Research Output 1977 2018

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PhD Thesis - Research VU, graduation VU
2018

Drug induced liver injury: assessment of inter-individual variation in the balance of bioactivation and inactivation as risk factor

den Braver, M. W. 2018 288 p.

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
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Inter-individual variation in hepatic drug metabolism: The potential of in vitro assays in unraveling the role of metabolism in drug induced liver toxicity

den Braver-Sewradj, S. P. 2018 252 p.

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
File
2017
Open Access
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2015

Improved description of complex plasticity and interactions in protein-ligand simulations

Vosmeer, C. R. 2015

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
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Open Access
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2014

Engineered cytochrome P450 BM3 mutants as biocatalysts for metabolite production: Applications in biotechnology and toxicology

Venkataraman, H. 2014

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
File
2013

Glutathione-S-transferases: tools and targets for characterization of chemically reactive drug metabolites

Boerma, J. S. 2013

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
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Role of genetic polymorphisms of drug metabolising enzymes in idiosyncratic drug reactions In vitro to in vivo translation

Dragovic, S. 2013

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
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2012

Application of free energy calculations for drug design

de Beer, S. B. A. 2012

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
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Cytochrome P450 BM3 as versatile biocatalytic tool in drug development

Rea, V. 2012

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
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2011

The estrogen receptor, environmental estrogens and the role of cytochrome P450 in bioactivation

van Lipzig, M. M. H. 2011

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
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Yeast as a model eukaryote in drug safety studies: New insights on diclofenac-induced toxicity

van Leeuwen, J. S. 2011

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
File
2010

The role of biotransformation in the estrogenicity of xenobiotics

Reinen, J. 2010

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
File
2009

Bioactivation of Drugs by Cytochromes P450: New Tools and Concepts for the Characterization of Reactive Metabolites of Drugs

Damsten, M. C. 2009

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
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Drug Biotransformation Enzyme Interactions Studies with Curcumin, Curcumin analogues and other Plant0derived Components

Appiah Opong, R. 2009

Research output: ThesisPhD Thesis - Research VU, graduation VU

2007

Resonance Raman spectroscopy of human cytochrome P450 2D6: in solution and on nanostructured biocompatible metal surfaces

Bonifacio, A. 2007

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
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Theoretical Investigation of the Hydroxylation Mechanism by Cytochromes P450

Groenhof, A. R. 2007 182 p.

Research output: ThesisPhD Thesis - Research VU, graduation VU

Open Access
File
2006

Probing human cytochromes P450: mutational and spectroscopic Analysis of CYP2D6

Keizers, P. H. J. 2006

Research output: ThesisPhD Thesis - Research VU, graduation VU

2000

Hepatotoxicity of paracetamol and structural analogues - Molecular mechanisms of bioactivation and of chemoprotection

Bessems, J. G. M. 2000

Research output: ThesisPhD Thesis - Research VU, graduation VU

1998

Development of non-invasive biomarkers for free radical induced damage. Model studies in experimental animals and applications in humans.

de Zwart, L. L. 1998 Amsterdam: Zwart, L.L.. 239 p.

Research output: ThesisPhD Thesis - Research VU, graduation VU

1997

Mercapturic acids in biological monotoring; Applications to industrial chemicals.

de Rooij, B. M. 1997

Research output: ThesisPhD Thesis - Research VU, graduation VU

1995

Disposition and biological effects of fotemustine, a new anticancer agent. A molecular toxicological study in rats and humans.

Brakenhoff, J. P. G. 1995 215 p.

Research output: ThesisPhD Thesis - Research VU, graduation VU