., Hottenga, J. J., Slagboom, P. E., Christensen, K., Kyvik, K., Sorensen, T. I. A., Pedersen, N. L., Magnusson, P. K. E., Andrew, T., Spector, T. D., Widen, E. & 4 othersSilventoinen, K., Kaprio, J., Palotie, A. & Peltonen, L., 2009, In : International Journal of Obesity. 33, 11, p. 1235-1242

Research output: Contribution to JournalArticleAcademicpeer-review

File
Dizygotic Twins
Twin Studies
Denmark
Finland
Sweden

Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume

Ferreira, M. A. R., Hottenga, J. J., Warrington, N. M., Medland, S. E., Willemsen, G., Lawrence, R. W., Gordon, S., de Geus, E. J. C., Henders, A. K., Smit, J. H., Campbell, M. J., Wallace, L., Evans, D. M., Wright, M. J., Nyholt, DR., James, A. L., Beilby, J. P., Penninx, B. W. J. H., Palmer, L. J., Frazer, I. H. & 3 othersMontgomery, GW., Martin, N. G. & Boomsma, D. I., 2009, In : American Journal of Human Genetics. 85, 5, p. 745-749

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Erythrocyte Volume
Hematology
Monocytes
Physiological Phenomena
Erythrocyte Count

Suggestive linkage on chromosome 2, 8, and 17 for Lifetime Major Depression

Middeldorp, C. M., Sullivan, P. F., Wray, N. R., Hottenga, J. J., de Geus, E. J. C., van den Berg, M., Montgomery, GW., Coventry, W. L., Statham, D. J., Andrews, G., Slagboom, P. E., Boomsma, D. I. & Martin, N. G., 2009, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 150B, 3, p. 352-358

Research output: Contribution to JournalArticleAcademicpeer-review

File
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 2
Major Depressive Disorder
Serotonin Plasma Membrane Transport Proteins

Variants in MTNR1B influence fasting glucose levels

Prokopenko, I., Langenberg, C., Florez, J. C., Saxena, R., Soranzo, N., Thorleifsson, G., Loos, R. J. F., Manning, A. K., Jackson, A. U., Aulchenko, Y. S., Potter, S. C., Erdos, M. R., Sanna, S., Hottenga, J. J., Wheeler, E., Kaakinen, M., Lyssenko, V., Chen, W-M., Ahmadi, K., Beckmann, J. S. & 79 othersBergman, R. N., Bochud, M., Bonnycastle, L. L., Buchanan, T. A., Cao, A., Cervin, A., Coin, L., Collins, F. S., Crisponi, L., de Geus, E. J. C., Dehghan, A., Deloukas, P., Doney, A. S. F., Elliott, P., Freimer, N. B., Gateva, V., Herder, C., Hofman, A., Hughes, T. E., Hunt, S., Illig, T., Inouye, M., Isomaa, B., Johnson, T., Kong, A., Krestyaninova, M., Kuusisto, J., Laaks, M., Lim, N., Lindblad, U., Lindgren, C. M., McCann, O. T., Mohlke, K. L., Morris, A. D., Naitza, S., Orrù, M., Palmer, C. N. A., Pouta, A., Randall, J., Rathmann, W., Saramies, J., Scheet, P., Scott, L. J., Scuteri, A., Sharp, S., Sijbrands, E. J. G., Smit, J. H., Song, K., Steinthorsdottir, V., Stringham, H. M., Tuomi, T., Tuomilehto, J., Uitterlinden, A. G., Voight, B. F., Waterworth, D., Wichmann, H-E., Willemsen, G., Witteman, J. C. M., Yuan, X., Zha, J. H., Zeggini, E., Schlessinger, D., Sandhu, M., Boomsma, D. I., Uda, M., Spector, T. D., Penninx, B. W. J. H., Altshuler, D., Vollenweider, P., Jarvelin, M-R., Lakatta, E., Waeber, G., Fox, C. S., Peltonen, L., Groop, L. C., Mooser, V., Cupples, L. A., Thorsteinsdottir, U. & Abecasis, G. R., 2009, In : Nature Genetics. 41, 1, p. 77-81

Research output: Contribution to JournalArticleAcademicpeer-review

File
Melatonin MT2 Receptor
Fasting
Glucose
HapMap Project
Genetic Loci
2008
Open Access
File
Migraine without Aura
Migraine Disorders
Genome
Population

A whole genome association study of neuroticism using DNA pooling.

Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G., Hettema, J. M., An, S. S., Neale, M. C., van den Oord, E. J. C. G., Kendler, K., Chen, X., Boomsma, D. I., Middeldorp, C. M., Hottenga, J. J., Slagboom, P. E. & Flint, J., 2008, In : Molecular Psychiatry. 13, 3, p. 302-312

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Single Nucleotide Polymorphism
DNA
Odds Ratio
Genome

Chromosome 9: linkage for borderline personality disorder features.

Distel, M. A., Hottenga, J. J., Trull, T. J. & Boomsma, D. I., 2008, In : Psychiatric Genetics. 18, 6, p. 302-307

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Chromosomes, Human, Pair 9
Borderline Personality Disorder
Neurofibromin 2
Genotype
Chromosomes, Human, Pair 4

Design and implementation of a twin-family database for behavior genetics and genomics studies.

Boomsma, D. I., Willemsen, G., Vink, J. M., Bartels, M., Groot, P., Hottenga, J. J., van Beijsterveldt, C. E. M., Stroet, T. M., van Dijk, R., Wertheim, R., Visser, M. & van der Kleij, F., 2008, In : Twin Research and Human Genetics. 11, 3, p. 342-348

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genetic Databases
Genomics
Pedigree
Databases
Information Storage and Retrieval

Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype.

Middeldorp, C. M., Hottenga, J. J., Slagboom, P. E., Sullivan, P. F., de Geus, E. J. C., Posthuma, D., Willemsen, G. & Boomsma, D. I., 2008, In : Molecular Psychiatry. 13, 1, p. 84-89

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Chromosomes, Human, Pair 14
Anxiety
Genome
Phenotype
Anxiety Disorders

Vitamin D receptor gene polymorphisms have negligible effect on human height.

Macgregor, S., Hottenga, J. J., Lind, P. A., Suchiman, E., Willemsen, G., Slagboom, P. E., Montgomery, GW., Martin, N. G., Visscher, P. M. & Boomsma, D. I., 2008, In : Twin Research and Human Genetics. 11, 5, p. 488-494

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Calcitriol Receptors
Meta-Analysis
Genes
Physiological Phenomena
Vitamin D
2007

Combined genome scans for body stature in 6,602 European twins: Evidence for common Caucasian loci.

Perola, M., Sammalisto, S., Hiekkalinna, T., Martin, N. G., Visscher, P. M., Montgomery, GW., Benyamin, B., Harris, J. R., Boomsma, D. I., Willemsen, G., Hottenga, J. J., Christensen, K., Kyvik, K., Sorensen, T. I. A., Pedersen, N. L., Magnusson, P. K. E., Spector, T. D., Widen, E., Silventoinen, K., Kaprio, J. & 2 othersPalotie, A. & Peltonen, L., 2007, In : PLoS Genetics. 3, 6, 10 p., e97.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Quantitative Trait Loci
Software
genome
Genome
Chromosomes, Human, Pair 20

Family based association analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression

Middeldorp, C. M., de Geus, E. J. C., Beem, A. L., Lakenberg, N., Hottenga, J. J., Slagboom, P. E. & Boomsma, D. I., 2007, In : Behavior Genetics. 37, 2, p. 294-301

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Serotonin Plasma Membrane Transport Proteins
anxiety
serotonin
transporters
polymorphism

Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs

de Moor, M. H. M., Spector, T. D., Cherkas, L. F., Falchi, M., Hottenga, J. J., Boomsma, D. I. & de Geus, E. J. C., 2007, In : Twin Research and Human Genetics. 10, 6, p. 812-820

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Dizygotic Twins
Athletes
Genome
Genes
Single Nucleotide Polymorphism
Open Access
File
Genome
Chromosomes
Metabolic Equivalent
Genes
Muscles

Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q and 17P.

Hottenga, J. J., Whitfield, J. B., Posthuma, D., Willemsen, A. H. M., de Geus, E. J. C., Martin, N. G. & Boomsma, D. I., 2007, In : Hypertension. 49, 4, p. 832-838

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome
Blood Pressure
Chromosomes
Dizygotic Twins
Netherlands
2006

Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression

Beem, A. L., de Geus, E. J. C., Hottenga, J. J., Sullivan, P. F., Willemsen, G., Slagboom, P. E. & Boomsma, D. I., 2006, In : Behavior Genetics. 36, 1, p. 127-136

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
anxiety
linkage (genetics)
allele
Anxiety
Alleles

Empirical evaluation of the genetic similarity of samples from twin registries in Australia and the Netherlands using 359 STRP markers

Sullivan, P. F., Montgomery, GW., Hottenga, J. J., Wray, N. R., Boomsma, D. I. & Martin, N. G., 2006, In : Twin Research and Human Genetics. 9, 4, p. 600-602

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File