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dr. R Haselberg

    20062020

    Research output per year

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    Personal profile

    Personal information

    I am an all-round analytical chemist with a strong background in capillary electrophoresis and liquid chromatography hyphenated with mass spectrometry. I use these technologies to characterize intact proteins. This ranges from proteins as small as insulin up to large protein complexes. I am interested in determining protein heterogeneity, getting insights in degradation processes, mapping intentional modifications and studying protein-protein interactions. Recently, my first personal research project was granted in which I will also focus on the bioanalysis of proteins.

    In all this research the goal is to keep the protein intact from sample to detector, as this reduces data complexity and minimizes risk of introducing artefacts along the way. As studying these properties of intact proteins is not straightforward, I develop and apply the required advanced hyphenated analytics. All of this is done in the context of biopharmaceutical, clinical, and doping analysis, often in collaboration with companies and other university groups. 

    Ancillary activities

    • Capillary electrophoresis user group | Amsterdam | Bestuurder | 2015-01-01 - present
    • Discussion group Separation methods for Polymers | Amsterdam | Board member | 2016-08-01 - present
    • F. Hoffman la Roche | Basel | Adviseur | 2018-04-01 - present
    • Section Analytical Chemistry | Amsterdam | Board member | 2018-11-01 - present

    Ancillary activities are updated daily

    Academic qualification

    Analytical Chemistry, PhD, Utrecht University

    Apr 2006Jun 2010

    Award Date: 22 Dec 2010

    Analytical Sciences, Master, Vrije Universiteit Amsterdam

    Sep 2004Apr 2006

    Applied Analytical Chemistry , Bachelor, Saxion University of Applied Sciences, Handelskade 75, 7417 DH Deventer

    Sep 2000Sep 2004

    Keywords

    • QD Chemistry
    • intact protein analsysis
    • liquid chromatography
    • capillary electrophoresis
    • mass spectrometry
    • hyphenation
    • proteoform characterization
    • biopharmaceuticals

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