M.J. Smit

prof. dr.

1990 …2019
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Personal profile

Personal information

  • Professor Target and Systems Biochemistry in the division of Medicinal Chemistry 



The research of prof Smit focuses on novel concepts of G protein-coupled receptors (GPCRs) (e.g. constitutive activity, ligand-biased signaling, allosterism) and targeting/understanding of (oncogenic) signaling networks activated by human and viral chemokine receptors. These lines of research are closely linked to the design (modeling) and synthesis programs within the division of Medicinal Chemistry. This division has ample experience in drug discovery aspects of GPCRs and collaborate with leading pharmaceutical/biotech companies, resulting in several patents. In recent years Smit has identified several nanobodies (llama-derived antibodies) targeting and modulating GPCR function.


Personal and consortium grants

She has received a fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW) (1999-2003), and obtained a NWO Vidi (2004) and Vici (2013) grant.  Smit was involved in 3 TI Pharma projects and coordinator of a STW program on nanobodies (2011-2015). Smit is co-PI of NWO TOPPUNT (7 ways to modulate 7TM receptors) and is project coordinator of the European Union's Horizon2020 MSCA Programme ITN project ONCORNET (Oncogenic GPCR Network of Excellence and Training).



Smit was awarded the Organon Award for Pharmacology (2007) and the Galenus Research Prize (2002).



Prof. Martine J. Smit studied Pharmacochemistry (1986-1991) at the VU Universtiy in Amsterdam and obtained her PhD in Molecular Pharmacology/Medicinal Chemistry in 1995 on the regulation of histamine receptors at the VU University Amsterdam. She did a 3.5 year post-doc focusing on oncogenic signaling networks at the dept of Pharmacology, Mount Sinai School of Medicine in New York (lab Prof. R. Iyengar).

Ancillary activities

No ancillary activities

Ancillary activities are updated daily

Education/Academic qualification

Molecular Pharmacology, PhD, VU University

Jul 199116 Oct 1995

European Baccalaureate, European School Brussels

… → Jul 1985

Pharmacochemistry, Master, VU University

Sep 198620 Jun 1991

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  • 12 Similar Profiles
Chemokine Receptors Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
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Cytomegalovirus Medicine & Life Sciences
Ligands Medicine & Life Sciences
CXCR3 Receptors Medicine & Life Sciences
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1990 2019

Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs

De Groof, T. W. M., Bobkov, V., Heukers, R. & Smit, M. J., 15 Mar 2019, In : Molecular and Cellular Endocrinology. 484, p. 15-24 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Single-Domain Antibodies
G-Protein-Coupled Receptors
Imaging techniques
Immunoglobulin Fragments

Nanobodies detecting and modulating GPCRs outside in and inside out

Heukers, R., De Groof, T. W. M. & Smit, M. J., 1 Apr 2019, In : Current Opinion in Cell Biology. 57, p. 115-122 8 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Single-Domain Antibodies
G-Protein-Coupled Receptors
Immunoglobulin Fragments
Physiological Phenomena
Drug Discovery

Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells

De Groof, T. W. M., Mashayekhi, V., Fan, T. S., Bergkamp, N. D., Toraño, J. S., Van Senten, J. R., Heukers, R., Smit, M. J. & Oliveira, S., 1 Jan 2019, In : Molecular Pharmaceutics.

Research output: Contribution to JournalArticleAcademicpeer-review

Single-Domain Antibodies
Viral Proteins
G-Protein-Coupled Receptors

Biogenesis and function of extracellular vesicles in cancer

Bebelman, M. P., Smit, M. J., Pegtel, D. M. & Baglio, S. R., Aug 2018, In : Pharmacology and Therapeutics. 188, p. 1-11 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Biological Phenomena

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

Verweij, F. J., Bebelman, M. P., Jimenez, C. R., Garcia-Vallejo, J. J., Janssen, H., Neefjes, J., Knol, J. C., de Goeij-de Haas, R., Piersma, S. R., Baglio, S. R., Verhage, M., Middeldorp, J. M., Zomer, A., van Rheenen, J., Coppolino, M. G., Hurbain, I., Raposo, G., Smit, M. J., Toonen, R. F. G., van Niel, G. & 1 othersPegtel, D. M., 1 Mar 2018, In : Journal of Cell Biology. 217, 3, p. 1157 1 p.

Research output: Contribution to JournalComment / Letter to the editorAcademic

Open Access

Activities 1999 1999

  • 2 Lecture / Presentation

Viral-encoded G-protein coupled receptors: New targets for Drug Research?,

M.J. Smit (Speaker)

Activity: Lecture / PresentationAcademic

Signal transduction and tumor growth

M.J. Smit (Speaker)

Activity: Lecture / PresentationAcademic