Research output per year
Research output per year
Personal profile
Personal information
- Professor Target and Systems Biochemistry in the division of Medicinal Chemistry
Research
The research of prof Smit focuses on novel concepts of G protein-coupled receptors (GPCRs) (e.g. constitutive activity, endosomal signaling, dimerisation, EV biology) and targeting/understanding of (oncogenic) signaling networks activated by human and viral chemokine receptors. This division has ample experience in drug discovery aspects of GPCRs and collaborate with leading pharmaceutical/biotech companies, resulting in several patents. In the last decade Smit has identified several nanobodies (llama-derived antibodies) targeting and modulating human and viral chemokine receptor function.
Personal and consortium grants
She has received a fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW) (1999-2003), and obtained a NWO Vidi (2004) and Vici (2013) grant. Smit was involved in 3 TI Pharma projects and coordinator of a STW program on nanobodies (2011-2015). Smit was co-PI of NWO TOPPUNT (7 ways to modulate 7TM receptors) and project coordinator of the European Union's Horizon2020 MSCA Programme ITN project ONCORNET (Oncogenic GPCR Network of Excellence and Training)(2015-2019). Currently, she is heading the public private project (NWO-PPS TA) MAGNETIC (Multimeric Antibody formats targeting GPCR NETworks in leukemic cells) (2020-2025) and is coordinator of Horizon2020 MSCA Programme ITN project ONCORNET2.0 (2020-2024), a European PhD training network.
Awards
Smit was awarded the Organon Award for Pharmacology (2007) and the Galenus Research Prize (2002).
Education
Prof. Martine J. Smit studied Pharmacochemistry (1986-1991) at the VU Universtiy in Amsterdam and obtained her PhD in Molecular Pharmacology/Medicinal Chemistry in 1995 on the regulation of histamine receptors at the VU University Amsterdam. She did a 3.5 year post-doc focusing on oncogenic signaling networks at the dept of Pharmacology, Mount Sinai School of Medicine in New York (lab Prof. R. Iyengar).
Ancillary activities
No ancillary activities
Ancillary activities are updated daily
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Academic qualification
Molecular Pharmacology, PhD, Dynamic regulation of histamine receptors, Vrije Universiteit Amsterdam
Jul 1991 → 16 Oct 1995
Award Date: 16 Oct 1995
Pharmacochemistry, Master, Vrije Universiteit Amsterdam
Sept 1986 → 20 Jun 1991
Award Date: 20 Jun 1991
European Baccalaureate, European School Brussels
… → Jul 1985
Award Date: 3 Jul 1985
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Multivalent CXCR4-targeting nanobody formats differently affect affinity, receptor clustering, and antagonism
Anbuhl, S. M., Dervillez, X., Neubacher, S., Schriek, A. I., Bobkov, V., de Taeye, S. W., Szpakowska, M., Siderius, M., Grossmann, T. N., Chevigné, A., Smit, M. J. & Heukers, R., Sept 2024, In: Biochemical Pharmacology. 227, 116457.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
G protein-coupled receptors: a gateway to targeting oncogenic EVs?
Di Niro, L., Linders, A. C., Glynn, T., Pegtel, D. M., Siderius, M., Crudden, C. & Smit, M. J., May 2024, In: Extracellular Vesicles and Circulating Nucleic Acids. 5, 2, p. 233-248 16 p.Research output: Contribution to Journal › Review article › Academic › peer-review
Open Access -
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3
Zarca, A. M., Adlere, I., Viciano, C. P., Arimont-Segura, M., Meyrath, M., Simon, I. A., Bebelman, J. P., Laan, D., Custers, H. G. J., Janssen, E., Versteegh, K. L., Buzink, M. C. M. L., Nesheva, D. N., Bosma, R., de Esch, I. J. P., Vischer, H. F., Wijtmans, M., Szpakowska, M., Chevigné, A., Hoffmann, C., & 5 others, 1 Apr 2024, In: Molecular Pharmacology. 105, 4, p. 301-312 12 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies
Schlimgen, R. R., Peterson, F. C., Heukers, R., Smit, M. J., McCorvy, J. D. & Volkman, B. F., 2024, In: Nature Communications. 15, p. 1-10 10 p., 4611.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Wakileh, G. A., Bierholz, P., Kotthoff, M., Skowron, M. A., Bremmer, F., Stephan, A., Anbuhl, S. M., Heukers, R., Smit, M. J., Ströbel, P. & Nettersheim, D., 23 Nov 2023, In: Experimental Hematology and Oncology. 12, 1, p. 1-5 5 p., 96.Research output: Contribution to Journal › Comment / Letter to the editor › Academic
Open Access
Courses
Projects
- 1 Finished
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ONCORNET2.0: Horizon2020 ONCOgenic Receptor Network of Excellence and Training 2.0
van Muijlwijk-Koezen, J. & Smit, M.
1/02/20 → 31/01/24
Project: Research
Activities
- 2 Lecture / Presentation
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Signal transduction and tumor growth
M.J. Smit (Speaker)
1999Activity: Lecture / Presentation › Academic
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Viral-encoded G-protein coupled receptors: New targets for Drug Research?,
M.J. Smit (Speaker)
1999Activity: Lecture / Presentation › Academic
Datasets
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Chemokine G protein-coupled receptor (GPCR) mutation data set
Sun, S. (Contributor), Arimont, M. (Contributor), Leurs, R. (Contributor), Vass, M. (Contributor), de Esch, I. J. P. (Contributor), de Graaf, C. (Contributor) & Smit, M. (Contributor), Unknown Publisher, 17 Jul 2016
DOI: 10.5281/zenodo.58160, https://zenodo.org/record/58160
Dataset
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Chemokine G protein-coupled receptor (GPCR) mutation data set - revision
Arimont, M. (Contributor), Sun, S. (Contributor), Leurs, R. (Contributor), Smit, M. (Contributor), de Esch, I. (Contributor) & De Graaf, C. (Contributor), Zenodo, 2017
DOI: 10.5281/zenodo.268416, https://zenodo.org/record/268416
Dataset
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Chemokine G protein-coupled receptor (GPCR) mutation data set
Smit, M. (Contributor), De Graaf, G. C. (Contributor) & Leurs, R. (Contributor), Zenodo, 2016
DOI: 10.5281/zenodo.58160, https://zenodo.org/record/58160
Dataset