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Olivia Klatt obtained her bachelor’s degree in Chemical Biology at the Karlsruhe Institute of Technology (KIT) in 2020. She continued her studies at the Universiteit van Amsterdam (UvA) by pursuing a master’s degree in Biomedical Science with a specialization in Medical Biochemistry and Biotechnology. During her master’s she did a 7-month internship in cardiovascular science at the Academisch Medisch Centrum (AMC) Amsterdam, where she investigated the effects of a diabetic drug on perfused primary coronary artery endothelial cells. Additionally, she completed a 6-month research internship at the Science for Life Laboratory (SciLifeLab) Stockholm in structural biology. There she contributed to improving the understanding of allogeneic effects on the binding capacity of a cancer antigen with different MHC complexes using X-ray crystallography.
In May 2023 she joined the Division of Molecular and Computational Toxicology at the Vrije Universiteit (VU) Amsterdam as a PhD candidate under the supervision of Dr. Anja Wilmes. Her work is part of the EFSA funded project ‘ADME4NGRA: Implementing the EFSA NAMs roadmap through advancing toxicokinetic knowledge in chemical risk assessment’. She focuses on the absorption, distribution, metabolism and excretion (ADME) processes of different chemicals in various human and rat renal in vitro systems including subcellular fractions, immortalized cell lines, induced pluripotent stem cell (iPSC)-derived proximal tubule like cells and primary cells. The collected in vitro data should assess the transport and metabolism of several chemicals in proximal tubule cells and derive relevant kinetic parameters for generic physiologically based kinetic (PBK) models.