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Personal profile

Personal information

I am an enthusiastic and skilled systems biologist who can efficiently collaborate and communicate with researchers in various discipline”

In my research, I combine wetlab experiments with computational modelling to advance quantitative understanding of biological processes in healthy and disease cells. I have mainly applied this in metabolism and the gene expression cascade

Specialties: Metabolism, 'pathogens' in the context of the host environment (e.g. trypanosomes in the bloodstream, cancer cells amidst healthy cells), mathematical modeling, blood cells, tumerogenesis, mouse models

Research

Current projects

  • ErasysApp IMOMESIC:  This project aims to obtain systems understanding on how the integration of metabolism and signalling is altered in liver cancer cells compared to the healthy liver.
  • Together with bachelor and master students, I have several computational and experimental projects on energy metabolism in parasites

Ancillary activities

  • COST ACTION CM1307 | Amsterdam | Memberof the Management Committee for the Netherlands | 2015-03-02
  • VVE Ravelijn | Utrecht | Bestuurder | 2015-04-01

Ancillary activities are updated daily

Keywords

  • QR Microbiology
  • Trypanosoma brucei

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 6 Similar Profiles
Trypanosoma brucei brucei Medicine & Life Sciences
Trypanosomiasis Medicine & Life Sciences
Glycolysis Medicine & Life Sciences
Microbodies Medicine & Life Sciences
Parasites Medicine & Life Sciences
trypanothione synthetase Medicine & Life Sciences
RNA Stability Medicine & Life Sciences
Glucose Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2002 2018

Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M. J., De La Torre Cortés, P. & Teusink, B., 3 Apr 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 5576

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Facilitated Diffusion
Facilitative Glucose Transport Proteins
Glycolysis
Saccharomyces cerevisiae
Carrier Proteins

Metabolite Depletion Affects Flux Profiling of Cell Lines

Nilsson, A., Haanstra, J. R., Teusink, B. & Nielsen, J., Jun 2018, In : Trends in Biochemical Sciences. 43, 6, p. 395-397 3 p.

Research output: Contribution to JournalShort surveyAcademicpeer-review

Metabolites
Cells
Fluxes
Cell Line
Growth

Low affinity membrane transporters can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M., de la Torre Cortés, P. & Teusink, B., 2 Nov 2017, In : bioRxiv.

Research output: Contribution to JournalArticleAcademic

Targeting pathogen metabolism without collateral damage to the host.

Haanstra, J. R., Gerding, A., Dolga, A. M., Sorgdrager, F. J., Buist-Homan, M., du Toit, F., Faber, K. N., Holzhutter, H. G., Szoor, B., Matthews, K. R., Snoep, J. L., Westerhoff, H. V. & Bakker, B. M., 2017, In : Scientific Reports. 7, 40406

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Attacking Blood-Borne Parasites with Mathematics

van Niekerk, D. D., Penkler, G. P., du Toit, F., Snoep, J. L., Bakker, B. M. & Haanstra, J. R., 2016, Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. Muller, S., Cerdan, R., Radulescu, O. & Selzer, P. (eds.). 1 ed. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 7, p. 513 541 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic