Personal profile

Personal information

Dr. Maikel Wijtmans studied Organic Chemistry at Radboud University Nijmegen, where he graduated in August 1998. He subsequently worked at DSM Research as a temporary researcher on biocatalysis and organic oxidants until June 1999. Thereafter he moved to Vanderbilt University in Nashville, USA where he started his PhD on organic ligands for nanocrystals and on the development of novel antioxidants.

 

After completion of his PhD work in 2003, he returned to the Netherlands where he joined the Division of Medicinal Chemistry as a postdoctoral fellow. During the next few years, he participated in various projects involving e.g. the development of histamine- and chemokine-receptor ligands as well as the study of derivatization reagents for ESI-MS techniques. In 2009, he was appointed assistant professor of Synthetic Medicinal Chemistry. His current research interests involve the design and synthesis of compounds that are of interest in biological contexts.

 

Maikel Wijtmans also has an interest in educational innovation, preferably in a combination with chemistry. The focus in these efforts is on the use of IT tools to stimulate active learning and he has been exploring several of such approaches since 2010, supported by VU University educational innovation grants. In 2013, he received the Dutch national KNCV chemistry teaching award (awarded every three years to a teacher from academia).

 

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Research Output 2003 2018

  • 44 Article
  • 2 PhD Thesis - Research VU, graduation VU
  • 1 Chapter

Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology

Hauwert, N. J., Mocking, T. A. M., Da Costa Pereira, D., Kooistra, A. J., Wijnen, L. M., Vreeker, G. C. M., Verweij, E. W. E., De Boer, A. H., Smit, M. J., De Graaf, C., Vischer, H. F., De Esch, I. J. P., Wijtmans, M. & Leurs, R. 28 Mar 2018 In : Journal of the American Chemical Society. 140, 12, p. 4232-4243 12 p.

Research output: Contribution to journalArticle

4,6-diphenylpyridines as promising novel anti-influenza agents targeting the PA-PB1 protein-protein interaction: structure-activity relationships.

Trist, I. M., Nannetti, G., Tintori, C., Fallacara, A. L., Deodato, D., Mercorrelli, B., Palu, G., Wijtmans, M., Gospodova, T., Edink, E. S., Verheij, M. H. P., de Esch, I. J. P., Viteva, L., Loregian, A. & Botta, M. 2016 In : Journal of Medicinal Chemistry. 59, 6, p. 2688-2703

Research output: Contribution to journalArticle

Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors.

Ganghammer, S., Gutjahr, J., Hutterer, E., Krenn, P. W., Pucher, S., Zelle-Rieser, C., Johrer, K., Wijtmans, M., Leurs, R., Smit, M. J., Gattei, V., Greil, R. & Hartmann, T. N. 2016 In : Haematologica. 101, 3, p. 99-102 101 p.

Research output: Contribution to journalArticle

Open Access

Exploring the cxcr3 chemokine receptor with small-molecule antagonists and agonists

Wijtmans, M., Scholten, D., Mooij, W., Smit, M. J., De Esch, I. J. P., de Graaf, C. & Leurs, R. 2015 In : Topics in Medicinal Chemistry. 14, p. 119-186 68 p.

Research output: Contribution to journalArticle