Reggie Bosma

mr.

20162019
If you made any changes in Pure these will be visible here soon.

Research Output 2016 2019

  • 5 Article
  • 1 Chapter
  • 1 PhD Thesis - Research VU, graduation VU
Filter
Article
2019

Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor

Bosma, R., Stoddart, L. A., Georgi, V., Bouzo-Lorenzo, M., Bushby, N., Inkoom, L., Waring, M. J., Briddon, S. J., Vischer, H. F., Sheppard, R. J., Fernández-Montalván, A., Hill, S. J. & Leurs, R., 1 Dec 2019, In : Scientific Reports. 9, 1, 7906.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
G-Protein-Coupled Receptors
Rate constants
Ligands
Kinetics
Kinetic parameters

Route to prolonged residence time at the histamine H1 receptor: Growing from desloratadine to rupatadine

Bosma, R., Wang, Z., Kooistra, A. J., Bushby, N., Kuhne, S., Van Den Bor, J., Waring, M. J., De Graaf, C., De Esch, I. J., Vischer, H. F., Sheppard, R. J., Wijtmans, M. & Leurs, R., 25 Jul 2019, In : Journal of Medicinal Chemistry. 62, 14, p. 6630-6644 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H1 Receptors
Pharmaceutical Preparations
Amines
Ligands
rupatadine
2018
Open Access
Non-Sedating Histamine H1 Antagonists
Histamine H1 Receptors
fexofenadine
Pharmaceutical Preparations
Pyrilamine
2016

BRET-based beta-arrestin2 recruitmanet to the histamine H1 receptor for investigating antihistamine binding kinetics.

Bosma, R., Moritani, R., Leurs, R. & Vischer, H. F., 2016, In : Pharmacological Research. 111, p. 679-687

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H1 Receptors
Histamine Antagonists
Histamine
Ligands
Pharmaceutical Preparations

Identification of ligand binding hot spots of the histamine H1 receptor following structure-based fragment optimization.

Kuhne, S., Kooistra, A. J., Bosma, R., Bortolato, A., Wijtmans, M., Vischer, H. F., Mason, J. S., de Graaf, C., de Esch, I. J. P. & Leurs, R., 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 9047-9061

Research output: Contribution to JournalArticleAcademicpeer-review