J.P. Bebelman

Support Staff, Faculty of Science, Medicinal chemistry

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9 Similar Profiles

Saccharomyces cerevisiae Medicine & Life Sciences

Cell Wall Medicine & Life Sciences

Ligands Chemical Compounds

CXCR3 Receptors Medicine & Life Sciences

Chemokine Receptors Chemical Compounds

CXCR4 Receptors Medicine & Life Sciences

Phenotype Medicine & Life Sciences

Amino Acid Transport Systems Medicine & Life Sciences

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Research Output 1997 2019

13 Article
2 Abstract

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

Adlere, I., Sun, S., Zarca, A., Roumen, L., Gozelle, M., Viciano Perpiñá, C., Caspar, B., Arimont, M., Bebelman, J. P., Briddon, S. J., Hoffmann, C., Hill, S. J., Smit, M. J., Vischer, H. F., Wijtmans, M., de Graaf, C., de Esch, I. J. P. & Leurs, R., 15 Jan 2019, In : European Journal of Medicinal Chemistry. 162, p. 631-649 19 p.

Research output: Contribution to Journal › Article › Academic › peer-review

CXCR4 Receptors

Quantitative Structure-Activity Relationship

Chemokine Receptors

Screening

Pharmacology

Photoswitching the Efficacy of a Small-Molecule Ligand for a Peptidergic GPCR: from Antagonism to Agonism

Gómez-Santacana, X., de Munnik, S. M., Vijayachandran, P., Da Costa Pereira, D., Bebelman, J. P. M., de Esch, I. J. P., Vischer, H. F., Wijtmans, M. & Leurs, R., 3 Sep 2018, In : Angewandte Chemie - International Edition. 57, 36, p. 11608-11612 5 p.

Research output: Contribution to Journal › Article › Academic › peer-review

Ligands

Molecules

Chemical activation

Electrophysiology

Proteins

Surface plasmon resonance biosensor assay for the analysis of small-molecule inhibitor binding to human and parasitic phosphodiesterases.

Siderius, M. H., Shanmugham, A., England, P., van der Meer, T. K., Bebelman, J. P., Blaazer, A. R., de Esch, I. J. P. & Leurs, R., 2016, In : Analytical Biochemistry. 503, p. 41-49

Research output: Contribution to Journal › Article › Academic › peer-review

Surface Plasmon Resonance

Phosphoric Diester Hydrolases

Surface plasmon resonance

Biosensing Techniques

Biosensors

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.

Torraca, V., Cui, C., Boland, R., Bebelman, J. P., van der Sar, A. M., Smit, M. J., Siderius, M. H., Spaink, H. P. & Meijer, A. H., 2016, In : Disease Models and Mechanisms. 8, 3, p. 253-269

Research output: Contribution to Journal › Article › Academic › peer-review

Open Access

CXCR3 Receptors

Macrophages

Zebrafish

Infection

Tuberculosis

Thermosensitivity of the Saccharomyces cerevisiae gpp1gpp2 double deletion strain can be reduced by overexpression of genes involved in cell wall maintenance

Wojda, I., Bebelman, J. P., Jakubowicz, T. & Siderius, M. H., 2007, In : Archives of Microbiology. 188, 2, p. 175-84

Research output: Contribution to Journal › Article › Academic › peer-review

Open Access

File

Yeast

Cell Wall

Saccharomyces cerevisiae

Genes

Cells

Activities 2001 2001

3 Lecture / Presentation

hyper-osmotic stress response and regulation of cell wall integrity

R. Alonso Monge (Speaker), E Real (Speaker), I Wojda (Speaker), J.P. Bebelman (Speaker), W.H. Mager (Speaker), M.H. Siderius (Speaker)

25 Aug 2001

Activity: Lecture / Presentation › Academic

hyper-osmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects

R. Alonso Monge (Speaker), E Real (Speaker), I Wojda (Speaker), J.P. Bebelman (Speaker), W.H. Mager (Speaker), M.H. Siderius (Speaker)

25 Aug 2001

Activity: Lecture / Presentation › Academic

hyper-osmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects.

R. Alonso Monge (Speaker), E Real (Speaker), I Wojda (Speaker), J.P. Bebelman (Speaker), W.H. Mager (Speaker), M.H. Siderius (Speaker)

4 May 2001

Activity: Lecture / Presentation › Academic