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dr. Nick Pearce

    20172019

    Research output per year

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    Research Output

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    Article
    2019

    Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

    COMBAT Consortium, 4 Sep 2019, In : Frontiers in Immunology. 10, 2097.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access
    2018

    An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

    Keedy, D. A., Hill, Z. B., Biel, J. T., Kang, E., Rettenmaier, T. J., Brandão-Neto, J., Pearce, N. M., von Delft, F., Wells, J. A. & Fraser, J. S., 7 Jun 2018, In : eLife. 7, e36307.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access
    2017

    A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

    Pearce, N. M., Krojer, T., Bradley, A. R., Collins, P., Nowak, R. P., Talon, R., Marsden, B. D., Kelm, S., Shi, J., Deane, C. M. & Von Delft, F., 1 Jan 2017, In : Nature Communications. 8, 15123.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access

    Gentle, fast and effective crystal soaking by acoustic dispensing

    Collins, P. M., Ng, J. T., Talon, R., Nekrosiute, K., Krojer, T., Douangamath, A., Brandao-Neto, J., Wright, N., Pearce, N. M. & Von Delft, F., 1 Jan 2017, In : Acta Crystallographica Section D: Structural Biology. 73, p. 246-255 10 p.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access

    Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites

    Pearce, N. M., Bradley, A. R., Krojer, T., Marsden, B. D., Deane, C. M. & Delft, F. V., 1 May 2017, In : Structural Dynamics. 4, 3, 032104.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access

    Proper modelling of ligand binding requires an ensemble of bound and unbound states

    Pearce, N. M., Krojer, T. & Von Delft, F., 1 Jan 2017, In : Acta Crystallographica Section D: Structural Biology. 73, p. 256-266 11 p.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access

    The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination

    Krojer, T., Talon, R., Pearce, N., Collins, P., Douangamath, A., Brandao-Neto, J., Dias, A., Marsden, B. & Von Delft, F., 1 Jan 2017, In : Acta Crystallographica Section D: Structural Biology. 73, p. 267-278 12 p.

    Research output: Contribution to JournalArticleAcademicpeer-review

    Open Access