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René Pool

dr.

20092019
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Research Output 2009 2019

A linear mixed-model approach to study multivariate gene-environment interactions

BIOS Consortium, 't Hoen, P. A. , van Meurs, J. B. J. , Isaacs, A. , Jansen, R. , Franke, L. , Boomsma, D. I. , Pool, R. , van Dongen, J. , Hottenga, J. J. , Van Greevenbroek, M. J. , Stehouwer, C. D. A. , van der Kallen, C. J. H. , Schalkwijk, C. G. , Wijmenga, C. , Zhernakova, A. , Tigchelaar, E. F. , Slagboom, P. E. , Beekman, M. , Deelen, J. & 30 others van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M., van Galen, M., Bot, J., van’t Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Zhernakova, D. V., Luijk, R., Jan Bonder, M., van Dijk, F., Arindrarto, W., Kielbasa, P. S. M., Swertz, M. A. & van Zwet, E. W., Jan 2019, In : Nature Genetics. 51, 1, p. 180-186 7 p.

Research output: Contribution to Journal › Article › Academic › peer-review

Gene-Environment Interaction
Linear Models
Body Mass Index
Genotype
Diet

A SNP panel for identification of DNA and RNA specimens

Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van 't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P., 't Hoen, P. A. C., BIOS consortium, Boomsma, D. I., van Dongen, J., Hottenga, J. J. & Pool, R., 25 Jan 2018, In : BMC Genomics. 19, 1, p. 90

Research output: Contribution to Journal › Article › Academic › peer-review

Open Access
Single Nucleotide Polymorphism
RNA
DNA
Genotype
RNA Sequence Analysis

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

BIOS Consortium, Luijk, R. , Wu, H. , Ward-Caviness, C. K. , Hannon, E. , Carnero-Montoro, E. , Min, J. L. , Mandaviya, P. , Müller-Nurasyid, M. , Mei, H. , van der Maarel, S. M. , Beekman, M. , der Breggen, R. V. , Deelen, J. , Lakenberg, N. , Moed, M. , Suchiman, H. E. D. , Arindrarto, W. , van’t Hof, P. , Jan Bonder, M. & 32 others Deelen, P., Tigchelaar, E. F., Zhernakova, A., Zhernakova, D. V., van Dongen, J., Hottenga, J. J., Pool, R., Isaacs, A., Hofman, B. A., Jhamai, M., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., van den Berg, L. H., van Galen, M., Vermaat, M., van Rooij, J., Uitterlinden, A. G., Verbiest, M., Verkerk, M., Kielbasa, P. S. M., Bot, J., Nooren, I., van Dijk, F., Swertz, M. A., van Heemst, D., Relton, C., Mill, J., Waldenberger, M., Bell, J. T., Jansen, R. & Boomsma, D. I., 14 Sep 2018, In : Nature Communications. 9, 1, p. 1-9 9 p., 3738

Research output: Contribution to Journal › Article › Academic › peer-review

Open Access
X Chromosome Inactivation
methylation
chromosomes
DNA Methylation
Chromosomes

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

van der Lee, S. J. , Teunissen, C. E. , Pool, R. , Shipley, M. J. , Teumer, A. , Chouraki, V. , Melo van Lent, D. , Tynkkynen, J. , Fischer, K. , Hernesniemi, J. , Haller, T. , Singh-Manoux, A. , Verhoeven, A. , Willemsen, G. , de Leeuw, F. A. , Wagner, H. , van Dongen, J. , Hertel, J. , Budde, K. , Willems van Dijk, K. & 28 others Weinhold, L., Ikram, M. A., Pietzner, M., Perola, M., Wagner, M., Friedrich, N., Slagboom, P. E., Scheltens, P., Yang, Q., Gertzen, R. E., Egert, S., Li, S., Hankemeier, T., van Beijsterveldt, C. E. M., Vasan, R. S., Maier, W., Peeters, C. F. W., Jörgen Grabe, H., Ramirez, A., Seshadri, S., Metspalu, A., Kivimäki, M., Salomaa, V., Demirkan, A., Boomsma, D. I., van der Flier, W. M., Amin, N. & van Duijn, C. M., Jun 2018, In : Alzheimers & Dementia. 14, 6, p. 707-722 16 p.

Research output: Contribution to Journal › Article › Academic › peer-review

Aptitude
Cognition
Dementia
Cohort Studies
Life Style

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

LifeLines Cohort Study & CHARGE Inflammation Working Group, 1 Nov 2018, In : American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to Journal › Article › Academic › peer-review

C-Reactive Protein
Genome
Inflammation
Mendelian Randomization Analysis
Genome-Wide Association Study