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Research Output 2008 2016

  • 21 Article
  • 1 Chapter
  • 1 PhD Thesis - Research VU, graduation VU
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Article
2016

7TM Domain structure of adhesion GPCRs.

Nijmeijer, S., Wolf, S., Ernst, O. P. & de Graaf, C., 2016, In : Handbook of Experimental Pharmacology. 234, p. 43-55

Research output: Contribution to JournalArticleAcademicpeer-review

Adhesion CPCRs in immunology

Nijmeijer, S., Vischer, H. F. & Leurs, R., 2016, In : Biochemical Pharmacology. 114, p. 88-102

Research output: Contribution to JournalArticleAcademicpeer-review

Immunology
Allergy and Immunology
Leukocytes
Adhesion
Membranes

Classification, nomenclature, and structural aspects of adhesion GPCRs.

Krishnan, A., Nijmeijer, S., de Graaf, C. & Schioth, H. B., 2016, In : Handbook of Experimental Pharmacology. 234, p. 15-41

Research output: Contribution to JournalArticleAcademicpeer-review

2015

Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms

Monk, K. R., Hamann, J., Langenhan, T., Nijmeijer, S., Schoneberg, T. & Liebscher, I., 2015, In : Molecular Pharmacology. 88, 3, p. 617-623

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Pharmacology
Signal Transduction
Ligands
In Vitro Techniques
2013

Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode

Engelhardt, H., Schultes, S., de Graaf, C., Nijmeijer, S., Vischer, H. F., Zuiderveld, O. B., Dobler, J., Stachurski, K., Mayer, M., Arnhof, H., Scharn, D., Haaksma, E. J. J., de Esch, I. J. P. & Leurs, R., 2013, In : Journal of Medicinal Chemistry. 2013, 56, p. 4264-4276

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Structure-Activity Relationship
Histamine
Ligands

Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 of the human histamine H4 receptor

Nijmeijer, S., Engelhardt, H., Schultes, S., van de Stolpe, A., Lusink, V., de Graaf, C., Wijtmans, M., Haaksma, E. E., de Esch, I. J. P., Stachurski, K., Vischer, H. F. & Leurs, R., 2013, In : British Journal of Pharmacology. 2013, 170, p. 89-100

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine
Cysteine
Pharmacology
human HRH4 protein
4-(4-methylpiperazin-1-yl)-6-phenyl-2-vinylpyrimidine

Detailed analysis of biased histamine H4 receptor signalling by JNJ 7777120 analogues

Nijmeijer, S., Vischer, H. F., Sirci, F., Schultes, S., Engelhardt, H., de Graaf, C., Rosethorne, E., Charlton, S. & Leurs, R., 2013, In : British Journal of Pharmacology. 2013, 170, p. 78-88

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Histamine
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine

Small and colorful stones make beautiful mosaics: Fragment-Based Chemogenomics

de Graaf, C., Vischer, H. F., de Kloe, G. E., Kooistra, A. J., Nijmeijer, S., Kuijer, M., Verheij, M. H. P., England, P., van Muijlwijk-Koezen, J. E., Leurs, R. & de Esch, I. J. P., 2013, In : Drug Discovery Today. 2013, 18, p. 323-330

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Protein Binding
Color
Binding Sites
Proteins
2012

Analysis of Multiple Histamine H4 Receptor Compound Classes Uncovers Gαi Protein- and β-Arrestin2-Biased Ligands

Nijmeijer, S., Vischer, H. F., Rosethorne, E. M., Charlton, S. J. & Leurs, R., 2012, In : Molecular Pharmacology. 82, 6, p. 1174-1182

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Histamine
Ligands
Proteins

Biochemical and pharmacological characterization of the histamine H4 receptor

Nijmeijer, S., de Graaf, C., Leurs, R. & Vischer, H. F., 2012, In : Frontiers in Bioscience. 17, p. 2089-2106

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Histamine
Pharmacology

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling.

Nijmeijer, S., Vischer, H. F., Rudebeck, A. F., Fleurbaaij, F., Falck, D., Leurs, R., Niessen, W. M. A. & Kool, J., 2012, In : Journal of Biomolecular Screening. 17, p. 1329-1338

Research output: Contribution to JournalArticleAcademicpeer-review

Chromatography
Reporter Genes
Mass spectrometry
Assays
Mass Spectrometry

High-resolution metabolic profiling towards G-protein coupled receptors: rapid and comprehensive screening of histamine H4 receptor ligands

Kool, J., Rudebeck, A. F., Fleurbaaij, F., Nijmeijer, S., Falck, D., Smits, R. A., Vischer, H. F., Leurs, R. & Niessen, W. M. A., 2012, In : Journal of Chromatography A. 1259, p. 213-220

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Bioassay
G-Protein-Coupled Receptors
Biological Assay
Histamine

Optimizing virtual fragment screening for GPCRs: Identification of novel ligands for the histamine H3 receptor using ligand- and structure-based molecular fingerprints

Sirci, F., Istyastono, E. P., Vischer, H. F., Nijmeijer, S., Kuijer, M., Kooistra, A. J., Wijtmans, M., Mannhold, R., Leurs, R., de Esch, I. J. P. & de Graaf, C., 2012, In : Journal of Chemical Information and Modeling. 52, p. 3308-3324

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine H3 Receptors
Screening
Ligands
Molecules
drug
2011

fragment library screening reveals remarkable similarities between histamine H4 receptors and serotonin 5-HT3 receptors

Verheij, M. H. P., de Graaf, C., de Kloe, G. E., Nijmeijer, S., Vischer, H. F., Smits, R. A., Zuiderveld, O. P., Thompson, A. J., van Muijlwijk- Koezen, J. E., Lummis, S. C. R., Leurs, R. & De Esch, I. J., 2011, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
Receptors, Serotonin, 5-HT3
Histamine Receptors
GTP-Binding Proteins
Histamine
Screening

G-protein-coupled receptors: walking hand-in-hand, talking hand-in-hand?

Vischer, H. F., Watts, A. O., Nijmeijer, S. & Leurs, R., 2011, In : British Journal of Pharmacology. p. 163-246

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Walking
Pharmacology
Ligands
Protein Subunits

Molecular determinants of ligand binding modes in the histamine H4 receptor: Linking ligand-based 3D-QSAR models to in silico guided receptor mutagenesis studies

Istyastono, E. P., Nijmeijer, S., Lim, H. D., van de Stolpe, A., Roumen, L., Kooistra, A. J., Vischer, H. F., de Esch, I. J. P., Leurs, R. & de Graaf, C., 2011, In : Journal of Medicinal Chemistry. 54, p. 8136-8147 11 p.

Research output: Contribution to JournalArticleAcademicpeer-review

Histamine Receptors
Quantitative Structure-Activity Relationship
Mutagenesis
Computer Simulation
Histamine
2010

A structural insight into the reorientation of transmembrane domains 3 and 5 during family A GPCR activation

Sansuk, K., Deupi, X., Torrecillas, I., Jongejan, A., Nijmeijer, S., Bakker, R. A., Pardo, L. & Leurs, R., 2010, In : Molecular Pharmacology.

Research output: Contribution to JournalArticleAcademicpeer-review

G-Protein-Coupled Receptors
Mutagenesis
Histamine

Constitutive activity of the histamine H(1) receptor.

Nijmeijer, S., Leurs, R. & Vischer, H. F., 2010, In : Methods in Enzymology. 484, p. 127-147

Research output: Contribution to JournalArticleAcademicpeer-review

Open Access
File
G-Protein-Coupled Receptors
Human Herpesvirus 4
Viruses
Proteins
Bioluminescence
2009

Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28

Richter, R., Casarosa, P., Standker, L., Munch, J., Springael, J. Y., Nijmeijer, S., Forssmann, W. G., Vischer, H. F., Vakili, J., Detheux, M., Parmentier, M., Leurs, R. & Smit, M. J., 2009, In : Journal of Immunology. 183, 2, p. 1229-37

Research output: Contribution to JournalArticleAcademicpeer-review

2008

Viral hijacking of human receptors through heterodimerization

Vischer, H. F., Nijmeijer, S., Smit, M. J. & Leurs, R., 2008, In : Biochemical and Biophysical Research Communications. 377, 1, p. 93-7

Research output: Contribution to JournalArticleAcademicpeer-review