Personal profile

Personal information

I am an enthusiastic and skilled systems biologist who can efficiently collaborate and communicate with researchers in various discipline”

In my research, I combine wetlab experiments with computational modelling to advance quantitative understanding of biological processes in healthy and disease cells. I have mainly applied this in metabolism and the gene expression cascade

Specialties: Metabolism, 'pathogens' in the context of the host environment (e.g. trypanosomes in the bloodstream, cancer cells amidst healthy cells), mathematical modeling, blood cells, tumerogenesis, mouse models

Research

Current projects

  • ErasysApp IMOMESIC:  This project aims to obtain systems understanding on how the integration of metabolism and signalling is altered in liver cancer cells compared to the healthy liver.
  • Together with bachelor and master students, I have several computational and experimental projects on energy metabolism in parasites

Ancillary activities

  • COST ACTION CM1307 | Amsterdam | Memberof the Management Committee for the Netherlands | 2015-03-02
  • VVE Ravelijn | Utrecht | Bestuurder | 2015-04-01

Last update Ancillary Activities: Amsterdam (2018-01-22)

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2002 2017

  • 14 Article
  • 1 Chapter
  • 1 Conference contribution
  • 1 PhD Thesis - Research VU, graduation VU

Targeting pathogen metabolism without collateral damage to the host.

Haanstra, J. R., Gerding, A., Dolga, A. M., Sorgdrager, F. J., Buist-Homan, M., du Toit, F., Faber, K. N., Holzhutter, H. G., Szoor, B., Matthews, K. R., Snoep, J. L., Westerhoff, H. V. & Bakker, B. M. 2017 In : Scientific Reports. 7, 40406

Research output: Scientific - peer-reviewArticle

Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites.

Haanstra, J. R., González-Marcano, E. B., Gualdrón-López, M. & Michels, P. A. 2016 In : Biochimica et Biophysica Acta. Molecular Cell Research. 1863, 5, p. 1038-1048

Research output: Scientific - peer-reviewArticle

Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression.

Antwi, E. B., Haanstra, J. R., Ramasamy, G., Jensen, B., Droll, D., Rojas, F., Minia, I., Terrao, M., Merce, C., Matthews, K., Myler, P. J., Parsons, M. & Clayton, C. 2016 In : BMC Genomics. 17, 306

Research output: Scientific - peer-reviewArticle

Open Access

Drug target identification through systems biology.

Haanstra, J. R. & Bakker, B. M. 2015 In : Drug Discovery Today: Technologies. 15, p. 17-22

Research output: Scientific - peer-reviewArticle

Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids.

Szoor, B., Haanstra, J. R., Gualdron-Lopez, M. & Michels, P. A. M. 2014 In : Current Opinion in Microbiology. 22, p. 79-87 9 p.

Research output: Scientific - peer-reviewArticle