dr. M. Wijtmans

dr.

20032019
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Personal profile

Personal information

Dr. Maikel Wijtmans studied Organic Chemistry at Radboud University Nijmegen, where he graduated in August 1998. He subsequently worked at DSM Research as a temporary researcher on biocatalysis and organic oxidants until June 1999. Thereafter he moved to Vanderbilt University in Nashville, USA where he started his PhD on organic ligands for nanocrystals and on the development of novel antioxidants.

After completion of his PhD work in 2003, Maikel returned to the Netherlands where he joined the Division of Medicinal Chemistry as a postdoctoral fellow. During the next few years, he participated in various projects involving e.g. the development of histamine- and chemokine-receptor ligands as well as the study of derivatization reagents for ESI-MS techniques. In 2009, he was appointed assistant professor of Synthetic Medicinal Chemistry. His current research interests involve the design and synthesis of compounds that are of interest in biological contexts. Here is a presentation he gave in April 2019 on one of the research topics he is involved in (GPCR photopharmacology).

Maikel also has an interest in educational innovation, preferably in a combination with chemistry. The focus in these efforts is on the use of IT tools to stimulate active learning and he has been exploring several of such approaches since 2010, supported by VU University educational innovation grants. In 2013, he received the Dutch national KNCV chemistry teaching award (awarded every three years to a teacher from academia). Here and here you will find presentations he gave in May/June 2019 on some of his educational innovations (application of Blended Learning and Flipped Classroom).

 

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  • 15 Similar Profiles
Ligands Medicine & Life Sciences
Chemokine Receptors Medicine & Life Sciences
Histamine H3 Receptors Medicine & Life Sciences
Histamine Medicine & Life Sciences
Pharmacology Medicine & Life Sciences
Histamine Agonists Medicine & Life Sciences
Molecules Chemical Compounds
G-Protein-Coupled Receptors Chemical Compounds

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Research Output 2003 2019

  • 53 Article
  • 2 PhD Thesis - Research VU, graduation VU
  • 1 Chapter
  • 1 Short survey

4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H3 Receptor Agonists with in Vivo Central Nervous System Activity

Wágner, G., Mocking, T. A. M., Arimont, M., Provensi, G., Rani, B., Silva-Marques, B., Latacz, G., Da Costa Pereira, D., Karatzidou, C., Vischer, H. F., Wijtmans, M., Kieć-Kononowicz, K., De Esch, I. J. P. & Leurs, R., 1 Nov 2019, In : Journal of Medicinal Chemistry. 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine H3 Receptors
Histamine Agonists
Amines
Central Nervous System
Cytochrome P-450 Enzyme System

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors

de Heuvel, E., Singh, A. K., Edink, E., van der Meer, T., van der Woude, M., Sadek, P., Krell-Jørgensen, M. P., van den Bergh, T., Veerman, J., Caljon, G., Kalejaiye, T. D., Wijtmans, M., Maes, L., de Koning, H. P., Jan Sterk, G., Siderius, M., de Esch, I. J. P., Brown, D. G. & Leurs, R., 18 Jun 2019, In : Bioorganic and Medicinal Chemistry. p. 1-15 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Trypanosoma brucei brucei
Phosphoric Diester Hydrolases
Parasites
Cyclic Nucleotides
Cytotoxicity

A Photoswitchable Agonist for the Histamine H 3 Receptor, a Prototypic Family A G-Protein-Coupled Receptor

Hauwert, N. J., Mocking, T. A. M., Da Costa Pereira, D., Lion, K., Huppelschoten, Y., Vischer, H. F., De Esch, I. J. P., Wijtmans, M. & Leurs, R., 26 Mar 2019, In : Angewandte Chemie - International Edition. 58, 14, p. 4531-4535 5 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine Agonists
G-Protein-Coupled Receptors
Histamine
Proteins
Chemical activation

A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light

Gómez-Santacana, X., De Munnik, S. M., Mocking, T. A. M., Hauwert, N. J., Sun, S., Vijayachandran, P., De Esch, I. J. P., Vischer, H. F., Wijtmans, M. & Leurs, R., 23 Oct 2019, In : Beilstein Journal of Organic Chemistry. 15, p. 2509-2523 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chemokine Receptors
Switches
Ligands
Halogens
Chemokines

Covalent inhibition of the histamine H3 receptor

Wágner, G., Mocking, T. A. M., Kooistra, A. J., Slynko, I., Ábrányi-Balogh, P., Keser u, G. M., Wijtmans, M., Vischer, H. F., de Esch, I. J. P. & Leurs, R., 11 Dec 2019, In : Molecules. 24, 24, p. 1-19 19 p., 4541.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Histamine H3 Receptors
histamines
Scaffolds
Ligands
reactivity