• De Boelelaan 1085, kamernummer B431, W&N

    1081HV Amsterdam

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Fingerprint Dive into the research topics where Rik van der Kant is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Endosomes Medicine & Life Sciences
Cholesterol Medicine & Life Sciences
Dyneins Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Proteins Medicine & Life Sciences
Mutation Medicine & Life Sciences
Neuronal Ceroid-Lipofuscinoses Medicine & Life Sciences
Exosomes Medicine & Life Sciences

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Research Output 2009 2019

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., Ovaa, H., Giera, M., Wagner, S. L., Bang, A. G. & Goldstein, L. S. B., 7 Mar 2019, In : Cell Stem Cell. 24, 3, p. 363-375.e9

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Induced Pluripotent Stem Cells
Cholesterol Esters
Alzheimer Disease

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations

Woodruff, G., Reyna, S. M., Dunlap, M., Van Der Kant, R., Callender, J. A., Young, J. E., Roberts, E. A. & Goldstein, L. S. B., 11 Oct 2016, In : Cell Reports. 17, 3, p. 759-773 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Alzheimer Disease

Cellular functions of the amyloid precursor protein from development to dementia

van der Kant, R. & Goldstein, L. S. B., 23 Feb 2015, In : Dev Cell. 32, 4, p. 502-15 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Amyloid beta-Protein Precursor
Alzheimer Disease
Serum Amyloid A Protein
Gene Duplication

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity

van der Kant, R., Jonker, C. T. H., Wijdeven, R. H., Bakker, J., Janssen, L., Klumperman, J. & Neefjes, J., 18 Dec 2015, In : Journal of Biological Chemistry. 290, 51, p. 30280-90 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Fusion reactions
rab GTP-Binding Proteins

GPR43 Potentiates β-Cell Function in Obesity

McNelis, J. C., Lee, Y. S., Mayoral, R., van der Kant, R., Johnson, A. M. F., Wollam, J. & Olefsky, J. M., Sep 2015, In : Diabetes. 64, 9, p. 3203-17 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

High Fat Diet
Volatile Fatty Acids
Knockout Mice