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  • 7 Similar Profiles
Histamine H1 Receptors Medicine & Life Sciences
Non-Sedating Histamine H1 Antagonists Medicine & Life Sciences
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Pharmaceutical Preparations Medicine & Life Sciences
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Ligands Medicine & Life Sciences
fexofenadine Medicine & Life Sciences
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Research Output 2016 2019

  • 3 Article
  • 1 Chapter
  • 1 PhD Thesis - Research VU, graduation VU

Drug-receptor binding kinetics in drug discovery: Sticking around at the histamine H1 receptor

Bosma, R., 2019, 177 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
Open Access
Non-Sedating Histamine H1 Antagonists
Histamine H1 Receptors
Pharmaceutical Preparations

BRET-based beta-arrestin2 recruitmanet to the histamine H1 receptor for investigating antihistamine binding kinetics.

Bosma, R., Moritani, R., Leurs, R. & Vischer, H. F., 2016, In : Pharmacological Research. 111, p. 679-687

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H1 Receptors
Histamine Antagonists
Pharmaceutical Preparations

Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.

Kuhne, S., Kooistra, A. J., Bosma, R., Bortolato, A., Wijtmans, M., Vischer, H. F., Mason, J. S., de Graaf, C., de Esch, I. J. P. & Leurs, R., 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9047-9061

Research output: Contribution to JournalArticleAcademicpeer-review

Molecular Aspects of Histamine Receptors

Mocking, T., Bosma, R., Rahman, S. N., Verweij, E. W. E., McNaught-Flores, D. A., Vischer, H. F. & Leurs, R., 2016, Histamine Receptors. Preclinical and clinical aspects.. Blandina, P. & Passani, M. B. (eds.). Humana Press, p. 1-49 (The Receptors; no. 28).

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review