Research Output per year
Personal profile
Personal information
- Professor Target and Systems Biochemistry in the division of Medicinal Chemistry
Research
The research of prof Smit focuses on novel concepts of G protein-coupled receptors (GPCRs) (e.g. constitutive activity, ligand-biased signaling, allosterism) and targeting/understanding of (oncogenic) signaling networks activated by human and viral chemokine receptors. These lines of research are closely linked to the design (modeling) and synthesis programs within the division of Medicinal Chemistry. This division has ample experience in drug discovery aspects of GPCRs and collaborate with leading pharmaceutical/biotech companies, resulting in several patents. In recent years Smit has identified several nanobodies (llama-derived antibodies) targeting and modulating GPCR function.
Personal and consortium grants
She has received a fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW) (1999-2003), and obtained a NWO Vidi (2004) and Vici (2013) grant. Smit was involved in 3 TI Pharma projects and coordinator of a STW program on nanobodies (2011-2015). Smit is co-PI of NWO TOPPUNT (7 ways to modulate 7TM receptors) and is project coordinator of the European Union's Horizon2020 MSCA Programme ITN project ONCORNET (Oncogenic GPCR Network of Excellence and Training).
Awards
Smit was awarded the Organon Award for Pharmacology (2007) and the Galenus Research Prize (2002).
Education
Prof. Martine J. Smit studied Pharmacochemistry (1986-1991) at the VU Universtiy in Amsterdam and obtained her PhD in Molecular Pharmacology/Medicinal Chemistry in 1995 on the regulation of histamine receptors at the VU University Amsterdam. She did a 3.5 year post-doc focusing on oncogenic signaling networks at the dept of Pharmacology, Mount Sinai School of Medicine in New York (lab Prof. R. Iyengar).
Ancillary activities
No ancillary activities
Ancillary activities are updated daily
Education/Academic qualification
Molecular Pharmacology, PhD, VU University
Jul 1991 → 16 Oct 1995
Pharmacochemistry, Master, VU University
Sep 1986 → 20 Jun 1991
European Baccalaureate, European School Brussels
… → Jul 1985
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 1990 2018
Biogenesis and function of extracellular vesicles in cancer
Bebelman, M. P., Smit, M. J., Pegtel, D. M. & Baglio, S. R. 21 Feb 2018 In : Pharmacology and Therapeutics.Research output: Contribution to journal › Review article
Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling
Verweij, F. J. , Bebelman, M. P. , Jimenez, C. R. , Garcia-Vallejo, J. J. , Janssen, H. , Neefjes, J. , Knol, J. C. , de Goeij-de Haas, R. , Piersma, S. R. , Baglio, S. R. , Verhage, M. , Middeldorp, J. M. , Zomer, A. , van Rheenen, J. , Coppolino, M. G. , Hurbain, I. , Raposo, G. , Smit, M. J. , Toonen, R. F. G. , van Niel, G. & 1 others 23 Jan 2018 In : Journal of Cell Biology.Research output: Contribution to journal › Article
Open Access
Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling
Verweij, F. J. , Bebelman, M. P. , Jimenez, C. R. , Garcia-Vallejo, J. J. , Janssen, H. , Neefjes, J. , Knol, J. C. , de Goeij-de Haas, R. , Piersma, S. R. , Baglio, S. R. , Verhage, M. , Middeldorp, J. M. , Zomer, A. , van Rheenen, J. , Coppolino, M. G. , Hurbain, I. , Raposo, G. , Smit, M. J. , Toonen, R. F. G. , van Niel, G. & 1 others 5 Mar 2018 In : Journal of Cell Biology. 217, 3, p. 1129-1142 14 p.Research output: Contribution to journal › Article
Open Access
Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology
Hauwert, N. J., Mocking, T. A. M., Da Costa Pereira, D., Kooistra, A. J., Wijnen, L. M., Vreeker, G. C. M., Verweij, E. W. E., De Boer, A. H., Smit, M. J., De Graaf, C., Vischer, H. F., De Esch, I. J. P., Wijtmans, M. & Leurs, R. 28 Mar 2018 In : Journal of the American Chemical Society. 140, 12, p. 4232-4243 12 p.Research output: Contribution to journal › Article
Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges
Ayoub, M. A., Crépieux, P., Koglin, M., Parmentier, M., Pin, J. P., Poupon, A., Reiter, E., Smit, M., Steyaert, J., Watier, H. & Wilkinson, T. 4 Jul 2017 In : MABS. 9, 5, p. 735-741 7 p.Research output: Contribution to journal › Article