Research output per year
Research output per year
Personal profile
Personal information
Nico P.E. Vermeulen (MSc in Chemistry (University of Nijmegen, NL, 1975) and a PhD in Pharmacology (University of Leiden, NL, 1980), was appointed professor of Molecular Toxicology in the Department of Chemistry and Pharmaceutical Sciences (CPS) at VU University Amsterdam, in 1985.
Employment (selected):
1975 Staff-member at the Subfaculty of Pharmacy, Univ. of Leiden, Leiden, NL; 1980 Senior staff-member Center for Bio-Pharmaceutical Sciences, Univ. of Leiden, Leiden; 1985 Professor of Molecular Toxicology, Section of Molecular Toxicology, Vrije Universiteit, Amsterdam, NL (www.moltox.chem.vu.nl ; 1985 - ); 1997 Dean Faculty of Chemistry, Vrije Universiteit (1997 - 2000); 2005 Scientific Director Leiden-Amsterdam Center for Drug Research (LACDR) (2005-‘11); 2010 Coordinator/ Manager IMI-SafeSciMET: ‘Modular Education and Training programme for Translational Safety Sciences for Medicines’ (2010 - ‘17); 2010 Head Department of Chemistry and Pharmaceutical Sciences (CPS), Vrije Universiteit (2010 - ‘15); 2010 Director Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit (AIMMS, www.aimms.vu.nl ; 2010 - 2017). 2018 Emeritus professor Molecular Toxicology, Vrije Universiteit (2018 - ).
His general research interests are concerned with the roles molecular and computational toxicology can play in drug discovery, development and (human/environmental) safety assessment. More specifically, he is interested in toxication/detoxication mechanisms, in silico and in vitro prediction and screening of ADME-Tox properties, (biocatalytic) metabolite production and profiling and translational biomarkers of adverse drug reactions (ADRs). The large majority of his research was externally funded, e.g. by Pure & Applied Science foundations, EU-grants and industrial collaborations.
He is author / co-author of more than 400 scientific publications in the fields of molecular toxicology / pharmacology, bioanalysis and medicinal chemistry. In 2010 and 2015, he was listed as highly-cited author at www.ISIhighlycited.com. WOS: # Citations 17114, H-index 57, Google Scholar: # Citations 30845, H-index 72.
He has been promotor/supervisor of > 60 PhD-students.
Selected professional activities:
** President-elect (2000-2001), President (2002 - 2003) and Past-president (2004 - 2005) of ISSX, the International Society for the Study of Xenobiotics; ** Joint 19th Microsomes & Drug Oxidation (MDO) / 12th European ISSX meeting, 17-21 June, 2012, Noordwijk aan Zee, The Netherlands (Chairman); ** Coordinator / Managing Entity IMI-JU programme SafeSciMET, a European Modular Education & Training Programme in Safety Sciences for Medicines (2010 – 2017);
** Editor / Editor in Chief of Environmental Toxicology & Pharmacology (1997 - / 2001 - 2017); ** Associate-editor of Frontiers in Pharmacology (2020 - ), Current Drug Metabolism (2007 -), Drug Metabolism Letters (2007 -) and Biomarkers (1996 - 2008); ** Member of Editorial Boards of: Biochem. Pharmacol., J Biomed. & Environm. Sci., Chem. & Biodiversity, Chemico-Biol. Interact., Chem. Res. Toxicol., Chirality, Drug Metab. Rev., Expert Opinions Drug Metab. & Toxicol., Toxicol. and Xenobiotica
He was/is a Member of several Scientific Advisory/Peer Review committees, e.g. Leuven/2016, Vienna/2018, Finnish Academy of Science/2018-2021, Croation Science Foundation/2020, EU-EDCMET (2020 - ), UAEU/2021, ESF/2020 - ), RCN-Norway (2022-’23).
Consultancy: He has long-term and substantial advisory experience in societal roles toxicology and drug disposition can play in drug discovery, drug development and (environmental/human) risk and safety assessment.
Prizes and Awards
Recognitions (selected):
1985 Officially registered as Toxicologist (at SMBWO and NVT (1988, 2013, per 5 years); 1987 Anna DiCarlo Award (Best platform paper, ISSX/SOT Meeting, Sarasota, USA); 2004 Honorary membership of ISSX (2004, lifetime); 2006 European ISSX Scientific Achievement Award 2006, Manchester, UK; 2006 Ernst Schering Lecturer, Ernst Schering Research Foundation, Berlin, Germany; 2011 Honorary doctorate University of Copenhagen, via Faculty of Pharmaceutical Sciences; 2016 Distinguished ISSX Service Achievement Award 2016, ISSX Busan, South Korea. 2017 World Class Professor (WCP-programme) via Universitas Indonesia.
Education
1975 Degree in Chemistry (M.Sc.) Catholic University of Nijmegen, NL (Pharmacology & Org. Chemistry (Nijmegen), Mass Spectrometry (Univ. Amsterdam)
1980 Ph.D.-degree in Bio-Pharmaceutical Sciences, Univ. of Leiden. Supervisors: Prof. dr. D.D. Breimer and Prof. dr. H.J. de Jong. Thesis: The epoxide-diol pathway in the metabolism of Hexobarbital and related Barbiturates
Ancillary activities
No ancillary activities
Ancillary activities are updated daily
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- QD Chemistry
- drug discovery
- drug development
- Drug safety
- RM Therapeutics. Pharmacology
- Drug safety
- Drug metabolism
- Toxicology
User created Keywords
- Drug Safety
- Drug discovery
- Toxicology
- Interindividual differences
- Genetics & genomics
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The EU chemicals strategy for sustainability: in support of the BfR position
Barile, F. A., Berry, S. C., Blaauboer, B., Boobis, A., Bolt, H. M., Borgert, C., Dekant, W., Dietrich, D., Domingo, J. L., Galli, C. L., Gori, G. B., Greim, H., Hengstler, J. G., Heslop-Harrison, P., Kacew, S., Marquardt, H., Mally, A., Pelkonen, O., Savolainen, K., Testai, E., & 2 others, Sept 2021, In: Archives of Toxicology. 95, 9, p. 3133-3136 4 p.Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Corrigendum to “Critique of the “Comment” etitled “Pyrethroid exposure: not so harmless after all” by Demeniex et al. (2020) published in the lancet diabetes endocrinology"
Barile, F. A., Berry, S. C., Blaauboer, B., Boobis, A., Bolt, H., Borgert, C. J., Dekant, W., Dietrich, D., Domingo, J. L., Gori, G. B., Greim, H., Hengstler, J., Kacew, S., Marquardt, H., Pelkonen, O., Savolainen, K., Heslop-Harrison, P., Tsatsakis, A. & Vermeulen, N. P., 1 Aug 2021, In: Toxicology Letters. 346, p. 57-57 1 p.Research output: Contribution to Journal › Comment / Letter to the editor › Academic
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Critique of the “Comment” etitled “Pyrethroid exposure: Not so harmless after all” by Demeneix et al. (2020) published in the lancet diabetes endocrinology
Barile, F. A., Berry, S. C., Blaauboer, B., Boobis, A., Bolt, H., Borgert, C. J., Dekant, W., Dietrich, D., Domingo, J. L., Gori, G. B., Greim, H., Hengstler, J., Kacew, S., Marquardt, H., Pelkonen, O., Savolainen, K., Heslop-Harrison, P., Tsatsakis, A. & Vermeulen, N. P., 1 Apr 2021, In: Toxicology Letters. 340, p. 1-3 3 p.Research output: Contribution to Journal › Comment / Letter to the editor › Academic
Open AccessFile55 Downloads (Pure) -
Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
Erhardt, P., Bachmann, K., Birkett, D., Boberg, M., Bodor, N., Gibson, G., Hawkins, D., Hawksworth, G., Hinson, J., Koehler, D., Kress, B., Luniwal, A., Masumoto, H., Novak, R., Portoghese, P., Sarver, J., Serafini, M. T., Trabbic, C., Vermeulen, N. & Wrighton, S., 1 Mar 2021, In: Pure and Applied Chemistry. 93, 3, p. 273-403Research output: Contribution to Journal › Article › Academic › peer-review
Open Access -
Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?
Autrup, H., Barile, F. A., Berry, S. C., Blaauboer, B. J., Boobis, A., Bolt, H., Borgert, C. J., Dekant, W., Dietrich, D., Domingo, J. L., Gori, G. B., Greim, H., Hengstler, J., Kacew, S., Marquardt, H., Pelkonen, O., Savolainen, K., Heslop-Harrison, P. & Vermeulen, N. P., 1 Oct 2020, In: Toxicology Letters. 331, p. 259-264 6 p.Research output: Contribution to Journal › Editorial › Academic › peer-review
Open AccessFile46 Downloads (Pure)
Prizes
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Anna DiCarlo Award (Best platform paper, ISSX/SOT Meeting, Sarasota.
Vermeulen, Nico P.E. (Recipient), 1987
Prize / Grant: Prize › Academic
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Ernst Schering Lecturer, Berlin, Germany
Vermeulen, Nico P.E. (Recipient), 2006
Prize / Grant: Prize › Academic
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European Scientific Achievement Award ISSX
Vermeulen, Nico P.E. (Recipient), 2006
Prize / Grant: Prize › Academic
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F.J. di Carlo ISSX Distinguished Service Award, ISSX Busan, South Korea.
Vermeulen, Nico P.E. (Recipient), 2016
Prize / Grant: Prize › Academic
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Honorary Doctorate, University of Copenhagen
Vermeulen, Nico P.E. (Recipient), 2011
Prize / Grant: Prize › Academic