M.J. Smit

prof. dr.

1990 …2018
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Personal profile

Personal information

  • Professor Target and Systems Biochemistry in the division of Medicinal Chemistry 



The research of prof Smit focuses on novel concepts of G protein-coupled receptors (GPCRs) (e.g. constitutive activity, ligand-biased signaling, allosterism) and targeting/understanding of (oncogenic) signaling networks activated by human and viral chemokine receptors. These lines of research are closely linked to the design (modeling) and synthesis programs within the division of Medicinal Chemistry. This division has ample experience in drug discovery aspects of GPCRs and collaborate with leading pharmaceutical/biotech companies, resulting in several patents. In recent years Smit has identified several nanobodies (llama-derived antibodies) targeting and modulating GPCR function.


Personal and consortium grants

She has received a fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW) (1999-2003), and obtained a NWO Vidi (2004) and Vici (2013) grant.  Smit was involved in 3 TI Pharma projects and coordinator of a STW program on nanobodies (2011-2015). Smit is co-PI of NWO TOPPUNT (7 ways to modulate 7TM receptors) and is project coordinator of the European Union's Horizon2020 MSCA Programme ITN project ONCORNET (Oncogenic GPCR Network of Excellence and Training).



Smit was awarded the Organon Award for Pharmacology (2007) and the Galenus Research Prize (2002).



Prof. Martine J. Smit studied Pharmacochemistry (1986-1991) at the VU Universtiy in Amsterdam and obtained her PhD in Molecular Pharmacology/Medicinal Chemistry in 1995 on the regulation of histamine receptors at the VU University Amsterdam. She did a 3.5 year post-doc focusing on oncogenic signaling networks at the dept of Pharmacology, Mount Sinai School of Medicine in New York (lab Prof. R. Iyengar).

Ancillary activities

No ancillary activities

Ancillary activities are updated daily

Education/Academic qualification

Molecular Pharmacology, PhD, VU University

Jul 199116 Oct 1995

European Baccalaureate, European School Brussels

… → Jul 1985

Pharmacochemistry, Master, VU University

Sep 198620 Jun 1991

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1990 2018

Biogenesis and function of extracellular vesicles in cancer

Bebelman, M. P., Smit, M. J., Pegtel, D. M. & Baglio, S. R., Aug 2018, In : Pharmacology and Therapeutics. 188, p. 1-11 11 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Biological Phenomena

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

Verweij, F. J. , Bebelman, M. P. , Jimenez, C. R. , Garcia-Vallejo, J. J. , Janssen, H. , Neefjes, J. , Knol, J. C. , de Goeij-de Haas, R. , Piersma, S. R. , Baglio, S. R. , Verhage, M. , Middeldorp, J. M. , Zomer, A. , van Rheenen, J. , Coppolino, M. G. , Hurbain, I. , Raposo, G. , Smit, M. J. , Toonen, R. F. G. , van Niel, G. & 1 others Pegtel, D. M., 23 Jan 2018, In : Journal of Cell Biology.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

Van Hout, A., Klarenbeek, A., Bobkov, V., Doijen, J., Arimont, M., Zhao, C., Heukers, R., Rimkunas, R., de Graaf, C., Verrips, T., van der Woning, B., de Haard, H., Rucker, J. B., Vermeire, K., Handel, T., Van Loy, T., Smit, M. J. & Schols, D., 1 Dec 2018, In : Biochemical Pharmacology. 158, p. 402-412 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Single-Domain Antibodies
HIV Receptors
Calcium-Sensing Receptors
Anti-HIV Agents

Heterogeneity assessment of antibody-derived therapeutics at the intact and middle-up level by low-flow sheathless capillary electrophoresis-mass spectrometry

Haselberg, R., De Vijlder, T., Heukers, R., Smit, M. J., Romijn, E. P., Somsen, G. W. & Domínguez-Vega, E., 1 Jan 2018, (Accepted/In press) In : Analytica Chimica Acta.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Capillary electrophoresis
Capillary Electrophoresis
low flow
Mass spectrometry

Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions

Bobkov, V., Zarca, A. M., Van Hout, A., Arimont, M., Doijen, J., Bialkowska, M., Toffoli, E., Klarenbeek, A., van der Woning, B., van der Vliet, H. J., Van Loy, T., de Haard, H., Schols, D., Heukers, R. & Smit, M. J., Dec 2018, In : Biochemical Pharmacology. 158, p. 413-424 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Single-Domain Antibodies
Chemokine Receptors

Activities 1999 1999

  • 2 Lecture / Presentation

Viral-encoded G-protein coupled receptors: New targets for Drug Research?,

Smit, M. J. (Speaker)

Activity: Lecture / PresentationAcademic

Signal transduction and tumor growth

Smit, M. J. (Speaker)

Activity: Lecture / PresentationAcademic