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Mark Verheijen is Associate Professor of ‘Glial-regulated Neuronal Plasticity’ at the Vrije Universiteit Amsterdam (VU). He was trained as a biologist with specialization biochemistry at Utrecht University, where he also obtained is PhD in developmental biology in 1997. After a post-doc at the Netherlands Cancer Institute, Amsterdam, on signal transduction in C. Elegans, he started his neuroscience career in 2000 as a post-doc on Schwann cell biology in the lab of Greg Lemke at the Salk Institute for Biological Studies, La Jolla. In 2004 he returned to the Netherlands to start his own team on Neuron-Glia interactions at the Center for Neurogenomics and Cognitive Research (CNCR) at the VU, were he is also director of the master program Neurosciences. With his research he aims to contribute to a better understanding of the role of glial cells in the regulation of neuronal plasticity in health and disease. For this purpose, his team mainly focusses on the role of perisynaptic astrocyte molecules in learning and memory, and to translate findings on the diseased tripartite synapse in preclinical disease models, e.g. Alzheimer Disease, mild cognitive impairment, (MCI) and post-traumatic stress disorders (PTSD). Experiments are being performed both in vitro (e.g. neuron-glial cell cocultures) and in vivo (e.g. proteomic analysis, imaging and genetic manipulation of astrocytes).
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Astrocyte-synapse structural plasticity in neurodegenerative and neuropsychiatric diseases
Badia-Soteras, A., Mak, A., Blok, T. M., Boers-Escuder, C., van den Oever, M. C., Min, R., Smit, A. B. & Verheijen, M. H. G., Apr 2025, In: Biological psychiatry. 11 p.Research output: Contribution to Journal › Review article › Academic › peer-review
Open Access -
How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms
Lucassen, P. J., Korosi, A., de Rooij, S. R., Smit, A. B., Van Dam, A. M., Daskalakis, N. P., Van Kesteren, R. E., Verheijen, M. H. G., Lesuis, S. L., Kessels, H. W. & Krugers, H. J., 15 Feb 2025, In: Biological psychiatry. 97, 4, p. 372-381 10 p.Research output: Contribution to Journal › Review article › Academic › peer-review
Open Access -
Activation of Gs Signaling in Cortical Astrocytes Does Not Influence Formation of a Persistent Contextual Memory Engram
Mak, A., Abramian, A., Driessens, S. L. W., Boers Escuder, C., van der Loo, R. J., Smit, A. B., van den Oever, M. C. & Verheijen, M. H. G., Jun 2024, In: eNeuro. 11, 6, p. 1-11 11 p., ENEURO.0056-24.2024.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice
Oshima, T., Kater, M. S. J., Huffels, C. F. M., Wesseling, E. M., Middeldorp, J., Hol, E. M., Verheijen, M. H. G., Smit, A. B., Boddeke, E. W. G. M. & Eggen, B. J. L., Mar 2024, In: Journal of Neuroscience Research. 102, 3, p. 1-14 14 p., e25295.Research output: Contribution to Journal › Article › Academic › peer-review
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Early-life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism
Kotah, J. M., Kater, M. S. J., Brosens, N., Lesuis, S. L., Tandari, R., Blok, T. M., Marchetto, L., Yusaf, E., Koopmans, F. T. W., Smit, A. B., Lucassen, P. J., Krugers, H. J., Verheijen, M. H. G. & Korosi, A., Mar 2024, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 20, 3, p. 1637-1655Research output: Contribution to Journal › Article › Academic › peer-review