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Research Output 1999 2018

2018

Effects of environmental pollutants on calcium release and uptake by rat cortical microsomes

Dusza, H. M., Cenijn, P. H., Kamstra, J. H., Westerink, R. H. S., Leonards, P. E. G. & Hamers, T., Dec 2018, In : Neurotoxicology. 69, p. 266-277 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Environmental Pollutants
Endosulfan
Microsomes
Rats
Diethylhexyl Phthalate
2017

Altered Adipogenesis in Zebrafish Larvae Following High Fat Diet and Chemical Exposure Is Visualised by Stimulated Raman Scattering Microscopy

den Broeder, M. J., Moester, M. J. B., Kamstra, J. H., Cenijn, P. H., Davidoiu, V., Kamminga, L. M., Ariese, F., de Boer, J. F. & Legler, J., Apr 2017, In : International Journal of Molecular Sciences. 18, 4

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Mode of Action Assignment of Chemicals Using Toxicogenomics: A Case Study with Oxidative Uncouplers

Hawliczek-Ignarski, A., Cenijn, P. H., Legler, J., Segner, H. & Legradi, J., 29 Nov 2017, In : Frontiers of Environmental Science. 5, p. 1-14 14 p., 80.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Toxicogenetics
Pharmacologic Actions
Toxic Actions
Oxidative Phosphorylation
Narcotics
2014

Disruption of oxidative phosphorylation (OXPHOS) by hydroxylated polybrominated diphenyl ethers (OH-PBDEs) present in the marine environment

Legradi, J., Dahlberg, A-K., Cenijn, P., Marsh, G., Asplund, L., Bergman, Å. & Legler, J., 16 Dec 2014, In : Environmental Science and Technology. 48, 24, p. 14703-11 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Halogenated Diphenyl Ethers
Oxidative Phosphorylation
Poisons
Mytilus edulis
Mitochondrial Membrane Potential

OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing

Busquet, F., Strecker, R., Rawlings, J. M., Belanger, S. E., Braunbeck, T., Carr, G. J., Cenijn, P. H., Fochtman, P., Gourmelon, A., Hübler, N., Kleensang, A., Knöbel, M., Kussatz, C., Legler, J., Lillicrap, A., Martínez-Jerónimo, F., Polleichtner, C., Rzodeczko, H., Salinas, E., Schneider, K. E. & 7 othersScholz, S., van den Brandhof, E. J., van der Ven, L. T., Walter-Rohde, S., Weigt, S., Witters, H. & Halder, M., 2014, In : Regulatory Toxicology and Pharmacology. 69, 3, p. 496-511

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Acute Toxicity Tests
Validation Studies
Zebrafish
Toxicity
Embryonic Structures
2013

Effects of endocrine disrupting chemicals on in vitro global DNA methylation and adipocyte differentation

Bastos Sales, L., Kamstra, J. H., Cenijn, P. H., van Rijt, L. S., Hamers, T. & Legler, J., 2013, In : Toxicology in Vitro. 27, 6, p. 1634-1643

Research output: Contribution to JournalArticleAcademicpeer-review

2,4,5,2',4',5'-hexachlorobiphenyl
Endocrine Disruptors
DNA Methylation
Hexachlorobenzene
Adipocytes
2012

Developmental toxicity and endocrine disrupting potency of 4-azapyrene, benzo(b)fluorene and retene in the zebrafish Danio rerio.

Hawliczek, A., Nota, B., Cenijn, P., Kamstra, J., Pieterse, B., Winter, R., Winkens, K., Hollert, H., Segner, H. & Legler, J., 2012, In : Reproductive Toxicology. 33, p. 213-223

Research output: Contribution to JournalArticleAcademicpeer-review

Zebrafish
Toxicity
Microarray Analysis
Microarrays
Polycyclic aromatic hydrocarbons

In vivo measurement of OXPHOS disruption in zebrafish embryos

Legradi, J., Cenijn, P., Carvalho, R., Dahlberg, A-K., Asplund, L., Bergman, A. & Legler, J., 17 Jun 2012, In : Toxicology Letters. 211, p. S118-S118

Research output: Contribution to JournalArticleAcademicpeer-review

Toxicology Letters

Legradi, J. B., Cenijn, P. H., Carvalho, R. P., Dahlberg, A. K., Asplund, L., Bergman, A. & Legler, J., 2012, Volume 211, Supplement, 17. p. S118-S118

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Oxidative Phosphorylation
Toxicology
Zebrafish
Embryonic Structures
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
2011

Development of a polydimethysiloxane film-based passive dosing method in the in vitro DR-CALUX assay

Booij, P., Lamoree, M. H., Leonards, P. E. G., Cenijn, P. H., Klamer, H. J. C., van Vliet, L. A., Akerman, J. & Legler, J., 2011, In : Environmental Toxicology and Chemistry. 30, 4, p. 898-904 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Bioassay
Assays
assay
Biological Assay
bioassay

Effect-Directed Analysis of Municipal Landfill Soil Reveals Novel Developmental Toxicants in the Zebrafish Danio rerio

Legler, J., van Velzen, M. J. M., Cenijn, P. H., Houtman, C. J., Lamoree, M. H. & Wegener, J. W. M., 2011, In : Environmental Science and Technology. 45, 19, p. 8552-8558

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Land fill
Soils
Chemical detection
Impurities
Liquid chromatography

Effects of endocrine disrupting chemicals on global DNA methylation and differentiation using in vitro models

Bastos Sales, L., van Boxtel, A. L., Kamstra, J. H., Cenijn, P. H., van Rijt, L., Hamers, T. H. M. & Legler, J., 2011, In : Organohalogen Compounds. 73, p. 1509-1512 2 p.

Research output: Contribution to JournalArticleAcademicpeer-review

In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl (NDL-PCB) congeners and their relative toxic contribution to PCB-mixtures in humans

Hamers, T. H. M., Kamstra, J. H., Cenijn, P. H., Palkova, L., Simeckova, P., Vondracek, J., Andersson, P. L., Stenberg, M. & Machala, M., 2011, In : Toxicological Sciences. 121, 1, p. 88-100

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Poisons
Polychlorinated Biphenyls
Toxicity
Dioxins
Aryl Hydrocarbon Receptors

Zebrafish as a model for understanding the role of environmental chemicals in obesity

Legler, J., Carvalho, R. P., Cenijn, P. H. & Kamstra, J. H., 2011, In : Organohalogen Compounds. 73, p. 1521-1522

Research output: Contribution to JournalArticleAcademicpeer-review

2010

Dithiocarbamates Induce Craniofacial Abnormalities and Downregulate sox9a during Zebrafish Development

van Boxtel, A. L., Pieterse, B., Cenijn, P., Kamstra, J. H., Brouwer, A. M., van Wieringen, W. N., de Boer, J. & Legler, J., 2010, In : Toxicological Sciences. 117, 1, p. 209-217

Research output: Contribution to JournalArticleAcademicpeer-review

Craniofacial Abnormalities
Zebrafish
Down-Regulation
Genes
Teratogenesis

In vitro assay shows that PCB metabolites completely saturate thyroid hormone transport capacity in blood of wild polar bears (Ursus maritimus)

Gutleb, A. C., Cenijn, P. H., van Velzen, P., Lie, E., Ropstad, E., Skaare, J. U., Malmberg, T., Bergman, A., Gabrielsen, G. W. & Legler, J., 2010, In : Environmental Science and Technology. 44, 8, p. 3149-3154

Research output: Contribution to JournalArticleAcademicpeer-review

Polychlorinated Biphenyls
Metabolites
Thyroid Hormones
Assays
Blood
2008

Effect directed analysis of municipal landfill soil reveals teratogenic compounds in the zebrafish Danio rerio

Legler, J., van Velzen, M. J. M., Cenijn, P. H., de Voogt, P., Houtman, C. J., Lamoree, M. H. & Wegener, J. W. M., 2008, p. 56-56.

Research output: Contribution to ConferenceAbstractOther research output

Effect directed analysis performed on European river sediments with emphasis on the identification of thyroid hormone and androgen disrupting compounds

Weiss, J. M., Cenijn, P. H., Hamers, T., Leonards, P. E. G. & Lamoree, M. H., 2008, Extended Abstracts - SETAC Europe 18th Annual meeting. Brussels: Europe, p. 477-478

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Microarray analysis reveals a mechanism of phenolic polybrominated diphenylether toxicity in zebrafish

van Boxtel, A. L., Kamstra, J. H., Cenijn, P. H., Pieterse, B., Wagner, M. J., Antink, M., Krab, K., van der Burg, B., Marsh, G., Brouwer, A. & Legler, J., 2008, In : Environmental Science and Technology. 42, 5, p. 1773-1779 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Zebrafish
Microarray Analysis
Oxidative Phosphorylation
Electron Transport Complex II
Aquatic Organisms

Update visdiefdataset 2007 en toxicologische profielen van zeehonden

Leonards, P. E. G., van Velzen, M. J. M., Brandsma, S. H., Hopman-Ubbels, G. H. J., van der Veen, I. & Cenijn, P. H., 2008, Amsterdam: Instituut voor Milieuvraagstukken, Vrije Universiteit. (IVM Report; no. W-08/31)

Research output: Book / ReportReportAcademic

2007

Recombinational micro-evolution of functionally different metallothionein promoter alleles from Orchesella cincta

Janssens, T. K. S., Mariën, J., Cenijn, P., Legler, J., van Straalen, N. M. & Roelofs, D., 11 Jun 2007, In : BMC Evolutionary Biology. 7, p. 88

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Orchesella cincta
metallothionein
allele
promoter regions
alleles

Recombinational micro-evolution of functionally different metallothionein promoter alleles from Orchesella cincta.

Janssens, T. K. S., Mariën, A. G. H., Cenijn, P. H., Legler, J., van Straalen, N. M. & Roelofs, D., 2007, In : BMC Evolutionary Biology. 7, p. 88

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Orchesella cincta
metallothionein
allele
promoter regions
alleles
2006

A genomics approach to unravel the mechanisms of developmental toxicity of brominated flame retardants in zebrafish

van Boxtel, A. L., Cenijn, P. H., Kamstra, J. H., Hamers, T., Bergman, Å., Pieterse, B. & Legler, J., 2006.

Research output: Contribution to ConferencePosterOther research output

Expression profiling of zebrafish embryonic fibroblast cells exposed to 6-OH-BDE 47

van Boxtel, A. L., Cenijn, P. H., Kamstra, J. H., Hamers, T. H. M., Bergman, Å., Pieterse, B., Brouwer, A. & Legler, J., 2006.

Research output: Contribution to ConferencePosterOther research output

Prenatal exposure of rats to hydroxylated PCBs and some brominated flame retardants

Buitenhuis, C. J. K., Cenijn, P. H., van Velzen, M. J. M., Lilienthal, H., Malmberg, T., Bergman, Å., Gutleb, A. C., Legler, J. & Brouwer, A., 2006, Amsterdam: Instituut voor Milieuvraagstukken. 7 p. (IVM Report; no. I-06/01)

Research output: Book / ReportReportAcademic

Sample collection and chemical analyses of flounder samples for the FIRE project

Leonards, P. E. G., Booij, P., Brandsma, S., Cenijn, P. H. & van Velzen, M. J. M., 2006, Amsterdam: Dept. of Chemistry and Biology. 17 p. (IVM Report; no. L-06/05)

Research output: Book / ReportReportAcademic

2005

Hepatic T4-glucuronyl transferase activity in rats orally exposed to the brominated flame retardant hexabromocyclododecane (HBCD)

Hamers, T., Hopman-Ubbels, G. H. J. & Cenijn, P. H., 2005, Amsterdam: Dept. of Chemistry and Biology. 18 p. (IVM Report; no. L-05/01)

Research output: Book / ReportReportAcademic

2004

Effects of prenatal exposure to hydroxylated PCB metabolites and some brominated flame retardants on the development of rats

Buitenhuis, C. J. K., Cenijn, P. H., van Velzen, M. J. M., Lilienthal, H., Malmberg, T., Bergman, A., Gutleb, A. C., Legler, J. & Brouwer, A., 2004, In : Organohalogen Compounds. 66, p. 3586-3592 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Toxicological profiling of sediments using in vitro bioassays, with emphasis on endocrine disruption

Houtman, C. J., Cenijn, P. H., Hamers, T., Lamoree, M. H., Legler, J., Murk, A. J. & Brouwer, A., 2004, In : Environmental Toxicology and Chemistry. 23, 1, p. 32-40 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Dioxins
Bioassay
Luciferases
Biological Assay
Toxicology
2002

Determination of the endocrine disrupting potency of hydroxylated PCB's and flame retardants with in vitro bioassays

Legler, J., Cenijn, P. H., Malmberg, T., Bergman, A. & Brouwer, A., 2002, In : Organohalogen Compounds. p. 53-56 4 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat

Meerts, I. A. T. M., Assink, Y., Cenijn, P. H., van den Berg, J. H. J., Weijers, B. M., Bergman, A., Koeman, J. H. & Brouwer, A., 2002, In : Toxicological Sciences. 68, 2, p. 361-371 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Polychlorinated Biphenyls
Thyroid Hormones
Rats
Homeostasis
Mothers
2001

Identification and risk assessment of endocrine disrupting compounds. Part I: toxicity profile measurements in Dutch aquatic sediments

Houtman, C. J., Cenijn, P. H., Hamers, T., Lamoree, M. H., Legler, J. & Brouwer, A., 2001.

Research output: Contribution to ConferencePosterOther research output

2000

Comparison of chemical-activated luciferase gene expression bioassay and gas chromatography for PCB determination in human serum and follicular fluid

Pauwels, A., Cenijn, P. H., Schepens, P. J. & Brouwer, A., 2000, In : Environmental Health Perspectives. 108, 6, p. 553-557

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
1999

Distribution of the flame retardant tetrabromobisphenol A in pregnant and fetal rats and effect of thyroid hormone homeostasis

Meerts, I. A. T. M., Assink, Y., Cenijn, P. H., van den Berg, J. H. J., Bergman, A., Koeman, J. H. & Brouwer, A., 1999, In : Organohalogen Compounds. 40, p. 375-378

Research output: Contribution to JournalArticleAcademicpeer-review