R Haselberg

Emailr.haselberg@vu.nl

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Personal information

I am a senior scientist with a strong background in liquid-phase separation techniques hyphenated to mass spectrometry. I focus on the characterization of biomacromolecules. This means e.g. determining heterogeneity, getting insights in degradation processes, mapping intentional modifications, and studying interactions. In all this research the goal is to keep the protein intact from sample to detector, as this reduces data complexity and minimizes risk of introducing artefacts along the way. As studying these properties of intact proteins is not straightforward, I develop and apply the required advanced hyphenated analytics. All of this is done in the context of biopharmaceutical, clinical, and doping analysis, often in collaboration with companies and other university groups.

Ancillary activities

Capillary electrophoresis user group | Amsterdam | Bestuurder | 2015-01-01 - present
Discussion group Separation methods for Polymers | Amsterdam | Bestuurslid | 2016-08-01 - present
F. Hoffman la Roche | Basel | Adviseur | 2018-04-01 - present
Section Analytical Chemistry | Amsterdam | Bestuurslid | 2018-11-01 - present

Ancillary activities are updated daily

Academic qualification

Analytical Chemistry, PhD, Utrecht University

Apr 2006 → Jun 2010

Award Date: 22 Dec 2010

Analytical Sciences, Master, Vrije Universiteit Amsterdam

Sep 2004 → Apr 2006

Applied Analytical Chemistry , Bachelor, Saxion University of Applied Sciences, Handelskade 75, 7417 DH Deventer

Sep 2000 → Sep 2004

Keywords

QD Chemistry
intact protein analsysis
liquid chromatography
capillary electrophoresis
mass spectrometry
hyphenation
proteoform characterization
biopharmaceuticals

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39 Article
3 Chapter
2 Review article
1 Conference contribution

Asymmetrical flow field-flow fractionation to probe the dynamic association equilibria of β-D-galactosidase
Ventouri, I. K., Astefanei, A., Kaal, E. R., Haselberg, R., Somsen, G. W. & Schoenmakers, P. J., 4 Jan 2021, In: Journal of Chromatography A. 1635, p. 10 10 p., 461719.
Research output: Contribution to Journal › Article › Academic › peer-review

Open Access
Limited lactosylation of beta-lactoglobulin from cow’s milk exerts strong influence on antigenicity and degranulation of mast cells
Bosman, G. P., Oliveira, S., Simons, P. J., Sastre Torano, J., Somsen, G. W., Knippels, L. M. J., Haselberg, R., Pieters, R. J., Garssen, J. & Knipping, K., Jun 2021, In: Nutrients. 13, 6, p. 1-13 13 p., 2041.
Research output: Contribution to Journal › Article › Academic › peer-review

Open Access
Microfluidic ion stripper for removal of trifluoroacetic acid from mobile phases used in HILIC-MS of intact proteins
Wouters, S., Eeltink, S., Haselberg, R., Somsen, G. W. & Gargano, A. F. G., 1 Jul 2021, In: Analytical and Bioanalytical Chemistry. 413, 17, p. 4379-4386
Research output: Contribution to Journal › Article › Academic › peer-review

Open Access
Probing Polyester Branching by Hybrid Trapped Ion-Mobility Spectrometry-Tandem Mass Spectrometry
Voeten, R. L. C., Van De Put, B., Jordens, J., Mengerink, Y., Peters, R. A. H., Haselberg, R. & Somsen, G. W., 2 Jun 2021, In: Journal of the American Society for Mass Spectrometry. 32, 6, p. 1498-1507
Research output: Contribution to Journal › Article › Academic › peer-review

Open Access
NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods
De Leoz, M. L. A., Duewer, D. L., Fung, A., Liu, L., Yau, H. K., Potter, O., Staples, G. O., Furuki, K., Frenkel, R., Hu, Y., Sosic, Z., Zhang, P., Altmann, F., Gru Nwald-Grube, C., Shao, C., Zaia, J., Evers, W., Pengelley, S., Suckau, D., Wiechmann, A. & 142 others, Resemann, A., Jabs, W., Beck, A., Froehlich, J. W., Huang, C., Li, Y., Liu, Y., Sun, S., Wang, Y., Seo, Y., An, H. J., Reichardt, N. C., Ruiz, J. E., Archer-Hartmann, S., Azadi, P., Bell, L., Lakos, Z., An, Y., Cipollo, J. F., Pucic-Bakovic, M., Štambuk, J., Lauc, G., Li, X., Wang, P. G., Bock, A., Hennig, R., Rapp, E., Creskey, M., Cyr, T. D., Nakano, M., Sugiyama, T., Leung, P. K. A., Link-Lenczowski, P., Jaworek, J., Yang, S., Zhang, H., Kelly, T., Klapoetke, S., Cao, R., Kim, J. Y., Lee, H. K., Lee, J. Y., Yoo, J. S., Kim, S. R., Suh, S. K., de Haan, N., Falck, D., Lageveen-Kammeijer, G. S. M., Wuhrer, M., Emery, R. J., Kozak, R. P., Liew, L. P., Royle, L., Urbanowicz, P. A., Packer, N. H., Song, X., Everest-Dass, A., Lattová, E., Cajic, S., Alagesan, K., Kolarich, D., Kasali, T., Lindo, V., Chen, Y., Goswami, K., Gau, B., Amunugama, R., Jones, R., Stroop, C. J. M., Kato, K., Yagi, H., Kondo, S., Yuen, C. T., Harazono, A., Shi, X., Magnelli, P. E., Kasper, B. T., Mahal, L., Harvey, D. J., O'Flaherty, R., Rudd, P. M., Saldova, R., Hecht, E. S., Muddiman, D. C., Kang, J., Bhoskar, P., Menard, D., Saati, A., Merle, C., Mast, S., Tep, S., Truong, J., Nishikaze, T., Sekiya, S., Shafer, A., Funaoka, S., Toyoda, M., de Vreugd, P., Caron, C., Pradhan, P., Tan, N. C., Mechref, Y., Patil, S., Rohrer, J. S., Chakrabarti, R., Dadke, D., Lahori, M., Zou, C., Cairo, C., Reiz, B., Whittal, R. M., Lebrilla, C. B., Wu, L., Guttman, A., Szigeti, M., Kremkow, B. G., Lee, K. H., Sihlbom, C., Adamczyk, B., Jin, C., Karlsson, N. G., Örnros, J., Larson, G., Nilsson, J., Meyer, B., Wiegandt, A., Komatsu, E., Perreault, H., Bodnar, E. D., Said, N., Francois, Y. N., Leize-Wagner, E., Maier, S., Zeck, A., Heck, A. J. R., Yang, Y., Haselberg, R., Yu, Y. Q., Alley, W., Leone, J. W., Yuan, H. & Stein, S. E., 1 Jan 2020, In: MCP : Molecular & cellular proteomics. 19, 1, p. 11-30 20 p.
Research output: Contribution to Journal › Article › Academic › peer-review

Open Access

dr. R Haselberg

Personal profile

Personal information

Ancillary activities

Academic qualification

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Dive into details

Asymmetrical flow field-flow fractionation to probe the dynamic association equilibria of β-D-galactosidase

Limited lactosylation of beta-lactoglobulin from cow’s milk exerts strong influence on antigenicity and degranulation of mast cells

Microfluidic ion stripper for removal of trifluoroacetic acid from mobile phases used in HILIC-MS of intact proteins

Probing Polyester Branching by Hybrid Trapped Ion-Mobility Spectrometry-Tandem Mass Spectrometry

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

dr. R Haselberg

Personal profile

Personal information

Ancillary activities

Academic qualification

Keywords

Fingerprint

Network

Research output

Asymmetrical flow field-flow fractionation to probe the dynamic association equilibria of β-D-galactosidase

Limited lactosylation of beta-lactoglobulin from cow’s milk exerts strong influence on antigenicity and degranulation of mast cells

Microfluidic ion stripper for removal of trifluoroacetic acid from mobile phases used in HILIC-MS of intact proteins

Probing Polyester Branching by Hybrid Trapped Ion-Mobility Spectrometry-Tandem Mass Spectrometry

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods