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Personal profile

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Personal information

I obtained my double-doctorate on muscle physiology in 2009 from the Manchester Metropolitan University and the VU University Amsterdam, in which I studied why smokers are more prone to fatigue. From 2009-2012, I worked at the University of Leeds (UK) on the control of mitochondrial respiration during exercise. After returning to the Netherlands, I worked on various projects related to cardiac metabolism and mitochondrial function at the Amsterdam UMC, locations VUmc and AMC. Since 2019, I am assistant-professor at the department of Human Movement Sciences of the VU University. I am involved in teaching and research in the areas of clinical exercise physiology, cellular physiology and mitochondrial function. Recently, I am involved in a large ESA/NASA-funded bedrest-study where the effects of microgravity are studied on the cellular and molecular level. I received different grants from The Physiological Society, Dutch Heart foundation, Amsterdam Cardiovascular Research and Amsterdam Movement Sciences.

Research

General interests

My main research interest lies in the regulation of cardiac and skeletal muscle metabolism and mitochondrial function. I am interested in the fundamental aspects of mitochondrial bio-energetics as well as its consequence for whole cell and organ function. To study this, I use research methods ranging from imaging and spectroscopy, fluorescence microscopy and cellular and molecular techniques.

 

Achievements

I have contributed to the understanding of how the skeletal muscle cell is able to adapt mitochondrial ATP production to demand. For this, I investigate muscle oxygen uptake under various conditions. Because of the link between mitochondrial dysfunction and exercise intolerance, and cardiac dysfunction, I have contributed to further understanding the consequences of mitochondrial dysfunction to functional outcomes in different conditions and chronic diseases. Some examples include the understanding of fatigue in current smokers and COPD patients, metabolic dysfunction in patients with right ventricular heart failure and cardiac dysfunction in patients with diabetes.

Besides, I have contributed to the development of various methodologies to assess metabolic and mitochondrial pathways from the whole-body level (including magnetic resonance imaging), via mitochondrial respirometry down to the molecular level (including live cell imaging).

Because of my time abroad, I have gathered a large network of collaborating scientists across the planet, including Japan, USA, Canada, Sweden, UK, Italy, Germany and Switzerland. This can provide ample opportunities for students to find internships abroad.

 

Current Research

My current research involves different projects in the area of 1) Muscle atrophy and metabolic alterations after inactivity (in collaboration with ESA/NASA), 2) Exercise capacity in various patient populations, 3) Development of new techniques assessing fundamental mitochondrial function in skeletal and cardiac muscle, and 4) Effects of inflammation on cardiac and skeletal muscle function.

Teaching

Currently, I am teaching in the following courses:

Exercise and Clinical Immunology (Research Master Human Movement Sciences)

Training and Exercise Physiology

Hormones and Homeostasis (Amsterdam University College)

 

Besides, I supervise students during their internships and literature review projects.

Keywords

  • QP Physiology
  • mitochondria
  • bioenergetics
  • muscle
  • metabolism
  • cardiac
  • Exercise Physiology
  • Exercise Endocrinology
  • hormones

Fingerprint Dive into the research topics where Rob Wust is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Skeletal Muscle Medicine & Life Sciences
Muscles Medicine & Life Sciences
Muscle Fatigue Medicine & Life Sciences
Succinate Dehydrogenase Medicine & Life Sciences
Exercise Medicine & Life Sciences
Fatigue Medicine & Life Sciences
Mitochondrial Diseases Medicine & Life Sciences
Myocardium Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2018

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5

Research output: Contribution to JournalArticleAcademicpeer-review

Pentoses
Pentose Phosphate Pathway
Macrophages
Hypercholesterolemia
Metabolism

Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle

Knottnerus, S. J. G., Bleeker, J. C., Wüst, R. C. I., Ferdinandusse, S., IJlst, L., Wijburg, F. A., Wanders, R. J. A., Visser, G. & Houtkooper, R. H., 1 Mar 2018, In : Reviews in Endocrine and Metabolic Disorders. 19, 1, p. 93-106 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Mitochondrial Diseases
Carnitine
Fatty Acids
Fasting
Exercise

Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle

Knottnerus, S. J. G., Bleeker, J. C., Wüst, R. C. I., Ferdinandusse, S., IJlst, L., Wijburg, F. A., Wanders, R. J. A., Visser, G. & Houtkooper, R. H., Mar 2018, In : Reviews in endocrine & metabolic disorders. 19, 1, p. 93-106 14 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Mitochondrial Diseases
Carnitine
Fatty Acids
Fasting
Exercise

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I. & Houtkooper, R. H., 1 Aug 2018, In : Endocrine Reviews. 39, 4, p. 489-517 29 p.

Research output: Contribution to JournalReview articleAcademicpeer-review

Open Access
Caloric Restriction
Aptitude
Health
Health Expenditures
Metabolic Networks and Pathways

Successive contractile periods activate mitochondria at the onset of contractions in intact rat cardiac trabeculae

Wüst, R. C. I. & Stienen, G. J. M., 1 Apr 2018, In : Journal of Applied Physiology. 124, 4, p. 1003-1011 9 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Oxidative Phosphorylation
Pyruvic Acid
Mitochondria
Flavin-Adenine Dinucleotide
NAD