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Research Output 2002 2018

2018

Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M. J., De La Torre Cortés, P. & Teusink, B., 3 Apr 2018, In : Scientific Reports. 8, 1, p. 1-9 9 p., 5576.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Facilitated Diffusion
Facilitative Glucose Transport Proteins
Glycolysis
Saccharomyces cerevisiae
Carrier Proteins

Metabolite Depletion Affects Flux Profiling of Cell Lines

Nilsson, A., Haanstra, J. R., Teusink, B. & Nielsen, J., Jun 2018, In : Trends in Biochemical Sciences. 43, 6, p. 395-397 3 p.

Research output: Contribution to JournalShort surveyAcademicpeer-review

Metabolites
Cells
Fluxes
Cell Line
Growth
2017

Low affinity membrane transporters can increase net substrate uptake rate by reducing efflux

Bosdriesz, E., Wortel, M. T., Haanstra, J. R., Wagner, M., de la Torre Cortés, P. & Teusink, B., 2 Nov 2017, In : bioRxiv.

Research output: Contribution to JournalArticleAcademic

Targeting pathogen metabolism without collateral damage to the host.

Haanstra, J. R., Gerding, A., Dolga, A. M., Sorgdrager, F. J., Buist-Homan, M., du Toit, F., Faber, K. N., Holzhutter, H. G., Szoor, B., Matthews, K. R., Snoep, J. L., Westerhoff, H. V. & Bakker, B. M., 2017, In : Scientific Reports. 7, 40406.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2016

Attacking Blood-Borne Parasites with Mathematics

van Niekerk, D. D., Penkler, G. P., du Toit, F., Snoep, J. L., Bakker, B. M. & Haanstra, J. R., 2016, Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. Muller, S., Cerdan, R., Radulescu, O. & Selzer, P. (eds.). 1 ed. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 7. p. 513 541 p.

Research output: Chapter in Book / Report / Conference proceedingChapterAcademic

Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites.

Haanstra, J. R., González-Marcano, E. B., Gualdrón-López, M. & Michels, P. A., 2016, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1863, 5, p. 1038-1048

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Microbodies
Life Cycle Stages
Peroxisomes
Parasites
Maintenance

Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression.

Antwi, E. B., Haanstra, J. R., Ramasamy, G., Jensen, B., Droll, D., Rojas, F., Minia, I., Terrao, M., Merce, C., Matthews, K., Myler, P. J., Parsons, M. & Clayton, C., 2016, In : BMC Genomics. 17, 306.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2015

Drug target identification through systems biology.

Haanstra, J. R. & Bakker, B. M., 2015, In : Drug Discovery Today: Technologies. 15, p. 17-22

Research output: Contribution to JournalArticleAcademicpeer-review

Systems Biology
Pharmaceutical Preparations
Neoplasms
2014

Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids.

Szoor, B., Haanstra, J. R., Gualdron-Lopez, M. & Michels, P. A. M., 2014, In : Current Opinion in Microbiology. 22, p. 79-87 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

In or out? On the tightness of glycosomal compartmentalizatin of metabolites and enzymes in Trypanosoma brucei.

Haanstra, J. R., Bakker, B. M. & Michels, P. A. M., 2014, In : Molecular and Biochemical Parasitology. 198, p. 18-28

Research output: Contribution to JournalArticleAcademicpeer-review

Trypanosoma brucei brucei
Microbodies
Peroxisomes
Membranes
Trypanosomiasis

The silicon trypanosome: a test case of iterative model extension in systems biology.

Achcar, F., Fadda, A., Haanstra, J. R., Kerkhoven, E. J., Kim, D. H., Leroux, A. E., Papmarkou, T., Rojas, F., Bakker, B. M., Barrett, M. P., Clayton, C., Girolami, M., Krauth-Siegel, R. L., Matthews, K. R. & Breitling, R., 2014, Advance in microbial physiology. Poole, R. K. (ed.). Elsevier Ltd, p. 115-143

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels.

Fadda, A., Ryten, M., Droll, D., Rojas, F., Farber, V., Haanstra, J. R., Merce, C., Bakker, B. M., Matthews, K. & Clayton, C., 2014, In : Molecular Microbiology. 94, p. 307-326 12764.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Trypanosomiasis
RNA Stability
Gene Expression Profiling
Messenger RNA
Polyadenylation
2013

Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modelling.

Leroux, A. E., Haanstra, J. R., Bakker, B. M. & Krauth-Siegel, R. L., 2013, In : Journal of Biological Chemistry. 288, p. 23751-23764

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
trypanothione synthetase
Trypanosoma brucei brucei
Kinetics
Spermidine
Kinetic parameters

Naphthoquinone derivates exert their antitrypanosomal activity via a multi-target mechanism.

Pieretti, S., Haanstra, J. R., Mazet, M., Perozzo, R., Bergamini, C., Prati, F., Fato, R., Lenaz, G., Capranico, G., Brun, R., Bakker, B. M., Michels, P. A. M., Scapozza, L., Bolognesi, M. L. & Cavalli, A., 2013, In : PLoS Neglected Tropical Diseases. 7, p. 1-12 e2012.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Naphthoquinones
Lead
1,4-naphthoquinone
2012

Proliferating bloodstream- form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes.

Haanstra, J. R., van Tuijl, J. H., van Dam, J., van Winden, W., Tielens, A. G. M., van Hellemond, J. J. & Bakker, B. M., 2012, In : International Journal for Parasitology. 42, p. 667-673

Research output: Contribution to JournalArticleAcademicpeer-review

Trypanosoma brucei brucei
Carbon
Carbon Cycle
Glucose
Trypanosomiasis
2011

A domino effect in drug action: from metabolic assault towards parasite differentiation.

Haanstra, J. R., Kerkhoven, E. J., van Tuijl, J. H., Blits, M., Wurst, M., van Nuland, R., Albert, M. A., Michels, P. A. M., Bouwman, J., Clayton, C., Westerhoff, H. V. & Bakker, B. M., 2011, In : Molecular Microbiology. 79, 1, p. 94-108

Research output: Contribution to JournalArticleAcademicpeer-review

Parasites
Pharmaceutical Preparations
Trypanosomiasis
Glycolysis
Proteins
2009

The power of network-based drug design and the interplay between metabolism and gene expression in Trypanosoma brucei

Haanstra, J. R., 2009, 271 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File
2008

Compartmentation prevents a lether turbo-explosion of glycolysis in trypanosomes.

Haanstra, J. R., van Tuijl, J. H., Kessler, P., Reijnders, W. N. M., Michels, P. A. M., Westerhoff, H. V., Parsons, M. & Bakker, B. M., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, p. 17718-17723

Research output: Contribution to JournalArticleAcademicpeer-review

Trypanosomiasis
Explosions
Glycolysis
Glycerol
Adenosine Triphosphate

Control and regulation of gene expression: quantitative analysis of the expression of phosphoglycerate kinase in bloodstream form Trypanosoma brucei.

Haanstra, J. R., Stewart, M., Luu, V-D., van Tuijl, J. H., Westerhoff, H. V., Clayton, C. & Bakker, B. M., 2008, In : Journal of Biological Chemistry. 283, p. 2495-2507

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Phosphoglycerate Kinase
Trypanosoma brucei brucei
Gene Expression Regulation
Gene expression
RNA Stability
2006

Exploiting metabolic and gene-expression networks for drug design.

Haanstra, J. R., van Tuijl, J. H., van Nuland, R., Bouwman, J., Albert, M. A., Michels, P. A. M., Holzhutter, H. G., Westerhoff, H. V. & Bakker, B. M., 2006, Proceedings of the 11 th international congress of parasitology. Medimond, p. 91-96

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

2002

Network-based selectivity of antiparasitic inhibitors.

Bakker, B. M., Assmus, H. E., Bruggeman, F. J., Haanstra, J. R., Klipp, E. & Westerhoff, H. V., 2002, In : Molecular Biology Reports. 29, p. 1-5

Research output: Contribution to JournalArticleAcademicpeer-review