Paul Jennings

Prof. dr., Priv. Doz., BSc

  • De Boelelaan 1108, O|2 building. Room 03W51

    1081HZ Amsterdam

    Netherlands

20022018

Personal profile

Research

Links: PubmedGoogle ScholarResearch Gate

 

Current research interests include: 

  • Development of improved human renal and hepatic in vitro models
  • Mechanistic understanding using integrated omic approaches in carefully designed exposure scenarios (transcriptomics, proteomics, metabolomics and epigenetics)
  • The understanding of how cells cope with stress and the delineation of stress response pathways, including oxidative stress (Nrf2), DNA damage (p53), hypoxia (HIF-1alpha) and the unfolded protein response.
  • Chemical-induced dedifferentiation and recovery after exposure
  • In vitro biokinetic studies
  • Integrating cheminformatics, kinetics and dynamics into computational systems toxicological models
  • Collaboration with specialists to build tiered integrated approaches for testing and assessment (IATA) / integrated testing systems (ITS) – (eg. BBB, liver, lung, brain, heart, skin) which are regulatory relevant (i.e. built with application to Adverse Outcome Pathways)
  • Understanding genetic diversity of dynamics and kinetics using iPSC.
  • Development of clinically-translational mechanistic biomarkers 

Grants

In3: An integrated interdisciplinary approach to animal-free nanomaterial and chemical safety assessment.  http://estiv.org/in3/

OpenRiskNet: Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment https://openrisknet.org/

EUToxRisk: An Integrated EUropean ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century http://www.eu-toxrisk.eu/

StemBANCC: Stem cells for Biological Assays of Novel drugs and predictive toxiCology http://stembancc.org/

Personal information

Paul Jennings is from July 2017 appointed Professor at the Division of Molecular and Computational Toxicology, VU, Amsterdam. His background is in epithelial and renal biology, in vitro cell culture system development and mechanistic toxicology. Paul hails from Dublin Ireland. He did his BSc and PhD in University College Dublin. He then moved to Innsbruck, Austria working with Prof. Walter Pfaller. In 2009 Paul habiliated in Epithelial Physiology.

Education

2009 Habilitation (Venia Docendi) in Physiology at the Division of Physiology, Dept. of Physiology and Medical Physics, Innsbruck Medical University entitled “Epithelial Cell Cultures as tools to study human disease and the adverse effects of pharmaceuticals and chemicals.”

1996 - 2001 PhD fellowship at the Department of Pharmacology, University College Dublin, Ireland. Supervised by Professor Michael P. Ryan, Head of Department. PhD thesis was entitled, “Novel Approaches For In Vitro Nephrotoxicity Testing”.

1992 - 1996 Honours Bachelor of Science Degree, specialising in Pharmacology. University College Dublin, Ireland.

1987 - 1992 Second level education. Moyle Park College, Clondalkin, Dublin 22, Ireland.

1979 - 1987 Primary level education. St. Killians National School, Kingswood Hts. Dublin 24, Ireland.

Ancillary activities

No ancillary activities

Ancillary activities are updated daily

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Research Output 2002 2018

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Pamies, D., Bal-Price, A., Chesné, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M. 13 Apr 2018 In : Altex.

Research output: Contribution to journalArticle

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M. , Ghallab, A. , Graepel, R. , Marchan, R. , Hassan, R. , Bennekou, S. H. , Limonciel, A. , Vinken, M. , Schildknecht, S. , Waldmann, T. , Danen, E. H. J. , van Ravenzwaay, B. , Kamp, H. , Gardner, I. , Godoy, P. , Bois, F. Y. , Braeuning, A. , Reif, R. , Oesch, F. , Drasdo, D. & 33 others Höhme, S., Schwarz, M., Hartung, T., Braunbeck, T., Beltman, J., Vrieling, H., Sanz, F., Forsby, A., Gadaleta, D., Fisher, C., Kelm, J., Fluri, D., Ecker, G. F., Zdrazil, B., Terron, A., Jennings, P., van der Burg, B., Dooley, S., Meijer, A. H., Willighagen, E., Martens, M., Evelo, C. T., Mombelli, E., Taboureau, O., Mantovani, A., Hardy, B., Koch, B., Escher, S., van Thriel, C., Cadenas, C., Kroese, D., van de Water, B. & Hengstler, J. G. 19 Oct 2017 In : Archives of Toxicology.

Research output: Contribution to journalArticle

A snapshot on the progress of in vitro toxicology for safety assessment

Jennings, P., Corvi, R. & Culot, M. Dec 2017 In : Toxicology in Vitro. 45, Pt 3, p. 269-271 3 p.

Research output: Contribution to journalArticle

A snapshot on the progress of in vitro toxicology for safety assessment

Jennings, P., Corvi, R. & Culot, M. 1 Dec 2017 In : Toxicology in Vitro. 45, p. 269-271 3 p.

Research output: Contribution to journalEditorial

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

Corvi, R., Madia, F., Guyton, K. Z., Kasper, P., Rudel, R., Colacci, A., Kleinjans, J. & Jennings, P. 12 Sep 2017 In : Toxicology in Vitro.

Research output: Contribution to journalArticle

Open Access