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Research Output 2009 2019

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Article
2019

A linear mixed-model approach to study multivariate gene-environment interactions

't Hoen, P. A., van Meurs, J. B. J., Isaacs, A., Jansen, R., Franke, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, A., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D. & 30 othersVeldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M., van Galen, M., Bot, J., van’t Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Zhernakova, D. V., Luijk, R., Jan Bonder, M., van Dijk, F., Arindrarto, W., Kielbasa, P. S. M., Swertz, M. A., van Zwet, E. W. & BIOS Consortium, Jan 2019, In : Nature Genetics. 51, 1, p. 180-186 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Gene-Environment Interaction
Linear Models
Genotype
Body Mass Index
Diet

A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms

The EAGLE-ADHD Consortium, 18 Jan 2019, In : Behavior Genetics. p. 1-16 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
Impulsive Behavior
Single Nucleotide Polymorphism
Meta-Analysis
signs and symptoms (animals and humans)
meta-analysis

Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool

Odintsova, V. V., Roetman, P. J., Ip, H. F., Pool, R., Van der Laan, C. M., Tona, K. D., Vermeiren, R. R. J. M. & Boomsma, D. I., 1 Oct 2019, In : Psychiatric genetics. 29, 5, p. 170-190 21 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Genomics
Aggression
Genome-Wide Association Study
Genome
Attention Deficit and Disruptive Behavior Disorders

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

BBMRI Metabolomics Consortium, 16 Apr 2019, In : Neurology. 92, 16, p. e1899-e1911 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolome
HDL Lipoproteins
Migraine Disorders
Metabolomics
Omega-3 Fatty Acids

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

eQTLGen Consortium, BIOS Consortium, Boomsma, D. I., Nivard, M., Hottenga, J. J., Pool, R. & van Dongen, J., 24 Jul 2019, In : Nature Communications. 10, 1, 3300.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
genome
Genome-Wide Association Study
Random Allocation
determinants
Genes

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., Isaacs, A. & 19 othersMedland, S. E., Montgomery, G. W., Mooijaart, S. P., Strauch, K., Suchiman, H. E. D., Vaarhorst, A. A. M., van Heemst, D., Wang-Sattler, R., Whitfield, J. B., Willemsen, G., Wright, M. J., Martin, N. G., Samani, N. J., Metspalu, A., Eline Slagboom, P., Spector, T. D., Boomsma, D. I., van Duijn, C. M. & Gieger, C., 12 Aug 2019, In : Scientific Reports. 9, 1, p. 11623

Research output: Contribution to JournalArticleAcademicpeer-review

Metabolomics
Telomere
Homocysteine
Lipid Metabolism
Leukocytes

Skewed X-inactivation is common in the general female population

Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Willemsen, G. & BIOS Consortium, Mar 2019, In : European Journal of Human Genetics. 27, 3, p. 455-465 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
X Chromosome Inactivation
X Chromosome
Population
Genes
Alleles
2018

A SNP panel for identification of DNA and RNA specimens

Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van 't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P., 't Hoen, P. A. C., BIOS consortium, Boomsma, D. I., van Dongen, J., Hottenga, J. J. & Pool, R., 25 Jan 2018, In : BMC Genomics. 19, 1, p. 90

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Single Nucleotide Polymorphism
RNA
DNA
Genotype
RNA Sequence Analysis

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

Luijk, R., Wu, H., Ward-Caviness, C. K., Hannon, E., Carnero-Montoro, E., Min, J. L., Mandaviya, P., Müller-Nurasyid, M., Mei, H., van der Maarel, S. M., Beekman, M., der Breggen, R. V., Deelen, J., Lakenberg, N., Moed, M., Suchiman, H. E. D., Arindrarto, W., van’t Hof, P., Jan Bonder, M., Deelen, P. & 32 othersTigchelaar, E. F., Zhernakova, A., Zhernakova, D. V., van Dongen, J., Hottenga, J. J., Pool, R., Isaacs, A., Hofman, B. A., Jhamai, M., van der Kallen, C. J. H., Schalkwijk, C. G., Stehouwer, C. D. A., van den Berg, L. H., van Galen, M., Vermaat, M., van Rooij, J., Uitterlinden, A. G., Verbiest, M., Verkerk, M., Kielbasa, P. S. M., Bot, J., Nooren, I., van Dijk, F., Swertz, M. A., van Heemst, D., Relton, C., Mill, J., Waldenberger, M., Bell, J. T., Jansen, R., Boomsma, D. I. & BIOS Consortium, 14 Sep 2018, In : Nature Communications. 9, 1, p. 1-9 9 p., 3738.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
X Chromosome Inactivation
methylation
chromosomes
DNA Methylation
Chromosomes

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., Haller, T., Singh-Manoux, A., Verhoeven, A., Willemsen, G., de Leeuw, F. A., Wagner, H., van Dongen, J., Hertel, J., Budde, K., Willems van Dijk, K. & 28 othersWeinhold, L., Ikram, M. A., Pietzner, M., Perola, M., Wagner, M., Friedrich, N., Slagboom, P. E., Scheltens, P., Yang, Q., Gertzen, R. E., Egert, S., Li, S., Hankemeier, T., van Beijsterveldt, C. E. M., Vasan, R. S., Maier, W., Peeters, C. F. W., Jörgen Grabe, H., Ramirez, A., Seshadri, S., Metspalu, A., Kivimäki, M., Salomaa, V., Demirkan, A., Boomsma, D. I., van der Flier, W. M., Amin, N. & van Duijn, C. M., Jun 2018, In : Alzheimers & Dementia. 14, 6, p. 707-722 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Aptitude
Cognition
Dementia
Cohort Studies
Life Style

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

LifeLines Cohort Study & CHARGE Inflammation Working Group, 1 Nov 2018, In : American Journal of Human Genetics. 103, 5, p. 691-706 16 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
C-Reactive Protein
Genome
Inflammation
Mendelian Randomization Analysis
Genome-Wide Association Study

Genome-wide identification of directed gene networks using large-scale population genomics data

BIOS (Biobank-based Integrative Omics Study) Consortium, 6 Aug 2018, In : Nature Communications. 9, p. 1-10 10 p., 3097.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metagenomics
genome
Gene Regulatory Networks
genes
Genes

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

Molnos, S., Wahl, S., Haid, M., Eekhoff, E. M. W., Pool, R., Floegel, A., Deelen, J., Much, D., Prehn, C., Breier, M., Draisma, H. H., van Leeuwen, N., Simonis-Bik, A. M. C., Jonsson, A., Willemsen, G., Bernigau, W., Wang-Sattler, R., Suhre, K., Peters, A., Thorand, B. & 24 othersHerder, C., Rathmann, W., Roden, M., Gieger, C., Kramer, M. H. H., van Heemst, D., Pedersen, H. K., Gudmundsdottir, V., Schulze, M. B., Pischon, T., de Geus, E. J. C., Boeing, H., Boomsma, D. I., Ziegler, A. G., Slagboom, P. E., Hummel, S., Beekman, M., Grallert, H., Brunak, S., McCarthy, M. I., Gupta, R., Pearson, E. R., Adamski, J. & 't Hart, L. M., 1 Jan 2018, In : Diabetologia. 61, 1, p. 117-129 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Type 2 Diabetes Mellitus
Glucose Tolerance Test
Biomarkers
Glucagon-Like Peptide 1
Arginine
2017

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

de Vries, P. S., Sabater-Lleal, M., Chasman, D. I., Trompet, S., Ahluwalia, T. S., Teumer, A., Kleber, M. E., Chen, M-H., Wang, J. J., Attia, J. R., Marioni, R. E., Steri, M., Weng, L-C., Pool, R., Grossmann, V., Brody, J. A., Venturini, C., Tanaka, T., Rose, L. M., Oldmeadow, C. & 66 othersMazur, J., Basu, S., Frånberg, M., Yang, Q., Ligthart, S., Hottenga, J. J., Rumley, A., Mulas, A., De Craen, A. J. M., Grotevendt, A., Taylor, K. D., Delgado, G. E., Kifley, A., Lopez, L. M., Berentzen, T. L., Mangino, M., Bandinelli, S., Morrison, A. C., Hamsten, A., Tofler, G., de Maat, M. P. M., Draisma, H. H. M., Lowe, G. D., Zoledziewska, M., Sattar, N., Lackner, K. J., Völker, U., McKnight, B., Huang, J., Holliday, E. G., McEvoy, M. A., Starr, J. M., Hysi, P. G., Hernandez, D. G., Guan, W., Rivadeneira, F., McArdle, W. L., Slagboom, P. E., Zeller, T., Psaty, B. M., Uitterlinden, A. G., de Geus, E. J. C., Stott, D. J., Binder, H., Hofman, A., Franco, O. H., Rotter, J. I., Ferrucci, L., Spector, T. D., Deary, I. J., März, W., Greinacher, A., Wild, P. S., Cucca, F., Boomsma, D. I., Watkins, H., Tang, W., Ridker, P. M., Jukema, J. W., Scott, R. J., Mitchell, P., Hansen, T., O'Donnell, C. J., Smith, N. L., Strachan, D. P. & Dehghan, A., 20 Jan 2017, In : PLoS ONE. 12, 1, p. e0167742

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
HapMap Project
Genome-Wide Association Study
Genes
Genome
loci

Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

van Iterson, M., van Zwet, E. W., Heijmans, B. T., ’t Hoen, P. A. C., van Meurs, J. B. J., Jansen, R., Franke, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Eline Slagboom, P., Beekman, M. & 31 othersDeelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Isaacs, A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Galen, M., Bot, J., Zhernakova, D. V., van 't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Luijk, R., Bonder, M. J., van Dijk, F., Arindrarto, W., Kielbasa, S. M., Swertz, M. A. & 't Hoen, P. B., 27 Jan 2017, In : Genome Biology. 18, 1, 19.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
inflation
Economic Inflation
Transcriptome
transcriptome
Social Adjustment

Disease variants alter transcription factor levels and methylation of their binding sites

Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., van Iterson, M., van Dijk, F., van Galen, M., Bot, J., Slieker, R. C., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Arindrarto, W., Kielbasa, S. M. & 31 othersJonkers, I., van 't Hof, P., Nooren, I., Beekman, M., Deelen, J., van Heemst, D., Zhernakova, A., Tigchelaar, E. F., Swertz, M. A., Hofman, A., Uitterlinden, A. G., Pool, R., van Dongen, J., Hottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., van den Berg, L. H., van Zwet, E. W., Mei, H., Li, Y., Lemire, M., Hudson, T. J., Slagboom, P. E., Wijmenga, C., Veldink, J. H., Van Greevenbroek, M. J., van Duijn, C. M., Boomsma, D. I., Isaacs, A. & BIOS Consortium, Jan 2017, In : Nature Genetics. 49, 1, p. 131-138 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Methylation
Transcription Factors
Binding Sites
DNA Methylation
Single Nucleotide Polymorphism

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

Richard, M. A., Huan, T., Ligthart, S., Gondalia, R., Jhun, M. A., Brody, J. A., Irvin, M. R., Marioni, R., Shen, J., Tsai, P-C., Montasser, M. E., Jia, Y., Syme, C., Salfati, E. L., Boerwinkle, E., Guan, W., Mosley, T. H., Bressler, J., Morrison, A. C., Liu, C. & 31 othersMendelson, M. M., Uitterlinden, A. G., van Meurs, J. B., Franco, O. H., Zhang, G., Li, Y., Stewart, J. D., Bis, J. C., Psaty, B. M., Chen, Y-D. I., Kardia, S. L. R., Zhao, W., Turner, S. T., Absher, D., Aslibekyan, S., Starr, J. M., McRae, A. F., Hou, L., Just, A. C., Schwartz, J. D., Vokonas, P. S., Menni, C., Spector, T. D., Shuldiner, A., Damcott, C. M., Rotter, J. I., BIOS Consortium, Boomsma, D. I., Pool, R., van Dongen, J. & Hottenga, J. J., 7 Dec 2017, In : American Journal of Human Genetics. 101, 6, p. 888-902 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
DNA Methylation
Blood Pressure
Methylation
Gene Expression
Mendelian Randomization Analysis

Identification of context-dependent expression quantitative trait loci in whole blood

Zhernakova, D. V., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H-J., Bonder, M. J., van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R., van Dongen, J. & 27 othersHottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Zhernakova, A., Li, Y., Tigchelaar, E. F., de Klein, N., Beekman, M., Deelen, J., van Heemst, D., van den Berg, L. H., Hofman, A., Uitterlinden, A. G., Van Greevenbroek, M. J., Veldink, J. H., Boomsma, D. I., van Duijn, C. M., Wijmenga, C., Slagboom, P. E., Swertz, M. A., Isaacs, A., van Meurs, J. B. J., Jansen, R., Heijmans, B. T., ’t Hoen, P. A. C. & Franke, L., Jan 2017, In : Nature Genetics. 49, 1, p. 139-145 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Quantitative Trait Loci
Interferon Type I
Genetic Association Studies
Single Nucleotide Polymorphism
Transcription Factors

Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis

Minicã, C. C., Mbarek, H., Pool, R., Dolan, C. V., Boomsma, D. I. & Vink, J. M., Jan 2017, In : Molecular Psychiatry. 22, 1, p. 82-88 7 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Tobacco
Meta-Analysis
Smoking
Genes
Untranslated RNA

The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples

Minică, C. C., Genovese, G., Hultman, C. M., Pool, R., Vink, J. M., Neale, M. C., Dolan, C. V. & Neale, B. M., Apr 2017, In : Twin Research and Human Genetics. 20, 2, p. 108-118 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Weights and Measures
Exome
Schizophrenia
Gene Frequency
Power (Psychology)
2016

Discovery of Biochemical Biomarkers for Aggression: A Role for Metabolomics in Psychiatry

Hagenbeek, F. A., Kluft, C., Hankemeier, T., Bartels, M., Draisma, H. H. M., Middeldorp, C. M., Berger, R., Noto, A., Lussu, M., Pool, R., Fanos, V. & Boomsma, D. I., 2016, In : American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171, 5, p. 719-732

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Metabolomics
Aggression
Psychiatry
Biomarkers
Diagnostic and Statistical Manual of Mental Disorders

Genetic and environmental influences interact with age and sex in shaping the human methylome

van Dongen, J., Nivard, M. G., Willemsen, G., Hottenga, J. J., Helmer, Q., Dolan, C. V., Ehli, E. A., Davies, G. E., van Iterson, M., Breeze, C. E., Beck, S., Pool, R., Suchiman, H. E. D., Jansen, R., van Meurs, J. B., Heijmans, B. T., Slagboom, P. E. & Boomsma, D. I., 2016, In : Nature Communications. 7, 11115, p. 1-13 11115.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
methylation
genome
Methylation
Genes
Genome

Genetic Relationship between Schizophrenia and Nicotine Dependence

Chen, J., Bacanu, S. A., Yu, H., Zhao, Z., Jia, P., Kendler, K. S., Kranzler, H. R., Gelernter, J., Farrer, L., Minica, C. C., Pool, R., Milaneschi, Y., Boomsma, D. I., Penninx, B. W. J. H., Tyndale, R. F., Ware, J. J., Vink, J. M., Kaprio, J., Munafò, M. & Chen, X., 2016, In : Scientific Reports. 6, 25671.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2

Ware, J. J., Chen, X., Vink, J. M., Loukola, A., Minica, C. C., Pool, R., Milaneschi, Y., Mangino, M., Menni, C., Chen, J., Peterson, R. E., Auro, K., Lyytikäinen, L. P., Wedenoja, J., Stiby, A. I., Hemani, G., Willemsen, G., Hottenga, J. J., Korhonen, T., Heliövaara, M. & 18 othersPerola, M., Rose, R. J., Paternoster, L., Timpson, N., Wassenaar, C. A., Zhu, A. Z. X., Davey Smith, G., Raitakari, O. T., Lehtimäki, T., Kähönen, M., Koskinen, S., Spector, T. D., Penninx, B. W. J. H., Salomaa, V., Boomsma, D. I., Tyndale, R. F., Kaprio, J. & Munafò, M., 2016, In : Scientific Reports. 6, 20092, 20092.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cotinine
Genome-Wide Association Study
Tobacco Products
Meta-Analysis
Nicotine

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Kettunen, J., Demirkan, A., Würtz, P., Draisma, H. H. M., Haller, T., Rawal, R., Vaarhorst, A. A. M., Kangas, A. J., Lyytikäinen, L. P., Pirinen, M., Pool, R., Sarin, A-P., Soininen, P., Tukiainen, T., Wang, Q., Tiainen, M., Tynkkynen, T., Amin, N., Zeller, T., Beekman, M. & 30 othersDeelen, J., Willems van Dijk, K., Esko, T., Hottenga, J. J., van Leeuwen, E. M., Lehtimäki, T., Mihailov, E., Rose, R. J., de Craen, A. J., Gieger, C., Kähönen, M., Perola, M., Blankenberg, S., Savolainen, M. J., Verhoeven, A., Viikari, J., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Eriksson, J., Jula, A., Järvelin, M. R., Kaprio, J., Metspalu, A., Raitakari, O., Salomaa, V., Slagboom, P. E., Waldenberger, M., Ripatti, S. & Ala-Korpela, M., 2016, In : Nature Communications. 7, 11122.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
lipoproteins
Lipoprotein(a)
genome
metabolites
Genome-Wide Association Study

GWIS: Genome-Wide Inferred Statistics for Functions of Multiple Phenotypes

Nieuwboer, H. A., Pool, R., Dolan, C. V., Boomsma, D. I. & Nivard, M. G., 2016, In : American Journal of Human Genetics. 99, 4, p. 917-927

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Genome-Wide Association Study
Genome
Phenotype
Bipolar Disorder
Schizophrenia

Obsessive–compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs

den Braber, A., Rodrigues Zilhao Nogueira, N., Fedko, I. O., Hottenga, J. J., Pool, R., Smit, D. J. A., Cath, D. C. & Boomsma, D. I., 2016, In : Translational Psychiatry. 6, e731

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

Ricano-Ponce, I., Zhernakova, D. V., Deelen, P., Luo, O., Li, X., Isaacs, A., Karjalainen, J., Di. Tommaso, J., Borek, Z. A., Zorro, M. M., Gutierrez-Achury, J., Uitterlinden, A. G., Hofman, A., van Meurs, J., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Neteaf, M. G., Jonkers, I. H. & 7 othersWithoff, S., van Duijn, C. M., Li, Y., Ruan, Y., Franke, L., Wijmenga, C. & Kumar, V., 2016, In : Journal of Autoimmunity. 68, p. 62-74

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes

Ligthart, S., Steenaard, R. V., Peters, M. J., van Meurs, J. B. J., Sijbrands, E. J. G., Uitterlinden, A. G., Bonder, M. J., Pool, R., Hofman, A., Franco, O. H. & Dehghan, A., 2016, In : Diabetologia. 59, 5, p. 998-1006

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
2015

Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes

Xu, T., Brandmaier, S., Messias, A. C., Herder, C., Draisma, H. H. M., Demirkan, A., Yu, Z., Ried, J. S., Haller, T., Heier, M., Campillos, M., Fobo, G., Stark, R., Holzapfel, C., Adam, J., Chi, S., Rotter, M., Panni, T., Quante, A. S., He, Y. & 28 othersPrehn, C., Roemisch-Margl, W., Kastenmüller, G., Willemsen, G., Pool, R., Kasa, K., Willems van Dijk, K., Hankemeier, T., Meisinger, C., Thorand, B., Ruepp, A., Hrabé de Angelis, M., Li, Y., Wichmann, H-E., Stratmann, B., Strauch, K., Metspalu, A., Gieger, C., Suhre, K., Adamski, J., Illig, T., Rathmann, W., Roden, M., Peters, A., van Duijn, C. M., Boomsma, D. I., Meitinger, T. & Wang-Sattler, R., 2015, In : Diabetes Care. 38, 10, p. 1858-1867 10 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Metformin
LDL Cholesterol
Type 2 Diabetes Mellitus
AMP-Activated Protein Kinases
Phosphatidylcholines

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Draisma, H. H. M., Pool, R., Kobl, M., Jansen, R., Petersen, A. K., Vaarhorst, A. A. M., Yet, I., Haller, T., Demirkan, A., Esko, T., Zhu, G., Böhringer, S., Beekman, M., van Klinken, J. B., Römisch-Margl, W., Prehn, C., Adamski, J., de Craen, A. J., van Leeuwen, E. M., Amin, N. & 28 othersDharuri, H., Westra, H. J., Franke, L., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Henders, A. K., Montgomery, G. W., Nyholt, DR., Whitfield, J. B., Penninx, B. W. J. H., Spector, T. D., Metspalu, A., Slagboom, P. E., Willems van Dijk, K., 't Hoen, P. A. C., Strauch, K., Martin, N. G., van Ommen, G. J. B., Illig, T., Bell, J. T., Mangino, M., Suhre, K., McCarthy, M. I., Gieger, C., Isaacs, A., van Duijn, C. M. & Boomsma, D. I., 2015, In : Nature Communications. 6, p. 7208 9 p., 7208.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
genome
metabolites
Genome-Wide Association Study
Metabolites
blood

Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset

Minica, C. C., Dolan, C. V., Hottenga, J. J., Pool, R., Fedko, I. O., Mbarek, H., Huppertz, C., Bartels, M., Boomsma, D. I. & Vink, J. M., 2015, In : Behavior Genetics. 45, 5, p. 503-513 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Cannabis
heritability
Age of Onset
single nucleotide polymorphism
Single Nucleotide Polymorphism

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

Shah, S., Bonder, M. J., Marioni, R. E., Zhu, Z., McRae, A. F., Zhernakova, A., Harris, S. E., Liewald, D. C. M., Henders, A. K., Mendelson, M. M., Liu, C., Joehanes, R., Liang, L., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Levy, D., Martin, N. G., Starr, J. M. & 7 othersWijmenga, C., Wray, N. R., Yang, J., Montgomery, G. W., Franke, L., Deary, I. J. & Visscher, P. M., 2015, In : American Journal of Human Genetics. 97, 1, p. 75-85 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Epigenomics
Body Mass Index
Methylation
Genome-Wide Association Study
DNA Methylation

Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait

Franic, S., Blokhuis, M. M., Dolan, C. V., Kattenberg, V. M., Pool, R., Xiao, X., Scheet, P., Ehli, E. A., Davies, G. E., van der Sluis, S., Abdellaoui, A., Hansell, N. K., Martin, N. G., Hudziak, J. J., van Beijsterveldt, C. E. M., Swagerman, S. C., Hulshoff Pol, H. E., de Geus, E. J. C., Bartels, M., Ropers, H-H. & 2 othersHottenga, J. J. & Boomsma, D. I., 2015, In : European Journal of Human Genetics. 23, 10, p. 1378-1383 6 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Multifactorial Inheritance
Intelligence
Genes
Medical Genetics
Single Nucleotide Polymorphism

Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence

Franic, S., Dolan, C. V., Broxholme, J., Hu, H., Zemojtel, T., Davies, G. E., Nelson, K. A., Ehli, E. A., Pool, R., Hottenga, J. J., Ropers, H-H. & Boomsma, D. I., 2015, In : Intelligence. 49, p. 10-22 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Multifactorial Inheritance
Intelligence
Intellectual Disability
Reference Values
Genes
2014

Coarse-grained versus atomistic simulations: realistic interaction free energies for real proteins

May, A., Pool, R., van Dijk, E., Bijlard, J., Abeln, S., Heringa, J. & Feenstra, K. A., 1 Feb 2014, In : Bioinformatics. 30, 3, p. 326-34 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Atomistic Simulation
Free energy
Free Energy
Energy barriers
Proteins

Towards automated binding affinity prediction using an iterative linear interaction energy approach

Vosmeer, C. R., Pool, R., van Stee, M. F., Peric-Hassler, L., Vermeulen, N. P. E. & Geerke, D. P., 2014, In : International Journal of Molecular Sciences. 15, 1, p. 798-816 19 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
affinity
Ligands
proteins
Proteins
Protein Conformation
2013

Charge group partitioning in biomolecular simulation

Canzar, S., El-Kebir, M., Pool, R., Elbassioni, K., Malde, A. K., Mark, A. E., Geerke, D. P., Stougie, L. & Klau, G. W., 2013, In : Journal of Computational Biology. 20, 3, p. 188-198

Research output: Contribution to JournalArticleAcademicpeer-review

Hardness
Partitioning
Charge
Force Field
Molecules

Familial Resemblance for Serum Metabolite Concentrations

Draisma, H. H. M., Beekman, M., Pool, R., van Ommen, G. J. B., Vaarhorst, A. A. M., de Craen, A. J., Willemsen, G., Slagboom, P. E. & Boomsma, D. I., 2013, In : Twin Research and Human Genetics. 16, 05, p. 948-961

Research output: Contribution to JournalArticleAcademicpeer-review

Monozygotic Twins
Metabolomics
Serum
Spouses
Netherlands

The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection

Willemsen, G., Vink, J. M., Abdellaoui, A., den Braber, A., van Beek, J. H. D. A., Draisma, H. H. M., van Dongen, J., van t Ent, D., Geels, L. M., van Lien, R., Ligthart, R. S. L., Kattenberg, V. M., Mbarek, H., de Moor, M. H. M., Neijts, M., Pool, R., Stroo, N., Kluft, C., Suchiman, H. E. D., Slagboom, P. E. & 2 othersde Geus, E. J. C. & Boomsma, D. I., 2013, In : Twin Research and Human Genetics. 16, 1, p. 271-281

Research output: Contribution to JournalArticleAcademicpeer-review

Netherlands
Life Style
RNA Sequence Analysis
Gene-Environment Interaction
Metabolomics
2012

Enabling grand-canonical Monte Carlo: extending the flexibility of GROMACS through the GromPy python interface module

Pool, R., Heringa, J., Hoefling, M., Schulz, R., Smith, J. C. & Feenstra, K. A., 5 May 2012, In : Journal of Computational Chemistry. 33, 12, p. 1207-14 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Python
Canonical Ensemble
Molecular dynamics
Flexibility
Module
2010

Independent position correction on tumor and lymph nodes; consequences for bladder cancer irradiation with two combined IMRT plans

van Rooijen, D. C., Pool, R., van de Kamer, J. B., Hulshof, M. C. C. M., Koning, C. C. E. & Bel, A., 2010, In : Radiation Oncology. 5, p. 53 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File

The Influence of Micelle Formation on the Stability of Colloid Surfactant Mixtures

Pool, R. & Bolhuis, P. G., 2010, In : Physical Chemistry Chemical Physics - PCCP. 12, 44, p. 14789-14797 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

colloids
micelles
surfactants
surface reactions
stabilization
2009

Accelerated ray tracing for radiotherapy dose calculations on a GPU

de Greef, M., Crezee, J., van Eijk, J., Pool, R. & Bel, A., 2009, In : Medical Physics. 36, 9, p. 4095-4102 13 p.

Research output: Contribution to JournalArticleAcademicpeer-review

The effect of on-line position correction on the dose distribution in focal radiotherapy for bladder cancer

van Rooijen, D. C., van de Kamer, J. B., Pool, R., Hulshof, M. C. C. M., Koning, C. C. E. & Bel, A., 2009, In : Radiation Oncology. 4, p. 38 8 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File