Research Output 1977 2018

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Review article
2011

Managing the challenge of chemically reactive metabolites in drug development

Park, B. K., Boobis, A., Clarke, S., Goldring, C. E. P., Jones, D. T., Kenna, J. G., Lambert, C., Laverty, H. G., Naisbitt, D. J., Nelson, S., Nicoll-Griffith, D. A., Obach, R. S., Routledge, P., Smith, D. A., Tweedie, D. J., Vermeulen, N., Williams, D. P., Wilson, I. D. & Baillie, T. A. Apr 2011 In : Nature Reviews Drug Discovery. 10, 4, p. 292-306 15 p.

Research output: Contribution to journalReview article

2003

Prediction of drug metabolism: the case of cytochrome P450 2D6

Vermeulen, N. P. E. 2003 In : Current Topics in Medicinal Chemistry. 3, 11, p. 1227-39 13 p.

Research output: Contribution to journalReview article

2001

Chemistry and biological activity of novel selenium-containing compounds

Commandeur, J. N., Rooseboom, M. & Vermeulen, N. P. 2001 In : Advances in Experimental Medicine and Biology. 500, p. 105-12 8 p.

Research output: Contribution to journalReview article

1997

Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes

De Groot, M. J. & Vermeulen, N. P. Aug 1997 In : Drug Metabolism Reviews. 29, 3, p. 747-99 53 p.

Research output: Contribution to journalReview article

1996

Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin

Commandeur, J. N. & Vermeulen, N. P. Jul 1996 In : Xenobiotica. 26, 7, p. 667-80 14 p.

Research output: Contribution to journalReview article

Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway

Goeptar, A. R., Commandeur, J. N., van Ommen, B., van Bladeren, P. J. & Vermeulen, N. P. 1 Jan 1995 In : Chemical Research in Toxicology. 8, 1, p. 3-21 19 p.

Research output: Contribution to journalReview article

1993

Cytochromes P450: their active-site structure and mechanism of oxidation

Koymans, L., Donné-op den Kelder, G. M., te Koppele, J. M. & Vermeulen, N. P. 1993 In : Drug Metabolism Reviews. 25, 3, p. 325-87 63 p.

Research output: Contribution to journalReview article

Cytochromes P450 and drug resistance

Doehmer, J., Goeptar, A. R. & Vermeulen, N. P. 1993 In : Cytotechnology. 12, 1-3, p. 357-66 10 p.

Research output: Contribution to journalReview article

Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents

Koymans, L., Donné-Op den Kelder, G. M., te Koppele, J. M. & Vermeulen, N. P. Jun 1993 In : Xenobiotica. 23, 6, p. 633-48 16 p.

Research output: Contribution to journalReview article

1992

Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals

van Welie, R. T. H., van Dijck, R. G., Vermeulen, N. P. & van Sittert, N. J. 1992 In : Critical Reviews in Toxicology. 22, 5-6, p. 271-306 36 p.

Research output: Contribution to journalReview article

Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention

Vermeulen, N. P., Bessems, J. G. & Van de Straat, R. 1992 In : Drug Metabolism Reviews. 24, 3, p. 367-407 41 p.

Research output: Contribution to journalReview article

Monitoring of oxidative free radical damage in vivo: analytical aspects

Hageman, J. J., Bast, A. & Vermeulen, N. P. May 1992 In : Chemico-Biological Interactions. 82, 3, p. 243-93 51 p.

Research output: Contribution to journalReview article

1989

N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies?: A critical evaluation of possibilities and limitations

Vermeulen, N. P., de Jong, J., van Bergen, E. J. & van Welie, R. T. H. 1989 In : Archives of Toxicology. 63, 3, p. 173-84 12 p.

Research output: Contribution to journalReview article

N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies?: A critical evaluation of possibilities and limitations

Vermeulen, N. P., de Jong, J., van Bergen, E. J. & van Welie, R. T. H. 1989 In : Archives of Toxicology. 63, 3, p. 173-84 12 p.

Research output: Contribution to journalReview article

1988

Disposition of hexobarbital: 15 years of an intriguing model substrate

van der Graaff, M., Vermeulen, N. P. & Breimer, D. D. 1988 In : Drug Metabolism Reviews. 19, 2, p. 109-64 56 p.

Research output: Contribution to journalReview article