If you made any changes in Pure these will be visible here soon.

Personal profile

Research

To process information the brain is constantly changing the strength of the individual contacts (synapses) between nerve cells. Strict control of this synaptic plasticity is important, as dysregulation is often associated with neurological and psychiatric disorders.

The main goal of my lab is to advance our understanding of the mechanisms that support synaptic plasticity and their dysfunction in disorders such as Alzheimer’s, epilepsy, schizophrenia and autism to eventually be able to provide novel therapeutic targets.

We study:

Presynaptic mechanisms of synaptic plasticity

Both pre- and postsynaptic mechanisms contribute to changes in synaptic strength. We focus on presynaptic mechanisms by studying the function of key proteins of the synaptic vesicle fusion machinery, their interactors and downstream effectors in wildtype and disease model systems. One important goal is to understand the role of posttranslational modifications (phosphorylation, Ubi/SUMOylation) of presynaptic proteins in the dynamics of synaptic transmission.

Secretory vesicle dynamics and release

In addition to synaptic vesicles, neurons contain vesicles that store and release many different types of neuromodulatory cargo (neuropeptides and Neurotrophins o.a.). We study the molecular mechanisms that transport and recruit these vesicles to the plasma membrane, their calcium dependent fusion and the effect of secreted cargo on synaptic plasticity.

Teaching

I am coordinator of the Fundamental Neurocience track in the second year of the Research Master Neurosc ience.

I coordinate the Minor Biomolecular and Neurosciences track Neuroscience, and the Master courses Live Cell Imaging and Developmental Neuroscience.

I am a member of the Master of Neurocience education committee and the ONWAR PhD teaching committee 

Ancillary activities

No ancillary activities

Ancillary activities are updated daily

Education/Academic qualification

Neuroscience, PhD, Utrecht University

Keywords

  • synapse
  • brain function
  • secretory vesicles
  • synaptic plasticity
  • neuropeptides
  • neuronal cilia

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 20 Similar Profiles
SNARE Proteins Medicine & Life Sciences
Secretory Vesicles Medicine & Life Sciences
Neurons Medicine & Life Sciences
Synaptic Vesicles Medicine & Life Sciences
Synapses Medicine & Life Sciences
Synaptic Transmission Medicine & Life Sciences
Munc18 Proteins Medicine & Life Sciences
Exocytosis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2003 2019

  • 52 Article
  • 12 PhD Thesis - Research VU, graduation VU

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

Meijer, M., Rehbach, K., Brunner, J. W., Classen, J. A., Lammertse, H. C. A., van Linge, L. A., Schut, D., Krutenko, T., Hebisch, M., Cornelisse, L. N., Sullivan, P. F., Peitz, M., Toonen, R. F., Brüstle, O. & Verhage, M., 14 May 2019, In : Cell Reports. 27, 7, p. 2199-2211.e6

Research output: Contribution to JournalArticleAcademicpeer-review

Neuronal Plasticity
Synaptic Transmission
Neurons
Plasticity
Synapses

Fbxo41 Promotes Disassembly of Neuronal Primary Cilia

King, C. R., Ana, A. R., Chazeau, A., Saarloos, I., van der Graaf, A. J., Verhage, M. & Toonen, R. F., 1 Dec 2019, In : Scientific Reports. 9, 1, 8179.

Research output: Contribution to JournalArticleAcademicpeer-review

Cilia
Centrioles
Aurora Kinase A
Centrosome
Ubiquitin-Protein Ligases

Molecular mechanisms of dense core vesicle exocytosis in mature and developing mouse neurons

van Keimpema, L., 2019, 156 p.

Research output: PhD ThesisPhD Thesis - Research VU, graduation VUAcademic

Open Access
File

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

Verweij, F. J., Bebelman, M. P., Jimenez, C. R., Garcia-Vallejo, J. J., Janssen, H., Neefjes, J., Knol, J. C., de Goeij-de Haas, R., Piersma, S. R., Baglio, S. R., Verhage, M., Middeldorp, J. M., Zomer, A., van Rheenen, J., Coppolino, M. G., Hurbain, I., Raposo, G., Smit, M. J., Toonen, R. F. G., van Niel, G. & 1 othersPegtel, D. M., 23 Jan 2018, In : Journal of Cell Biology.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access

Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B

Dominguez, N., van Weering, J. R. T., Borges, R., Toonen, R. F. G. & Verhage, M., Feb 2018, In : Journal of Neurochemistry. 144, 3, p. 241-254 14 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Chromogranin B
Chromogranin A
Exocytosis
Secretory Vesicles
Neurons