Research Output per year
Personal profile
Personal information
I am an enthusiastic and skilled systems biologist who can efficiently collaborate and communicate with researchers in various discipline”
In my research, I combine wetlab experiments with computational modelling to advance quantitative understanding of biological processes in healthy and disease cells. I have mainly applied this in metabolism and the gene expression cascade
Specialties: Metabolism, 'pathogens' in the context of the host environment (e.g. trypanosomes in the bloodstream, cancer cells amidst healthy cells), mathematical modeling, blood cells, tumerogenesis, mouse models
Research
Current projects
- ErasysApp IMOMESIC: This project aims to obtain systems understanding on how the integration of metabolism and signalling is altered in liver cancer cells compared to the healthy liver.
- Together with bachelor and master students, I have several computational and experimental projects on energy metabolism in parasites
Ancillary activities
- COST ACTION CM1307 | Amsterdam | Memberof the Management Committee for the Netherlands | 2015-03-02 - present
- VVE Ravelijn | Utrecht | Bestuurder | 2015-04-01 - present
Ancillary activities are updated daily
Keywords
- QR Microbiology
- Trypanosoma brucei
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Trypanosoma brucei brucei
Medicine & Life Sciences
Trypanosomiasis
Medicine & Life Sciences
Glycolysis
Medicine & Life Sciences
Microbodies
Medicine & Life Sciences
Parasites
Medicine & Life Sciences
trypanothione synthetase
Medicine & Life Sciences
RNA Stability
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Glucose
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2002 2018
Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux
Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M. J., De La Torre Cortés, P. & Teusink, B., 3 Apr 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 5576.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access
Facilitated Diffusion
Facilitative Glucose Transport Proteins
Glycolysis
Saccharomyces cerevisiae
Carrier Proteins
Metabolite Depletion Affects Flux Profiling of Cell Lines
Nilsson, A., Haanstra, J. R., Teusink, B. & Nielsen, J., Jun 2018, In : Trends in Biochemical Sciences. 43, 6, p. 395-397 3 p.Research output: Contribution to Journal › Short survey › Academic › peer-review
Metabolites
Cells
Fluxes
Cell Line
Growth
Low affinity membrane transporters can increase net substrate uptake rate by reducing efflux
Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M., de la Torre Cortés, P. & Teusink, B., 2 Nov 2017, In : bioRxiv.Research output: Contribution to Journal › Article › Academic
Targeting pathogen metabolism without collateral damage to the host.
Haanstra, J. R., Gerding, A., Dolga, A. M., Sorgdrager, F. J., Buist-Homan, M., du Toit, F., Faber, K. N., Holzhutter, H. G., Szoor, B., Matthews, K. R., Snoep, J. L., Westerhoff, H. V. & Bakker, B. M., 2017, In : Scientific Reports. 7, 40406.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access
Attacking Blood-Borne Parasites with Mathematics
van Niekerk, D. D., Penkler, G. P., du Toit, F., Snoep, J. L., Bakker, B. M. & Haanstra, J. R., 2016, Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. Muller, S., Cerdan, R., Radulescu, O. & Selzer, P. (eds.). 1 ed. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 7. p. 513 541 p.Research output: Chapter in Book / Report / Conference proceeding › Chapter › Academic