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Personal profile

Personal information

I am an all-round analytical chemist with a strong background in capillary electrophoresis and liquid chromatography hyphenated with mass spectrometry. I use these technologies to characterize intact proteins. This ranges from proteins as small as insulin up to large protein complexes. I am interested in determining protein heterogeneity, getting insights in degradation processes, mapping intentional modifications and studying protein-protein interactions. Recently, my first personal research project was granted in which I will also focus on the bioanalysis of proteins.

In all this research the goal is to keep the protein intact from sample to detector, as this reduces data complexity and minimizes risk of introducing artefacts along the way. As studying these properties of intact proteins is not straightforward, I develop and apply the required advanced hyphenated analytics. All of this is done in the context of biopharmaceutical, clinical, and doping analysis, often in collaboration with companies and other university groups. 

Ancillary activities

  • Capillary electrophoresis user group | Amsterdam | Bestuurder | 2015-01-01 - present
  • Discussion group Separation methods for Polymers | Amsterdam | Board member | 2016-08-01 - present
  • F. Hoffman la Roche | Basel | Adviseur | 2018-04-01 - present
  • Section Analytical Chemistry | Amsterdam | Board member | 2018-11-01 - present

Ancillary activities are updated daily

Education/Academic qualification

Analytical Chemistry, PhD, Utrecht University

Apr 2006Jun 2010

Analytical Sciences, Master, Vrije Universiteit Amsterdam

Sep 2004Apr 2006

Applied Analytical Chemistry , Bachelor, Saxion University of Applied Sciences, Handelskade 75, 7417 DH Deventer

Sep 2000Sep 2004

Keywords

  • QD Chemistry
  • intact protein analsysis
  • liquid chromatography
  • capillary electrophoresis
  • mass spectrometry
  • hyphenation
  • proteoform characterization
  • biopharmaceuticals

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 6 Similar Profiles
Capillary electrophoresis Chemical Compounds
Mass spectrometry Chemical Compounds
Capillary Electrophoresis Medicine & Life Sciences
Proteins Chemical Compounds
Single-Domain Antibodies Chemical Compounds
Mass Spectrometry Medicine & Life Sciences
Liquid chromatography Chemical Compounds
Glycosylation Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2006 2019

  • 30 Article
  • 3 Chapter
  • 3 Review article
  • 1 Conference contribution
Hydrophobic and Hydrophilic Interactions
Liquid chromatography
Liquid Chromatography
Glycoproteins
Liquids

Experimental design and measurement uncertainty in ligand binding studies by affinity capillary electrophoresis

Stein, M., Haselberg, R., Mozafari-Torshizi, M. & Wätzig, H., 14 Jan 2019, In : Electrophoresis. p. 1-14

Research output: Contribution to JournalArticleAcademicpeer-review

Capillary electrophoresis
Capillary Electrophoresis
Design of experiments
Uncertainty
Research Design

Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing

Lakayan, D., Haselberg, R., Gahoual, R., Somsen, G. W. & Kool, J., 1 Dec 2018, In : Analytical and Bioanalytical Chemistry. 410, 30, p. 7837-7848 12 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Drug Compounding
Surface Plasmon Resonance
Liquid chromatography
Surface plasmon resonance
Liquid Chromatography

Capillary Electrophoresis: Trends and Recent Advances

Voeten, R. L. C., Ventouri, I. K., Haselberg, R. & Somsen, G. W., 6 Feb 2018, In : Analytical Chemistry. 90, 3, p. 1464-1481 18 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access

Development of a capillary zone electrophoresis method to quantify E. coli L-asparaginase and its acidic variants

Yao, H., Vandenbossche, J., Sänger-van de Griend, C. E., Janssens, Y., Fernández, C. S., Xu, X., Wynendaele, E., Somsen, G. W., Haselberg, R. & De Spiegeleer, B., 15 May 2018, In : Talanta. 182, p. 83-91 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Asparaginase
Electrophoresis
Escherichia coli
Electrolytes
Recovery