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Personal profile

Personal information

I am an all-round analytical chemist with a strong background in capillary electrophoresis and liquid chromatography hyphenated with mass spectrometry. I use these technologies to characterize intact proteins. This ranges from proteins as small as insulin up to large protein complexes. I am interested in determining protein heterogeneity, getting insights in degradation processes, mapping intentional modifications and studying protein-protein interactions. Recently, my first personal research project was granted in which I will also focus on the bioanalysis of proteins.

In all this research the goal is to keep the protein intact from sample to detector, as this reduces data complexity and minimizes risk of introducing artefacts along the way. As studying these properties of intact proteins is not straightforward, I develop and apply the required advanced hyphenated analytics. All of this is done in the context of biopharmaceutical, clinical, and doping analysis, often in collaboration with companies and other university groups. 

Ancillary activities

  • Discussion group Separation methods for Polymers | Amsterdam | Board member | 2016-08-01

Ancillary activities are updated daily

Education/Academic qualification

Analytical Chemistry, PhD, Utrecht University

Apr 2006Jun 2010

Analytical Sciences, Master, Vrije Universiteit Amsterdam

Sep 2004Apr 2006

Applied Analytical Chemistry , Bachelor, Saxion University of Applied Sciences, Handelskade 75, 7417 DH Deventer

Sep 2000Sep 2004

Keywords

  • QD Chemistry
  • intact protein analsysis
  • liquid chromatography
  • capillary electrophoresis
  • mass spectrometry
  • hyphenation
  • proteoform characterization
  • biopharmaceuticals

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 2006 2018

  • 27 Article
  • 2 Chapter
  • 2 Review article
  • 1 Conference contribution

Capillary Electrophoresis: Trends and Recent Advances

Voeten, R. L. C., Ventouri, I. K., Haselberg, R. & Somsen, G. W. 6 Feb 2018 In : Analytical Chemistry. 90, 3, p. 1464-1481 18 p.

Research output: Contribution to journalReview article

Development of a capillary zone electrophoresis method to quantify E. coli L-asparaginase and its acidic variants

Yao, H., Vandenbossche, J., Sänger-van de Griend, C. E., Janssens, Y., Fernández, C. S., Xu, X., Wynendaele, E., Somsen, G. W., Haselberg, R. & De Spiegeleer, B. 15 May 2018 In : Talanta. 182, p. 83-91 9 p.

Research output: Contribution to journalArticle

Asparaginase
Electrophoresis
Escherichia coli
Electrolytes
Recovery

Development of a surface plasmon resonance sensor for coupling to capillary electrophoresis allowing affinity assessment of protein mixture components

Domínguez-Vega, E., Haselberg, R., Iperen, D. V., Kool, J., Somsen, G. W. & de Jong, G. J. 1 Jan 2018 In : Sensors and Actuators B-Chemical. 254, p. 1040-1047 8 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Surface plasmon resonance
electrophoresis
surface plasmon resonance
affinity

High-resolution glycoform profiling of intact therapeutic proteins by hydrophilic interaction chromatography-mass spectrometry

Domínguez-Vega, E., Tengattini, S., Peintner, C., van Angeren, J., Temporini, C., Haselberg, R., Massolini, G. & Somsen, G. W. Jul 2018 In : Talanta. 184, July, p. 375-381 7 p.

Research output: Contribution to journalArticle

Chromatography
Mass spectrometry
Liquid chromatography
Erythropoietin
Glycosylation

A Novel Platinum(II)-Based Bifunctional ADC Linker Benchmarked Using Zr-89-Desferal and Auristatin F-Conjugated Trastuzumab

Sijbrandi, N. J., Merkul, E., Muns, J. A., Waalboer, D. C. J., Adamzek, K., Bolijn, M., Montserrat, V., Somsen, G. W., Haselberg, R., Steverink, P. J. G. M., Houthoff, H-J. & van Dongen, G. A. M. S. 15 Jan 2017 In : Cancer Research. 77, 2, p. 257-267

Research output: Contribution to journalArticle