• De Boelelaan 1108, O|2 building. Room 03W51

    1081HZ Amsterdam

    Netherlands

20022018
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Personal profile

Research

Links: PubmedGoogle ScholarResearch Gate

 

Research interests include: 

  • Development of improved human renal and hepatic in vitro models
  • Mechanistic understanding using integrated omic approaches in carefully designed exposure scenarios (transcriptomics, proteomics, metabolomics and epigenetics)
  • The understanding of how cells cope with stress and the delineation of stress response pathways, including oxidative stress (Nrf2), DNA damage (p53), hypoxia (HIF-1alpha) and the unfolded protein response.
  • Chemical-induced dedifferentiation and recovery after exposure
  • In vitro biokinetic studies
  • Integrating cheminformatics, kinetics and dynamics into computational systems toxicological models
  • Collaboration with specialists to build tiered integrated approaches for testing and assessment (IATA) / integrated testing systems (ITS) – (eg. BBB, liver, lung, brain, heart, skin) which are regulatory relevant (i.e. built with application to Adverse Outcome Pathways)
  • Understanding genetic diversity of dynamics and kinetics using iPSC.
  • Development of clinically-translational mechanistic biomarkers 

 

Paul's Henry Stewart Talk contribution

 

Jennings, P. (2016), "Molecular basis of genetic renal diseases 1 and 2", in The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at https://hstalks.com/bs/3413/https://hstalks.com/bs/3414/ )

 

Grants

In3: An integrated interdisciplinary approach to animal-free nanomaterial and chemical safety assessment.  http://estiv.org/in3/

OpenRiskNet: Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment https://openrisknet.org/

EUToxRisk: An Integrated EUropean ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century http://www.eu-toxrisk.eu/

StemBANCC: Stem cells for Biological Assays of Novel drugs and predictive toxiCology http://stembancc.org/

Personal information

Paul Jennings is from July 2017 appointed Professor at the Division of Molecular and Computational Toxicology, VU, Amsterdam. His background is in epithelial and renal biology, in vitro cell culture system development and mechanistic toxicology. Paul hails from Dublin Ireland. He did his BSc and PhD in University College Dublin. He then moved to Innsbruck, Austria working with Prof. Walter Pfaller. In 2009 Paul habiliated in Epithelial Physiology.

Education

2009 Habilitation (Venia Docendi) in Physiology at the Division of Physiology, Dept. of Physiology and Medical Physics, Innsbruck Medical University entitled “Epithelial Cell Cultures as tools to study human disease and the adverse effects of pharmaceuticals and chemicals.”

1996 - 2001 PhD fellowship at the Department of Pharmacology, University College Dublin, Ireland. Supervised by Professor Michael P. Ryan, Head of Department. PhD thesis was entitled, “Novel Approaches For In Vitro Nephrotoxicity Testing”.

1992 - 1996 Honours Bachelor of Science Degree, specialising in Pharmacology. University College Dublin, Ireland.

1987 - 1992 Second level education. Moyle Park College, Clondalkin, Dublin 22, Ireland.

1979 - 1987 Primary level education. St. Killians National School, Kingswood Hts. Dublin 24, Ireland.

Ancillary activities

Board member of the European Society for Toxicology in Vitro (ESTIV, estiv.org)
Editor in Chief, Toxicology in Vitro (TIV, https://www.journals.elsevier.com/toxicology-in-vitro)
Assosciated Editor, Archives of Toxocology (AOT, https://link.springer.com/journal/204)

 

Ancillary activities

No ancillary activities

Ancillary activities are updated daily

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 3 Similar Profiles
Kidney Medicine & Life Sciences
Toxicity Chemical Compounds
Toxicology Medicine & Life Sciences
Proximal Kidney Tubule Medicine & Life Sciences
Uromodulin Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Cell Culture Techniques Medicine & Life Sciences
Cyclosporine Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2002 2018

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

Limonciel, A., Ates, G., Carta, G., Wilmes, A., Watzele, M., Shepard, P. J., VanSteenhouse, H. C., Seligmann, B., Yeakley, J. M., van de Water, B., Vinken, M. & Jennings, P., Aug 2018, In : Archives of Toxicology. 92, 8, p. 2517-2531 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Workflow
Toxic Actions
Costs and Cost Analysis
Glycolysis
Computational Biology

Delineation of the key aspects in the regulation of epithelial monolayer formation

Aschauer, L., Gruber, L. N., Pfaller, W., Limonciel, A., Athersuch, T. J., Cavill, R., Khan, A., Gstraunthaler, G., Grillari, J., Grillari-Voglauer, R., Hewitt, P., Leonard, M. O., Wilmes, A. & Jennings, P., Jul 2013, In : Molecular and Cellular Biology. 33, 13, p. 2535-2550 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genes
Proximal Kidney Tubule
Metabolomics
Cilia
Tight Junctions

An overview of transcriptional regulation in response to toxicological insult

Jennings, P., Limonciel, A., Felice, L. & Leonard, M. O., Jan 2013, In : Archives of Toxicology. 87, 1, p. 49-72 24 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Toxicology
Xenobiotics
Transcription Factors
Genes
Cell Dedifferentiation

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

Wilmes, A. , Limonciel, A. , Aschauer, L. , Moenks, K. , Bielow, C. , Leonard, M. O. , Hamon, J. , Carpi, D. , Ruzek, S. , Handler, A. , Schmal, O. , Herrgen, K. , Bellwon, P. , Burek, C. , Truisi, G. L. , Hewitt, P. , Di Consiglio, E. , Testai, E. , Blaauboer, B. J. , Guillou, C. & 7 others Huber, C. G., Lukas, A., Pfaller, W., Mueller, S. O., Bois, F. Y., Dekant, W. & Jennings, P., 21 Feb 2013, In : Journal of Proteomics. 79, p. 180-94 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolomics
Proteomics
Cyclosporine
Pharmaceutical Preparations
Chemical activation

"The future of in vitro toxicology"

Jennings, P., Sep 2015, In : Toxicology in Vitro. 29, 6, p. 1217-21 5 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Toxicology
Lab-On-A-Chip Devices
Tissue culture
Telomerase
Biomarkers