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Fingerprint Dive into the research topics where R. Bosma is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Histamine H1 Receptors Medicine & Life Sciences
Non-Sedating Histamine H1 Antagonists Medicine & Life Sciences
Histamine Antagonists Medicine & Life Sciences
G-Protein-Coupled Receptors Chemical Compounds
Pharmaceutical Preparations Medicine & Life Sciences
Histamine Medicine & Life Sciences
Rate constants Chemical Compounds
Ligands Medicine & Life Sciences

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Research Output 2016 2019

  • 4 Article
  • 1 Chapter
  • 1 PhD Thesis - Research VU, graduation VU

Drug-receptor binding kinetics in drug discovery: Sticking around at the histamine H1 receptor

Bosma, R., 2019, 177 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor

Bosma, R., Stoddart, L. A., Georgi, V., Bouzo-Lorenzo, M., Bushby, N., Inkoom, L., Waring, M. J., Briddon, S. J., Vischer, H. F., Sheppard, R. J., Fernández-Montalván, A., Hill, S. J. & Leurs, R., 1 Dec 2019, In : Scientific Reports. 9, 1, 7906.

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Rate constants
Ligands
Kinetics
Kinetic parameters
Open Access
Non-Sedating Histamine H1 Antagonists
Histamine H1 Receptors
fexofenadine
Pharmaceutical Preparations
Pyrilamine

BRET-based beta-arrestin2 recruitmanet to the histamine H1 receptor for investigating antihistamine binding kinetics.

Bosma, R., Moritani, R., Leurs, R. & Vischer, H. F., 2016, In : Pharmacological Research. 111, p. 679-687

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H1 Receptors
Histamine Antagonists
Histamine
Ligands
Pharmaceutical Preparations

Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.

Kuhne, S., Kooistra, A. J., Bosma, R., Bortolato, A., Wijtmans, M., Vischer, H. F., Mason, J. S., de Graaf, C., de Esch, I. J. P. & Leurs, R., 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9047-9061

Research output: Contribution to JournalArticleAcademicpeer-review