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Personal information

Madeleine Brouns (1970) obtained her PhD degree from Utrecht University (1999). She was a postdoctoral fellow and assistant professor at Maastricht University until 2008. She then joined the Vrije Universiteit and is currently lecturer and Program coordinator of the BSc Program Gezondheid en Leven.


Research interests: developmental biology, signal transduction, neurobiology.

In her research, Madeleine focused on the genetic causes of neural tube closure defects using both reverse and forward genetic approaches. During her PhD research at Massachusetts General Hospital / Harvard Medical School she developed a genetic mouse model displaying exencephaly. During her postdoctoral work, she identified causative genes for spina bifida. The latter research was performed on a VENI grant of NWO (2003-2007). At the Vrije Universiteit she participated in the EU DENAMIC project focusing on the effects of neurotoxic compounds on zebrafish development.


Humane levenscyclus 1, Humane ontwikkeling, thesis supervision

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Fingerprint Dive into the research topics where Madeleine Brouns is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

rho GTP-Binding Proteins Medicine & Life Sciences
Neural Tube Medicine & Life Sciences
Homocysteine Medicine & Life Sciences
Neural Tube Defects Medicine & Life Sciences
GTPase-Activating Proteins Medicine & Life Sciences
Chick Embryo Medicine & Life Sciences
Spinal Dysraphism Medicine & Life Sciences
Actins Medicine & Life Sciences

Research Output 1992 2013

The dynamics of autism spectrum disorders: how neurotoxic compounds and neurotransmitters interact

Quaak, I., Brouns, M. R. & Van de Bor, M., 6 Aug 2013, In : International Journal of Environmental Research and Public Health. 10, 8, p. 3384-408 25 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Neurotransmitter Agents
Autism Spectrum Disorder

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

Brouns, M. R., De Castro, S. C. P., Terwindt-Rouwenhorst, E. A., Massa, V., Hekking, J. W., Hirst, C. S., Savery, D., Munts, C., Partridge, D., Lamers, W., Köhler, E., van Straaten, H. W., Copp, A. J. & Greene, N. D. E., 15 Apr 2011, In : Human Molecular Genetics. 20, 8, p. 1536-46 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Spinal Dysraphism
Neural Tube Defects
Embryonic Structures

Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice

Németh, T., Futosi, K., Hably, C., Brouns, M. R., Jakob, S. M., Kovács, M., Kertész, Z., Walzog, B., Settleman, J. & Mócsai, A., 1 Sep 2010, In : Journal of Immunology. 185, 5, p. 3064-75 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Integrin beta Chains
Bone Marrow

Distinct but overlapping functions for the closely related p190 RhoGAPs in neural development

Matheson, S. F., Hu, K-Q., Brouns, M. R., Sordella, R., VanderHeide, J. D. & Settleman, J., 2006, In : Developmental Neuroscience. 28, 6, p. 538-50 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

rho GTP-Binding Proteins
GTPase-Activating Proteins
Corpus Callosum
Lateral Ventricles

Inhibition of transmethylation disturbs neurulation in chick embryos

Afman, L. A., Blom, H. J., Drittij, M-J., Brouns, M. R. & van Straaten, H. W. M., 8 Aug 2005, In : Developmental Brain Research. 158, 1-2, p. 59-65 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Chick Embryo
Methionine Adenosyltransferase