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Research

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Endosomes Medicine & Life Sciences
Cholesterol Medicine & Life Sciences
Dyneins Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Proteins Medicine & Life Sciences
Mutation Medicine & Life Sciences
Neuronal Ceroid-Lipofuscinoses Medicine & Life Sciences
Exosomes Medicine & Life Sciences

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Research Output 2009 2019

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., Ovaa, H., Giera, M., Wagner, S. L., Bang, A. G. & Goldstein, L. S. B., 7 Mar 2019, In : Cell Stem Cell. 24, 3, p. 363-375.e9

Research output: Contribution to JournalArticleAcademicpeer-review

Induced Pluripotent Stem Cells
Cholesterol Esters
Amyloid
Alzheimer Disease
Cholesterol

Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations

Woodruff, G., Reyna, S. M., Dunlap, M., Van Der Kant, R., Callender, J. A., Young, J. E., Roberts, E. A. & Goldstein, L. S. B., 11 Oct 2016, In : Cell Reports. 17, 3, p. 759-773 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Transcytosis
Lipoproteins
Neurons
Alzheimer Disease
Endocytosis

Cellular functions of the amyloid precursor protein from development to dementia

van der Kant, R. & Goldstein, L. S. B., 23 Feb 2015, In : Dev Cell. 32, 4, p. 502-15 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Amyloid beta-Protein Precursor
Dementia
Alzheimer Disease
Gene Duplication
Amyloid Plaques

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity

van der Kant, R., Jonker, C. T. H., Wijdeven, R. H., Bakker, J., Janssen, L., Klumperman, J. & Neefjes, J., 18 Dec 2015, In : Journal of Biological Chemistry. 290, 51, p. 30280-90 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Endosomes
Yeast
Yeasts
Fusion reactions
rab GTP-Binding Proteins

GPR43 Potentiates β-Cell Function in Obesity

McNelis, J. C., Lee, Y. S., Mayoral, R., van der Kant, R., Johnson, A. M. F., Wollam, J. & Olefsky, J. M., Sep 2015, In : Diabetes. 64, 9, p. 3203-17 15 p.

Research output: Contribution to JournalArticleAcademicpeer-review

High Fat Diet
Volatile Fatty Acids
Obesity
Knockout Mice
Insulin