dr. L.N. Cornelisse

dr.

20062019
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Research Output 2006 2019

  • 22 Article
  • 2 PhD Thesis - Research VU, graduation VU
  • 1 Comment / Letter to the editor
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Article
2019

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Meijer, M., Rehbach, K., Brunner, J. W., Classen, J. A., Lammertse, H. C. A., van Linge, L. A., Schut, D., Krutenko, T., Hebisch, M., Cornelisse, L. N., Sullivan, P. F., Peitz, M., Toonen, R. F., Brüstle, O. & Verhage, M., 14 May 2019, In : Cell Reports. 27, 7, p. 2199-2211.e6

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Neuronal Plasticity
Synaptic Transmission
Neurons
Plasticity
Synapses

Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner

Huson, V., van Boven, M. A., Stuefer, A., Verhage, M. & Cornelisse, L. N., 1 Dec 2019, In : Scientific Reports. 9, 1, 11341.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synaptotagmin I
Action Potentials
Synapses
Temperature
Neurotransmitter Agents

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., Hussain, N. K., Imig, C., de Jong, A. P. H., Jung, H., Kohansalnodehi, M., Kramarz, B., Lipstein, N., Lovering, R. C., MacGillavry, H., Mariano, V. & 53 othersMi, H., Ninov, M., Osumi-Sutherland, D., Pielot, R., Smalla, K. H., Tang, H., Tashman, K., Toonen, R. F. G., Verpelli, C., Reig-Viader, R., Watanabe, K., van Weering, J., Achsel, T., Ashrafi, G., Asi, N., Brown, T. C., De Camilli, P., Feuermann, M., Foulger, R. E., Gaudet, P., Joglekar, A., Kanellopoulos, A., Malenka, R., Nicoll, R. A., Pulido, C., de Juan-Sanz, J., Sheng, M., Südhof, T. C., Tilgner, H. U., Bagni, C., Bayés, À., Biederer, T., Brose, N., Chua, J. J. E., Dieterich, D. C., Gundelfinger, E. D., Hoogenraad, C., Huganir, R. L., Jahn, R., Kaeser, P. S., Kim, E., Kreutz, M. R., McPherson, P. S., Neale, B. M., O'Connor, V., Posthuma, D., Ryan, T. A., Sala, C., Feng, G., Hyman, S. E., Thomas, P. D., Smit, A. B. & Verhage, M., 17 Jul 2019, In : Neuron. 103, 2, p. 217-234.e4 22 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Knowledge Bases
Synapses
Genes
Gene Ontology
Molecular Sequence Annotation
2018

Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy

Kovačević, J., Maroteaux, G., Schut, D., Loos, M., Dubey, M., Pitsch, J., Remmelink, E., Koopmans, B., Crowley, J., Cornelisse, L. N., Sullivan, P. F., Schoch, S., Toonen, R. F., Stiedl, O. & Verhage, M., 1 May 2018, In : Brain. 141, 5, p. 1350-1374 25 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Haploinsufficiency
Brain Diseases
Proteins
etiracetam
Electroencephalography
2017

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

He, E., Wierda, K., van Westen, R., Broeke, J. H., Toonen, R. F., Cornelisse, L. N. & Verhage, M., 21 Jun 2017, In : Nature Communications. 8, p. 15915

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
N-Ethylmaleimide-Sensitive Proteins
priming
Ethylmaleimide
Synaptic Vesicles
Synapses
2016
Open Access

Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1.

Schmitz, S. K., King, C., Kortleven, C. A., Huson, V. W. J., Kroon, T., Kevenaar, J. T., Schut, D., Saarloos, I., Hoetjes, J. P., de Wit, H., Stiedl, O., Spijker, S., Li, K. W., Mansvelder, H. D., Smit, A. B., Cornelisse, L. N., Verhage, M. & Toonen, R. F. G., 2016, In : EMBO Journal. 35, p. 1236-1250 11.

Research output: Contribution to JournalArticleAcademicpeer-review

2015

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate.

Schotten, S., Meijer, M., Walter, A. M., Huson, V. W. J., Mamer, L., Kalogreades, L., Veer, M. T., Ruiter, M., Brose, N., Rosenmund, C., Sorensen, J. B., Verhage, M. & Cornelisse, L. N., 2015, In : eLife. 4, e05531.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Hypertonic Solutions
Synaptic Vesicles
Energy barriers
Fusion reactions
Phorbol Esters

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences

Giniatullina, A., Maroteaux, G. P., Geerts, C. J., Koopmans, B., Loos, M., Klaassen, R. V., Chen, N., van der Schors, R. C., van Nierop, P., Li, K. W., de Jong, A. P. H., Altrock, W. D., Cornelisse, L. N., Toonen, R. F. G., van der Sluis, S., Sullivan, P. F., Stiedl, O., Posthuma, D., Smit, A. B., Groffen, A. J. A. & 1 othersVerhage, M., 2015, In : Neuroscience. 300, p. 518-538

Research output: Contribution to JournalArticleAcademicpeer-review

Major Depressive Disorder
Phenotype
Calcium
Genetic Heterogeneity
Synaptic Vesicles
2014

Empirical Bayesian Random Censoring Threshold Model Improves Detection of Differentially Abundant Proteins

Koopmans, F. T. W., Cornelisse, L. N., Heskes, T. & Dijkstra, T. M. H., 2014, In : Journal of Proteome Research. 13, 9, p. 3871-3880

Research output: Contribution to JournalArticleAcademicpeer-review

Benchmarking
Proteins
Proteomics
Peptides
Labels
2012

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia

Lips, E. S., Cornelisse, L. N., Toonen, R. F. G., Min, J. L., Hultman, C., Holmans, P. A., O'Donovan, M. C., Purcell, S. M., Smit, A. B., Verhage, M., Sullivan, P. F., Visscher, P. M. & Posthuma, D., 2012, In : Molecular Psychiatry. 17, 10, p. 996-1006

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Schizophrenia
Genes
Cell Adhesion
Signal Transduction
Multifactorial Inheritance

Molecular Machines in the Synapse: Overlapping Protein Sets Control Distinct Steps in Neurosecretion

Cornelisse, L. N., Tsivtsivadze, E., Meijer, M., Dijkstra, T. M. H., Heskes, T. & Verhage, M., 2012, In : PLoS Computational Biology. 8, 4, p. e1002450 e1002450.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Neurosecretion
neurosecretion
Control Sets
Synapse
synapse
2011

Automated analysis of neuronal morphology, synapse number and synaptic recruitment

Schmitz, S. K., Hjorth, J. J. J., Joemai, R. M. S., Wijntjes, R., Eijgenraam, S., de Bruijn, P., Georgiou, C., de Jong, A. P. H., van Ooyen, A., Verhage, M., Cornelisse, L. N., Toonen, R. F. & Veldkamp, W. J. H., 2011, In : Journal of Neuroscience Methods. 195, 2, p. 185-193

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Synapses
Dendrites
Fluorescence
Neurons
Synaptic Vesicles
2010

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

Groffen, A. J. A., Martens, S., Diez Arazola, R., Cornelisse, L. N., Lozovaya, N., de Jong, A. P. H., Goriounova, N. A., Habets, R. L., Takai, Y., Borst, J. G., Brose, N., McMahon, H. T. & Verhage, M., 2010, In : Science. 327, 5973, p. 1614-1618 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Action Potentials
Neurotransmitter Agents
Synaptotagmin II
Synaptotagmin I
Synaptic Vesicles

Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability

Ruano, D., Abecasis, G. R., Glaser, B., Lips, E. S., Cornelisse, L. N., de Jong, A. P. H., Evans, D. M., Smith, D. G., Thimpson, N. J., Smit, A. B., Heutink, P., Verhage, M. & Posthuma, D., 2010, In : American Journal of Human Genetics. 86, 2, p. 113-125

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Heterotrimeric GTP-Binding Proteins
Genes
Guanine Nucleotides
GTP-Binding Proteins
Carrier Proteins
2009

Automated quantification of cellular traffic in living cells

Broeke, J. H. P., Ge, H. F., Dijkstra, I. M., Cemgil, A. T., Riedl, J. A., Cornelisse, L. N., Toonen, R. F., Verhage, M. & Fitzgerald, W. J., 2009, In : Journal of Neuroscience Methods. 178, 2, p. 378-384 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Automation
Parturition
Health
2008

Automated analysis of secretory vesicle distribution at the ultrastructural level

van Weering, J. R. T., Wijntjes, R., de Wit, H., Wortel, J., Cornelisse, L. N., Veldkamp, W. J. & Verhage, M., 2008, In : Journal of Neuroscience Methods. 173, p. 83-90

Research output: Contribution to JournalArticleAcademicpeer-review

Secretory Vesicles
Electrons
Neuroendocrine Cells
Chromaffin Cells
Endocrine Cells
2007

High speed two-photon imaging of calcium dynamics in dendritic spines: consequences for spine calcium kinetics and buffer capacity

Cornelisse, L. N., van Elburg, R. A. J., Meredith, R. M., Yuste, R. & Mansvelder, H. D., 2007, In : PLoS ONE. 2, 10, p. e1073 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Dendritic Spines
Photons
Buffers
Spine
buffers

Reduced 5-HT1A- and GABAB receptor function in dorsal raphé neurons upon chronic fluoxetine treatment of socially stressed rats

Cornelisse, L. N., van der Harst, J. E., Lodder, J. C., Baarendse, P. J. J., Timmerman, A. J., Mansvelder, H. D., Spruijt, B. M. & Brussaard, A. B., 2007, In : Journal of Neurophysiology. 98, 1, p. 196-204

Research output: Contribution to JournalArticleAcademicpeer-review

Receptor, Serotonin, 5-HT1A
Fluoxetine
Serotonin
Neurons
2006

Docking of secretory vesicles is syntaxin dependent

de Wit, H., Cornelisse, L. N., Toonen, R. F. G. & Verhage, M., 2006, In : PLoS ONE. 1, 1, 10 p., e126.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
chromaffin cells
Qa-SNARE Proteins
secretory granules
Secretory Vesicles
plasma membrane

Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

Toonen, R. F. G., Wierda, K., Sons, M. S., de Wit, H., Cornelisse, L. N., Brussaard, A., Plomp, J. J. & Verhage, M., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18332-18337 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Synapses
Gene Expression
Genes

NMDA receptors trigger neurosecretion of 5-HT within dorsal raphé nucleus of the rat in the absence of action potential firing

de Kock, C. P. J., Cornelisse, L. N., Burnashev, N., Lodder, J. C., Timmerman, A. J., Couey, J. J., Mansvelder, H. D. & Brussaard, A. B., 2006, In : Journal of Physiology - London. 577, 3, p. 891-905 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Neurosecretion
N-Methyl-D-Aspartate Receptors
Action Potentials
Serotonin
Calcium