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Personal profile

Personal information

Nico P.E. Vermeulen (MSc in Chemistry (University of Nijmegen, NL, 1975) and a PhD in Pharmacology (University of Leiden, NL, 1980), was appointed professor of Molecular Toxicology in the Department of Chemistry and Pharmaceutical Sciences (CPS) at VU University Amsterdam, in 1985.

Employment (selected):

1975 Staff-member at the Subfaculty of Pharmacy, Univ. of Leiden, Leiden, NL; 1980 Senior staff-member Center for Bio-Pharmaceutical Sciences, Univ. of Leiden, Leiden; 1985 Professor of Molecular Toxicology, Section of Molecular Toxicology, Vrije  Universiteit, Amsterdam, NL (www.moltox.chem.vu.nl ; 1985 - ); 1997 Dean Faculty of Chemistry, Vrije Universiteit (1997 - 2000); 2005 Scientific Director Leiden-Amsterdam Center for Drug Research (LACDR) (2005-‘11); 2010 Coordinator/ Manager IMI-SafeSciMET: ‘Modular Education and Training programme for Translational Safety Sciences for Medicines’ (2010 - ‘17); 2010 Head Department of Chemistry and Pharmaceutical Sciences (CPS), Vrije Universiteit (2010 - ‘15); 2010 Director Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit (AIMMS, www.aimms.vu.nl ; 2010 -).

His general research interests are concerned with the roles molecular and computational toxicology can play in drug discovery, development and safety assessment. More specifically, he is interested in toxication/detoxication mechanisms, in silico and in vitro prediction and screening of ADME-Tox properties, (biocatalytic) metabolite production and profiling and translational biomarkers of adverse drug reactions (ADRs).

He is author / co-author of more than 400 scientific publications in the fields of molecular toxicology / pharmacology, bioanalysis and medicinal chemistry. In 2010 and 2015, he was listed as highly-cited author at www.ISIhighlycited.com. He has been promotor/supervisor of > 50 PhD-students.

Selected professional activities:

** President-elect (2000-2001), President (2002 - 2003) and Past-president (2004 - 2005) of ISSX, the International Society for the Study of Xenobiotics; ** Joint 19th Microsomes & Drug Oxidation (MDO) / 12th European ISSX meeting, 17-21 June, 2012, Noordwijk aan Zee, The Netherlands (Chairman); ** Coordinator / Managing Entity IMI-JU programme SafeSciMET, a European Modular Education & Training Programme in Safety Sciences for Medicines (2010 – 2017);

** Editor / Editor in Chief of Environmental Toxicology & Pharmacology (1997 - / 2001 - ); ** Associate-editor of Biomarkers (1996 - 2008), Current Drug Metabolism (2007 -) and Drug Metabolism Letters (2007 -); ** Member of Editorial Boards of: Biochem. Pharmacol., J Biomed. & Environm. Sci., Chem. & Biodiversity, Chemico-Biol. Interact., Chem. Res. Toxicol., Chirality, Drug Metab. Rev., Expert Opinions Drug Metab. & Toxicol., Toxicol. and Xenobiotica

 

Prizes and Awards

Recognitions (selected):

1985 Officially registered as Toxicologist (at SMBWO and NVT (1988, 2013, per 5 years);  1987 Anna DiCarlo Award (Best platform paper, ISSX/SOT Meeting, Sarasota, USA);  2004 Honorary membership of ISSX (2004, lifetime);  2006 European ISSX Scientific Achievement Award 2006, Manchester, UK;  2006 Ernst Schering Lecturer, Ernst Schering Research Foundation, Berlin, Germany;  2011 Honorary doctorate University of Copenhagen, via Faculty of Pharmaceutical Sciences;  2016 Distinguished ISSX Service Achievement Award 2016, ISSX Busan, South Korea.

Education

1975 Degree in Chemistry (M.Sc.) Catholic University of Nijmegen, NL (Pharmacology & Org. Chemistry (Nijmegen), Mass Spectrometry (Univ. Amsterdam)

1980 Ph.D.-degree in Bio-Pharmaceutical Sciences, Univ. of Leiden. Supervisors: Prof. dr. D.D. Breimer and Prof. dr. H.J. de Jong. Thesis: The epoxide-diol pathway in the metabolism of Hexobarbital and related Barbiturates

Ancillary activities

No ancillary activities

Ancillary activities are updated daily

Keywords

  • QD Chemistry
  • drug discovery
  • drug development
  • Drug safety
  • RM Therapeutics. Pharmacology
  • Drug safety
  • Drug metabolism
  • Toxicology
  • Drug Safety
  • Drug discovery
  • Toxicology
  • Interindividual differences
  • Genetics & genomics

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1977 2018

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion

Huseinovic, A., Dekker, S. J., Boogaard, B., Vermeulen, N. P. E., Kooter, J. M. & Vos, J. C., Oct 2018, In : Amino Acids. 50, 10, p. 1377-1390 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Amino Acid Transport Systems
Acetaminophen
Tryptophan
Proteins
Yeast

A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants

Luirink, R. A., Dekker, S. J., Capoferri, L., Kuiper, C. L., Janssen, L. F. H., Ari, M. E., Vermeulen, N. P. E., Vos, J. C., Commandeur, J. N. M. & Geerke, D. P., Jul 2018, In : Journal of Inorganic Biochemistry. 184, p. 115-122 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Floxacillin
Hydroxylation
Cytochrome P-450 Enzyme System
Metabolites
Enzymes

Drug induced liver injury: assessment of inter-individual variation in the balance of bioactivation and inactivation as risk factor

den Braver, M. W., 2018, 288 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine

Huseinovic, A., van Dijk, M., Vermeulen, N. P. E., van Leeuwen, F., Kooter, J. M. & Vos, J. C., Mar 2018, In : Toxicology in Vitro. 47, p. 259-268 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Acetaminophen
Drug-Related Side Effects and Adverse Reactions
Yeast
Toxicity
Saccharomyces cerevisiae

Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism

Lazarska, K. E., Dekker, S. J., Vermeulen, N. P. E. & Commandeur, J. N. M., 1 Mar 2018, In : Toxicology Letters. 284, 1 March, p. 70-78 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Diclofenac
Polymorphism
Metabolism
Liver
Chemical and Drug Induced Liver Injury

Prizes

Recognitions (selected):

N.P.E. Vermeulen (Recipient), 1985

Prize: Prize / AwardAcademic

Republic of Korea
Berlin
Germany
Research
Pharmaceutical Preparations