Nico Vermeulen

em. prof. dr.

  • De Boelelaan 1108, O|2 Lab Building (3E-09)

    1081 HZ Amsterdam

1977 …2019
If you made any changes in Pure these will be visible here soon.

Research Output 1977 2019

Filter
Review article
2011

Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates

Orhan, H. & Vermeulen, N. P. E., May 2011, In : Current Drug Metabolism. 12, 4, p. 383-394 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Metabolites
Pharmaceutical Preparations
Biotransformation
Toxicity
Molecules

Managing the challenge of chemically reactive metabolites in drug development

Park, B. K., Boobis, A., Clarke, S., Goldring, C. E. P., Jones, D. T., Kenna, J. G., Lambert, C., Laverty, H. G., Naisbitt, D. J., Nelson, S., Nicoll-Griffith, D. A., Obach, R. S., Routledge, P., Smith, D. A., Tweedie, D. J., Vermeulen, N., Williams, D. P., Wilson, I. D. & Baillie, T. A., Apr 2011, In : Nature Reviews Drug Discovery. 10, 4, p. 292-306 15 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Drug Industry
Pharmaceutical Preparations
Pharmaceutical Chemistry
Risk Management
Drug Discovery
2003

Prediction of drug metabolism: the case of cytochrome P450 2D6

Vermeulen, N. P. E., 2003, In : Current Topics in Medicinal Chemistry. 3, 11, p. 1227-39 13 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Cytochrome P-450 CYP2D6
Pharmaceutical Preparations
Biotransformation
Isoenzymes
Ligands
2001

Chemistry and biological activity of novel selenium-containing compounds

Commandeur, J. N., Rooseboom, M. & Vermeulen, N. P., 2001, In : Advances in Experimental Medicine and Biology. 500, p. 105-12 8 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

1997

Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes

De Groot, M. J. & Vermeulen, N. P., Aug 1997, In : Drug Metabolism Reviews. 29, 3, p. 747-99 53 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

1996

Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin

Commandeur, J. N. & Vermeulen, N. P., Jul 1996, In : Xenobiotica. 26, 7, p. 667-80 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

1995

Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics

Commandeur, J. N., Stijntjes, G. J. & Vermeulen, N. P., Jun 1995, In : Pharmacological Reviews. 47, 2, p. 271-330 60 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway

Goeptar, A. R., Commandeur, J. N., van Ommen, B., van Bladeren, P. J. & Vermeulen, N. P., 1 Jan 1995, In : Chemical Research in Toxicology. 8, 1, p. 3-21 19 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

1993

Cytochromes P450: their active-site structure and mechanism of oxidation

Koymans, L., Donné-op den Kelder, G. M., te Koppele, J. M. & Vermeulen, N. P., 1993, In : Drug Metabolism Reviews. 25, 3, p. 325-87 63 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Cytochromes P450 and drug resistance

Doehmer, J., Goeptar, A. R. & Vermeulen, N. P., 1993, In : Cytotechnology. 12, 1-3, p. 357-66 10 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Drug Resistance
Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Nutrition
Drug interactions

Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents

Koymans, L., Donné-Op den Kelder, G. M., te Koppele, J. M. & Vermeulen, N. P., Jun 1993, In : Xenobiotica. 23, 6, p. 633-48 16 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Oxygenation
Phenacetin
Acetaminophen
Cytochrome P-450 Enzyme System
Acetanilides
1992

Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals

van Welie, R. T. H., van Dijck, R. G., Vermeulen, N. P. & van Sittert, N. J., 1992, In : Critical Reviews in Toxicology. 22, 5-6, p. 271-306 36 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

DNA Adducts
Acetylcysteine
Biomarkers
Proteins
Metabolites

Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention

Vermeulen, N. P., Bessems, J. G. & Van de Straat, R., 1992, In : Drug Metabolism Reviews. 24, 3, p. 367-407 41 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Monitoring of oxidative free radical damage in vivo: analytical aspects

Hageman, J. J., Bast, A. & Vermeulen, N. P. E., May 1992, In : Chemico-Biological Interactions. 82, 3, p. 243-293 51 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Free Radicals
Monitoring
Pathologic Processes
Toxicology
Fluids
1989

Analysis of mercapturic acids as a tool in biotransformation, biomonitoring and toxicological studies

Vermeulen, N. P., May 1989, In : Trends in Pharmacological Sciences. 10, 5, p. 177-81 5 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations

Vermeulen, N. P., de Jong, J., van Bergen, E. J. & van Welie, R. T. H., 1989, In : Archives of Toxicology. 63, 3, p. 173-84 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Environmental Monitoring
Monitoring
Xenobiotics
Metabolites
Poisons

N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations

Vermeulen, N. P., de Jong, J., van Bergen, E. J. & van Welie, R. T. H., 1989, In : Archives of Toxicology. 63, 3, p. 173-84 12 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Environmental Monitoring
Monitoring
Xenobiotics
Metabolites
Poisons
1988

Disposition of hexobarbital: 15 years of an intriguing model substrate

van der Graaff, M., Vermeulen, N. P. & Breimer, D. D., 1988, In : Drug Metabolism Reviews. 19, 2, p. 109-64 56 p.

Research output: Contribution to JournalReview articleAcademicpeer-review