Research output per year
Supervised theses per year
Supervised PhD Theses
- 1 - 50 out of 52 results
Search results
-
2021
Calibration of next generation first-principle derived polarizable force fields
Visscher, K. M., 11 Mar 2021, s.I.: s.n.. 182 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile797 Downloads (Pure) -
2019
Applicability and performance of linear interaction energy based binding affinity calculation
Rifai, E. A., 2019, 183 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1518 Downloads (Pure) -
Mistaken identity: Paracetamol induces amino acid starvation through mimicry of tyrosine and changes ubiquitin homeostasis
Huseinovic, A., 2019, 202 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1671 Downloads (Pure) -
2018
Characterization of biotransformation enzymes involved in Adverse Drug Reactions: The cases of Nevirapine, Ticlopidine, Flucloxacillin and Clozapine
Dekker, S. J., 2018, 239 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1112 Downloads (Pure) -
Drug induced liver injury: assessment of inter-individual variation in the balance of bioactivation and inactivation as risk factor
den Braver, M. W., 2018, 288 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile2359 Downloads (Pure) -
Inter-individual variation in hepatic drug metabolism: The potential of in vitro assays in unraveling the role of metabolism in drug induced liver toxicity
den Braver-Sewradj, S. P., 2018, 252 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile2128 Downloads (Pure) -
In vitro and cellular systems for the characterization of bioactivating and inactivating drug metabolizing enzymes in adverse drug reactions: Insights into amodiaquine idiosyncratic toxicity
Zhang, Y., 2018, 154 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1083 Downloads (Pure) -
2017
Development of human Cytochrome P450 competent genotoxicity tester bacterial systems for high throughput screening: Functional characterization of human Cytochrome P450 1A2 polymorphic variants
Espadinha de Brito Palma, B. J., 2017, 233 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile194 Downloads (Pure) -
2015
Improved description of complex plasticity and interactions in protein-ligand simulations
Vosmeer, C. R., 2015, 175 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1383 Downloads (Pure) -
Interplay between phase I and phase II biotransformation of drugs: In vitro approaches to study the formation and fate of reactive metabolites
Vredenburg, G., 2015, 173 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1489 Downloads (Pure) -
2014
Engineered cytochrome P450 BM3 mutants as biocatalysts for metabolite production: Applications in biotechnology and toxicology
Venkataraman, H., 2014Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1190 Downloads (Pure) -
2013
Glutathione-S-transferases: tools and targets for characterization of chemically reactive drug metabolites
Boerma, J. S., 2013Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1016 Downloads (Pure) -
Role of genetic polymorphisms of drug metabolising enzymes in idiosyncratic drug reactions In vitro to in vivo translation
Dragovic, S., 2013Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1243 Downloads (Pure) -
2012
Application of free energy calculations for drug design
de Beer, S. B. A., 2012Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1305 Downloads (Pure) -
Cytochrome P450 BM3 as versatile biocatalytic tool in drug development
Rea, V., 2012Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile734 Downloads (Pure) -
2011
The estrogen receptor, environmental estrogens and the role of cytochrome P450 in bioactivation
van Lipzig, M. M. H., 2011Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile545 Downloads (Pure) -
Yeast as a model eukaryote in drug safety studies: New insights on diclofenac-induced toxicity
van Leeuwen, J. S., 2011Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1751 Downloads (Pure) -
2010
The role of biotransformation in the estrogenicity of xenobiotics
Reinen, J., 2010Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1398 Downloads (Pure) -
2009
Bioactivation of Drugs by Cytochromes P450: New Tools and Concepts for the Characterization of Reactive Metabolites of Drugs
Damsten, M. C., 2009Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile563 Downloads (Pure) -
Drug Biotransformation Enzyme Interactions Studies with Curcumin, Curcumin analogues and other Plant-derived Components
Appiah-Opong, R., 2009Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1289 Downloads (Pure) -
2008
Metabolic profiling of drugs and other xenobiotics with hyphenated analytical techniques
van Liempd, S. M., 2008Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
2007
High Resolution Screening of biologically active compounds and metabolites
Kool, J., 2007Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile448 Downloads (Pure) -
Resonance Raman spectroscopy of human cytochrome P450 2D6: in solution and on nanostructured biocompatible metal surfaces
Bonifacio, A., 2007Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile315 Downloads (Pure) -
Theoretical Investigation of the Hydroxylation Mechanism by Cytochromes P450
Groenhof, A. R., 2007, 182 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile1461 Downloads (Pure) -
Towards novel biocatalysts for drugs and drug-like molecules
van Vugt, B. M. A., 2007Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile927 Downloads (Pure) -
2006
Cytochrome P450-drug interactions: Computational binding mode and affinity predictions in CYP2D6
de Graaf, C., 2006Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile866 Downloads (Pure) -
Probing human cytochromes P450: mutational and spectroscopic analysis of CYP2D6
Keizers, P. H. J., 2006Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
Open AccessFile517 Downloads (Pure) -
2005
Molecular Toxicology of Thiourea-Containing Compounds
Onderwater, R. C. A., 2005Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
2003
High-Throughput Screening and Molecular Modeling of Biotransformation Enzymes
Venhorst, J., 2003Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
Novel Organoselenium Prodrugs: Mechanisms of Bioactivation, Kidney Selectivity and Chemoprotective Properties of Selenocysteine PAS-OP Se CURSIEF/AANEEN-Conjugates
Rooseboom, M., 2003Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
2002
Modulating the expression of biotransformation enzymes: studies with enzyme inducers and antisense oligonucleotides
Hoen, P.-B. '., 2002, 175 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
2000
Hepatotoxicity of paracetamol and structural analogues - Molecular mechanisms of bioactivation and of chemoprotection
Bessems, J. G. M., 2000Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1999
Development of New Escherichia coli Mutagenicity Test Systems - Engineering of Cytochrome P450 Competent Tester Bacteria for Biotransformation Studies of Carcinogens.
Kranendonk, M., 1999Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1998
Development of non-invasive biomarkers for free radical induced damage. Model studies in experimental animals and applications in humans.
de Zwart, L. L., 1998, Amsterdam: Zwart, L.L.. 239 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
Fish biomarkers for inland water pollution: An environmental field survey on the relationships between bioaccumulation and biochemical responses in freshwater fish
van der Oost, R., 1998, Amsterdam: Tensen scientific. 295 p.Research output: PhD Thesis › PhD-Thesis – Research external, graduation internal
-
Inter-individual variability in drug metabolism. Model studies with 1,2-dibromoethane using in vitro approaches and physiologically based pharmacokinetic modeling.
Wormhoudt, L. W., 1998, Amsterdam: L.W. Wormhoudt. 294 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1997
Mercapturic acids in biological monotoring; Applications to industrial chemicals.
de Rooij, B. M., 1997Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
Structure-activity relationships and active site characterization of gluthione S-transferases.
van der Aar, E. M., 1997Research output: PhD Thesis › PhD-Thesis – Research external, graduation internal
-
1996
Computational chemistry and molecular modeling approaches to biotransformation enzymes. Enzyme mechanisms, substrate and protein models of selected cytochrome P450 and glutathione S-transferase isoenzymes.
de Groot, M. J., 1996, 247 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1995
Disposition and biological effects of fotemustine, a new anticancer agent. A molecular toxicological study in rats and humans.
Brakenhoff, J. P. G., 1995, 215 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1993
Renal cysteine conjugate β-lyase: molecular mechanism of action and role in the nephrotoxicity of xenobiotics
Stijntjes, G. J., 1993, 223 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
The role of cytochrome P450 in the reductive bioactivation of cytostatic quinones
Goeptar, A. R., 1993, 180 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1992
Computational chemistry in biotransformational and toxicological research: mechanisms of oxidation by and active site structure of cytochromes P450
Koymans, L. M. H., 1992, 199 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1991
Mercapturic acids in biological monitoring: applications to 1,3-dichloropropene and other pesticides
Welie, R. T. H. V., 1991, 200 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
Molecular mechanisms of chemically induced nephrotoxicity: role of the mercapturic acid pathway in the bioactivation of halogenated hydrocarbons
Commandeur, J. N. M., 1991, 222 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
The pond snail Lymnaea stagnalis in toxicological research: fate and effects of dihalogenated biphenyls
Wilbrink, M., 1991, 162 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1990
Chemoprotection against cisplatin nephrotoxicity: a molecular approach with selenium compounds
Baldew, G. S., 1990, 182 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1989
Thiols in oxidative stress: some implications for catecholamine toxicity
Haenen, G. R. M. M., 1989, 182 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
1987
Paracetamol-induced hepatotoxicity and prevention by structural modification: a molecular toxicological study
Straat, R. V. D., 1987, Amsterdam: Free University Press. 149 p.Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
-
Preparation of capillary columns for gas chromatography: free release static coating and aerobic silylating deactivation
Xu, B., 1987, 164 p.Research output: PhD Thesis › PhD-Thesis – Research and graduation external