Personal profile

Personal information

I am an enthusiastic and skilled systems biologist who can efficiently collaborate and communicate with researchers in various discipline”

In my research, I combine wetlab experiments with computational modelling to advance quantitative understanding of biological processes in healthy and disease cells. I have mainly applied this in metabolism and the gene expression cascade

Specialties: Metabolism, 'pathogens' in the context of the host environment (e.g. trypanosomes in the bloodstream, cancer cells amidst healthy cells), mathematical modeling, blood cells, tumerogenesis, mouse models

Research

Current projects

  • ErasysApp IMOMESIC:  This project aims to obtain systems understanding on how the integration of metabolism and signalling is altered in liver cancer cells compared to the healthy liver.
  • Together with bachelor and master students, I have several computational and experimental projects on energy metabolism in parasites

Ancillary activities

  • COST ACTION CM1307 | Amsterdam | Memberof the Management Committee for the Netherlands | 2015-03-02
  • VVE Ravelijn | Utrecht | Bestuurder | 2015-04-01

Ancillary activities are updated daily

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2002 2018

  • 16 Article
  • 2 Chapter
  • 1 Conference contribution
  • 1 PhD Thesis - Research VU, graduation VU

Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M. J., De La Torre Cortés, P. & Teusink, B. 3 Apr 2018 In : Scientific Reports. 8, 1, p. 1-9 9 p., 5576

Research output: Scientific - peer-reviewArticle

Low affinity membrane transporters can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M., de la Torre Cortés, P. & Teusink, B. 2 Nov 2017 In : bioRxiv.

Research output: ScientificArticle

Targeting pathogen metabolism without collateral damage to the host.

Haanstra, J. R., Gerding, A., Dolga, A. M., Sorgdrager, F. J., Buist-Homan, M., du Toit, F., Faber, K. N., Holzhutter, H. G., Szoor, B., Matthews, K. R., Snoep, J. L., Westerhoff, H. V. & Bakker, B. M. 2017 In : Scientific Reports. 7, 40406

Research output: Scientific - peer-reviewArticle

Attacking Blood-Borne Parasites with Mathematics

van Niekerk, D. D., Penkler, G. P., du Toit, F., Snoep, J. L., Bakker, B. M. & Haanstra, J. R. 2016 Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. Muller, S., Cerdan, R., Radulescu, O. & Selzer, P. (eds.). 1 ed. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 7, p. 513 541 p.

Research output: ScientificChapter

Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites.

Haanstra, J. R., González-Marcano, E. B., Gualdrón-López, M. & Michels, P. A. 2016 In : Biochimica et Biophysica Acta. Molecular Cell Research. 1863, 5, p. 1038-1048

Research output: Scientific - peer-reviewArticle