20172019
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Research Output 2017 2019

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Article
2019

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P. C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S. J. & 37 othersBressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M. F., Rotter, J. I., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D. I., Bell, J. T., Demirkan, A. & van Duijn, C. M., 13 Jun 2019, In : Nature Communications. 10, p. 1-11 11 p., 2581.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
homeostasis
insulin
methylation
Methylation
DNA Methylation

Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population

Alemany, S., Jansen, P. R., Muetzel, R. L., Marques, N., El Marroun, H., Jaddoe, V. W. V., Polderman, T. J. C., Tiemeier, H., Posthuma, D. & White, T., 9 Jan 2019, (Accepted/In press) In : Journal of the American Academy of Child and Adolescent Psychiatry. p. 1-8 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Cognition Disorders
Attention Deficit Disorder with Hyperactivity
Psychiatry
Pediatrics
Intelligence

Genetic mapping and evolutionary analysis of human-expanded cognitive networks

Wei, Y., de Lange, S. C., Scholtens, L. H., Watanabe, K., Ardesch, D. J., Jansen, P. R., Savage, J. E., Li, L., Preuss, T. M., Rilling, J. K., Posthuma, D. & van den Heuvel, M. P., 24 Oct 2019, In : Nature Communications. 10, 1, p. 4839

Research output: Contribution to JournalArticleAcademicpeer-review

Brain
Genes
genes
brain
Genetic Loci

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

The 23andMe Research Team, Mar 2019, In : Nature Genetics. 51, 3, p. 394-403 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Sleep Initiation and Maintenance Disorders
Genome
Sleep
Genes
Neurons

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 11 Jun 2019, In : Nature Communications. 10, p. 1-18 18 p., 2548.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
methylation
DNA Methylation
Fetal Blood
blood
Blood

Interaction of schizophrenia polygenic risk and cortisol level on pre-adolescent brain structure

Bolhuis, K., Tiemeier, H., Jansen, P. R., Muetzel, R. L., Neumann, A., Hillegers, M. H. J., van den Akker, E. T. L., van Rossum, E. F. C., Jaddoe, V. W. V., Vernooij, M. W., White, T. & Kushner, S. A., Mar 2019, In : Psychoneuroendocrinology. 101, p. 295-303 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Hydrocortisone
Schizophrenia
Brain
Hair
Neuroimaging

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

eQTLGen Consortium, BIOS Consortium, Boomsma, D. I., Nivard, M., Hottenga, J. J., Pool, R. & van Dongen, J., 24 Jul 2019, In : Nature Communications. 10, 1, 3300.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
genome
Genome-Wide Association Study
Random Allocation
determinants
Genes

Obesity, Brain Volume, and White Matter Microstructure at MRI: A Cross-sectional UK Biobank Study

Dekkers, I. A., Jansen, P. R. & Lamb, H. J., 1 Jun 2019, In : Radiology. 291, 3, p. 763-771 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Adipose Tissue
Obesity
Brain
Anisotropy
Globus Pallidus

Polygenic Scores for Neuropsychiatric Traits and White Matter Microstructure in the Pediatric Population

Jansen, P. R., Muetzel, R. L., Polderman, T. J. C., Jaddoe, V. W., Verhulst, F. C., van der Lugt, A., Tiemeier, H., Posthuma, D. & White, T., Mar 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 3, p. 243-250 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Anisotropy
Intelligence
Pediatrics
Psychiatry
Diffusion Tensor Imaging
2018

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

de Jong, S., Diniz, M. J. A., Saloma, A., Gadelha, A., Santoro, M. L., Ota, V. K., Noto, C., Curtis, C., Newhouse, S. J., Patel, H., Hall, L. S., O`Reilly, P. F., Belangero, S. I., Bressan, R. A., Breen, G. & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, 8 Oct 2018, In : Communications biology. 1, p. 1-10 10 p., 163.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
behavior disorders
Major Depressive Disorder
Bipolar Disorder
Psychiatry
Pedigree

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

Coleman, J. R. I., Bryois, J., Gaspar, H. A., Jansen, P. R., Savage, J. E., Skene, N., Plomin, R., Muñoz-Manchado, A. B., Linnarsson, S., Crawford, G., Hjerling-Leffler, J., Sullivan, P. F., Posthuma, D. & Breen, G., 8 Mar 2018, In : Molecular Psychiatry. 2018, p. 1-16 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genetic Loci
Intelligence
Meta-Analysis
Genome-Wide Association Study
Genes

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Savage, J. E., Jansen, P. R., Stringer, S., Watanabe, K., Bryois, J., de Leeuw, C. A., Nagel, M., Awasthi, S., Barr, P. B., Coleman, J. R. I., Grasby, K. L., Hammerschlag, A. R., Kaminski, J. A., Karlsson, R., Krapohl, E., Lam, M., Nygaard, M., Reynolds, C. A., Trampush, J. W., Young, H. & 97 othersZabaneh, D., Hägg, S., Hansell, N. K., Karlsson, I. K., Linnarsson, S., Montgomery, G. W., Muñoz-Manchado, A. B., Quinlan, E. B., Schumann, G., Skene, N. G., Webb, B. T., White, T., Arking, D. E., Avramopoulos, D., Bilder, R. M., Bitsios, P., Burdick, K. E., Cannon, T. D., Chiba-Falek, O., Christoforou, A., Cirulli, E. T., Congdon, E., Corvin, A., Davies, G., Deary, I. J., DeRosse, P., Dickinson, D., Djurovic, S., Donohoe, G., Conley, E. D., Eriksson, J. G., Espeseth, T., Freimer, N. A., Giakoumaki, S., Giegling, I., Gill, M., Glahn, D. C., Hariri, A. R., Hatzimanolis, A., Keller, M. C., Knowles, E., Koltai, D., Konte, B., Lahti, J., Le Hellard, S., Lencz, T., Liewald, D. C., London, E., Lundervold, A. J., Malhotra, A. K., Melle, I., Morris, D., Need, A. C., Ollier, W., Palotie, A., Payton, A., Pendleton, N., Poldrack, R. A., Räikkönen, K., Reinvang, I., Roussos, P., Rujescu, D., Sabb, F. W., Scult, M. A., Smeland, O. B., Smyrnis, N., Starr, J. M., Steen, V. M., Stefanis, N. C., Straub, R. E., Sundet, K., Tiemeier, H., Voineskos, A. N., Weinberger, D. R., Widen, E., Yu, J., Abecasis, G., Andreassen, O. A., Breen, G., Christiansen, L., Debrabant, B., Dick, D. M., Heinz, A., Hjerling-Leffler, J., Ikram, M. A., Kendler, K. S., Martin, N. G., Medland, S. E., Pedersen, N. L., Plomin, R., Polderman, T. J. C., Ripke, S., van der Sluis, S., Sullivan, P. F., Vrieze, S. I., Wright, M. J. & Posthuma, D., 1 Jul 2018, In : Nature Genetics. 50, 7, p. 912-919 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genome-Wide Association Study
Intelligence
Meta-Analysis
Mendelian Randomization Analysis
Genes

Higher Polygenetic Predisposition for Asthma in Cow's Milk Allergic Children

Jansen, P. R., Petrus, N. C. M., Venema, A., Posthuma, D., Mannens, M. M. A. M., Sprikkelman, A. B. & Henneman, P., Nov 2018, In : Nutrients. 10, 11, p. 1-12 12 p., 1582.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
milk allergy
Milk Hypersensitivity
asthma
Milk
Asthma

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

23Andme Research Team, 1 Jul 2018, In : Nature Genetics. 50, 7, p. 920-927 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Genetic Loci
Genome-Wide Association Study
Meta-Analysis
Mendelian Randomization Analysis
Psychiatry

Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population

Jansen, P. R., Polderman, T. J. C., Bolhuis, K., van der Ende, J., Jaddoe, V. W. V., Verhulst, F. C., White, T., Posthuma, D. & Tiemeier, H., 1 Jan 2018, In : Journal of Child Psychology and Psychiatry. 59, 1, p. 39-47 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Psychiatry
Schizophrenia
Child Behavior
Checklist
Population
2017

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Sniekers, S., Stringer, S., Watanabe, K., Jansen, P. R., Coleman, J. R. I., Krapohl, E., Taskesen, E., Hammerschlag, A. R., Okbay, A., Zabaneh, D., Amin, N., Breen, G., Cesarini, D., Chabris, C. F., Iacono, W. G., Ikram, M. A., Johannesson, M., Koellinger, P., Lee, J. J., Magnusson, P. K. E. & 10 othersMcGue, M., Miller, M. B., Ollier, W. E. R., Payton, A., Pendleton, N., Plomin, R., Rietveld, C. A., Tiemeier, H., van Duijn, C. M. & Posthuma, D., Jul 2017, In : Nature Genetics. 49, 7, p. 1107-1112 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Intelligence
Meta-Analysis
Genes
Single Nucleotide Polymorphism

Incidental Findings on Brain Imaging in the General Pediatric Population

Jansen, P. R., Dremmen, M., van den Berg, A., Dekkers, I. A., Blanken, L. M. E., Muetzel, R. L., Bolhuis, K., Mulder, R. M., Kocevska, D., Jansen, T. A., de Wit, M-C. Y., Neuteboom, R. F., Polderman, T. J. C., Posthuma, D., Jaddoe, V. W. V., Verhulst, F. C., Tiemeier, H., van der Lugt, A. & White, T. J. H., 19 Oct 2017, In : New England Journal of Medicine. 377, 16, p. 1593-1595 3 p.

Research output: Contribution to JournalArticleAcademicpeer-review