Paul Jennings

Prof. dr., Priv. Doz., BSc

  • De Boelelaan 1108, O|2 building. Room 03W51

    1081HZ Amsterdam

    Netherlands

20022017

Personal profile

Personal information

Paul Jennings is from July 2017 appointed Professor at the Division of Molecular and Computational Toxicology, VU, Amsterdam. His background is in epithelial and renal biology, in vitro cell culture system development and mechanistic toxicology. Paul hails from Dublin Ireland. He did his BSc and PhD in University College Dublin. He then moved to Innsbruck, Austria working with Prof. Walter Pfaller. In 2009 Paul habiliated in Epithelial Physiology.

Education

2009 Habilitation (Venia Docendi) in Physiology at the Division of Physiology, Dept. of Physiology and Medical Physics, Innsbruck Medical University entitled “Epithelial Cell Cultures as tools to study human disease and the adverse effects of pharmaceuticals and chemicals.”

1996 - 2001 PhD fellowship at the Department of Pharmacology, University College Dublin, Ireland. Supervised by Professor Michael P. Ryan, Head of Department. PhD thesis was entitled, “Novel Approaches For In Vitro Nephrotoxicity Testing”.

1992 - 1996 Honours Bachelor of Science Degree, specialising in Pharmacology. University College Dublin, Ireland.

1987 - 1992 Second level education. Moyle Park College, Clondalkin, Dublin 22, Ireland.

1979 - 1987 Primary level education. St. Killians National School, Kingswood Hts. Dublin 24, Ireland.

Research

Current research interests include: 

  • Development of improved human renal and hepatic in vitro models
  • Mechanistic understanding using integrated omic approaches in carefully designed exposure scenarios (transcriptomics, proteomics, metabolomics and epigenetics)
  • The understanding of how cells deal with stress and the delineation of stress response pathways, including oxidative stress (Nrf2), DNA damage (p53), hypoxia (HIF-1alpha) and the unfolded protein response.
  • Chemical induced dedifferentiation and recovery after exposure
  • In vitro biokinetic studies
  • Integrating cheminformatics, kinetics and dynamics into computational systems toxicological models
  • Collaboration with specialists to build tiered integrated approaches for testing and assessment (IATA) / integrated testing systems (ITS) – (eg. BBB, liver, lung, brain, heart, skin) which are regulatory relevant (i.e. built with application to Adverse Outcome Pathways)
  • Understanding genetic diversity of dynamics and kinetics using iPSC.
  • Development of clinically-translational mechanistic biomarkers 

 

Links: PubmedGoogle ScholarResearch Gate

Grants

In3: An integrated interdisciplinary approach to animal-free nanomaterial and chemical safety assessment.  http://estiv.org/in3/

Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment https://openrisknet.org/

EUToxRisk: An Integrated EUropean ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century http://www.eu-toxrisk.eu/

Stem cells for Biological Assays of Novel drugs and predictive toxiCology http://stembancc.org/

Ancillary activities

No ancillary activities

Last mutation Ancillary Activities: Amsterdam(2017-04-19)

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Research Output 2002 2017

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M. , Ghallab, A. , Graepel, R. , Marchan, R. , Hassan, R. , Bennekou, S. H. , Limonciel, A. , Vinken, M. , Schildknecht, S. , Waldmann, T. , Danen, E. H. J. , van Ravenzwaay, B. , Kamp, H. , Gardner, I. , Godoy, P. , Bois, F. Y. , Braeuning, A. , Reif, R. , Oesch, F. , Drasdo, D. & 33 others Höhme, S., Schwarz, M., Hartung, T., Braunbeck, T., Beltman, J., Vrieling, H., Sanz, F., Forsby, A., Gadaleta, D., Fisher, C., Kelm, J., Fluri, D., Ecker, G. F., Zdrazil, B., Terron, A., Jennings, P., van der Burg, B., Dooley, S., Meijer, A. H., Willighagen, E., Martens, M., Evelo, C. T., Mombelli, E., Taboureau, O., Mantovani, A., Hardy, B., Koch, B., Escher, S., van Thriel, C., Cadenas, C., Kroese, D., van de Water, B. & Hengstler, J. G. 19 Oct 2017 In : Archives of Toxicology.

Research output: Scientific - peer-reviewArticle

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

Corvi, R., Madia, F., Guyton, K. Z., Kasper, P., Rudel, R., Colacci, A., Kleinjans, J. & Jennings, P. 12 Sep 2017 In : Toxicology in Vitro.

Research output: Scientific - peer-reviewArticle

Systems Toxicology: Real World Applications and Opportunities

Hartung, T., FitzGerald, R. E., Jennings, P., Mirams, G. R., Peitsch, M. C., Rostami-Hodjegan, A., Shah, I., Wilks, M. F. & Sturla, S. J. 17 Apr 2017 In : Chemical Research in Toxicology. 30, 4, p. 870-882 13 p.

Research output: Scientific - peer-reviewArticle

Towards optimisation of induced pluripotent cell culture: Extracellular acidification results in growth arrest of iPSC prior to nutrient exhaustion

Wilmes, A., Rauch, C., Carta, G., Kern, G., Meier, F., Posch, W., Wilflingseder, D., Armstrong, L., Lako, M., Beilmann, M., Gstraunthaler, G. & Jennings, P. 15 Aug 2017 In : Toxicology in Vitro.

Research output: Scientific - peer-reviewArticle

Ensuring the Quality of Stem Cell-Derived In Vitro Models for Toxicity Testing

Stacey, G. N., Coecke, S., Price, A-B., Healy, L., Jennings, P., Wilmes, A., Pinset, C., Ingelman-Sundberg, M., Louisse, J., Haupt, S., Kidd, D., Robitski, A., Jahnke, H-G., Lemaitre, G. & Myatt, G. 28 Sep 2016 In : Advances in Experimental Medicine and Biology. 856, p. 259-297 39 p.

Research output: Scientific - peer-reviewReview article